Redox-responsive, core-crosslinked degradable micelles for controlled drug release

2016 ◽  
Vol 7 (41) ◽  
pp. 6330-6339 ◽  
Author(s):  
Yingchun Xia ◽  
Hua He ◽  
Xiangyu Liu ◽  
Ding Hu ◽  
Lichen Yin ◽  
...  
Keyword(s):  
Drug Release ◽  
Click Chemistry ◽  
Controlled Drug Release ◽  
Redox Responsive ◽  
One Step ◽  
Crosslinked Micelles

We developed novel redox-responsive, core-crosslinked micelles (CCLMs) via a simple, one-step click chemistry reaction.

One-Pot Synthesis of Redox-Responsive Polymers-Coated Mesoporous Silica Nanoparticles and Their Controlled Drug Release

2013 ◽  
Vol 34 (17) ◽  
pp. 1387-1394 ◽  
Author(s):  
Jiao-Tong Sun ◽  
Ji-Gang Piao ◽  
Long-Hai Wang ◽  
Mohsin Javed ◽  
Chun-Yan Hong ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release ◽  
One Pot ◽  
Responsive Polymers ◽  
One Pot Synthesis ◽  
Redox Responsive

scholarly journals Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release

Nanoscale ◽  
2016 ◽  
Vol 8 (15) ◽  
pp. 8101-8110 ◽  
Author(s):  
Stefan Datz ◽  
Christian Argyo ◽  
Michael Gattner ◽  
Veronika Weiss ◽  
Korbinian Brunner ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Click Chemistry ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release ◽  
Cell Uptake

We describe a novel enzyme-based cap system for mesoporous silica nanoparticles combined with bio-orthogonal click chemistry.

Triple Redox Responsive Poly(Ethylene Glycol)-Polycaprolactone Polymeric Nanocarriers for Fine-Controlled Drug Release

2016 ◽  
Vol 17 (4) ◽  
pp. 1600295 ◽  
Author(s):  
Caiyan Zhao ◽  
Leihou Shao ◽  
Jianqing Lu ◽  
Chenying Zhao ◽  
Yujie Wei ◽  
...  
Keyword(s):  
Drug Release ◽  
Ethylene Glycol ◽  
Controlled Drug Release ◽  
Poly Ethylene Glycol ◽  
Polymeric Nanocarriers ◽  
Redox Responsive ◽  
Poly Ethylene

scholarly journals Hybrid mesoporous silica with controlled drug release

2019 ◽  
Vol 84 (9) ◽  
pp. 1027-1039 ◽  
Author(s):  
László Almásy ◽  
Ana-Maria Putz ◽  
Qiang Tian ◽  
Gennady Kopitsa ◽  
Tamara Khamova ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Drug Loading ◽  
Sol Gel ◽  
Nitrogen Adsorption ◽  
Controlled Drug Release ◽  
Ammonium Bromide ◽  
Structure Directing Agent ◽  
One Step

The mesoporous silica particles were prepared by the sol?gel method in one-step synthesis, in acidic conditions, from tetraethoxysilane (TEOS) and methyltriethoxysilane (MTES), varying the mole ratio of the silica precursors. Nitric acid was used as catalyst at room temperature and hexadecyltrimethyl ammonium bromide (CTAB) as structure directing agent. Optical properties, porosity and microstructure of the materials in function of the MTES/TEOS ratio were evaluated using infrared spectroscopy, nitrogen adsorption and small angle X-ray scattering. All materials showed the ordered pore structure and the high specific surfaces, making them suitable as the drug delivery systems. Drug loading and release tests using ketoprofen were performed to assess their performance for drug delivery applications. The amount of the methylated precursor used in the synthesis had little effect on the drug loading capacity, but had a strong influence on the initial rate of the drug release.

scholarly journals Combined Magnetoliposome Formation and Drug Loading in One Step for Efficient Alternating Current-Magnetic Field Remote-Controlled Drug Release

2020 ◽  
Vol 12 (4) ◽  
pp. 4295-4307 ◽  
Author(s):  
Maria Eugenia Fortes Brollo ◽  
Ana Domínguez-Bajo ◽  
Andrea Tabero ◽  
Vicente Domínguez-Arca ◽  
Victor Gisbert ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Release ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Alternating Current ◽  
One Step ◽  
Current Magnetic Field

scholarly journals Pillar[5]arene pseudo[1]rotaxane-based redox-responsive supramolecular vesicles for controlled drug release

2019 ◽  
Vol 3 (7) ◽  
pp. 1427-1432 ◽  
Author(s):  
Ya-Han Cui ◽  
Rong Deng ◽  
Zheng Li ◽  
Xu-Sheng Du ◽  
Qiong Jia ◽  
...  
Keyword(s):  
Drug Release ◽  
Anticancer Drugs ◽  
Controlled Drug Release ◽  
Redox Responsive

Pillar[5]arene pseudo[1]rotaxane-based supramolecular vesicles loaded with anticancer drugs could deliver the payload to the targeted area of high GSH concentrations.

One Step Preparation of Controlled Drug Release Systems in Supercritical Carbon Dioxide

2009 ◽  
Vol 27 (2) ◽  
pp. 267-272 ◽  
Author(s):  
Liqin CAO ◽  
Chengwei WANG ◽  
Liuping CHEN
Keyword(s):  
Carbon Dioxide ◽  
Drug Release ◽  
Supercritical Carbon Dioxide ◽  
Controlled Drug Release ◽  
One Step ◽  
Supercritical Carbon

scholarly journals Actively Targeted and Redox Responsive Delivery of Anticancer Drug by Chitosan Nanoparticles

Pharmaceutics ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 26 ◽  
Author(s):  
Elisabetta Mazzotta ◽  
Selene De Benedittis ◽  
Antonio Qualtieri ◽  
Rita Muzzalupo
Keyword(s):  
Drug Release ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Water Solubility ◽  
Chitosan Nanoparticles ◽  
Controlled Drug Release ◽  
Dependent Manner ◽  
High Concentration ◽  
Redox Responsive

The clinical efficacy of methotrexate (MTX) is limited by its poor water solubility, its low bioavailability, and the development of resistance in cancer cells. Herein, we developed novel folate redox-responsive chitosan (FTC) nanoparticles for intracellular MTX delivery. l-Cysteine and folic acid molecules were selected to be covalently linked to chitosan in order to confer it redox responsiveness and active targeting of folate receptors (FRs). NPs based on these novel polymers could possess tumor specificity and a controlled drug release due to the overexpression of FRs and high concentration of reductive agents in the microenvironment of cancer cells. Nanoparticles (NPs) were prepared using an ionotropic gelation technique and characterized in terms of size, morphology, and loading capacity. In vitro drug release profiles exhibited a glutathione (GSH) dependence. In the normal physiological environment, NPs maintained good stability, whereas, in a reducing environment similar to tumor cells, the encapsulated MTX was promptly released. The anticancer activity of MTX-loaded FTC-NPs was also studied by incubating HeLa cells with formulations for various time and concentration intervals. A significant reduction in viability was observed in a dose- and time-dependent manner. In particular, FTC-NPs showed a better inhibition effect on HeLa cancer cell proliferation compared to non-target chitosan-based NPs used as control. The selective cellular uptake of FTC-NPs via FRs was evaluated and confirmed by fluorescence microscopy. Overall, the designed NPs provide an attractive strategy and potential platform for efficient intracellular anticancer drug delivery.

Facile fabrication of reduction-responsive nanocarriers for controlled drug release

2014 ◽  
Vol 5 (17) ◽  
pp. 4879-4883 ◽  
Author(s):  
Rui Sun ◽  
Qiaojie Luo ◽  
Chen Gao ◽  
Ying Wang ◽  
Lilong Gao ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
One Pot ◽  
Facile Fabrication ◽  
Crosslinked Micelles ◽  
Ether Ester

An amphiphilic multiblock poly(ether–ester) containing multiple thiols was facilely synthesized by “one-pot” polycondensation, and was used to prepare reduction-responsive core-crosslinked micelles for controlled drug release.

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