The role of the medium in the effective-sphere interpretation of holographic particle characterization data

Mary Ann Odete; Fook Chiong Cheong; Annemarie Winters; Jesse J. Elliott; Laura A. Philips; David G. Grier

doi:10.1039/c9sm01916b

The role of the medium in the effective-sphere interpretation of holographic particle characterization data

Soft Matter ◽

10.1039/c9sm01916b ◽

2020 ◽

Vol 16 (4) ◽

pp. 891-898 ◽

Cited By ~ 3

Author(s):

Mary Ann Odete ◽

Fook Chiong Cheong ◽

Annemarie Winters ◽

Jesse J. Elliott ◽

Laura A. Philips ◽

...

Keyword(s):

Refractive Index ◽

Colloidal Particles ◽

Particle Characterization ◽

Sphere Model

Holographic particle characterization measurements can be interpreted with the effective-sphere model to obtain the size, refractive index and porosity of porous and irregularly shaped colloidal particles.

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On the role of Ge-doping concentration in the refractive index rollover and thermal annealing characteristics of type IIa fiber Bragg gratings

Optical Engineering ◽

10.1117/1.oe.53.11.117103 ◽

2014 ◽

Vol 53 (11) ◽

pp. 117103

Author(s):

Jitendra Kumar ◽

Om Prakash ◽

Ramakant Mahakud ◽

Sachin Kumar Agrawal ◽

Sudhir K. Dixit ◽

...

Keyword(s):

Refractive Index ◽

Thermal Annealing ◽

Doping Concentration ◽

Fiber Bragg Gratings ◽

Bragg Gratings ◽

Ge Doping

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Multivalent weak interactions enhance selectivity of interparticle binding

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.2003968117 ◽

2020 ◽

Vol 117 (37) ◽

pp. 22690-22697 ◽

Cited By ~ 1

Author(s):

M. R. W. Scheepers ◽

L. J. van IJzendoorn ◽

M. W. J. Prins

Keyword(s):

Targeted Drug Delivery ◽

Colloidal Particles ◽

High Selectivity ◽

Weak Interactions ◽

Theoretical Work ◽

Coated Particles ◽

Receptor Interactions ◽

Two Factors ◽

Experimental Findings

Targeted drug delivery critically depends on the binding selectivity of cargo-transporting colloidal particles. Extensive theoretical work has shown that two factors are necessary to achieve high selectivity for a threshold receptor density: multivalency and weak interactions. Here, we study a model system of DNA-coated particles with multivalent and weak interactions that mimics ligand–receptor interactions between particles and cells. Using an optomagnetic cluster experiment, particle aggregation rates are measured as a function of ligand and receptor densities. The measured aggregation rates show that the binding becomes more selective for shorter DNA ligand–receptor pairs, proving that multivalent weak interactions lead to enhanced selectivity in interparticle binding. Simulations confirm the experimental findings and show the role of ligand–receptor dissociation in the selectivity of the weak multivalent binding.

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