scholarly journals Immunological detection of thymine dimers in indigenous genomic DNA from pre-disinfection drinking water as an ultraviolet disinfection dosimeter

2021 ◽  
Author(s):  
James Blyth ◽  
Lucinda Hazell ◽  
Michael R. Templeton
Keyword(s):  
Drinking Water ◽  
Dose Response ◽  
Genomic Dna ◽  
Elisa Assay ◽  
Ultraviolet Disinfection ◽  
Mixed Species ◽  
Immunological Detection ◽  
Thymine Dimers ◽  
Uv Dose

A linear UV dose response is demonstrated using an ELISA assay that measures thymine dimers formed in the genomic DNA extracted from the mixed species of microorganisms filtered from UV treated pre-disinfection drinking water.

scholarly journals Dose-response meta-analysis of arsenic exposure in drinking water and hypertension

Heliyon ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. e06409
Author(s):  
Afsaneh Amiri ◽  
Yaser Mokhayeri ◽  
Rasool Mohammadi ◽  
Mohammad Amin Karami ◽  
Mansour Ghaderpoori ◽  
...  
Keyword(s):  
Drinking Water ◽  
Dose Response ◽  
Meta Analysis ◽  
Arsenic Exposure

Analysis of Polymorphisms in Genes Differentially Expressed in the Enamel of Mice with Different Genetic Susceptibilities to Dental Fluorosis

2018 ◽  
Vol 53 (2) ◽  
pp. 228-233 ◽  
Author(s):  
Senda Charone ◽  
Erika Calvano Küchler ◽  
Aline de Lima Leite ◽  
Mileni Silva Fernandes ◽  
Vinicius Taioqui Pelá ◽  
...  
Keyword(s):  
Drinking Water ◽  
Real Time ◽  
Dna Extraction ◽  
Genetic Polymorphisms ◽  
Clinical Evaluation ◽  
Real Time Pcr ◽  
Genomic Dna ◽  
Dental Fluorosis ◽  
Clinical Aspects ◽  
Genomic Dna Extraction

Genes expressed during amelogenesis are candidates to increase the risk of dental fluorosis (DF). Thus, this study aimed to evaluate the association between polymorphisms in enamel development genes and susceptibility to DF in mice. Mice of both sexes, representing strains 129P3/J (n = 20; resistant to DF) and A/J (n = 20; susceptible to DF), were divided into 2 groups. Each strain received a diet with a low concentration of fluoride (F) and drinking water containing 0 or 50 mg/L of F for 6 weeks. Clinical evaluation and analysis of Vickers enamel microhardness of the incisors were performed. Livers were collected for genomic DNA extraction. Seventeen genetic polymorphisms in Amelx, Ambn, Ambn, Col14a1, Col1a1, Col5a2, Enam, Fam20a, Fam83h, Foxo1, Klk4, Mmp20, Serpinf1, Serpinh1, Smad3, Tuft1, and Wdr72 were genotyped by real-time PCR using Taqman chemistry. Overrepresentation of alleles and genotypes in DF was evaluated using the χ2 test with an alpha of 5%. The clinical aspects of the enamel and the surface enamel microhardness confirmed the DF condition. In the polymorphisms rs29569969, rs13482592, and rs13480057 in Ambn, Col14a1, and Mmp20, respectively, genotype and allele distributions were statistically significantly different between A/J and 129P3/J strains (p < 0.05). In conclusion, polymorphisms in Ambn, Col14a1, and Mmp20 are associated with the susceptibility to DF.

Removal methods of nematoda contained in the effluent of activated carbon

2002 ◽  
Vol 2 (3) ◽  
pp. 183-190 ◽  
Author(s):  
N. Matsumoto ◽  
T. Aizawa ◽  
S. Ohgaki ◽  
T. Hirata ◽  
K. Toyooka ◽  
...  
Keyword(s):  
Drinking Water ◽  
Activated Carbon ◽  
Ultraviolet Radiation ◽  
Uv Radiation ◽  
21St Century ◽  
Chlorine Dioxide ◽  
Membrane Filtration ◽  
Sand Filtration ◽  
Uv Dose ◽  
Physical Treatments

Effects of various alternative disinfectants, e.g. chlorine dioxide, ozone, ultraviolet radiation and chloramine, either alone or in combination with other physical treatments like sand filtration and membrane filtration, on the inactivation and removal of nematoda were studied. Ozone and chloramines were found to be effective for nematoda inactivation. Filtration alone was unable to remove nematoda completely. But the combination of UV radiation and sand filtration turned out to be very effective in the removal of nematoda from drinking water. 90% inactivation of nematoda needed a UV dose of (D10-value) 135 mJ/cm2, while 99% inactivation required 232.5 (135 + 97.5) mJ/cm2. This study was a part of a five-year national research project “Advanced Aqua Clean Technology for 21st Century” (ACT21).

scholarly journals Fecal coliform concentrations in effluent from ultraviolet disinfection units installed in onsite wastewater treatment systems

2018 ◽  
Vol 17 (1) ◽  
pp. 113-123 ◽  
Author(s):  
Meagan R. Jackson ◽  
John Scott Meschke ◽  
Jeremy Simmons ◽  
Tania Busch Isaksen
Keyword(s):  
Fecal Coliform ◽  
Geometric Mean ◽  
P Value ◽  
Ultraviolet Disinfection ◽  
Tobit Regression ◽  
Effluent Quality ◽  
Physiochemical Parameters ◽  
Onsite Wastewater Treatment Systems ◽  
Site Characteristics ◽  
Uv Dose

Abstract Ultraviolet disinfection (UVD) units enhance onsite sewage systems (OSSs) in areas where conventional treatment is limited by site characteristics. Although UVD units are efficacious under testing conditions, few studies have considered their effectiveness when installed. This study used a mixed-methods approach to examine UVD unit effluent quality and determine the association between UV bulb status and fecal coliform levels. Samples from UVD units and pump chambers were tested for bacterial and physiochemical parameters. Field data were supplemented with data from retrospective compliance samples. A multivariate Tobit regression model predicted that the geometric mean (GM) fecal coliform concentration was 122% higher when the UV bulb was deficient than when it was not deficient, adjusted for other OSS deficiencies (95% CI: 36–428, p-value &lt;0.001). The predicted GM fecal coliform concentration in malfunctioning UVD unit effluent (745 CFU/100 mL) exceeded field compliance standards (400 CFU/100 mL), and the odds of exceedance were 7.48 times higher when the UV bulb was deficient, adjusted for other OSS deficiencies (95% CI: 4.03–13.9, p-value &lt;0.001). Despite limitations in the characterization of UV dose, the results validate the importance of UVD units to reduce bacterial loads and the need for further research into their field effectiveness.

scholarly journals Dose-response for assessing the cancer risk of inorganic arsenic in drinking water: the scientific basis for use of a threshold approach

2019 ◽  
Vol 49 (1) ◽  
pp. 36-84 ◽  
Author(s):  
Joyce S. Tsuji ◽  
Ellen T. Chang ◽  
P. Robinan Gentry ◽  
Harvey J. Clewell ◽  
Paolo Boffetta ◽  
...  
Keyword(s):  
Drinking Water ◽  
Cancer Risk ◽  
Dose Response ◽  
Inorganic Arsenic ◽  
Scientific Basis ◽  
Threshold Approach

Aldicarb immunomodulation in mice: An inverse dose-response to parts per billion levels in drinking water

1987 ◽  
Vol 16 (4) ◽  
pp. 433-439 ◽  
Author(s):  
Leon John Olson ◽  
Barbara J. Erickson ◽  
Ronald D. Hinsdill ◽  
Jeffrey A. Wyman ◽  
Warren P. Porter ◽  
...  
Keyword(s):  
Drinking Water ◽  
Dose Response

1182 Dose-response Curves of Bleomycin Activity on in Vitro Genomic DNA for Dosimetric Purposes

2012 ◽  
Vol 48 ◽  
pp. S284-S285
Author(s):  
M.J. Ruiz-Gomez ◽  
B. López-Díaz ◽  
S. Mercado-Sáenz ◽  
L. Lumbreras ◽  
L. Gil ◽  
...  
Keyword(s):  
Dose Response ◽  
Genomic Dna ◽  
Response Curves ◽  
Dose Response Curves
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