Computational analysis of the effect of [Tea][Ms] and [Tea][H2PO4] ionic liquids on the structure and stability of Aβ(17–42) amyloid fibrils

Tight coordination of peptides by organic anions driven by hydrogen bonding affects the fibrillation kinetics of Aβ peptides in ionic liquid/water solutions.

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Solvatochromic Behaviour of Coumarin 102 in PEGs + Ionic Liquid/ Water Solutions: Role of solute-solvent or solvent-solvent interactions

Journal of Molecular Liquids ◽

10.1016/j.molliq.2021.116483 ◽

2021 ◽

pp. 116483

Author(s):

Md Rabiul Islam ◽

Faiz Warsi ◽

Md Sayem Alam ◽

Maroof Ali

Keyword(s):

Ionic Liquid ◽

Liquid Water ◽

Solvent Interactions ◽

Water Solutions ◽

Coumarin 102 ◽

Solvent Solvent

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An overview of neutron scattering and molecular dynamics simulation studies of phospholipid bilayers in room-temperature ionic liquid/water solutions

Physica B Condensed Matter ◽

10.1016/j.physb.2018.02.043 ◽

2018 ◽

Vol 551 ◽

pp. 227-231 ◽

Cited By ~ 7

Author(s):

Antonio Benedetto ◽

Pietro Ballone

Keyword(s):

Molecular Dynamics ◽

Ionic Liquid ◽

Molecular Dynamics Simulation ◽

Neutron Scattering ◽

Liquid Water ◽

Room Temperature ◽

Phospholipid Bilayers ◽

Dynamics Simulation ◽

Simulation Studies ◽

Water Solutions

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Synthesis of the symmetrical methylene diesters from carboxylic ionic liquids

Canadian Journal of Chemistry ◽

10.1139/cjc-2017-0042 ◽

2017 ◽

Vol 95 (7) ◽

pp. 744-750 ◽

Cited By ~ 2

Author(s):

D. Gómora-Herrera ◽

I.V. Lijanova ◽

O. Olivares-Xometl ◽

A. Toscano ◽

N.V. Likhanova

Keyword(s):

Ionic Liquid ◽

Hydrogen Bonding ◽

Ionic Liquids ◽

Hydrogen Atom ◽

Crystal Packing ◽

Spectroscopic Techniques ◽

Amine Group ◽

Carboxylic Group ◽

Microwave Reactor ◽

Trimer Formation

The reaction between carboxylic ionic liquids and dichloromethane, which provokes the formation of symmetrical methylene diesters, was carried out. The synthesis of these ionic liquid compounds was carried out in a microwave reactor, and the characterization by spectroscopic techniques of methylene diesters (methylene di-2-furoate, methylene di-2-picolinate, methylene dianthranilate, and methylene dioleate) is described and the crystal structures discussed. The crystal packing of methylene dianthranilate is characterized by trimer formation due to hydrogen bonding via interactions between the hydrogen atom of the primary amine group and the oxygen of the carboxylic group.

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Multi-spectroscopic monitoring of molecular interactions between an amino acid-functionalized ionic liquid and potential anti-Alzheimer's drugs

RSC Advances ◽

10.1039/d0ra06323a ◽

2020 ◽

Vol 10 (64) ◽

pp. 38873-38883

Author(s):

Srishti Sharma ◽

Manoj Kumar Banjare ◽

Namrata Singh ◽

Jan Korábečný ◽

Kamil Kuča ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Ionic Liquid ◽

Ionic Liquids ◽

Amino Acid ◽

Molecular Interactions ◽

Amyloid Fibrils ◽

Functionalized Ionic Liquid ◽

Inhibition Effect ◽

Spectroscopic Monitoring

Ionic liquids mediated interactions are an expedient approach that exhibit inhibition effect on amyloid fibrils which is beneficial for the treatment of Alzheimer's disease.

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Surfactant Adsorption at the Surface of Mixed Ionic Liquids and Ionic Liquid Water Mixtures

Langmuir ◽

10.1021/la302184h ◽

2012 ◽

Vol 28 (37) ◽

pp. 13224-13231 ◽

Cited By ~ 22

Author(s):

Deborah Wakeham ◽

Gregory G. Warr ◽

Rob Atkin

Keyword(s):

Ionic Liquid ◽

Ionic Liquids ◽

Liquid Water ◽

Surfactant Adsorption

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Role of Cation in Enhancing the Conversion of the Alzheimer’s Peptide into Amyloid Fibrils Using Protic Ionic Liquids

Australian Journal of Chemistry ◽

10.1071/ch12316 ◽

2012 ◽

Vol 65 (11) ◽

pp. 1502 ◽

Cited By ~ 5

Author(s):

Natalie Debeljuh ◽

Swapna Varghese ◽

Colin J. Barrow ◽

Nolene Byrne

Keyword(s):

Ionic Liquid ◽

Ionic Liquids ◽

Primary Amine ◽

Amyloid Fibrils ◽

Tertiary Amines ◽

Protic Ionic Liquids ◽

Protic Ionic Liquid ◽

The Difference ◽

The Impact

We report on the impact of changes in the protic ionic liquid (pIL) cation on the fibrilisation kinetics and the conversion of the Aβ 16–22 from monomers to amyloid fibrils. When we compare the use of primary, secondary, and tertiary amines we find that the primary amine results in the greatest conversion into amyloid fibrils. We show that the pIL is directly interacting with the peptide and this likely drives the difference in conversion and kinetics observed.

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