The role of BCG in prevention of tuberculosis and the strategies to improve its immunogenicity

2018 ◽  
Vol 2 (1) ◽  
pp. 21-26
Author(s):  
Jolanta Mazurek
Keyword(s):  
Public Health ◽  
Antibiotic Resistance ◽  
Mycobacterium Tuberculosis ◽  
Health Problem ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Human Pathogen ◽  
Deadly Disease ◽  
A Current

Tuberculosis (TB) remains a major public health problem and the main cause of death from the infectious diseases worldwide. Mycobacterium tuberculosis (Mtb), a causative agent of tuberculosis, is the oldest known human pathogen. The only available TB vaccine, BCG, was first administered in 1921 and since then remains the only protecting tool against TB. Yet, its efficacy is limited and there is an urgent need to design and produce a novel vaccine that will protect against this deadly disease in the era of emerging problems with antibiotic resistance. In this review a current, global TB situation is outlined and the characteristics of BCG are presented. Finally, the strategies leading to generation of BCG variants providing improved protecting efficacy are shortly described.

scholarly journals Old therapies, new science

2002 ◽  
Vol 23 (5) ◽  
pp. 18
Author(s):  
Thomas V Riley
Keyword(s):  
Public Health ◽  
Antibiotic Resistance ◽  
Pharmaceutical Company ◽  
Health Problem ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
New Science

With the emergence of antibiotic resistance as a major public health problem and the apparent decline in pharmaceutical company drive to produce new antimicrobials, there has been an increase in interest in revisiting remedies and agents once popular before the advent of the antibiotic era.

scholarly journals Whole-Genome Shotgun Sequences of Three Multidrug-Resistant Mycobacterium tuberculosis Strains Isolated from Morocco

2017 ◽  
Vol 5 (46) ◽  
Author(s):  
Lamiaa Lahlou ◽  
Nadia El Mrimar ◽  
Meriem Laamarti ◽  
Tarek Alouane ◽  
Mohammed A. Bendahou ◽  
...  
Keyword(s):  
Public Health ◽  
Mycobacterium Tuberculosis ◽  
Health Problem ◽  
Public Health Problem ◽  
Multidrug Resistant ◽  
Whole Genome Shotgun ◽  
The Body ◽  
Major Public Health Problem ◽  
Whole Genome ◽  
Content Type

ABSTRACT Tuberculosis is a contagious disease that usually attacks the lungs but sometimes attacks other parts of the body, such as the kidneys, glands, and bones. It is an endemic and major public health problem in Morocco. Tuberculosis is transmitted through the airways via the inhalation of microdroplets containing Mycobacterium tuberculosis. We present here the whole-genome shotgun sequences of three multidrug-resistant M. tuberculosis strains isolated from Morocco.

scholarly journals THE UNEXPECTED MEDIASTINAL EXTENSION IN A CASE OF LUNG CANCER: THE ROLE OF IMAGING AND MULTIPLE SIDE-EFFECTS WITH CLINICAL RELEVANCE FOLLOWING TOPIRAMATE THERAPY

2018 ◽  
Vol 6 (9) ◽  
pp. 478-486
Author(s):  
Daniela Cipu ◽  
Dan Simion Cipu ◽  
Agneta Maria Pusztai ◽  
Anca Alexandra Matusz
Keyword(s):  
Public Health ◽  
Lung Cancer ◽  
Side Effects ◽  
Health Problem ◽  
Correct Diagnosis ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
The World ◽  
Mediastinal Extension

Bronchopulmonary neoplasm is the first cause of cancer mortality in the world and a major public health problem, affecting 17% of men and 12% of women; in this context it is very important and necessary to establish the correct diagnosis in the early stages of the disease in order to initiate the required surgical therapy [1]

Crucial role of physiotherapy in treating COVID-19 patients

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 967-971
Author(s):  
Poonam Thakre ◽  
Waqar M. Naqvi ◽  
Trupti Deshmukh ◽  
Nikhil Ingole ◽  
Sourabh Deshmukh
Keyword(s):  
Public Health ◽  
Distress Syndrome ◽  
Public Health Problem ◽  
Public Health Emergency ◽  
High Rate ◽  
Major Public Health Problem ◽  
Front Line ◽  
The Many ◽  
Sixth International

The emergence in China of 2019 of severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) previously provisionally names 2019-nCoV disease (COVID19) caused major global outbreak and is a major public health problem. On 30 January 2020, the WHO declared COVID19 to be the sixth international public health emergency. This present pandemic has engrossed the globe with a high rate of mortality. As a front line practitioner, physiotherapists are expected to be getting in direct contact with patients infected with the virus. That’s why it is necessary for understanding the many aspects of their role in the identification, contains, reduces and treats the symptoms of this disease. The main presentation is the involvement of respiratory system with symptoms like fever, cough, sore throat, sneezing and characteristics of pneumonia leads to ARDS(Acute respiratory distress syndrome) also land up in multiorgan dysfunction syndrome. This text describes and suggests physiotherapy management of acute COVID-19 patients. It also includes recommendations and guidelines for physiotherapy planning and management. It also covers the guidelines regarding personal care and equipment used for treatment which can be used in the treatment of acute adult patients with suspected or confirmed COVID-19.

scholarly journals NEW WORLD LEISHMANIOSIS IN RUSSIAN TOURISTS WHO VISITED SOUTH AMERICAN COUNTRIES AND THE FIRST EXPERIENCE OF THE TREATMENT WITH PERU BALSAM

2017 ◽  
Vol 22 (2) ◽  
pp. 106-112
Author(s):  
A. M Bronshteyn ◽  
N. G Kochergin ◽  
N. A Malyshev ◽  
V. Ya Lashin ◽  
S. V Burova ◽  
...  
Keyword(s):  
Public Health ◽  
Cutaneous Leishmaniasis ◽  
Health Problem ◽  
New World ◽  
Folk Medicine ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
South American ◽  
Parasite Resistance ◽  
Local Species

Two cases of New World cutaneous leishmaniasis acquired by Russian tourists in Peru and possibly in Bolivia are presented. L. viannia ( L.braziliensis complex) was identified in Liverpool School of Tropical medicine in the patient travelled to Bolivia. The present study aimed to investigate Balsamum peruvianum one of the product of folk medicine of Indians of Amazon region against local species of Leishmania resulted in healing the ulcers. Leishmaniasis is a major public health problem, and the alarming spread of parasite resistance has increased the importance of discovering new therapeutic products.

Development of new dinuclear Fe(III) coordination compounds with in vitro nanomolar antitrypanosomal activity

2021 ◽  
Author(s):  
Felipe Figuerôa Moreira ◽  
Juliana de Araujo Portes ◽  
Nathalia Florencia Barros Azeredo ◽  
Christiane Fernandes ◽  
Adolfo Horn ◽  
...  
Keyword(s):  
Public Health ◽  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Health Problem ◽  
Coordination Compounds ◽  
Public Health Problem ◽  
Neglected Tropical Disease ◽  
Major Public Health Problem ◽  
Protozoan Pathogen

Chagas disease is a neglected tropical disease caused by the protozoan pathogen Trypanosoma cruzi. The disease is the major public health problem affecting about 6 to 7 million people worldwide,...

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