scholarly journals A covalent organic framework as a nanocarrier for synergistic phototherapy and immunotherapy

2020 ◽  
Vol 8 (25) ◽  
pp. 5451-5459 ◽  
Author(s):  
Ying Zhou ◽  
Sainan Liu ◽  
Chunling Hu ◽  
Lihan Cai ◽  
Maolin Pang
Keyword(s):  
Photodynamic Therapy ◽  
Local Recurrence ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Tumor Metastasis ◽  
Primary Tumors ◽  
Treatment Methods ◽  
Covalent Organic Framework ◽  
Organic Framework

As traditional cancer treatment methods, photodynamic therapy (PDT) and photothermal therapy (PTT) can eliminate primary tumors, but they cannot inhibit extensive tumor metastasis and local recurrence.

Covalent organic framework based nanoagent for enhanced mild-temperature photothermal therapy

2021 ◽  
Author(s):  
Qiaoqiao Sun ◽  
Kun Tang ◽  
Liqun Song ◽  
Yanhua Li ◽  
Wei Pan ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Covalent Organic Framework ◽  
Mild Temperature ◽  
Organic Framework

Photothermal therapy effectively ablate tumor by the hyperthermia (>50 °C), which was caused by laser irradiation. However, the hyperthermia may inevitably diffuse to the surrounding healthy tissues and induce additional...

Phototherapy and multimodal imaging of cancers based on perfluorocarbon nanomaterials

2021 ◽  
Author(s):  
Zhaoguo Han ◽  
xianshuang tu ◽  
Lina Qiao ◽  
Yige Sun ◽  
Zibo Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Multimodal Imaging

Phototherapy, such as photodynamic therapy (PDT) and photothermal therapy (PTT) possesses unique characteristics of non-invasiveness and minimal side effects in cancer treatment, compared with conventional therapies. However, the ubiquitous tumor...

scholarly journals A COF-based nanoplatform for highly efficient cancer diagnosis, photodynamic therapy and prognosis

2020 ◽  
Vol 11 (26) ◽  
pp. 6882-6888 ◽  
Author(s):  
Peng Gao ◽  
Mengzhen Wang ◽  
Yuanyuan Chen ◽  
Wei Pan ◽  
Ping Zhou ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Diagnosis ◽  
Cancer Imaging ◽  
Covalent Organic Framework ◽  
Highly Efficient ◽  
Organic Framework

A covalent organic framework-based nanoplatform has been developed for cancer imaging, photodynamic therapy, and prognosis.

Nanoscale Covalent Organic Framework for Combinatorial Antitumor Photodynamic and Photothermal Therapy

ACS Nano ◽  
2019 ◽  
Vol 13 (11) ◽  
pp. 13304-13316 ◽  
Author(s):  
Qun Guan ◽  
Le-Le Zhou ◽  
Yan-An Li ◽  
Wen-Yan Li ◽  
Shumei Wang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Covalent Organic Framework ◽  
Organic Framework

scholarly journals The Application of Nanoparticle-Based Drug Delivery Systems in Checkpoint Blockade Cancer Immunotherapy

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Huan Zhao ◽  
Yuanqi Li ◽  
Dan Wei ◽  
Hongrong Luo
Keyword(s):  
Cancer Treatment ◽  
Small Molecule ◽  
Photothermal Therapy ◽  
Drug Delivery Systems ◽  
Tumor Metastasis ◽  
Checkpoint Inhibitors ◽  
Treatment Strategies ◽  
Checkpoint Blockade ◽  
Human Beings ◽  
Cancer Immunity

Tumor is the most serious threat to human beings. Although war against cancer has been launched over forty years, cancer treatment is still far away from being satisfactory. Immunotherapy, especially checkpoint blockade immunotherapy, is a rising star that shows a promising future. To fulfill the requirement of depleting primary tumor and inhibiting tumor metastasis and recurrence, many researchers combined checkpoint blockade immunotherapy with other treatment strategies to extend the treatment outcome. Photodynamic therapy could induce immunogenic cell death, and checkpoint blockade could further accelerate the immunity; therefore, combining these two strategies publishes many papers. Additionally, photothermal therapy and immunotherapy were also utilized for combining with checkpoint blockade, which were also reviewed in this paper. Furthermore, antibodies, siRNA, and small molecule inhibitors are developed to block the checkpoint; therefore, we categorized the papers into three sections, combination nanoparticles with checkpoint blockade antibody, combination nanoparticles with checkpoint blockade siRNA, and combination nanoparticles with small molecule checkpoint inhibitors, and related researches were summarized. In conclusion, the combination nanoparticle with checkpoint blockade cancer immunity is a promising direction that may fulfill the requirement of cancer treatment.

Template-free synthesis and metalation of hierarchical covalent organic framework spheres for photothermal therapy

2019 ◽  
Vol 55 (95) ◽  
pp. 14315-14318 ◽  
Author(s):  
Yanshu Shi ◽  
Sainan Liu ◽  
Zhixiang Zhang ◽  
Ying Liu ◽  
Maolin Pang
Keyword(s):  
Photothermal Therapy ◽  
Room Temperature ◽  
Covalent Organic Framework ◽  
Template Free ◽  
Organic Framework

Room temperature synthesized hierarchical COF spheres were metalated with Fe3+ and utilized for photothermal therapy.

scholarly journals Inorganic Nanoparticles for Cancer Treatment

2020 ◽  
Author(s):  
Heidi Abrahamse ◽  
Hanieh Montaseri ◽  
Cherie Kruger
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Reactive Oxygen ◽  
Inorganic Nanoparticles ◽  
Future Perspectives ◽  
The Past ◽  
Photosensitizing Agents

The application of porphyrins and their derivatives have been investigated extensively over the past years for phototherapy cancer treatment. Phototherapeutic Porphyrins have the ability to generate high levels of reactive oxygen with a low dark toxicity and these properties have made them robust photosensitizing agents. In recent years, Porphyrins have been combined with various nanomaterials in order to improve their bio-distribution. These combinations allow for nanoparticles to enhance photodynamic therapy (PDT) cancer treatment and adding additional nanotheranostics (photothermal therapy—PTT) as well as enhance photodiagnosis (PDD) to the reaction. This review examines various porphyrin-based inorganic nanoparticles developed for phototherapy nanotheranostic cancer treatment over the last three years (2017 to 2020). Furthermore, current challenges in the development and future perspectives of porphyrin-based nanomedicines for cancer treatment are also highlighted.

Integration of a highly monodisperse covalent organic framework photosensitizer with cation exchange synthesized Ag2Se nanoparticles for enhanced phototherapy

2019 ◽  
Vol 55 (62) ◽  
pp. 9164-9167 ◽  
Author(s):  
Chunling Hu ◽  
Lihan Cai ◽  
Sainan Liu ◽  
Maolin Pang
Keyword(s):  
Cation Exchange ◽  
Photothermal Therapy ◽  
Covalent Organic Framework ◽  
Se Nanoparticles ◽  
Organic Framework

COF–Ag2Se nanoparticles were synthesized via a cation exchange approach and utilized for combined photodynamic and photothermal therapy.

Fluorescence-enhanced covalent organic framework nanosystem for tumor imaging and photothermal therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (21) ◽  
pp. 10429-10438 ◽  
Author(s):  
Yang Liu ◽  
Yapei Zhang ◽  
Xiaomin Li ◽  
Xuefeng Gao ◽  
Xiaoyan Niu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Imaging ◽  
Ph Responsive ◽  
Covalent Organic Framework ◽  
Enhanced Imaging ◽  
Organic Framework

Fluorescence-enhanced imaging and photothermal therapy based on pH-responsive covalent organic framework nanoplatform.

Boron-based nanosheets for combined cancer photothermal and photodynamic therapy

2020 ◽  
Vol 8 (21) ◽  
pp. 4609-4619
Author(s):  
Yong Kang ◽  
Xiaoyuan Ji ◽  
Zhengjun Li ◽  
Zhiguo Su ◽  
Songping Zhang
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Treatment Methods

Tumor phototherapy is of great significance for the expansion and advancement of cancer treatment methods.

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