Long-term effects of lysine concentration on growth performance, intestinal microbiome, and metabolic profiles in a pig model

2018 ◽  
Vol 9 (8) ◽  
pp. 4153-4163 ◽  
Author(s):  
Jie Yin ◽  
Yuying Li ◽  
Hui Han ◽  
Zhaojin Liu ◽  
Xiangfang Zeng ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Amino Acid ◽  
Growth Performance ◽  
Pig Model ◽  
Intestinal Microbiome ◽  
Metabolic Profiles ◽  
Long Term Effects ◽  
Lysine Concentration ◽  
Limiting Amino Acid

Lysine is a common limiting amino acid in human and animal diets and plays an important role in cell proliferation and metabolism.

Long-term Effects of Feeding a Novel Phytoadditive on Nutrient Utilization, Growth Performance, Metabolic Profile and Antioxidant Status of Goats

2017 ◽  
Vol 6 (1) ◽  
pp. 82-90
Author(s):  
Santosh L. Ingale ◽  
Ashok K. Pattanaik ◽  
Shalini Baliyan ◽  
Sarita Kankoriya ◽  
Narayan Dutta ◽  
...  
Keyword(s):  
Growth Performance ◽  
Metabolic Profile ◽  
Antioxidant Status ◽  
Nutrient Utilization ◽  
Long Term Effects

Effects of ornithine α-ketoglutarate on growth performance and gut microbiota in a chronic oxidative stress pig model induced by d-galactose

2020 ◽  
Vol 11 (1) ◽  
pp. 472-482 ◽  
Author(s):  
Yuying Li ◽  
Peng Wang ◽  
Jie Yin ◽  
Shunshun Jin ◽  
Wenxuan Su ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Amino Acid ◽  
Gut Microbiota ◽  
Growth Performance ◽  
Growth Suppression ◽  
Pig Model ◽  
Positive Effects ◽  
Chronic Oxidative Stress ◽  
Gut Microbe

d-Galactose induced chronic oxidative stress and also proved the positive effects of 0.5% ornithine α-ketoglutarate on altering the pig gut microbe, restoring serum amino acid and alleviating the growth-suppression induced by d-galactose chronic oxidative stress.

scholarly journals Amino acid concentrations in the hamster central auditory system and long-term effects of intense tone exposure

2012 ◽  
Vol 90 (11) ◽  
pp. 2214-2224 ◽  
Author(s):  
Donald A. Godfrey ◽  
James A. Kaltenbach ◽  
Kejian Chen ◽  
Omer Ilyas ◽  
Xiaochen Liu ◽  
...  
Keyword(s):  
Amino Acid ◽  
Auditory System ◽  
Central Auditory System ◽  
Long Term Effects ◽  
Amino Acid Concentrations

scholarly journals Long term effects of morphine on mesangial cell proliferation and matrix synthesis

1992 ◽  
Vol 41 (6) ◽  
pp. 1560-1570 ◽  
Author(s):  
Pravin C. Singhal ◽  
Nora Gibbons ◽  
Mirel Abramovici
Keyword(s):  
Cell Proliferation ◽  
Mesangial Cell ◽  
Long Term Effects ◽  
Matrix Synthesis ◽  
Mesangial Cell Proliferation

scholarly journals Feeding a Low-protein Maternal Diet Affects Qinghai Bamei Piglet Jejunal Microbiome-metabolome Response

2021 ◽  
Author(s):  
Jipeng Jin ◽  
Liping Zhang ◽  
Qian Chen ◽  
Cunming Ma ◽  
Jianlei Jia ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Bacterial Species ◽  
Relative Weight ◽  
Integrated Approach ◽  
Intestinal Microbiome ◽  
Rrna Gene ◽  
Metabolic Profiles ◽  
Microbial Composition ◽  
Suckling Piglets

Abstract This experiment investigated the impacts of feeding a maternal low-CP concentration diet having iso-essential amino acids on new born suckling piglets intestinal microbial composition and metabolic profiles. The Bamei swine breed was selected due to high meat quality and flavor, but demonstrates slower growth rates which may be related to jejunal nutrient supply. Forty randomly selected purebred Bamei sows were divided into two groups and fed a low dietary CP (12%, LP) or a normal CP (14%, CON) diet, respectively, but formulated to contain similar (iso-) essential amino acid concentrations per current recommendations. At 21 days, 12 piglets were randomly selected from each treatment and euthanized with jejunum content samples collected. The 16S rRNA gene sequencing and mass spectrometry-based metabolomics profiling were combined as an integrated approach for evaluating the functional impact of maternal CP concentrations on piglet intestinal microbiome. Even though piglets demonstrated similar 0 to 21 d ADG among treatments, the jejunum relative weight, villus width, crypt depth and muscular thickness were increased (P < 0.05), while villus height, and villus height:crypt depth were reduced (P < 0.05) for the material LP compared to the maternal fed CON diet. Maternal CP concentrations can modify the intestinal microbial composition of Bamei suckling piglets. The relative abundances of the bacterial species Escherichia-Shigella, Actinobacillus, Clostridium_sensu_stricto_1, Veillonella, and Turicibacter were increased (P < 0.05) in the maternal LP fed diet compared with the maternal fed CON diet. Jejunal digesta metabolomics analysis indicated that several amino acids were metabolized (i.e. cys, met, tyr phe and trp), biosynthesized (arg phe, tyr, and trp), or degraded (lys) were enriched (P < 0.05) for the maternal fed LP compared with the maternal fed CON. Correlation analysis demonstrated that certain intestinal bacterial genera were highly related to the histomorphology and altered intestinal microbiota metabolites. In conclusion, maternal dietary CP concentrations in excess of protein and amino acid requirements not only altered suckling Bamei piglets histomorphology, microbial composition and function, but also modulated jejunum microbial metabolic profiles, which aids in understanding the beneficial effects when feeding a maternal LP diet on piglet intestinal health.

Early post-weaning benefits of porcine plasma re-emerge in later growth performance

2000 ◽  
Vol 2000 ◽  
pp. 120-120 ◽  
Author(s):  
R. D. Slade ◽  
H. M. Miller
Keyword(s):  
Growth Performance ◽  
Growth Period ◽  
Poor Health ◽  
Long Term Effects ◽  
Health Challenge

Porcine plasma is known to improve immediate post-weaning performance but this is often only evident in the first week to ten days after weaning (Toplis and Miller, 1999). Few if any studies have investigated whether there are any long term effects over the entire growth period. It has previously been shown that piglets in poor health situations (Coffey and Cromwell, 1995) demonstrate markedly greater responses to porcine plasma. The objective of this study was to determine whether porcine plasma produced long-term benefits and whether this was modulated by health challenge during the weaning period.

Modification of An Amino Acid Solution for Peritoneal Dialysis to Reduce Risk of Acidemia

1997 ◽  
Vol 17 (1) ◽  
pp. 66-71 ◽  
Author(s):  
Michael Jones ◽  
Roberto Kalil ◽  
Peter Blake ◽  
Leo Martis ◽  
Dimitrios G. Oreopoulos
Keyword(s):  
Amino Acids ◽  
Body Weight ◽  
Peritoneal Dialysis ◽  
Amino Acid ◽  
Acid Solution ◽  
Long Term Effects ◽  
Amino Acid Solution ◽  
Nutritional Benefits ◽  
Modified Formula

Objective Some patients develop a mild acidemia during treatment with amino acid-based peritoneal dialysis solutions due to hydrogen ion produced by metabolism of lysine, arginine, and methionine. In this study we modified the formulation of such a solution by reducing these amino acids and adding anionic amino acids so as to provide minimal net acid production. Design A modified formula (MF) was compared to a conventional formula (CF) of the solution in a randomized crossover study in 12 stable continuous ambulatory peritoneal dialysis patients. Patients were given each solution for 14 days without a wash-out period. Each patient replaced one or two dextrose dialysis exchanges with amino acid solution, depending upon oral protein intake and body weight. Total intake (oral protein plus amino acids absorbed) was equivalent to 1.1 -1.3 g protein/kg body weight/day.Plasma bicarbonate and urea were assessed at the beginning and end of each 14-day period. Results In the group as a whole, without regard to the order in which the solutions were given, patients had a decrease in serum bicarbonate with CF and an increase in bicarbonate when they received MF. Similar trends were observed regardless of the order in which the solutions were administered. Serum urea did not differ between the two solutions. Conclusion The results suggest that patients are less prone to develop acidemia when receiving MF as opposed to CF. Further studies will be necessary to determine the long-term effects and the relative nutritional benefits of the two solutions.

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