Understanding the interactions of imidazolium-based ionic liquids with cell membrane models

Understanding the role of biomolecules in cells at the molecular level has been the trade of Prof. Marcio Francisco Colombo and Prof. Jo�o Ruggiero Neto in their carriers, which is why it was found appropriate to address the use of Langmuir monolayers as cell membrane models in this special issue. In the review paper, we elaborate upon the reasons why Langmuir monolayers are good models with the possible control of membrane composition and molecular packing. After describing several experimental methods to characterize the Langmuir monolayers, we discuss selected results from the last five years where monolayers were made to interact with pharmaceutical drugs, emerging pollutants and other biologically-relevant molecules. The challenges to take the field forward are also commented upon.

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Surface chemistry and spectroscopy studies on 1,4-naphthoquinone in cell membrane models using Langmuir monolayers

Journal of Colloid and Interface Science ◽

10.1016/j.jcis.2013.04.005 ◽

2013 ◽

Vol 402 ◽

pp. 300-306 ◽

Cited By ~ 17

Author(s):

Nadia Hussein ◽

Carla C. Lopes ◽

Paulo Castanho A. Pernambuco Filho ◽

Bruna R. Carneiro ◽

Luciano Caseli

Keyword(s):

Cell Membrane ◽

Surface Chemistry ◽

Langmuir Monolayers ◽

Membrane Models ◽

Spectroscopy Studies

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Effect of Aminated Chitosan-Coated Fe3O4 Nanoparticles with Applicational Potential in Nanomedicine on DPPG, DSPC, and POPC Langmuir Monolayers as Cell Membrane Models

International Journal of Molecular Sciences ◽

10.3390/ijms22052467 ◽

2021 ◽

Vol 22 (5) ◽

pp. 2467

Author(s):

Emilia Piosik ◽

Marta Ziegler-Borowska ◽

Dorota Chełminiak-Dudkiewicz ◽

Tomasz Martyński

Keyword(s):

Cell Membrane ◽

Adsorption Process ◽

Langmuir Monolayers ◽

Film Stability ◽

Alkyl Chains ◽

Head Groups ◽

Nanoparticle Interactions ◽

Application Potential ◽

Membrane Models ◽

Positively Charged

An adsorption process of magnetite nanoparticles functionalized with aminated chitosan (Fe3O4-AChit) showing application potential in nanomedicine into cell membrane models was studied. The cell membrane models were formed using a Langmuir technique from three selected phospholipids with different polar head-groups as well as length and carbon saturation of alkyl chains. The research presented in this work reveals the existence of membrane model composition-dependent regulation of phospholipid-nanoparticle interactions. The influence of the positively charged Fe3O4-AChit nanoparticles on a Langmuir film stability, phase state, and textures is much greater in the case of these formed by negatively charged 1,2-dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) (DPPG) than those created by zwitterionic 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and 2-oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine (POPC). The adsorption kinetics recorded during penetration experiments show that this effect is caused by the strongest adsorption of the investigated nanoparticles into the DPPG monolayer driven very likely by the electrostatic attraction. The differences in the adsorption strength of the Fe3O4-AChit nanoparticles into the Langmuir films formed by the phosphatidylcholines were also observed. The nanoparticles adsorbed more easily into more loosely packed POPC monolayer.

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Molecular simulations of glycolipids: Towards mammalian cell membrane models

Biochimie ◽

10.1016/j.biochi.2015.09.033 ◽

2016 ◽

Vol 120 ◽

pp. 105-109 ◽

Cited By ~ 18

Author(s):

David Shorthouse ◽

George Hedger ◽

Heidi Koldsø ◽

Mark S.P. Sansom

Keyword(s):

Cell Membrane ◽

Mammalian Cell ◽

Molecular Simulations ◽

Membrane Models

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Probing the interaction of oppositely charged gold nanoparticles with DPPG and DPPC Langmuir monolayers as cell membrane models

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2013.02.014 ◽

2013 ◽

Vol 108 ◽

pp. 120-126 ◽

Cited By ~ 44

Author(s):

Adriano A. Torrano ◽

Ângela S. Pereira ◽

Osvaldo N. Oliveira ◽

Ana Barros-Timmons

Keyword(s):

Gold Nanoparticles ◽

Cell Membrane ◽

Langmuir Monolayers ◽

Membrane Models ◽

Oppositely Charged

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Interactions of bioactive molecules & nanomaterials with Langmuir monolayers as cell membrane models

Thin Solid Films ◽

10.1016/j.tsf.2015.09.047 ◽

2015 ◽

Vol 593 ◽

pp. 158-188 ◽

Cited By ~ 63

Author(s):

Thatyane M. Nobre ◽

Felippe J. Pavinatto ◽

Luciano Caseli ◽

Ana Barros-Timmons ◽

Patrycja Dynarowicz-Łątka ◽

...

Keyword(s):

Cell Membrane ◽

Langmuir Monolayers ◽

Bioactive Molecules ◽

Membrane Models

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Comparative study of liponucleosides in Langmuir monolayers as cell membrane models

Biophysical Chemistry ◽

10.1016/j.bpc.2010.10.010 ◽

2011 ◽

Vol 153 (2-3) ◽

pp. 154-158 ◽

Cited By ~ 10

Author(s):

E.A. Montanha ◽

L. Caseli ◽

O. Kaczmarek ◽

J. Liebscher ◽

D. Huster ◽

...

Keyword(s):

Cell Membrane ◽

Comparative Study ◽

Langmuir Monolayers ◽

Membrane Models

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Formation of Giant Lipid Vesicles in the Presence of Nonelectrolytes—Glucose, Sucrose, Sorbitol and Ethanol

Processes ◽

10.3390/pr9060945 ◽

2021 ◽

Vol 9 (6) ◽

pp. 945

Author(s):

Qiong Wang ◽

Ning Hu ◽

Jincan Lei ◽

Qiurong Qing ◽

Jing Huang ◽

...

Keyword(s):

Sodium Chloride ◽

Cell Membrane ◽

Lipid Membranes ◽

Volume Fraction ◽

Hydrodynamic Force ◽

Lipid Vesicles ◽

Ethanol Solution ◽

Sugar Solution ◽

Ethanol Content ◽

Membrane Models

Lipid vesicles, especially giant lipid vesicles (GLVs), are usually adopted as cell membrane models and their preparation has been widely studied. However, the effects of some nonelectrolytes on GLV formation have not been specifically studied so far. In this paper, the effects of the nonelectrolytes, including sucrose, glucose, sorbitol and ethanol, and their coexistence with sodium chloride, on the lipid hydration and GLV formation were investigated. With the hydration method, it was found that the sucrose, glucose and sorbitol showed almost the same effect. Their presence in the medium enhanced the hydrodynamic force on the lipid membranes, promoting the GLV formation. GLV formation was also promoted by the presence of ethanol with ethanol volume fraction in the range of 0 to 20 percent, but higher ethanol content resulted in failure of GLV formation. However, the participation of sodium chloride in sugar solution and ethanol solution stabilized the lipid membranes, suppressing the GLV formation. In addition, the ethanol and the sodium chloride showed the completely opposite effects on lipid hydration. These results could provide some suggestions for the efficient preparation of GLVs.

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