scholarly journals Whole-Genome Shotgun Sequences of Three Multidrug-Resistant Mycobacterium tuberculosis Strains Isolated from Morocco

2017 ◽  
Vol 5 (46) ◽  
Author(s):  
Lamiaa Lahlou ◽  
Nadia El Mrimar ◽  
Meriem Laamarti ◽  
Tarek Alouane ◽  
Mohammed A. Bendahou ◽  
...  
Keyword(s):  
Public Health ◽  
Mycobacterium Tuberculosis ◽  
Health Problem ◽  
Public Health Problem ◽  
Multidrug Resistant ◽  
Whole Genome Shotgun ◽  
The Body ◽  
Major Public Health Problem ◽  
Whole Genome ◽  
Content Type

ABSTRACT Tuberculosis is a contagious disease that usually attacks the lungs but sometimes attacks other parts of the body, such as the kidneys, glands, and bones. It is an endemic and major public health problem in Morocco. Tuberculosis is transmitted through the airways via the inhalation of microdroplets containing Mycobacterium tuberculosis. We present here the whole-genome shotgun sequences of three multidrug-resistant M. tuberculosis strains isolated from Morocco.

scholarly journals Annotated Whole-Genome Shotgun Sequence of Multidrug-Resistant Mycobacterium tuberculosis MTB13_M Isolated from Morocco

2017 ◽  
Vol 5 (9) ◽  
Author(s):  
L. Lahlou ◽  
N. El Mrimar ◽  
T. Alouane ◽  
M. Laamarti ◽  
S. Karti ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Genome Sequence ◽  
Sputum Sample ◽  
Multidrug Resistant ◽  
Whole Genome Shotgun ◽  
Whole Genome ◽  
Content Type ◽  
Shotgun Sequence ◽  
Whole Genome Shotgun Sequence ◽  
Genome Shotgun Sequence

ABSTRACT Here, we describe the annotated genome sequence of Mycobacterium tuberculosis MTB13_M. The organism was isolated from a sputum sample in Morocco.

The role of BCG in prevention of tuberculosis and the strategies to improve its immunogenicity

2018 ◽  
Vol 2 (1) ◽  
pp. 21-26
Author(s):  
Jolanta Mazurek
Keyword(s):  
Public Health ◽  
Antibiotic Resistance ◽  
Mycobacterium Tuberculosis ◽  
Health Problem ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Human Pathogen ◽  
Deadly Disease ◽  
A Current

Tuberculosis (TB) remains a major public health problem and the main cause of death from the infectious diseases worldwide. Mycobacterium tuberculosis (Mtb), a causative agent of tuberculosis, is the oldest known human pathogen. The only available TB vaccine, BCG, was first administered in 1921 and since then remains the only protecting tool against TB. Yet, its efficacy is limited and there is an urgent need to design and produce a novel vaccine that will protect against this deadly disease in the era of emerging problems with antibiotic resistance. In this review a current, global TB situation is outlined and the characteristics of BCG are presented. Finally, the strategies leading to generation of BCG variants providing improved protecting efficacy are shortly described.

scholarly journals A Review of Superbug: A Global Threat in Health Care System

2018 ◽  
Vol 4 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Bhuiyan Mohammad Mahtab Uddin ◽  
Md Abdullah Yusuf ◽  
Zubair Ahmed Ratan
Keyword(s):  
Public Health ◽  
Health Problem ◽  
Antimicrobial Agents ◽  
Public Health Problem ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Major Public Health Problem ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Hospital Acquired

The rapid spread and dissemination of the multidrug-resistant bacteria worldwide represents a major public health problem. The development of antibiotics decreased the mortality among the human and animals leading to a better life expectancy. But the injudicious use of antimicrobials and selection pressure the microbes have developed resistance which became more prominent during last few decades. With the evolution of Methicilin-resistant Staphylococcus aureus (MRSA), Hospital-acquired MRSA, Communityacquired MRSA and MDR TB (Multidrug resistant tuberculosis) challenge for the clinicians have increased to a greater extent. The global emergence and dissemination of acquired carbapenemases among gram negative bacteria are considered a major public health problem. Gram-negative bacteria, most notably Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii, are among the most important causes of serious hospital-acquired and community-onset bacterial infections in humans, and resistance to antimicrobial agents in these bacteria has become an increasingly relevant problem. Recent development in nanotechnology based drug delivery system may prove to be solution for combating these resistant bacteria. However policies and regulations for antibiotic use should be formulated to control the further development of resistance among the microbes.Bangladesh Journal of Infectious Diseases 2017;4(1):25-28

scholarly journals Whole-genome sequencing analysis of multidrug-resistant Mycobacterium tuberculosis from Java, Indonesia

2020 ◽  
Vol 69 (7) ◽  
pp. 1013-1019
Author(s):  
Tryna Tania ◽  
Pratiwi Sudarmono ◽  
R. Lia Kusumawati ◽  
Andriansjah Rukmana ◽  
Wahyu Agung Pratama ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Public Health Problem ◽  
Multidrug Resistant ◽  
Drug Susceptibility Testing ◽  
Major Public Health Problem ◽  
Whole Genome ◽  
Sequencing Analysis ◽  
Mdr Tb

Introduction. Multidrug-resistant tuberculosis (MDR-TB) is a major public health problem globally, including in Indonesia. Whole-genome sequencing (WGS) analysis has rarely been used for the study of TB and MDR-TB in Indonesia. Aim. We evaluated the use of WGS for drug-susceptibility testing (DST) and to investigate the population structure of drug-resistant Mycobacterium tuberculosis in Java, Indonesia. Methodology. Thirty suspected MDR-TB isolates were subjected to MGIT 960 system (MGIT)-based DST and to WGS. Phylogenetic analysis was done using the WGS data. Results obtained using MGIT-based DST and WGS-based DST were compared. Results. Agreement between WGS and MGIT was 93.33 % for rifampicin, 83.33 % for isoniazid and 76.67 % for streptomycin but only 63.33 % for ethambutol. Moderate WGS–MGIT agreement was found for second-line drugs including amikacin, kanamycin and fluoroquinolone (73.33–76.67 %). MDR-TB was more common in isolates of the East Asian Lineage (63.3%). No evidence of clonal transmission of DR-TB was found among members of the tested population. Conclusion. Our study demonstrated the applicability of WGS for DST and molecular epidemiology of DR-TB in Java, Indonesia. We found no transmission of DR-TB in Indonesia.

scholarly journals Multidrug-resistant typhoid fever: a review

2011 ◽  
Vol 5 (05) ◽  
pp. 324-337 ◽  
Author(s):  
Syed Ahmed Zaki ◽  
Sunil Karande
Keyword(s):  
Public Health ◽  
Typhoid Fever ◽  
English Language ◽  
Public Health Problem ◽  
Public Health Education ◽  
Abdominal Distension ◽  
Clinical Results ◽  
Multidrug Resistant ◽  
Major Public Health Problem ◽  
Handling Practices

Introduction: Multidrug-resistant typhoid fever (MDRTF) is defined as typhoid fever caused by Salmonella enterica serovar Typhi strains (S. Typhi), which are resistant to the first-line recommended drugs for treatment such as chloramphenicol, ampicillin and trimethoprim-sulfamethoxazole. Since the mid-1980s, MDRTF has caused outbreaks in several countries in the developing world, resulting in increased morbidity and mortality, especially in affected children below five years of age and those who are malnourished. Methodology: Two methods were used to gather the information presented in this article. First PubMed was searched for English language references to published relevant articles. Secondly, chapters on typhoid fever in standard textbooks of paediatric infectious diseases and preventive and social medicine were reviewed. Results: Although there are no pathognomonic clinical features of MDRTF at the onset of the illness, high fever ( > 104°F), toxaemia, abdominal distension, abdominal tenderness, hepatomegaly and splenomegaly are often reported. The gold standard for the diagnosis of MDRTF is bacterial isolation of the organism in blood cultures. Ciprofloxacin and ceftriaxone are the drugs most commonly used for treatment of MDRTF and produce good clinical results. Conclusion: MDRTF remains a major public health problem, particularly in developing countries. Mass immunization in endemic areas with either the oral live attenuated Typhi 21a or the injectable unconjugated Vi typhoid vaccine, rational use of antibiotics, improvement in public sanitation facilities, availability of clean drinking water, promotion of safe food handling practices and public health education are vital in the prevention of MDRTF. 

scholarly journals NEW WORLD LEISHMANIOSIS IN RUSSIAN TOURISTS WHO VISITED SOUTH AMERICAN COUNTRIES AND THE FIRST EXPERIENCE OF THE TREATMENT WITH PERU BALSAM

2017 ◽  
Vol 22 (2) ◽  
pp. 106-112
Author(s):  
A. M Bronshteyn ◽  
N. G Kochergin ◽  
N. A Malyshev ◽  
V. Ya Lashin ◽  
S. V Burova ◽  
...  
Keyword(s):  
Public Health ◽  
Cutaneous Leishmaniasis ◽  
Health Problem ◽  
New World ◽  
Folk Medicine ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
South American ◽  
Parasite Resistance ◽  
Local Species

Two cases of New World cutaneous leishmaniasis acquired by Russian tourists in Peru and possibly in Bolivia are presented. L. viannia ( L.braziliensis complex) was identified in Liverpool School of Tropical medicine in the patient travelled to Bolivia. The present study aimed to investigate Balsamum peruvianum one of the product of folk medicine of Indians of Amazon region against local species of Leishmania resulted in healing the ulcers. Leishmaniasis is a major public health problem, and the alarming spread of parasite resistance has increased the importance of discovering new therapeutic products.

Development of new dinuclear Fe(III) coordination compounds with in vitro nanomolar antitrypanosomal activity

2021 ◽  
Author(s):  
Felipe Figuerôa Moreira ◽  
Juliana de Araujo Portes ◽  
Nathalia Florencia Barros Azeredo ◽  
Christiane Fernandes ◽  
Adolfo Horn ◽  
...  
Keyword(s):  
Public Health ◽  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Health Problem ◽  
Coordination Compounds ◽  
Public Health Problem ◽  
Neglected Tropical Disease ◽  
Major Public Health Problem ◽  
Protozoan Pathogen

Chagas disease is a neglected tropical disease caused by the protozoan pathogen Trypanosoma cruzi. The disease is the major public health problem affecting about 6 to 7 million people worldwide,...

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