Theoretical insight into the photophysical properties of long-lifetime Ir(iii) and Rh(iii) complexes for two-photon photodynamic therapy

2019 ◽  
Vol 21 (16) ◽  
pp. 8394-8401 ◽  
Author(s):  
Xue Yin ◽  
Xiao-Yong Lai ◽  
Xin Wang ◽  
Ying-Tao Liu
Keyword(s):  
Photodynamic Therapy ◽  
Photophysical Properties ◽  
Deep Penetration ◽  
Two Photon ◽  
Minimal Damage ◽  
Long Lifetime ◽  
Theoretical Insight ◽  
Insight Into

Two-photon photodynamic therapy (TP-PDT) plays crucial roles in curing tumors because it involves deep penetration of drugs into the tissue and has minimal damage to the surrounding cells.

scholarly journals Theoretical insight into the photophysical properties of six heteroleptic Ir(iii) phosphorescent complexes bearing ppy-type ligands

2019 ◽  
Vol 18 (11) ◽  
pp. 2766-2772 ◽  
Author(s):  
Deming Han ◽  
Lihui Zhao ◽  
Xuerong Han
Keyword(s):  
Density Functional Theory ◽  
Density Functional ◽  
Photophysical Properties ◽  
Time Dependent ◽  
Functional Theory ◽  
Theoretical Insight ◽  
Insight Into ◽  
Dependent Density

By using density functional theory and time-dependent density functional theory, the geometrical, electronic and photophysical properties of six complexes with two ppy-type ligands and one acetylacetone anion around the Ir center have been explored.

Theoretical Insight into the Origin of Large Stokes Shift and Photophysical Properties of Anilido-Pyridine Boron Difluoride Dyes

ChemPhysChem ◽  
2012 ◽  
Vol 13 (16) ◽  
pp. 3714-3722 ◽  
Author(s):  
Jun-Ling Jin ◽  
Hai-Bin Li ◽  
Yun Geng ◽  
Yong Wu ◽  
Yu-Ai Duan ◽  
...  
Keyword(s):  
Photophysical Properties ◽  
Stokes Shift ◽  
Large Stokes Shift ◽  
Boron Difluoride ◽  
Theoretical Insight ◽  
Insight Into

scholarly journals One‐photon and two‐photon photophysical properties of tetrafunctionalized Temoporfin (m‐THPC) derivatives as potential agents for two‐photon induced photodynamic therapy

ChemPhotoChem ◽  
2021 ◽  
Author(s):  
Piotr Gierlich ◽  
Sebastian G. Mucha ◽  
Emma Robbins ◽  
Lígia C. Gomes-da-Silva ◽  
Katarzyna Matczyszyn ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Photophysical Properties ◽  
Two Photon

Theoretical study on photophysical properties of three high water solubility polypyridyl complexes for two-photon photodynamic therapy

2018 ◽  
Vol 20 (26) ◽  
pp. 18074-18081 ◽  
Author(s):  
Ying-Tao Liu ◽  
Xue Yin ◽  
Xiao-Yong Lai ◽  
Xin Wang
Keyword(s):  
Photodynamic Therapy ◽  
Water Solubility ◽  
Theoretical Study ◽  
Photophysical Properties ◽  
High Water ◽  
Polypyridyl Complexes ◽  
Normal Cells ◽  
Two Photon ◽  
Promising Treatment ◽  
High Water Solubility

Two-photon photodynamic therapy (TP-PDT) is a very promising treatment that has drawn much attention in recent years due to its ability to penetrate deeper into tissues and minimize the damage to normal cells.

Photophysical properties and intracellular imaging of water-soluble porphyrin dimers for two-photon excited photodynamic therapy

2009 ◽  
Vol 7 (5) ◽  
pp. 889 ◽  
Author(s):  
Marina K. Kuimova ◽  
Hazel A. Collins ◽  
Milan Balaz ◽  
Emma Dahlstedt ◽  
James A. Levitt ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Photophysical Properties ◽  
Water Soluble ◽  
Intracellular Imaging ◽  
Two Photon ◽  
Water Soluble Porphyrin ◽  
Porphyrin Dimers

Phthalocyanine-cRGD conjugate: synthesis, photophysical properties and in vitro biological activity for targeting photodynamic therapy

2016 ◽  
Vol 14 (10) ◽  
pp. 2985-2992 ◽  
Author(s):  
Liqiang Luan ◽  
Wenjuan Fang ◽  
Wei Liu ◽  
Minggang Tian ◽  
Yuxing Ni ◽  
...  
Keyword(s):  
Biological Activity ◽  
Photodynamic Therapy ◽  
Cross Section ◽  
Cellular Uptake ◽  
Photophysical Properties ◽  
Photon Absorption ◽  
Absorption Cross ◽  
Two Photon Absorption ◽  
Two Photon

Phthalocyanine-RGD conjugate was synthesized and examined for its two-photon absorption cross section (TPACS), cellular uptake, and photocytotoxicity.

scholarly journals Theoretical insight into the photophysical properties of five phosphorescent heteroleptic iridium(iii) complexes bearing oxadiazol-substituted amide ligands

2019 ◽  
Vol 18 (5) ◽  
pp. 1075-1080 ◽  
Author(s):  
Xiaohong Shang ◽  
Deming Han ◽  
Lihui Zhao ◽  
Leijiao Li ◽  
Shuhui Lv
Keyword(s):  
Photophysical Properties ◽  
Structure Property ◽  
Structure Property Relationships ◽  
Amide Ligands ◽  
Theoretical Insight ◽  
Insight Into

A DFT/TDDFT study on the photophysical properties of five heteroleptic iridium(iii) complexes have been performed to obtain a better understanding of structure–property relationships.

scholarly journals Recent Emergence of Rhenium(I) Tricarbonyl Complexes as Photosensitisers for Cancer Therapy

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4176
Author(s):  
Hui Shan Liew ◽  
Chun-Wai Mai ◽  
Mohd Zulkefeli ◽  
Thiagarajan Madheswaran ◽  
Lik Voon Kiew ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Photophysical Properties ◽  
Two Photon ◽  
Alternative Approach ◽  
Recent Emergence ◽  
Combination Study ◽  
Basic Features ◽  
New Generation

Photodynamic therapy (PDT) is emerging as a significant complementary or alternative approach for cancer treatment. PDT drugs act as photosensitisers, which upon using appropriate wavelength light and in the presence of molecular oxygen, can lead to cell death. Herein, we reviewed the general characteristics of the different generation of photosensitisers. We also outlined the emergence of rhenium (Re) and more specifically, Re(I) tricarbonyl complexes as a new generation of metal-based photosensitisers for photodynamic therapy that are of great interest in multidisciplinary research. The photophysical properties and structures of Re(I) complexes discussed in this review are summarised to determine basic features and similarities among the structures that are important for their phototoxic activity and future investigations. We further examined the in vitro and in vivo efficacies of the Re(I) complexes that have been synthesised for anticancer purposes. We also discussed Re(I) complexes in conjunction with the advancement of two-photon PDT, drug combination study, nanomedicine, and photothermal therapy to overcome the limitation of such complexes, which generally absorb short wavelengths.

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