Portable Immunosensor Directly and Rapidly Detects Mycobacterium tuberculosis in Sputum

2022 ◽  
Author(s):  
Jinbiao Ma ◽  
Guanyu Jiang ◽  
Qingqing Ma ◽  
Manman Du ◽  
Hao Wang ◽  
...  
Keyword(s):  
Public Health ◽  
Mycobacterium Tuberculosis ◽  
Health Problem ◽  
Public Health Problem ◽  
Effective Control ◽  
Efficient Detection

Tuberculosis (TB) remains a public health problem that cannot be ignored. The portable and efficient detection of Mycobacterium tuberculosis (MTB) is important for the effective control of this disease. However,...

Rapid Detection of Airborne Protein from Mycobacterium tuberculosis through a Biosensor Detection System

The Analyst ◽  
2022 ◽  
Author(s):  
Jinbiao Ma ◽  
Guanyu Jiang ◽  
Qingqing Ma ◽  
Hao Wang ◽  
Manman Du ◽  
...  
Keyword(s):  
Public Health ◽  
Mycobacterium Tuberculosis ◽  
Human Health ◽  
Health Problem ◽  
Rapid Detection ◽  
Detection System ◽  
Public Health Problem ◽  
Effective Control

Tuberculosis (TB) caused by infection with airborne Mycobacterium tuberculosis (MTB) seriously threatens human health and has become a public health problem of worldwide concern. To achieve effective control of TB,...

The role of BCG in prevention of tuberculosis and the strategies to improve its immunogenicity

2018 ◽  
Vol 2 (1) ◽  
pp. 21-26
Author(s):  
Jolanta Mazurek
Keyword(s):  
Public Health ◽  
Antibiotic Resistance ◽  
Mycobacterium Tuberculosis ◽  
Health Problem ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Human Pathogen ◽  
Deadly Disease ◽  
A Current

Tuberculosis (TB) remains a major public health problem and the main cause of death from the infectious diseases worldwide. Mycobacterium tuberculosis (Mtb), a causative agent of tuberculosis, is the oldest known human pathogen. The only available TB vaccine, BCG, was first administered in 1921 and since then remains the only protecting tool against TB. Yet, its efficacy is limited and there is an urgent need to design and produce a novel vaccine that will protect against this deadly disease in the era of emerging problems with antibiotic resistance. In this review a current, global TB situation is outlined and the characteristics of BCG are presented. Finally, the strategies leading to generation of BCG variants providing improved protecting efficacy are shortly described.

scholarly journals Whole-Genome Shotgun Sequences of Three Multidrug-Resistant Mycobacterium tuberculosis Strains Isolated from Morocco

2017 ◽  
Vol 5 (46) ◽  
Author(s):  
Lamiaa Lahlou ◽  
Nadia El Mrimar ◽  
Meriem Laamarti ◽  
Tarek Alouane ◽  
Mohammed A. Bendahou ◽  
...  
Keyword(s):  
Public Health ◽  
Mycobacterium Tuberculosis ◽  
Health Problem ◽  
Public Health Problem ◽  
Multidrug Resistant ◽  
Whole Genome Shotgun ◽  
The Body ◽  
Major Public Health Problem ◽  
Whole Genome ◽  
Content Type

ABSTRACT Tuberculosis is a contagious disease that usually attacks the lungs but sometimes attacks other parts of the body, such as the kidneys, glands, and bones. It is an endemic and major public health problem in Morocco. Tuberculosis is transmitted through the airways via the inhalation of microdroplets containing Mycobacterium tuberculosis. We present here the whole-genome shotgun sequences of three multidrug-resistant M. tuberculosis strains isolated from Morocco.

scholarly journals Advances in Studies on Prevalence and Interaction Mechanism of Acquired Immunodeficiency Syndrome and Tuberculosis Coinfection

2016 ◽  
Vol 5 (4) ◽  
pp. 115-118
Author(s):  
Chao Meng ◽  
Na Li ◽  
Zhaoxiao Tong ◽  
Huangxin Yan ◽  
Shenxiao Min
Keyword(s):  
Public Health ◽  
Human Immunodeficiency Virus ◽  
Mycobacterium Tuberculosis ◽  
Health Problem ◽  
Acquired Immunodeficiency Syndrome ◽  
Interaction Mechanism ◽  
Public Health Problem ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

AbstractHuman immunodeficiency virus (HIV) and tuberculosis (TB) coinfection is a serious public health problem. HIV and TB promote each other, accelerating development of HIV to acquired immunodeficiency syndrome (AIDS) and heightening TB mortality. Determining interaction mechanism between HIV andMycobacterium tuberculosiscan lead to development of effective treatments. This study summarizes prevalence status of AIDS and TB coinfection and research advances concerning their interaction mechanism.

scholarly journals Plants from the Brazilian Cerrado with antimycobacterial effect

2019 ◽  
Vol 41 ◽  
pp. e37
Author(s):  
Franciano Dias Pereira Cardoso ◽  
Marcio Galdino Dos Santos ◽  
Sergio De Albuquerque ◽  
Zumira Aparecida Carneiro ◽  
Aparecido Osdimir Bertolin
Keyword(s):  
Public Health ◽  
Mycobacterium Tuberculosis ◽  
Health Problem ◽  
Public Health Problem ◽  
Hexane Fraction ◽  
Brazilian Cerrado ◽  
Cytotoxic Effects ◽  
In Vivo Assays

Tuberculosis constitutes a serious public health problem because it has multi-resistant forms that require treatment that is both difficult and extensive. There is a need to develop new antimycobacterial compounds, and plants represent a source of therapeutic resources. This study analyzed antimycobacterial action in eight extracts from plants found in the Brazilian Cerrado. The results showed significant inhibitory concentrations in relation to Mycobacterium tuberculosis, especially from the extracts of Apuleia molaris and Ouratea spectabilis, both of which presented reduced cytotoxic effects. Fractionation revealed a hexane fraction of A. molaris with significant and promising activity regarding future in vivo assays.

scholarly journals Classic and New Diagnostic Approaches to Childhood Tuberculosis

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Gladys Guadalupe López Ávalos ◽  
Ernesto Prado Montes de Oca
Keyword(s):  
Public Health ◽  
Mycobacterium Tuberculosis ◽  
Infrared Spectroscopy ◽  
Health Problem ◽  
Pediatric Patients ◽  
Clinical Care ◽  
Public Health Problem ◽  
Clinical Form ◽  
Diagnostic Approaches ◽  
Mycobacterial Growth

Tuberculosis in childhood differs from the adult clinical form and even has been suggested that it is a different disease due to its differential signs. However, prevention, diagnostics, and therapeutic efforts have been biased toward adult clinical care. Sensibility and specificity of new diagnostic approaches as GeneXpert, electronic nose (E-nose), infrared spectroscopy, accelerated mycobacterial growth induced by magnetism, and flow lateral devices in children populations are needed. Adequate and timely assessment of tuberculosis infection in childhood could diminish epidemiological burden because underdiagnosed pediatric patients can evolve to an active state and have the potential to disseminate the etiological agentMycobacterium tuberculosis, notably increasing this worldwide public health problem.

Kindesmisshandlung und deren Langzeitfolgen – Analyse einer repräsentativen deutschen Stichprobe

2019 ◽  
Vol 67 (2) ◽  
pp. 100-111 ◽  
Author(s):  
Andreas Witt ◽  
Rebecca Brown ◽  
Paul L. Plener ◽  
Elmar Brähler ◽  
Jörg M. Fegert ◽  
...  
Keyword(s):  
Public Health ◽  
Health Problem ◽  
Public Health Problem ◽  
Nachhaltige Entwicklung

Zusammenfassung. Kindesmisshandlung stellt einen bedeutenden Risikofaktor für die Entwicklung dar. Einzelne Formen von Kindesmisshandlung treten häufig nicht isoliert auf, sondern das gemeinsame Auftreten verschiedener Formen von Kindesmisshandlung stellt eher die Regel als die Ausnahme dar. Neben den langfristigen und vielfältigen individuellen Folgen führt Kindesmisshandlung jährlich zu einer hohen gesamtgesellschaftlichen Belastung. Die WHO hat Kindesmisshandlung als großes Public Health Problem identifiziert und die Vereinten Nationen haben den Kampf gegen Kindesmisshandlung zum Ziel in ihrer Agenda für nachhaltige Entwicklung gemacht. In dem vorliegenden Beitrag werden die Häufigkeit sowie das gemeinsame Auftreten unterschiedlicher Formen von Kindesmisshandlung sowie deren Assoziation mit psychischen und somatischen Folgen auf Basis einer bevölkerungsrepräsentativen Stichprobe untersucht und dargestellt. Die Ergebnisse verdeutlichen den Zusammenhang zwischen der Kumulation verschiedener Formen von Misshandlung und negativen Folgen für die Betroffenen. So ist das Risiko für negative Konsequenzen beim Erleben von vier oder mehr Formen von Misshandlung um das bis zu 10-fache erhöht. Viel zu selten werden die kumulativen Effekte von mehreren Belastungen berücksichtigt. Gerade weil die Wirkweisen über die Misshandlung, die Gesundheit beeinflusst, zunehmend gut untersucht sind, muss dieses Wissen im Gesundheitswesen stärker bei der Konzeption von Präventions- und Interventionsmaßnahmen berücksichtigt werden.

PUBLIC HEALTH PROBLEM IN THE HISTORY OF RUSSIAN SOCIOLOGY

2017 ◽  
Vol 19 (3) ◽  
pp. 155-159
Author(s):  
I.E. Levchenko ◽  
◽  
A.Y. Kuznetsov ◽  
E.G. Korniltseva ◽  
◽  
...  
Keyword(s):  
Public Health ◽  
Health Problem ◽  
Public Health Problem ◽  
History Of
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