Photoelectrocatalytic oxidation of 3-pyridinemethanol to 3-pyridinemethanal and vitamin B3 by TiO2 nanotubes

Ikan sidat (Anguilla marmorata (Q.) Gaimard) memiliki keunggulan gizi atau nutrisi yang tinggi seperti protein, asam lemak, dan vitamin. Penelitian ini bertujuan untuk membandingkan kadar vitamin B (B1, B2, B3, B5, B6, B7, B9, dan B12) pada ikan sidat fase yellow eel dan silver eel asal Sungai Palu Sulawesi Tengah. Metode yang digunakan yaitu purposive sampling berdasarkan pada tempat, ukuran, dan fase ikan. Hasil pengujian vitamin B (B1, B2, B3, B5, B6, dan B9) menggunakan Kromatografi Cair Kinerja Ultra menunjukkan bahwa vitamin B2 fase yellow eel sebesar 0,07 mg/100 g; silver eel sebesar 0,05 mg/100 g; vitamin B3 fase yellow eel sebesar 0,3 mg/100 g; silver eel sebesar 1,16 mg/100 g; dan untuk vitamin B1, B5, B6, dan B9 tidak terdeteksi kadarnya. Sedangkan pengujian vitamin B7 dan B12 menggunakan Kromatografi Cair-Spektrometri Massa menunjukkan bahwa vitamin B7 fase yellow eel sebesar 58,35 µg/100 g; silver eel sebesar 10,61 µg/100 g; vitamin B12 fase yellow eel sebesar 0,52 µg/100 g; dan silver eel sebesar 0,27 µg/100 g. Kesimpulan yaitu vitamin B7 dengan menggunakan Kromatografi Cair-Spektrometri Massa memiliki kadar vitamin tertinggi sebesar 58,35 µg/100 g pada fase yellow eel dan untuk vitamin B3 (Nicotinamide) menggunakan Kromatografi Cair Kinerja Ultra memiliki kadar vitamin terendah sebesar 0,3 mg/100 g pada fase yellow eel.

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The female mouse is resistant to mild vitamin B3 deficiency

European Journal of Nutrition ◽

10.1007/s00394-021-02651-8 ◽

2021 ◽

Author(s):

Inge van der Stelt ◽

Wenbiao Shi ◽

Melissa Bekkenkamp-Grovenstein ◽

Rubén Zapata-Pérez ◽

Riekelt H. Houtkooper ◽

...

Keyword(s):

Metabolic Diseases ◽

Whole Body ◽

Vitamin B ◽

Vitamin B3 ◽

Control Female ◽

Female Mice ◽

Triacylglycerol Metabolism ◽

Nicotinamide Mononucleotide ◽

Age Related ◽

Vitamin B3 Deficiency

Abstract Purpose Vitamin B3 provides nicotinamide adenine dinucleotide (NAD+), an essential coenzyme in oxidoreductase reactions. Severe vitamin B3 deficiency leads to the disease Pellagra, while mild vitamin B3 deficiency has been linked to age-related and metabolic diseases. Mild vitamin B3 deficiency is understudied, especially in females. Therefore, we examined how female mice responded to a diet that induced mild vitamin B3 deficiency in male mice. Methods Female C57BL/6RccHsd mice were subjected for 18 weeks to a diet without vitamin B3 and low but sufficient tryptophan (0.115%) (0NR) and were compared to control female mice on the same diet with the reference dose of vitamin B3 (30NR, 30 mg nicotinamide riboside/ kg diet). Results In the female mice, no differences between the two dietary groups were found in liver nicotinamide mononucleotide (NMN) levels, body composition, whole body energy and substrate metabolism measured by indirect calorimetry, or liver triacylglycerol metabolism. Expression of seven genes that previously were shown to respond to mild vitamin B3 deficiency in male white adipose tissue were not differentially expressed between the female dietary groups, neither was insulin sensitivity. Conclusion We concluded that the female 0NR mice were not vitamin B3 deficient; the role of age, sex and health status is discussed. Demonstrated by clear differences between females and males, the latter showing mild deficiency under the same conditions, this study highlights the importance of studying both sexes.

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Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines

Nature Communications ◽

10.1038/s41467-020-19610-2 ◽

2020 ◽

Vol 11 (1) ◽

Author(s):

Begur Vasanthkumar Varun ◽

Kannan Vaithegi ◽

Sihyeong Yi ◽

Seung Bum Park

Keyword(s):

Biomedical Research ◽

Late Stage ◽

Chemical Space ◽

Bond Cleavage ◽

Cross Coupling ◽

Vitamin B ◽

Vitamin B3 ◽

Synthetic Routes ◽

Biomimetic Method ◽

Pharmaceutical Agents

AbstractDespite the availability of numerous routes to substituted nicotinates based on the Bohlmann–Rahtz pyridine synthesis, the existing methods have several limitations, such as the inevitable ortho-substitutions and the inability to conjugate vitamin B3 to other pharmaceutical agents. Inspired by the biosynthesis of nicotinic acid (a form of vitamin B3) from tryptophan, we herein report the development of a strategy for the synthesis of meta-aminoaryl nicotinates from 3-formyl(aza)indoles. Our strategy is mechanistically different from the reported routes and involves the transformation of (aza)indole scaffolds into substituted meta-aminobiaryl scaffolds via Aldol-type addition and intramolecular cyclization followed by C–N bond cleavage and re-aromatization. Unlike previous synthetic routes, this biomimetic method utilizes propiolates as enamine precursors and thus allows access to ortho-unsubstituted nicotinates. In addition, the synthetic feasibility toward the halo-/boronic ester-substituted aminobiaryls clearly differentiates the present strategy from other cross-coupling strategies. Most importantly, our method enables the late-stage conjugation of bioactive (hetero)arylamines with nicotinates and nicotinamides and allows access to the previously unexplored chemical space for biomedical research.

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Meat Intake and the Dose of Vitamin B3 – Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures?

International Journal of Tryptophan Research ◽

10.1177/1178646917704662 ◽

2017 ◽

Vol 10 ◽

pp. 117864691770466 ◽

Cited By ~ 9

Author(s):

Lisa J Hill ◽

Adrian C Williams

Keyword(s):

Vitamin B ◽

Optimal Dosage ◽

Vitamin B3 ◽

Meat Intake ◽

Agricultural Revolution ◽

Meat Diet ◽

Causes Of Disease ◽

Gut Symbionts ◽

High Doses ◽

Old Friends

Meat and vitamin B3 – nicotinamide – intake was high during hunter-gatherer times. Intake then fell and variances increased during and after the Neolithic agricultural revolution. Health, height, and IQ deteriorated. Low dietary doses are buffered by ‘welcoming’ gut symbionts and tuberculosis that can supply nicotinamide, but this co-evolved homeostatic metagenomic strategy risks dysbioses and impaired resistance to pathogens. Vitamin B3 deficiency may now be common among the poor billions on a low-meat diet. Disease transitions to non-communicable inflammatory disorders (but longer lives) may be driven by positive ‘meat transitions’. High doses of nicotinamide lead to reduced regulatory T cells and immune intolerance. Loss of no longer needed symbiotic ‘old friends’ compounds immunological over-reactivity to cause allergic and auto-immune diseases. Inhibition of nicotinamide adenine dinucleotide consumers and loss of methyl groups or production of toxins may cause cancers, metabolic toxicity, or neurodegeneration. An optimal dosage of vitamin B3 could lead to better health, but such a preventive approach needs more equitable meat distribution. Some people may require personalised doses depending on genetic make-up or, temporarily, when under stress.

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Partial photoelectrocatalytic oxidation of 3-pyridinemethanol by Pt, Au and Pd loaded TiO2 nanotubes on Ti plate

Catalysis Today ◽

10.1016/j.cattod.2020.11.003 ◽

2021 ◽

Author(s):

Sedat Yurdakal ◽

Sıdıka Çetinkaya ◽

Levent Özcan ◽

Özer Gök ◽

Leonardo Palmisano

Keyword(s):

Tio2 Nanotubes ◽

Photoelectrocatalytic Oxidation

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Photoelectrocatalytic oxidation of phenol on TiO2 nanotubes under oxygen pressure

Russian Journal of Electrochemistry ◽

10.1134/s1023193515110130 ◽

2015 ◽

Vol 51 (12) ◽

pp. 1108-1114 ◽

Cited By ~ 4

Author(s):

F. F. Orudzhev ◽

Z. M. Aliev ◽

F. G. Gasanova ◽

A. B. Isaev ◽

N. S. Shabanov

Keyword(s):

Oxygen Pressure ◽

Tio2 Nanotubes ◽

Photoelectrocatalytic Oxidation ◽

Oxidation Of Phenol

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Analisis Kandungan Vitamin B Pada Ikan Sidat (Anguilla Marmorata (Q.) Gaimard) Fase Elver Asal Danau Poso

Ghidza Jurnal Gizi dan Kesehatan ◽

10.22487/ghidza.v2i2.8 ◽

2018 ◽

Vol 2 (2) ◽

pp. 49-54

Author(s):

Fenti Fenti ◽

Agustinus Widodo ◽

Jamaluddin Jamaluddin

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Vitamin B12 ◽

Vitamin B1 ◽

Vitamin B ◽

Vitamin B2 ◽

Liquid Chromatography Mass Spectrometry ◽

Vitamin B3 ◽

Anguilla Marmorata ◽

B Vitamin

Latar Belakang & Tujuan : Vitamin merupakan zat-zat organik kompleks yang diperlukan tubuh dalam jumlah yang kecil, umumnya tidak dapat disintetis oleh tubuh tetapi penting dalam proses metabolik salah satunya adalah vitamin B. Vitamin B terdiri dari vitamin B1, B2, B3, B6, B9 danB12. Sidat merupakan salah satu ikan yang memiliki kandungan nutrisi yang tinggi salah satunya vitamin B. Penelitian ini dilakukan untuk menentukan kadar vitamin B (B1, B2, B3, B6, B9, B12) pada ikan sidat (Anguilla marmorata (Q.) Gaimard) fase elver asal danau Poso . Bahan dan Metode : Penentuan kadar vitamin B1, B2, B3, B6, dan B9 menggunakan metode KCKT (Kromatografi Cair Kinerja Tinggi), dan pada vitamin B12 menggunakan metode LC-MS (Liquid Chromatography–Mass Spectrometry). Hasil : Vitamin B2 dengan kadar 0,133 mg/100g, vitamin B3 dengan kadar 1,895 mg/100g, dan vitamin B12 dengan kadar 0,017mg/100g sedangkan pada vitamin B1, B6, dan B9 tidak terdeteksi adanya kadar. Kesimpulan : Ikan sidat (Anguilla marmorata (Q.) Gaimard) fase elver asal danau Poso dapat dijadikan sumber vitamin B2, B3, dan B12.

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Estimation of Water-Soluble Vitamin B-Complex in Selected Leafy and Non-Leafy Vegetables by HPLC Method

Oriental Journal Of Chemistry ◽

10.13005/ojc/350414 ◽

2019 ◽

Vol 35 (4) ◽

pp. 1344-1351

Author(s):

N. H. M. Rubel Mozumder ◽

Most. Jesmin Akhter ◽

Anwara Akter Khatun ◽

Mohammad Rokibuzzaman ◽

M. Akhtaruzzaman

Keyword(s):

High Performance ◽

Vitamin B1 ◽

High Performance Liquid Chromatographic ◽

Hplc Method ◽

Water Soluble ◽

Leafy Vegetables ◽

Array Detector ◽

Vitamin B ◽

Vitamin B3 ◽

Water Soluble Vitamin

A high performance liquid chromatographic method (HPLC) equipped with photodiode array detector (PDA) has been used to determine the water-soluble vitamin B complex ( B1, B2, B3, and B6) in eleven selected vegetables of Bangladesh. The results showed varied levels of vitamin B-complexes. Precisely, Thankuni leaves showed the highest contents of vitamin B1; 0.19 mg/100 g, and vitamin B2; 0.25 mg/100g. Higher content of vitamin B3 (0.59 mg/100 g) were quantified in Coriander leaves, but absent in Jute leaves. On the other hand, the maximum quantified amount of B6 (0.73 mg/100 g) was detected in Carrot. In contrast, there was no detectable vitamin B6 in Jute, and Mint leaves and Cabbage. The findings of the current study may supplement the current Food Composition Table for Bangladesh (FCTB) by providing nutritional information of vitamin B complex in leafy and non-leafy vegetables which can also be used for calculating the habitual dietary intake and/or nutritional survey purposes.

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