Coaxial oblique interface shearing: tunable generation and sorting of double emulsions for spatial gradient drug release

Lab on a Chip ◽  
2020 ◽  
Vol 20 (7) ◽  
pp. 1249-1258 ◽  
Author(s):  
Fangsheng Huang ◽  
Zhiqiang Zhu ◽  
Ye Niu ◽  
Yi Zhao ◽  
Ting Si ◽  
...  
Keyword(s):  
Drug Release ◽  
Spatial Gradient ◽  
Double Emulsions ◽  
One Step ◽  
Interface Shearing

We propose a coaxial oblique interface shearing (COIS) process to one-step generate and sort double emulsions for thermal- and chemical-responsive spatial gradient releases.

scholarly journals 3D Printed Microfluidic Devices for Drug Release Assays

Pharmaceutics ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 13
Author(s):  
Benzion Amoyav ◽  
Yoel Goldstein ◽  
Eliana Steinberg ◽  
Ofra Benny
Keyword(s):  
3D Printing ◽  
Drug Release ◽  
Particle Production ◽  
Cost Effective ◽  
Drug Dissolution ◽  
Cytotoxicity Test ◽  
High Durability ◽  
One Step ◽  
Cost Effective Alternative ◽  
Multiple Recycling

Microfluidics research for various applications, including drug delivery, cell-based assays and biomedical research has grown exponentially. Despite this technology’s enormous potential, drawbacks include the need for multistep fabrication, typically with lithography. We present a one-step fabrication process of a microfluidic chip for drug dissolution assays based on a 3D printing technology. Doxorubicin porous and non-porous microspheres, with a mean diameter of 250µm, were fabricated using a conventional “batch” or microfluidic method, based on an optimized solid-in-oil-in-water protocol. Microspheres fabricated with microfluidics system exhibited higher encapsulation efficiency and drug content as compared with batch formulations. We determined drug release profiles of microspheres in varying pH conditions using two distinct dissolution devices that differed in their mechanical barrier structures. The release profile of the “V” shape barrier was similar to that of the dialysis sac test and differed from the “basket” barrier design. Importantly, a cytotoxicity test confirmed biocompatibility of the printed resin. Finally, the chip exhibited high durability and stability, enabling multiple recycling sessions. We show how the combination of microfluidics and 3D printing can reduce costs and time, providing an efficient platform for particle production while offering a feasible cost-effective alternative to clean-room facility polydimethylsiloxane-based chip microfabrication.

scholarly journals Preparation and Characterization of Coaxial Electrospinning rhBMP2-Loaded Nanofiber Membranes

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
He Zhao ◽  
Yali Ma ◽  
Dahui Sun ◽  
Wendi Ma ◽  
Jihang Yao ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Drug Release ◽  
Osteogenic Differentiation ◽  
Release Behavior ◽  
Promote Cell Proliferation ◽  
Drug Release Behavior ◽  
One Step ◽  
Nanofiber Membranes ◽  
Dual Release

DEX and rhBMP2-loaded core-shell nanofiber membranes were synthesized by electrospinning method in one step. Zein/PLLA, Zein-DEX/PLLA, Zein/PLLA-rhBMP2, and Zein-DEX/PLLA-rhBMP2 were fabricated; and morphology, hydrophilicity, mechanics properties, in vitro drug release behavior, cell proliferation, and osteogenic differentiation were investigated. The results showed that the dual-release system containing rhBMP2 and DEX prepared by electrospinning had rough surface, constant drug release behavior, and could also significantly promote cell proliferation and osteogenic differentiation of RMSCs, indicating that the scaffolds we fabricated might be suitable for bone tissue engineering.

One step preparation of plasma based polymer films for drug release

2012 ◽  
Vol 32 (7) ◽  
pp. 2103-2108 ◽  
Author(s):  
Cédric Amorosi ◽  
Vincent Ball ◽  
Jérôme Bour ◽  
Philippe Bertani ◽  
Valérie Toniazzo ◽  
...  
Keyword(s):  
Drug Release ◽  
Polymer Films ◽  
One Step

Redox-responsive, core-crosslinked degradable micelles for controlled drug release

2016 ◽  
Vol 7 (41) ◽  
pp. 6330-6339 ◽  
Author(s):  
Yingchun Xia ◽  
Hua He ◽  
Xiangyu Liu ◽  
Ding Hu ◽  
Lichen Yin ◽  
...  
Keyword(s):  
Drug Release ◽  
Click Chemistry ◽  
Controlled Drug Release ◽  
Redox Responsive ◽  
One Step ◽  
Crosslinked Micelles

We developed novel redox-responsive, core-crosslinked micelles (CCLMs) via a simple, one-step click chemistry reaction.

scholarly journals Preparation of and drug release from W/O/W type double emulsions containing anticancer agents using an oily lymphographic agent as an oil phase.

1987 ◽  
Vol 35 (8) ◽  
pp. 3375-3381 ◽  
Author(s):  
SHOJI FUKUSHIMA ◽  
MIKA NISHIDA ◽  
MASAHIRO NAKANO
Keyword(s):  
Drug Release ◽  
Anticancer Agents ◽  
Double Emulsions

scholarly journals Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery

Nanomaterials ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2328
Author(s):  
Zhao Wang ◽  
Xinhua Li ◽  
Xiaojuan Zhang ◽  
Ruilong Sheng ◽  
Qing Lin ◽  
...  
Keyword(s):  
Drug Release ◽  
Contact Lenses ◽  
Eye Drops ◽  
Water Contact ◽  
In Vitro Drug Release ◽  
Molding Method ◽  
Ophthalmic Drug ◽  
One Step

Therapeutic ophthalmic contact lenses with prolonged drug release and improved bioavailability have been developed to circumvent tedious eye drop instillation. In this work, zwitterionic nanogels based on poly(sulfobetaine methacrylate) (PSBMA) were easily fabricated by one-step reflux-precipitation polymerization, with the advantages of being surfactant-free and morphology controlled. Then, the ophthalmic drug levofloxacin (LEV) was encapsulated into the nanogels. A set of contact lenses with varied nanogel-loading content was fabricated by the cast molding method, with the drug-loaded nanogels dispersed in pre-monomer solutions composed of 2-hydroxyethyl methacrylate (HEMA) and N-vinyl-2-pyrrolidone (NVP). The structure, surface morphology, water contact angle (WCA), equilibrium water content (EWC), transmittance, and mechanical properties of the contact lenses were subsequently investigated, and in vitro drug release and biocompatibility were further evaluated. As a result, the optimized contact lens with nanogel-loading content of 8 wt% could sustainably deliver LEV for ten days, with critical lens properties within the range of recommended values for commercial contact lenses. Moreover, cell viability assays revealed that the prepared contact lenses were cytocompatible, suggesting their significant potential as an alternative to traditional eye drops or ointment formulations for long-term oculopathy treatment.

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