NIR responsive AuNRs/pNIPAM/PEGDA inverse opal hydrogel microcarriers for controllable drug delivery

2021 ◽  
Author(s):  
Lingzi Liu ◽  
Xiaoyan Sun ◽  
Baofen Ye ◽  
Zhengyu Yan
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Delivery System ◽  
Gold Nanorods ◽  
Controlled Drug Release ◽  
Inverse Opal

Particle-based delivery system has merged as a powerful platform in controlled drug release. The present study developed a new inverse opal hydrogel microcarriers system composed of gold nanorods (AuNRs) for...

Development of biodegradable polyesters based on a hydroxylated coumarin initiator towards fluorescent visible paclitaxel-loaded microspheres

2019 ◽  
Vol 7 (14) ◽  
pp. 2261-2276 ◽  
Author(s):  
Yufei Bian ◽  
Zhiyong Wei ◽  
Zefeng Wang ◽  
Zhu Tu ◽  
Liuchun Zheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Physical Properties ◽  
Drug Delivery System ◽  
Delivery System ◽  
Controlled Drug Release ◽  
Biodegradable Polyesters ◽  
Biomedical Field

A facile method of end-functionalization was used to synthesize a series of fluorescent biodegradable polyesters with tailorable physical properties, which can promisingly be applied in the biomedical field as a controllable and traceable drug delivery system, especially for long-term controlled drug release.

Synthesis of lipid–black phosphorus quantum dot bilayer vesicles for near-infrared-controlled drug release

2018 ◽  
Vol 54 (47) ◽  
pp. 6060-6063 ◽  
Author(s):  
Shengyong Geng ◽  
Lie Wu ◽  
Haodong Cui ◽  
Wenyong Tan ◽  
Tianfeng Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Drug Release ◽  
Quantum Dot ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Controlled Drug Release ◽  
Black Phosphorus ◽  
Black Phosphorus Quantum Dots

Black phosphorus quantum dots are incorporated into liposomal bilayers to produce a drug delivery system with excellent near-infrared (NIR) photothermal properties and drug release capability controlled by light.

Polymer–paclitaxel conjugates based on disulfide linkers for controlled drug release

RSC Advances ◽  
2015 ◽  
Vol 5 (10) ◽  
pp. 7559-7566 ◽  
Author(s):  
Wulian Chen ◽  
Luqman Ali Shah ◽  
Li Yuan ◽  
Mohammad Siddiq ◽  
Jianhua Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Diblock Copolymer ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Controlled Drug Delivery System ◽  
Disulfide Linkers ◽  
Covalently Linked

Controlled drug delivery system based on hydrophilic diblock copolymer covalently linked paclitaxel (PTX) via a disulfide linker.

Dual-functional SFP/PAN based nano drug release system for treatment and nutrients

2021 ◽  
pp. 004051752098809
Author(s):  
Ling Han ◽  
Yingbo Ma ◽  
Hao Dou ◽  
Wei Fan
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Controlled Drug Release ◽  
Order Kinetic ◽  
Antimicrobial Drugs ◽  
Dual Functional ◽  
Nano Drug Delivery

Nano drug delivery systems can control the ordered release of drugs. To achieve the target of supplying therapeutics and nutrients at the same time, a novel nano drug delivery system with a core–shell structure was prepared by coaxial electrospinning. Polyacrylonitrile (PAN) has been used to produce a drug release scaffold in the shell section, mixed with absorbable silk fibroin peptide (SFP) as a nutrient. Ciprofloxacin (CPFX), a broad-spectrum antibiotic, was used as the core, as well as an antibacterial agent. Owing to its low molecular weight, using a pure SFP thin solution to manufacture nanofibers by electrospinning is still technically challenging. Thus, different ratios of PAN to SFP were used in the shell electrospinning solution. In this research, a novel nano dual-functionality drug delivery system has been successfully prepared. In vitro testing demonstrated that nanofibers could supply more nutrients with increasing SFP in shell solutions; however, the ability to maintain controlled release was reduced. It was found that the nanofiber membrane had the best controlled drug release capability for a PAN-to-SFP mass ratio of 95:5. Overall, most ciprofloxacin was released in the first 12 h, while the release of SFP was constant throughout the first 24 h. Our modeling demonstrated that the release of CPFX and SFP is best described using a first-order kinetic model. The developed drug delivery system is designed to release antimicrobial drugs in a controlled manner and provide absorbable nutrients simultaneously.

Smart mesoporous silica nanoparticles gated by pillararene-modified gold nanoparticles for on-demand cargo release

2016 ◽  
Vol 52 (95) ◽  
pp. 13775-13778 ◽  
Author(s):  
Xin Wang ◽  
Li-Li Tan ◽  
Xi Li ◽  
Nan Song ◽  
Zheng Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release ◽  
On Demand

A new drug delivery system, based on mesoporous silica nanoparticles gated by carboxylatopillar[5]arene-modified gold nanoparticles, has been fabricated for controlled drug release.

scholarly journals Design of DOX-GNRs-PNIPAM@PEG-PLA Micelle With Temperature and Light Dual-Function for Potent Melanoma Therapy

2021 ◽  
Vol 8 ◽  
Author(s):  
Na Wang ◽  
Jing Shi ◽  
Cong Wu ◽  
Weiwei Chu ◽  
Wanru Tao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Gold Nanorods ◽  
Dual Function ◽  
Serum Stability ◽  
Melanoma Therapy

Objective: The aim of this study was to construct light and temperature dual-sensitive micellar carriers loaded with doxorubicin (DOX) and gold nanorods (DOX-GNRs-PNIPAM@PEG-PLA, DAPP) for melanoma therapy.Methods: The DAPP self-assembled using fine-tuned physicochemical properties in water. The DAPP structure, temperature- and photo-sensitivity, drug-release, in-vitro serum stability, and cytotoxicity against melanoma B16F10 cells were evaluated in detail. The corresponding in-vitro and in-vivo therapeutic mechanisms were then evaluated using a B16F10-melanoma bearing BALB/c nude mouse model (B16F10).Results: The light and temperature sensitive micellar drug-delivery system assembled from block copolymer and gold nanorods exhibited a narrow particle size and size distribution, good biocompatibility, well-designed photo-temperature conversion, controlled drug release, and high serum stability. Compared with the free DOX- and PBS-treated groups, the cell endocytosis-mediated cytotoxicity and intra-tumor accumulation of DAPP was markedly enhanced by the NIR-light exposure and induced potent in-vivo tumor inhibitory activity.Conclusion: The design of DAPP, a dual-functional micellar drug-delivery system with temperature- and light-sensitive properties, offers a new strategy for skin-cancer therapy with a potent therapeutic index.

Chitosan-based magnetic/fluorescent nanocomposites for cell labelling and controlled drug release

2017 ◽  
Vol 41 (4) ◽  
pp. 1736-1743 ◽  
Author(s):  
Yongling Ding ◽  
Hong Yin ◽  
Shirley Shen ◽  
Kangning Sun ◽  
Futian Liu
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Controlled Drug Release ◽  
Cell Labelling ◽  
Chitosan Matrix ◽  
Novel Drug Delivery System ◽  
Novel Drug

A novel drug delivery system, containing functional Fe3O4, CdTe@ZnS QDs, doxorubicin and a chitosan matrix, was designed via a polymer crosslinking method.

scholarly journals Visible-light-triggered supramolecular valves based on β-cyclodextrin-modified mesoporous silica nanoparticles for controlled drug release

RSC Advances ◽  
2019 ◽  
Vol 9 (30) ◽  
pp. 17179-17182 ◽  
Author(s):  
Qing Bian ◽  
Zhaolu Xue ◽  
Po Sun ◽  
Kejing Shen ◽  
Shangbing Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Visible Light ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release

Visible-light triggered drug delivery system based on tetra-ortho-methoxy-substituted azobenzene (mAzo) and β-cyclodextrin (β-CD) modified mesoporous silica nanoparticles (MSNs-CD).

pH-responsive cancer-targeted selenium nanoparticles: a transformable drug carrier with enhanced theranostic effects

2014 ◽  
Vol 2 (33) ◽  
pp. 5409-5418 ◽  
Author(s):  
Bo Yu ◽  
Xiaoling Li ◽  
Wenjie Zheng ◽  
Yanxian Feng ◽  
Yum-Shing Wong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Cell Organelles ◽  
Shape Transformation ◽  
Anticancer Efficacy

A cancer-targeted and structure-transformable drug delivery system has been constructed, which displays enhanced anticancer efficacy and exhibits the characteristics of shape transformation and pH-controlled drug release under acidifying cell organelles.

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