Near-infrared triggered generation of reactive oxygen species from upconverting nanoparticles decorated with an organoiridium complex

2016 ◽  
Vol 4 (18) ◽  
pp. 3113-3120 ◽  
Author(s):  
Joe Gerald Jesu Raj ◽  
Marta Quintanilla ◽  
Fiorenzo Vetrone
Keyword(s):  
Reactive Oxygen Species ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Excitation Light ◽  
Infrared Excitation

We developed an upconverting nanoparticle capable of (up)converting near-infrared excitation light to UV to sensitize an organoiridium complex for the production of reactive oxygen species.

Photosensitizer coated upconversion nanoparticles for triggering reactive oxygen species under 980 nm near-infrared excitation

2019 ◽  
Vol 7 (46) ◽  
pp. 7306-7313 ◽  
Author(s):  
Jinhua Wu ◽  
Shanshan Du ◽  
Yuhua Wang
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Rare Earth ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Great Promise ◽  
Upconversion Nanoparticles ◽  
Oxygen Species ◽  
Infrared Excitation

Rare-earth-based upconversion nanotechnology has recently shown great promise for photodynamic therapy (PDT).

Plasmon-Mediated Generation of Reactive Oxygen Species from Near-Infrared Light Excited Gold Nanocages for Photodynamic Therapyin Vitro

ACS Nano ◽  
2014 ◽  
Vol 8 (7) ◽  
pp. 7260-7271 ◽  
Author(s):  
Liang Gao ◽  
Ru Liu ◽  
Fuping Gao ◽  
Yaling Wang ◽  
Xinglu Jiang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Infrared Light ◽  
Oxygen Species ◽  
Near Infrared Light ◽  
Gold Nanocages

A reversible near-infrared fluorescence probe for reactive oxygen species based on Te–rhodamine

2012 ◽  
Vol 48 (25) ◽  
pp. 3091 ◽  
Author(s):  
Yuichiro Koide ◽  
Mitsuyasu Kawaguchi ◽  
Yasuteru Urano ◽  
Kenjiro Hanaoka ◽  
Toru Komatsu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Near Infrared ◽  
Fluorescence Probe ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Near Infrared Fluorescence

Plasmonic Enhanced Reactive Oxygen Species Activation on Low‐Work‐Function Tungsten Nitride for Direct Near‐Infrared Driven Photocatalysis

Small ◽  
2020 ◽  
Vol 16 (45) ◽  
pp. 2004557
Author(s):  
Weicheng Huang ◽  
Yan Gao ◽  
Jinxin Wang ◽  
Pengcheng Ding ◽  
Mei Yan ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Work Function ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Tungsten Nitride ◽  
Oxygen Species

scholarly journals Plasmonic Hot-Electron Reactive Oxygen Species Generation: Fundamentals for Redox Biology

2020 ◽  
Vol 8 ◽  
Author(s):  
Elisa Carrasco ◽  
Juan Carlos Stockert ◽  
Ángeles Juarranz ◽  
Alfonso Blázquez-Castro
Keyword(s):  
Reactive Oxygen Species ◽  
Near Infrared ◽  
Chemical Reactivity ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Ros Generation ◽  
Oxygen Species ◽  
Hot Electron ◽  
Redox Biology

For decades, the possibility to generate Reactive Oxygen Species (ROS) in biological systems through the use of light was mainly restricted to the photodynamic effect: the photoexcitation of molecules which then engage in charge- or energy-transfer to molecular oxygen (O2) to initiate ROS production. However, the classical photodynamic approach presents drawbacks, like per se chemical reactivity of the photosensitizing agent or fast molecular photobleaching due to in situ ROS generation, to name a few. Recently, a new approach, which promises many advantages, has entered the scene: plasmon-driven hot-electron chemistry. The effect takes advantage of the photoexcitation of plasmonic resonances in metal nanoparticles to induce a new cohort of photochemical and redox reactions. These metal photo-transducers are considered chemically inert and can undergo billions of photoexcitation rounds without bleaching or suffering significant oxidative alterations. Also, their optimal absorption band can be shape- and size-tailored in order to match any of the near infrared (NIR) biological windows, where undesired absorption/scattering are minimal. In this mini review, the basic mechanisms and principal benefits of this light-driven approach to generate ROS will be discussed. Additionally, some significant experiments in vitro and in vivo will be presented, and tentative new avenues for further research will be advanced.

scholarly journals Near Infrared-Activated Dye-Linked ZnO Nanoparticles Release Reactive Oxygen Species for Potential Use in Photodynamic Therapy

Materials ◽  
2019 ◽  
Vol 13 (1) ◽  
pp. 17 ◽  
Author(s):  
Jaspreet Singh Nagi ◽  
Kenneth Skorenko ◽  
William Bernier ◽  
Wayne E. Jones ◽  
Amber L. Doiron
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Near Infrared ◽  
Umbilical Vein ◽  
Particle Surface ◽  
Reactive Oxygen ◽  
Dependent Manner ◽  
Oxygen Species ◽  
Human Carcinoma ◽  
Zno Particles

Novel dye-linked zinc oxide nanoparticles (NPs) hold potential as photosensitizers for biomedical applications due to their excellent thermal- and photo-stability. The particles produced reactive oxygen species (ROS) upon irradiation with 850 nm near infrared (NIR) light in a concentration- and time-dependent manner. Upon irradiation, ROS detected in vitro in human umbilical vein endothelial cells (HUVEC) and human carcinoma MCF7 cells positively correlated with particle concentration and interestingly, ROS detected in MCF7 was higher than in HUVEC. Preferential cytotoxicity was also exhibited by the NPs as cell killing was higher in MCF7 than in HUVEC. In the absence of irradiation, dye-linked ZnO particles minimally affected the viability of cell (HUVEC) at low concentrations (<30 μg/mL), but viability significantly decreased at higher particle concentrations, suggesting a need for particle surface modification with poly (ethylene glycol) (PEG) for improved biocompatibility. The presence of PEG on particles after dialysis was indicated by an increase in size, an increase in zeta potential towards neutral, and spectroscopy results. Cell viability was improved in the absence of irradiation when cells were exposed to PEG-coated, dye-linked ZnO particles compared to non-surface modified particles. The present study shows that there is potential for biological application of dye-linked ZnO particles in photodynamic therapy.

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