Sustainable synthesis of ambrisentan – syringic acid cocrystal: employing mechanochemistry in the development of novel pharmaceutical solid form

CrystEngComm ◽  
2020 ◽  
Vol 22 (14) ◽  
pp. 2507-2516 ◽  
Author(s):  
Jamshed Haneef ◽  
Renu Chadha
Keyword(s):  
Syringic Acid ◽  
Pharmaceutical Cocrystal ◽  
Solid Form

Development of the pharmaceutical cocrystal of ambrisentan with syringic acid via mechanochemistry as a greener and sustainable methodology with improved biopharmaceutical parameters.

Nanoconfinement of a Pharmaceutical Cocrystal with Praziquantel in Mesoporous Silica: The Influence of the Solid Form on Dissolution Enhancement

2021 ◽  
Author(s):  
Reynaldo Salas-Zúñiga ◽  
Karina Mondragón-Vásquez ◽  
Sergio Alcalá-Alcalá ◽  
Enrique Lima ◽  
Herbert Höpfl ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Dissolution Enhancement ◽  
Pharmaceutical Cocrystal ◽  
Solid Form

Choice of diagnosis of solid form of papillary carcinoma in pathological investigation rather than fine needle aspiration

2020 ◽  
Author(s):  
Lali Tigishvili ◽  
Keti Tsomaia ◽  
Khatuna Khachapuridze ◽  
Nino Kekelidze ◽  
Giorgi Mchedlishvili ◽  
...  
Keyword(s):  
Papillary Carcinoma ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Solid Form

IDENTIFIKASI KARAKTERISTIK MEKANIS BANTALAN LUNCUR MOTOR STARTER DARI SERBUK TEMBAGA ALUMUNIUM

2013 ◽  
Vol 12 (3) ◽  
Author(s):  
Syamsul Rizal ◽  
Amin Suhandi
Keyword(s):  
Mechanical Test ◽  
Life Time ◽  
Extrusion Process ◽  
Automotive Application ◽  
Powder Metallurgy Method ◽  
Powder Metal ◽  
Time Operation ◽  
Different Temperatures ◽  
Automotive Parts ◽  
Solid Form

There are many attempts to support the development of industry in Indonesia, especially on automotive sector, one of them is by replacing import components with local component products. Bushing is one of imported component that widely used on automotive application including motor strater. Bushing usually made of  copper alloy such as brass, bronz or babbit in a solid form by casting or extrusion process. In this research powder metal technology is used to process Cu-Al powder to become slide bearing of motor starter. It is expected that powder metal process not only increasing local content in automotive parts but also providing better quality by increasing life time of bushing compared to ordinary one. Cu-Al metal powder was compacted at various pressure, i.e: 250 MPa, 350 MPa and 450 MPa, and then all specimens were sintered at different temperatures : 4000C, 5000C dan 6000C for 1 hour.  After sintering specimens were air cooled to room temperature. After physical and mechanical test it can be deduced that bushing made by powder metallurgy method could increase its mechanical properties and as aresult improve its life time operation.  

The Effect of Dry Mix Sodium Hydroxide onto Workability and Compressive Strength of Geopolymer Paste

2020 ◽  
Vol 12 (9) ◽  
Author(s):  
A. Z. Mohd Ali ◽  
◽  
N. A. Jalaluddin ◽  
N. Zulkiflee ◽  
◽  
...  
Keyword(s):  
Compressive Strength ◽  
Fly Ash ◽  
Sodium Hydroxide ◽  
Sodium Silicate ◽  
Alkaline Solution ◽  
High Emission ◽  
New Material ◽  
Curing Regime ◽  
Solid Form ◽  
Geopolymer Paste

The production of ordinary Portland cement (OPC) consumes considerable amount of natural resources, energy and at the same time contribute in high emission of CO2 to the atmosphere. A new material replacing cement as binder called geopolymer is alkali-activated concrete which are made from fly ash, sodium silicate and sodium hydroxide (NaOH). The alkaline solution mixed with fly ash producing alternative binder to OPC binder in concrete named geopolymer paste. In the process, NaOH was fully dissolved in water and cooled to room temperature. This study aims to eliminate this process by using NaOH in solid form together with fly ash before sodium silicate liquid and water poured into the mixture. The amount of NaOH solids were based on 10M concentration. The workability test is in accordance to ASTM C230. Fifty cubic mm of the geopolymer paste were prepared which consists of fly ash to alkaline solution ratio of 1: 0.5 and the curing regime of 80℃ for 24 hours with 100% humidity were implemented. From laboratory test, the workability of dry method geopolymer paste were decreased. The compressive strength of the dry mix of NaOH showed 55% and the workability has dropped to 58.4%, it showed strength reduction compared to the wet mix method.

Near Infrared Spectroscopy Used in Purification and Determination of Pharmaceutical Cocrystal

2013 ◽  
Vol 41 (12) ◽  
pp. 1928
Author(s):  
Zong-Liang CHI ◽  
Miao-Miao WANG ◽  
Xiao-Dong CONG ◽  
Shao-Guang LIU ◽  
Bao-Chang CAI
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Pharmaceutical Cocrystal

Nevirapine Pharmaceutical Cocrystal: Design, Development and Formulation

2019 ◽  
Vol 9 (3) ◽  
pp. 240-247
Author(s):  
Prabhakar Panzade ◽  
Priyanka Somani ◽  
Pavan Rathi
Keyword(s):  
Dosage Form ◽  
In Vitro Dissolution ◽  
Soluble Form ◽  
Ir Absorption ◽  
Stoichiometric Ratio ◽  
Design Development ◽  
Formulation Development ◽  
Scanning Calorimetry ◽  
Absorption Bands ◽  
Pharmaceutical Cocrystal

Background and Objective: The top approach to deliver poorly soluble drugs is the use of a highly soluble form. The present study was conducted to enhance the solubility and dissolution of a poorly aqueous soluble drug nevirapine via a pharmaceutical cocrystal. Another objective of the study was to check the potential of the nevirapine cocrystal in the dosage form. Methods: A neat and liquid assisted grinding method was employed to prepare nevirapine cocrystals in a 1:1 and 1:2 stoichiometric ratio of drug:coformer by screening various coformers. The prepared cocrystals were preliminary investigated for melting point and saturation solubility. The selected cocrystal was further confirmed by Infrared Spectroscopy (IR), Differential Scanning Calorimetry (DSC), and Xray Powder Diffraction (XRPD). Further, the cocrystal was subjected to in vitro dissolution study and formulation development. Results: The cocrystal of Nevirapine (NVP) with Para-Amino Benzoic Acid (PABA) coformer prepared by neat grinding in 1:2 ratio exhibited greater solubility. The shifts in IR absorption bands, alterations in DSC thermogram, and distinct XRPD pattern showed the formation of the NVP-PABA cocrystal. Dissolution of NVP-PABA cocrystal enhanced by 38% in 0.1N HCl. Immediate release tablets of NVP-PABA cocrystal exhibited better drug release and less disintegration time. Conclusion: A remarkable increase in the solubility and dissolution of NVP was obtained through the cocrystal with PABA. The cocrystal also showed great potential in the dosage form which may provide future direction for other drugs.

Reactions

2011 ◽  
Author(s):  
Peter Atkins
Keyword(s):  
Chemical Reactions ◽  
Molecular Level ◽  
Chemical Processes ◽  
Chemical Formula ◽  
Complex Processes ◽  
Full Color ◽  
Chemistry Textbooks ◽  
Simple Chemical ◽  
The Subject ◽  
Solid Form

Illustrated with remarkable new full-color images--indeed, one or more on every page--and written by one of the world's leading authorities on the subject, Reactions offers a compact, pain-free tour of the inner workings of chemistry. Reactions begins with the chemical formula almost everyone knows--the formula for water, H2O--a molecule with an "almost laughably simple chemical composition." But Atkins shows that water is also rather miraculous--it is the only substance whose solid form is less dense than its liquid (hence ice floats in water)--and incredibly central to many chemical reactions, as it is an excellent solvent, being able to dissolve gases and many solids. Moreover, Atkins tells us that water is actually chemically aggressive, and can react with and destroy the compounds dissolved in it, and he shows us what happens at the molecular level when water turns to ice--and when it melts. Moving beyond water, Atkins slowly builds up a toolkit of basic chemical processes, including precipitation (perhaps the simplest of all chemical reactions), combustion, reduction, corrosion, electrolysis, and catalysis. He then shows how these fundamental tools can be brought together in more complex processes such as photosynthesis, radical polymerization, vision, enzyme control, and synthesis. Peter Atkins is the world-renowned author of numerous best-selling chemistry textbooks for students. In this crystal-clear, attractively illustrated, and insightful volume, he provides a fantastic introductory tour--in just a few hundred colorful and lively pages - for anyone with a passing or serious interest in chemistry.

scholarly journals Evaluation of the Bioactive Compounds Found in Tomato Seed Oil and Tomato Peels Influenced by Industrial Heat Treatments

Foods ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 110
Author(s):  
Katalin Szabo ◽  
Francisc Vasile Dulf ◽  
Bernadette-Emőke Teleky ◽  
Panagiota Eleni ◽  
Christos Boukouvalas ◽  
...  
Keyword(s):  
Fatty Acid ◽  
High Performance ◽  
Seed Oil ◽  
Edible Oils ◽  
Action Plan ◽  
Syringic Acid ◽  
Tomato Seed ◽  
Tomato Processing ◽  
Main Fatty Acid ◽  
Tomato Seed Oil

The circular economy action plan involves principles related to food waste reduction and integration of recovered nutrients to the market. In this context, the present study aims to highlight the valuable bioactive components found in tomato processing by-products (carotenoids, phenolic compounds and fatty acids) influenced by industrial pre-treatments, particularly cold break (CB) process at 65–75 °C and hot break (HB) process at 85–95 °C. The fatty acid profile of the tomato seed oil was examined by gas chromatography coupled to mass spectrometry (GC-MS), individual carotenoid and phenolic compositions were determined by high performance liquid chromatography (HPLC) and the viscoelastic properties were evaluated by rheological measurements. The physicochemical properties revealed appropriate characteristics of the tomato seed oil to fit the standards of generally accepted edible oils, for both CB and HB derived samples, however, significant qualitative and quantitative differences were detected in their phenolic composition and carotenoids content. Lycopene (37.43 ± 1.01 mg/100 mL) was a major carotenoid in the examined samples, linoleic acid was the main fatty acid (61.73%) detected in the tomato seed oil and syringic acid appeared to be one of two major phenolic acids detected in the samples of CB process. Our findings extend the boundaries of tomato processing industry by validating that tomato seed oil is a bioactive rich edible oil with additional health benefits, which can be integrated in functional food products.

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