Cytoprotective effects of a proprietary red maple leaf extract and its major polyphenol, ginnalin A, against hydrogen peroxide and methylglyoxal induced oxidative stress in human keratinocytes

2020 ◽  
Vol 11 (6) ◽  
pp. 5105-5114
Author(s):  
Chang Liu ◽  
Hao Guo ◽  
Joel A. Dain ◽  
Yinsheng Wan ◽  
Xing-Hua Gao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Leaf Extract ◽  
Human Keratinocytes ◽  
Protective Effects ◽  
Red Maple ◽  
Maple Leaves

Maplifa™ (a proprietary red maple leaves extract) and its major polyphenol, ginnalin A, exert skin protective effects against oxidative stress.

scholarly journals Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 626
Author(s):  
Li Xiao ◽  
Nobuhiko Miwa
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Interleukin 6 ◽  
Lipid Accumulation ◽  
Metabolic Disorders ◽  
Three Dimensional ◽  
Human Keratinocytes ◽  
Ros Generation ◽  
Obese People ◽  
Subcutaneous Adipose

Reactive oxygen species (ROS)-induced oxidative stress in adipose tissue is associated with inflammation and the development of obesity-related metabolic disorders. The aim of this study is to investigate the effects of hydrogen nano-bubble water (HW) on ROS generation, adipogenesis, and interleukin-6 (IL-6) secretion in hydrogen peroxide (H2O2) or phorbol 12-myristate 13-acetate (PMA)-stimulated OP9 adipocytes, and three-dimensional (3D) subcutaneous adipose equivalents. Nanoparticle tracking analysis showed that fresh HW contains 1.17 × 108/mL of nano-sized hydrogen bubbles. Even after 8 to 13 months of storage, approximately half of the bubbles still remained in the water. CellROX® staining showed that HW could diminish H2O2- or PMA-induced intracellular ROS generation in human keratinocytes HaCaT and OP9 cells. We discovered that PMA could markedly increase lipid accumulation to 180% and IL-6 secretion 2.7-fold in OP9 adipocytes. Similarly, H2O2 (5 µM) also significantly stimulated lipid accumulation in OP9 cells and the 3D adipose equivalents. HW treatment significantly repressed H2O2- or PMA-induced lipid accumulation and IL-6 secretion in OP9 adipocytes and the 3D adipose equivalents. In conclusion, HW showed a possibility of repressing oxidative stress, inflammatory response, and adipogenesis at cellular/tissue levels. It can be used for preventing the development of metabolic disorders amongst obese people.

Remifentanil reduced the effects of hydrogen peroxide-induced oxidative stress in human keratinocytes via autophagy

2017 ◽  
Vol 58 (6) ◽  
pp. 597-605 ◽  
Author(s):  
Cheul Hong Kim ◽  
Seong Soon Jeong ◽  
Ji Young Yoon ◽  
Ji Uk Yoon ◽  
Su Bin Yu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Human Keratinocytes

scholarly journals Total Glucosides of Peony Protect Cardiomyocytes against Oxidative Stress and Inflammation by Reversing Mitochondrial Dynamics and Bioenergetics

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Mengmeng Wang ◽  
Qiang Li ◽  
Ying Zhang ◽  
Hao Liu
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Lupus Erythematosus ◽  
Mitochondrial Dynamics ◽  
Mitochondrial Bioenergetics ◽  
Protective Effects ◽  
Systemic Lupus ◽  
Regulatory Effects ◽  
Total Glucosides Of Peony

Total glucosides of peony (TGP) are used to treat rheumatoid arthritis and systemic lupus erythematosus. We explored the protective effects of TGP on cardiomyocyte oxidative stress and inflammation in the presence of hydrogen peroxide by focusing on mitochondrial dynamics and bioenergetics. Our study demonstrated that hydrogen peroxide significantly repressed cardiomyocyte viability and promoted cell apoptosis through induction of the mitochondrial death pathway. TGP treatment sustained cardiomyocyte viability, reduced cardiomyocyte apoptosis, and decreased inflammation and oxidative stress. Molecular investigation indicated that hydrogen peroxide caused mitochondrial dynamics disruption and bioenergetics reduction in cardiomyocytes, but this alteration could be normalized by TGP. We found that disruption of mitochondrial dynamics abolished the regulatory effects of TGP on mitochondrial bioenergetics; TGP modulated mitochondrial dynamics through the AMP-activated protein kinase (AMPK) pathway; and inhibition of AMPK alleviated the protective effects of TGP on mitochondria. Our results showed that TGP treatment reduces cardiomyocyte oxidative stress and inflammation in the presence of hydrogen peroxide by correcting mitochondrial dynamics and enhancing mitochondrial bioenergetics. Additionally, the regulatory effects of TGP on mitochondrial function seem to be mediated through the AMPK pathway. These findings are promising for myocardial injury in patients with rheumatoid arthritis and systemic lupus erythematosus.

Fucoidan refined by Sargassum confusum indicate protective effects suppressing photo-oxidative stress and skin barrier perturbation in UVB-induced human keratinocytes

2020 ◽  
Vol 164 ◽  
pp. 149-161 ◽  
Author(s):  
Ilekuttige Priyan Shanura Fernando ◽  
Mawalle Kankanamge Hasitha Madhawa Dias ◽  
Dissanayaka Mudiyanselage Dinesh Madusanka ◽  
Eui Jeong Han ◽  
Min Ju Kim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skin Barrier ◽  
Human Keratinocytes ◽  
Protective Effects
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