scholarly journals Targeted delivery of paclitaxel by functionalized selenium nanoparticles for anticancer therapy through ROS-mediated signaling pathways

RSC Advances ◽  
2018 ◽  
Vol 8 (70) ◽  
pp. 39957-39966 ◽  
Author(s):  
Guifang Gong ◽  
Bailing Fu ◽  
Caixin Ying ◽  
Zhiqin Zhu ◽  
Xiaoqian He ◽  
...  
Keyword(s):  
Side Effects ◽  
Signaling Pathways ◽  
Targeted Delivery ◽  
Anticancer Agent ◽  
Water Solubility ◽  
Anticancer Therapy ◽  
Selenium Nanoparticles ◽  
Clinical Use ◽  
Adverse Side Effects ◽  
Poor Water Solubility

As a therapeutic anticancer agent, the clinical use of paclitaxel (PTX) is limited by its poor water solubility and serious adverse side effects.

scholarly journals Implications of Corticotropin Releasing Factor in Targeted Anticancer Therapy

2010 ◽  
Vol 23 (2) ◽  
pp. 86-90 ◽  
Author(s):  
Byung-Jin Kim ◽  
Harlan P. Jones
Keyword(s):  
Side Effects ◽  
Immune Escape ◽  
Anticancer Therapy ◽  
Corticotropin Releasing Factor ◽  
Antitumor Therapy ◽  
Tumor Immune Escape ◽  
Adverse Side Effects ◽  
Psychological Indicators ◽  
Immune Escape Mechanisms

There is a need to develop novel anticancer therapies that eliminate adverse side effects produced by current treatments. Corticotropin releasing factor (CRF), an endogenous neuroedocrine factor, which typically regulates biological and psychological indicators of stress, has recently been found to be expressed by tumor malignancies. Here, we discuss the implications of CRF as a target for antitumor therapy through regulation of tumor immune escape mechanisms.

An anticancer agent-loaded PLGA nanomedicine with glutathione-response and targeted delivery for the treatment of lung cancer

2020 ◽  
Vol 8 (4) ◽  
pp. 655-665 ◽  
Author(s):  
Zhanxia Zhang ◽  
Wei Cheng ◽  
Yongfu Pan ◽  
Lijun Jia
Keyword(s):  
Lung Cancer ◽  
Side Effects ◽  
Targeted Delivery ◽  
Therapeutic Efficacy ◽  
Anticancer Agent

Anticancer agent-loaded PLGA nanomedicine with glutathione-response and targeted delivery possesses high therapeutic efficacy and minimum side effects for the treatment of lung cancer.

scholarly journals Lipid Systems for the Delivery of Amphotericin B in Antifungal Therapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 29 ◽  
Author(s):  
Faustino ◽  
Pinheiro
Keyword(s):  
Side Effects ◽  
Amphotericin B ◽  
Targeted Delivery ◽  
Oral Delivery ◽  
Water Solubility ◽  
Therapeutic Potential ◽  
Fungal Infections ◽  
Cost Effective ◽  
Oral Formulation ◽  
Life Threatening

Amphotericin B (AmB), a broad-spectrum polyene antibiotic in the clinic for more than fifty years, remains the gold standard in the treatment of life-threatening invasive fungal infections and visceral leishmaniasis. Due to its poor water solubility and membrane permeability, AmB is conventionally formulated with deoxycholate as a micellar suspension for intravenous administration, but severe infusion-related side effects and nephrotoxicity hamper its therapeutic potential. Lipid-based formulations, such as liposomal AmB, have been developed which significantly reduce the toxic side effects of the drug. However, their high cost and the need for parenteral administration limit their widespread use. Therefore, delivery systems that can retain or even enhance antimicrobial efficacy while simultaneously reducing AmB adverse events are an active area of research. Among those, lipid systems have been extensively investigated due to the high affinity of AmB for binding lipids. The development of a safe and cost-effective oral formulation able to improve drug accessibility would be a major breakthrough, and several lipid systems for the oral delivery of AmB are currently under development. This review summarizes recent advances in lipid-based systems for targeted delivery of AmB focusing on non-parenteral nanoparticulate formulations mainly investigated over the last five years and highlighting those that are currently in clinical trials.

Targeted delivery of siRNA using RGDfC-conjugated functionalized selenium nanoparticles for anticancer therapy

2017 ◽  
Vol 5 (33) ◽  
pp. 6941-6952 ◽  
Author(s):  
Yu Xia ◽  
Zhengfang Lin ◽  
Yinghua Li ◽  
Mingqi Zhao ◽  
Changbing Wang ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Targeted Delivery ◽  
Anticancer Therapy ◽  
Selenium Nanoparticles

Preparation of cancer-targeted functionalized selenium nanoparticles loaded with siRNA and their further mechanism in inhibiting tumor growth.

Application and Analysis of 6-Mercaptopurine Nanomedicine in the Treatment of Leukemia

2021 ◽  
Vol 21 (2) ◽  
pp. 1001-1007
Author(s):  
Xueying Lu ◽  
Yandong Xie ◽  
Fengyu Wang
Keyword(s):  
Acute Myeloid Leukemia ◽  
Hyaluronic Acid ◽  
Side Effects ◽  
Therapeutic Effect ◽  
Targeted Delivery ◽  
Myeloid Leukemia ◽  
Water Solubility ◽  
Drug Loading ◽  
Circulation Time ◽  
Acute Myeloid

As a first-line drug widely used in the treatment of leukemia, 6-MP has obvious effects on leukemia. However, 6-MP disadvantages such as poor solubility in water, easy binding with serum proteins, short circulation time, and large toxic and side effects greatly limit the application of 6-MP. For this reason, various 6-MP nano drug-loading systems have been designed to increase the water solubility of 6-MP, extend the circulation time, and increase the bioavailability of 6-MP to a certain extent, reducing its toxic and side effects. However, its therapeutic effect in vivo and in vitro is still far from expectations, and there is a lot of room for improvement. In order to solve the above problems encountered in the clinical application of 6-MP, we have tried two ways of polymer prodrugs and drug-loaded vesicles to achieve efficient targeted delivery and treatment of 6-MP. We designed hyaluronic acid (HA)-based gluteal-skin-responsive 6-MP polymer prodrug (HA-GS-MP) for highly effective targeted therapy of acute myeloid leukemia. Hyaluronic acid is a natural polysaccharide, which has excellent biocompatibility and biodegradability, and has a good ability to actively target malignant tumor cells overexpressing the CD44 receptor. 6-MP is connected to the HA chain through a vinyl sulfide bond, which is stable under physiological conditions (no drug release), and under intracellular reducing conditions, the connection bond is broken and 6-MP is quickly released. HA-GS-MP has a simple preparation process, good water solubility, long cycle time, and strong targeting ability. This GSH-responsive CD44 targeted 6-MP polymer prodrug is expected to improve the therapeutic effect on acute myeloid leukemia cells.

Topoisomerase Inhibitors and Targeted Delivery in Cancer Therapy

2019 ◽  
Vol 19 (9) ◽  
pp. 713-729 ◽  
Author(s):  
Fei You ◽  
Changshou Gao
Keyword(s):  
Side Effects ◽  
Anticancer Agents ◽  
Targeted Delivery ◽  
Topoisomerase I ◽  
Clinical Use ◽  
Topoisomerase Inhibitors ◽  
Strand Breakage ◽  
Dna Strand ◽  
New Generation ◽  
Dna Strand Breakage

DNA topoisomerases are enzymes that catalyze the alteration of DNA topology with transiently induced DNA strand breakage, essential for DNA replication. Topoisomerases are validated cancer chemotherapy targets. Anticancer agents targeting Topoisomerase I and II have been in clinical use and proven to be highly effective, though with significant side effects. There are tremendous efforts to develop new generation of topoisomerase inhibitors. Targeted delivery of topoisomerase inhibitors is another way to reduce the side effects. Conjugates of topoisomerases inhibitors with antibody, polymer, or small molecule are developed to target these inhibitors to tumor sites.

NMR Studies of the Inclusion Complexes Between Ezetimibe and Cyclodextrins

2018 ◽  
Vol 69 (7) ◽  
pp. 1838-1841
Author(s):  
Hajnal Kelemen ◽  
Angella Csillag ◽  
Bela Noszal ◽  
Gabor Orgovan
Keyword(s):  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Water Solubility ◽  
Solution Nmr ◽  
Spectroscopic Techniques ◽  
Nmr Studies ◽  
The Poor ◽  
Poor Water Solubility

Ezetimibe, the antihyperlipidemic drug of poor bioavailability was complexed with native and derivatized cyclodextrins.The complexes were characterized in terms stability, stoichiometry and structure using various 1D and 2D solution NMR spectroscopic techniques. The complexes were found to be of moderate stability (logK[3). The least stable inclusion complex is formed with b-cyclodextrin, while the ezetimibe-methylated-b--cyclodextrin has a 7-fold higher stability. The results can be useful to improve the poor water-solubility and the concomitant bioavailability of ezetimibe.

Targeted Delivery of Natural Bioactives and Lipid-nanocargos against Signaling Pathways Involved in Skin Cancer

2020 ◽  
Vol 27 ◽  
Author(s):  
Mohammad Kashif Iqubal ◽  
Aiswarya Chaudhuri ◽  
Ashif Iqubal ◽  
Sadaf Saleem ◽  
Madan Mohan Gupta ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Signaling Pathways ◽  
Signaling Pathway ◽  
Targeted Delivery ◽  
Skin Pigmentation ◽  
Wnt Signaling Pathway ◽  
Human Beings ◽  
Radiation Chemical ◽  
Cell Leukemia Virus Type ◽  
Human T Cell

: At present, skin cancer is a widespread malignancy in human beings. Among diverse population types, Caucasian populations are much more prone in comparison to darker skin populations due to the comparative lack of skin pigmentation. Skin cancer is divided into malignant and non-melanoma skin cancer, which is additionally categorized as basal and squamous cell carcinoma. The exposure to ultraviolet radiation, chemical carcinogen (polycyclic aromatic hydrocarbons, arsenic, tar, etc.), and viruses (herpes virus, human papillomavirus, and human T-cell leukemia virus type-1) are major contributing factors of skin cancer. There are distinct pathways available through which skin cancer develops, such as the JAKSTAT pathway, Akt pathway, MAPKs signaling pathway, Wnt signaling pathway, to name a few. Currently, several targeted treatments are available, such as monoclonal antibodies, which have dramatically changed the line of treatment of this disease but possess major therapeutic limitations. Thus, recently many phytochemicals have been evaluated either alone or in combination with the existing synthetic drugs to overcome their limitations and have found to play a promising role in the prevention and treatment. In this review, complete tracery of skin cancer, starting from the signaling pathways involved, newer developed drugs with their targets and limitations along with the emerging role of natural products alone or in combination as potent anticancer agents and their molecular mechanism involved has been discussed. Apart from this, various nanocargos have also been mentioned here, which can play a significant role in the management and treatment of different types of skin cancer.

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