Intracellular GSH-responsive camptothecin delivery systems

2019 ◽  
Vol 43 (47) ◽  
pp. 18673-18684 ◽  
Author(s):  
Dan Zhang ◽  
Le Li ◽  
Xiaohui Ji ◽  
Yanhong Gao
Keyword(s):  
Real Time ◽  
Delivery Systems ◽  
Real Time Monitoring

Smart GSH-responsive camptothecin delivery systems for treatment of tumors and real-time monitoring in vivo and in vitro were described.

Facile solvothermal synthesis of ultrathin spinel ZnMn2O4 nanospheres: An efficient electrocatalyst for in vivo and in vitro real time monitoring of H2O2

2021 ◽  
Vol 900 ◽  
pp. 115674
Author(s):  
Muthaiah Annalakshmi ◽  
Sakthivel Kumaravel ◽  
T.S.T. Balamurugan ◽  
Shen-Ming Chen ◽  
Ju-Liang He
Keyword(s):  
Real Time ◽  
Solvothermal Synthesis ◽  
Real Time Monitoring

scholarly journals Non-invasive, real-time reporting drug release in vitro and in vivo

2015 ◽  
Vol 51 (32) ◽  
pp. 6948-6951 ◽  
Author(s):  
Yanfeng Zhang ◽  
Qian Yin ◽  
Jonathan Yen ◽  
Joanne Li ◽  
Hanze Ying ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Near Infrared ◽  
Reporting System ◽  
Real Time Monitoring ◽  
Near Infrared Fluorescence ◽  
Non Invasive ◽  
Fluorescence Dye

Anin vitroandin vivodrug-reporting system is developed for real-time monitoring of drug release via the analysis of the concurrently released near-infrared fluorescence dye.

Real-time monitoring of anticancer drug release in vitro and in vivo on titania nanoparticles triggered by external glutathione

Talanta ◽  
2012 ◽  
Vol 88 ◽  
pp. 631-637 ◽  
Author(s):  
Mira Kim ◽  
Ji Hye Seo ◽  
Won Il Jeon ◽  
Mi-Yeon Kim ◽  
Keunchang Cho ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Anticancer Drug ◽  
Titania Nanoparticles ◽  
Real Time Monitoring ◽  
Release In Vitro

scholarly journals 181. Real-Time Monitoring of Transcription Factor Activity Using In Vitro and In Vivo Models of Cholestasis

2015 ◽  
Vol 23 ◽  
pp. S72
Author(s):  
Juliette M.K.M. Delhove ◽  
Dany Perocheau ◽  
Suzanne M.K. Buckley ◽  
Rajvinder Karda ◽  
Simon N. Waddington ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Real Time ◽  
Transcription Factor Activity ◽  
Factor Activity ◽  
Real Time Monitoring ◽  
In Vivo Models

scholarly journals Pro-organic radical contrast agents (“pro-ORCAs”) for real-time MRI of pro-drug activation in biological systems

2020 ◽  
Vol 11 (29) ◽  
pp. 4768-4779 ◽  
Author(s):  
Hung V.-T. Nguyen ◽  
Alexandre Detappe ◽  
Peter Harvey ◽  
Nolan Gallagher ◽  
Clelia Mathieu ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Real Time ◽  
Ring Opening ◽  
Organic Radical ◽  
Real Time Monitoring ◽  
Prodrug Activation ◽  
Metathesis Polymerization ◽  
Drug Activation

Pro-organic radical contrast agents (pro-ORCAs) that enable real-time monitoring of doxorubicin prodrug activation in vitro and in vivo are prepared through brush-first ring-opening metathesis polymerization (ROMP).

scholarly journals Refinement of a mouse cardiovascular model: Development, application and dissemination

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 593
Author(s):  
Kirk A. Taylor ◽  
Michael Emerson
Keyword(s):  
Real Time ◽  
Light Transmission ◽  
Ex Vivo ◽  
Model Development ◽  
Cell Counting ◽  
Real Time Monitoring ◽  
Mortality Models ◽  
Typical Experiment

European and UK legislation requires all animal procedures to be conducted with consideration to reduction, refinement and replacement. In this review, 3Rs developments are discussed in the field of platelet biology and thromboembolism. Platelet research requires the use of animal models, and mice are widely used in the field. When working in vitro, conventional light transmission techniques have been scaled down allowing reduction in animal numbers. In vivo, vascular injury models are widely used and work is ongoing to develop ex vivo approaches that use fewer animals. Thromboembolic mortality models, which inflict considerable pain and suffering, have also been used widely. A published and characterised refinement of this mortality model allows real-time monitoring of radiolabelled platelets under general anaesthesia and reduces both the severity level and the numbers of mice used in a typical experiment. This technique is more sensitive than the mortality approach and has opened up new avenues of research, which would not have been feasible by using death as an end-point. To drive uptake of real-time monitoring, a more simplistic approach has been developed involving micro-sampling and cell counting. Thromboembolic mortality models should therefore be considered obsolete due to the emergence of 3Rs models with improved scientific outcomes and that can be implemented relatively easily.

scholarly journals Self-carried curcumin nanoparticles for in vitro and in vivo cancer therapy with real-time monitoring of drug release

Nanoscale ◽  
2015 ◽  
Vol 7 (32) ◽  
pp. 13503-13510 ◽  
Author(s):  
Jinfeng Zhang ◽  
Shengliang Li ◽  
Fei-Fei An ◽  
Juan Liu ◽  
Shubin Jin ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Real Time ◽  
Real Time Monitoring ◽  
Curcumin Nanoparticles ◽  
Major Attention ◽  
Pharmaceutical Agents

The use of different nanocarriers for delivering hydrophobic pharmaceutical agents to tumor sites has garnered major attention.

scholarly journals Mechanisms and Pharmaceutical Action of Lipid Nanoformulation of Natural Bioactive Compounds as Efficient Delivery Systems in the Therapy of Osteoarthritis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1108
Author(s):  
Oana Craciunescu ◽  
Madalina Icriverzi ◽  
Paula Ecaterina Florian ◽  
Anca Roseanu ◽  
Mihaela Trif
Keyword(s):  
Drug Delivery ◽  
Bioactive Compounds ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Joint Disease ◽  
Duration Of Action ◽  
Immune System Activation

Osteoarthritis (OA) is a degenerative joint disease. An objective of the nanomedicine and drug delivery systems field is to design suitable pharmaceutical nanocarriers with controllable properties for drug delivery and site-specific targeting, in order to achieve greater efficacy and minimal toxicity, compared to the conventional drugs. The aim of this review is to present recent data on natural bioactive compounds with anti-inflammatory properties and efficacy in the treatment of OA, their formulation in lipid nanostructured carriers, mainly liposomes, as controlled release systems and the possibility to be intra-articularly (IA) administered. The literature regarding glycosaminoglycans, proteins, polyphenols and their ability to modify the cell response and mechanisms of action in different models of inflammation are reviewed. The advantages and limits of using lipid nanoformulations as drug delivery systems in OA treatment and the suitable route of administration are also discussed. Liposomes containing glycosaminoglycans presented good biocompatibility, lack of immune system activation, targeted delivery of bioactive compounds to the site of action, protection and efficiency of the encapsulated material, and prolonged duration of action, being highly recommended as controlled delivery systems in OA therapy through IA administration. Lipid nanoformulations of polyphenols were tested both in vivo and in vitro models that mimic OA conditions after IA or other routes of administration, recommending their clinical application.

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