Towards autonomous high-throughput multiscale modelling of battery interfaces

2022 ◽  
Author(s):  
Zeyu Deng ◽  
Vipin Kumar ◽  
Felix T. Bölle ◽  
Fernando Caro ◽  
Alejandro A. Franco ◽  
...  
Keyword(s):  
High Throughput ◽  
Rechargeable Batteries ◽  
Multiscale Modelling ◽  
Future Directions ◽  
Current Collectors

Understanding of interfaces in rechargeable batteries is crucial because they bridge electrodes, electrolytes, and current collectors. Current challenges that need to be overcome are reviewed, followed by future directions to reach this goal.

Computational Systems Biology Perspective on Tuberculosis in Big Data Era

Web Services ◽  
2019 ◽  
pp. 2230-2254
Author(s):  
Amandeep Kaur Kahlon ◽  
Ashok Sharma
Keyword(s):  
Big Data ◽  
Systems Biology ◽  
Data Management ◽  
High Throughput ◽  
Predictive Models ◽  
System Biology ◽  
Prediction Models ◽  
Computational Systems Biology ◽  
Future Directions ◽  
Computational Systems

The major concern in this chapter is to understand the need of system biology in prediction models in studying tuberculosis infection in the big data era. The overall complexity of biological phenomenon, such as biochemical, biophysical, and other molecular processes, within pathogen as well as their interaction with host is studied through system biology approaches. First, consideration is given to the necessity of prediction models integrating system biology approaches and later on for their replacement and refinement using high throughput data. Various ongoing projects, consortium, databases, and research groups involved in tuberculosis eradication are also discussed. This chapter provides a brief account of TB predictive models and their importance in system biology to study tuberculosis and host-pathogen interactions. This chapter also addresses big data resources and applications, data management, limitations, challenges, solutions, and future directions.

scholarly journals Current impact and future directions of high throughput sequencing in plant virus diagnostics

2014 ◽  
Vol 188 ◽  
pp. 90-96 ◽  
Author(s):  
Sebastien Massart ◽  
Antonio Olmos ◽  
Haissam Jijakli ◽  
Thierry Candresse
Keyword(s):  
High Throughput ◽  
Plant Virus ◽  
High Throughput Sequencing ◽  
Future Directions ◽  
Virus Diagnostics ◽  
Current Impact

scholarly journals How Do We Define the Genomic Landscape?

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. SCI-13-SCI-13
Author(s):  
Sandeep S. Dave
Keyword(s):  
High Throughput ◽  
High Throughput Sequencing ◽  
Conflicts Of Interest ◽  
Genomic Analysis ◽  
Future Directions ◽  
Tissue Samples ◽  
Genomic Landscape ◽  
Fresh Frozen ◽  
Definition Of ◽  
Formalin Fixed

High throughput sequencing is a revolutionary technology for the definition of the genomic features of tumors. This talk will provide a review of the relevant methodologies for non-experts in the field. The presentation will include a discussion of how high throughput sequencing is performed, its relative strengths and weaknesses, and how it is applicable to formalin-fixed and fresh/frozen tissue samples. The talk will also describe future directions in the genomic analysis of tumors. Disclosures No relevant conflicts of interest to declare.

Bacterial tick-associated infections in Australia: current studies and future directions

2018 ◽  
Vol 39 (4) ◽  
pp. 200
Author(s):  
Peter Irwin ◽  
Siobhon Egan ◽  
Telleasha Greay ◽  
Charlotte Oskam
Keyword(s):  
Northern Hemisphere ◽  
Lyme Borreliosis ◽  
High Throughput ◽  
Diagnostic Methods ◽  
Future Directions ◽  
Human Granulocytic Anaplasmosis ◽  
Boutonneuse Fever ◽  
Granulocytic Anaplasmosis ◽  
Tick Borne Encephalitis ◽  
Shed Light

It may seem perplexing that there is any uncertainty in Australia about the existence of zoonotic tick-associated infections1–3. Outside this country, particularly in the northern hemisphere, tick-borne diseases such as human granulocytic anaplasmosis, babesiosis, Boutonneuse fever, ehrlichiosis, Lyme borreliosis, and tick-borne encephalitis, have well documented aetiologies, epidemiology, diagnostic methods, and treatments. Why is Australia different and what research is being conducted to address this issue? This article briefly addresses these questions and explains how high-throughput metagenomic analysis has started to shed light on bacterial microbiomes in Australian ticks, providing new data on the presence and distribution of potentially zoonotic microbial taxa.

Taking the Pulse of Financial Activities with Online Graph Processing

2021 ◽  
Vol 55 (1) ◽  
pp. 84-87
Author(s):  
Xiaowei Zhu ◽  
Zhisong Fu ◽  
Zhenxuan Pan ◽  
Jin Jiang ◽  
Chuntao Hong ◽  
...  
Keyword(s):  
Big Data ◽  
High Throughput ◽  
Low Latency ◽  
Graph Processing ◽  
Future Directions ◽  
User Behaviors ◽  
Data Volume

Graph processing has been widely adopted in various financial scenarios at Ant Group to detect malicious and prohibited user behaviors. The low latency requirement under big data volume and high throughput raises rigorous challenges for efficient online graph processing. This paper gives a brief introduction of our encountered issues, the current solutions, and some future directions we are exploring.

scholarly journals Three-dimensional foam-type current collectors for rechargeable batteries: A short review

2021 ◽  
Vol 10 ◽  
pp. 100065
Author(s):  
Nurbolat Issatayev ◽  
Arailym Nuspeissova ◽  
Gulnur Kalimuldina ◽  
Zhumabay Bakenov
Keyword(s):  
Three Dimensional ◽  
Short Review ◽  
Rechargeable Batteries ◽  
Current Collectors

scholarly journals High-Throughput Cellular Thermal Shift Assays in Research and Drug Discovery

2019 ◽  
Vol 25 (2) ◽  
pp. 137-147 ◽  
Author(s):  
Mark J. Henderson ◽  
Marc A. Holbert ◽  
Anton Simeonov ◽  
Lorena A. Kallal
Keyword(s):  
Drug Discovery ◽  
High Throughput ◽  
Microtiter Plate ◽  
Target Engagement ◽  
Biochemical Activity ◽  
Future Directions ◽  
Protein Target ◽  
High Throughput Screens ◽  
Beta Galactosidase ◽  
Thermal Shift

Thermal shift assays (TSAs) can reveal changes in protein structure, due to a resultant change in protein thermal stability. Since proteins are often stabilized upon binding of ligand molecules, these assays can provide a readout for protein target engagement. TSA has traditionally been applied using purified proteins and more recently has been extended to study target engagement in cellular environments with the emergence of cellular thermal shift assays (CETSAs). The utility of CETSA in confirming molecular interaction with targets in a more native context, and the desire to apply this technique more broadly, has fueled the emergence of higher-throughput techniques for CETSA (HT-CETSA). Recent studies have demonstrated that HT-CETSA can be performed in standard 96-, 384-, and 1536-well microtiter plate formats using methods such as beta-galactosidase and NanoLuciferase reporters and AlphaLISA assays. HT-CETSA methods can be used to select and characterize compounds from high-throughput screens and to prioritize compounds in lead optimization by facilitating dose–response experiments. In conjunction with cellular and biochemical activity assays for targets, HT-CETSA can be a valuable addition to the suite of assays available to characterize molecules of interest. Despite the successes in implementing HT-CETSA for a diverse set of targets, caveats and challenges must also be recognized to avoid overinterpretation of results. Here, we review the current landscape of HT-CETSA and discuss the methodologies, practical considerations, challenges, and applications of this approach in research and drug discovery. Additionally, a perspective on potential future directions for the technology is presented.

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