scholarly journals Supramolecular nanomotors with “pH taxis” for active drug delivery in the tumor microenvironment

Nanoscale ◽  
2020 ◽  
Vol 12 (44) ◽  
pp. 22495-22501
Author(s):  
Motilal Mathesh ◽  
Jiawei Sun ◽  
Frans van der Sandt ◽  
Daniela A. Wilson
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Hela Cells ◽  
Targeted Drug Delivery ◽  
Active Drug ◽  
Ph Gradient ◽  
Supramolecular Architecture ◽  
Targeted Drug ◽  
Drug Delivery Applications

Supramolecular architecture-based truly “pH taxis” exhibiting nanomotors are fabricated by in-situ grown CaCO3 particles, which can sense the endogenously present pH gradient in HeLa cells making them suitable for targeted drug delivery applications.

Matrix Metalloproteinases (MMPs) in Targeted Drug Delivery: Synthesis of a Potent and Highly Selective Inhibitor against Matrix Metalloproteinase- 7

2020 ◽  
Vol 20 (27) ◽  
pp. 2459-2471
Author(s):  
Ling-Li Wang ◽  
Bing Zhang ◽  
Ming-Hua Zheng ◽  
Yu-Zhong Xie ◽  
Chang-Jiang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Matrix Metalloproteinases ◽  
Cancer Treatment ◽  
Targeted Drug Delivery ◽  
Selective Inhibitor ◽  
Migration And Invasion ◽  
Side Chains ◽  
Mesenchymal Transition ◽  
Targeted Drug

Background: Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that play a key role in both physiological and pathological tissue degradation. MMPs have reportedly shown great potentials in the degradation of the Extracellular Matrix (ECM), have shown great potentials in targeting bioactive and imaging agents in cancer treatment. MMPs could provoke Epithelial to Mesenchymal Transition (EMT) of cancer cells and manipulate their signaling, adhesion, migration and invasion to promote cancer cell aggressiveness. Therefore, targeting and particularly inhibiting MMPs within the tumor microenvironment is an effective strategy for cancer treatment. Based on this idea, different MMP inhibitors (MMPIs) have been developed to manipulate the tumor microenvironment towards conditions appropriate for the actions of antitumor agents. Studies are ongoing to improve the selectivity and specificity of MMPIs. Structural optimization has facilitated the discovery of selective inhibitors of the MMPs. However, so far no selective inhibitor for MMP-7 has been proposed. Aims: This study aims to comprehensively review the potentials and advances in applications of MMPs particularly MMP-7 in targeted cancer treatment approaches with the main focus on targeted drug delivery. Different targeting strategies for manipulating and inhibiting MMPs for the treatment of cancer are discussed. MMPs are upregulated at all stages of expression in cancers. Different MMP subtypes have shown significant targeting applicability at the genetic, protein, and activity levels in both physiological and pathophysiological conditions in a variety of cancers. The expression of MMPs significantly increases at advanced cancer stages, which can be used for controlled release in cancers in advance stages. Methods: Moreover, this study presents the synthesis and characteristics of a new and highly selective inhibitor against MMP-7 and discusses its applications in targeted drug delivery systems for therapeutics and diagnostics modalities. Results: Our findings showed that the structure of the inhibitor P3’ side chains play the crucial role in developing an optimized MMP-7 inhibitor with high selectivity and significant degradation activities against ECM. Conclusion: Optimized NDC can serve as a highly potent and selective inhibitor against MMP-7 following screening and optimization of the P3’ side chains, with a Ki of 38.6 nM and an inhibitory selectivity of 575 of MMP-7 over MMP-1.

scholarly journals Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment

2021 ◽  
Vol 22 (10) ◽  
pp. 5278
Author(s):  
Andrew E. Massey ◽  
Shabnam Malik ◽  
Mohammad Sikander ◽  
Kyle A. Doxtater ◽  
Manish K. Tripathi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Intercellular Communication ◽  
Targeted Drug Delivery ◽  
Clinical Implications ◽  
Disease States ◽  
Significant Research ◽  
The Common ◽  
Targeted Drug ◽  
Loading Methods

Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading methods of exosomes, some of the major roles of exosomes in the tumor microenvironment, as well as discuss recent applications of exosomes as drug delivery vessels and the resulting clinical implications.

scholarly journals Characterizing Riboflavin Antagonists for Targeted Drug Delivery Applications

2011 ◽  
Vol 100 (3) ◽  
pp. 553a
Author(s):  
Anna Plantinga ◽  
Amanda Witte ◽  
Seok-Ki Choi ◽  
Kumar Sinniah
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Drug ◽  
Drug Delivery Applications

scholarly journals Characterizing a Riboflavin-Dendrimer Platform for Targeted Drug Delivery Applications

2012 ◽  
Vol 102 (3) ◽  
pp. 66a
Author(s):  
Amanda Witte ◽  
Christine Timmer ◽  
Jeremy Gam ◽  
Seok Ki Choi ◽  
Kumar Sinniah
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Drug ◽  
Drug Delivery Applications

In situ crosslinked smart polypeptide nanoparticles for multistage responsive tumor-targeted drug delivery

Nanoscale ◽  
2016 ◽  
Vol 8 (11) ◽  
pp. 5985-5995 ◽  
Author(s):  
Huqiang Yi ◽  
Peng Liu ◽  
Nan Sheng ◽  
Ping Gong ◽  
Yifan Ma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Drug
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