Ellagic acid enhances muscle endurance by affecting muscle fiber type, mitochondrial biogenesis and function

Ellagic acid (EA) is a natural polyphenolic compound, which shows various effects, such as anti-inflammatory, antioxidant, and inhibition of platelet aggregation. In this study, we investigated the effect of EA...

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Effect of acute nutritional deprivation on diaphragm structure and function in adolescent rats

Journal of Applied Physiology ◽

10.1152/jappl.1992.73.3.974 ◽

1992 ◽

Vol 73 (3) ◽

pp. 974-978 ◽

Cited By ~ 14

Author(s):

M. I. Lewis ◽

G. C. Sieck

Keyword(s):

Body Mass ◽

Muscle Fiber ◽

Fiber Type ◽

Structure And Function ◽

Muscle Fiber Type ◽

Medial Gastrocnemius ◽

Diaphragm Muscle ◽

Nutritional Deprivation ◽

Ad Libitum ◽

And Function

The influence of 90 h of acute nutritional deprivation (ND; water ad libitum only) on in vitro contractile and fatigue properties, muscle fiber type proportions, and cross-sectional areas (CSA) of the adolescent rat diaphragm was determined. Diaphragm muscle properties in the ND rats were compared with those in control rats (CTL; food and water ad libitum). Acute ND resulted in a 32% reduction in body mass, whereas the body mass of CTL rats increased by 29%. Acute ND resulted in a significant reduction in the mass of the diaphragm (costal, 36%; crural, 43%), soleus (36%), and medial gastrocnemius (45%) muscles. Isometric twitch characteristics of the diaphragm muscle (contraction and half-relaxation times) were prolonged in the ND animals. Peak twitch and maximum tetanic forces were unaffected by ND. Fatigue resistance of the diaphragm muscle was improved in ND animals. Diaphragm muscle fiber type proportions were similar in ND and CTL groups. The CSA of type I and II diaphragm muscle fibers were reduced by 22 and 40%, respectively, in ND animals compared with CTL. We conclude that, whereas an identical protocol of acute ND had no significant effects on diaphragm muscle structure and function in adult rats, adolescent animals exhibit significantly less nutritional reserve. These differences may be due to curtailment of the rapid anabolic rate in growing animals.

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Impact of partitioning exercises on quadriceps muscle endurance and muscle fiber-type distribution following low-load/high-repetition resistance training (LLHR-RT) in people with advanced COPD.

10.1183/13993003.congress-2018.pa3830 ◽

2018 ◽

Author(s):

Mickaël Martin ◽

Andre Nyberg ◽

Didier Saey ◽

François Maltais

Keyword(s):

Resistance Training ◽

Muscle Fiber ◽

Fiber Type ◽

Quadriceps Muscle ◽

Muscle Fiber Type ◽

Muscle Endurance ◽

Type Distribution ◽

High Repetition ◽

Low Load ◽

Fiber Type Distribution

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Interactions among ryanodine receptor isotypes contribute to muscle fiber type development and function

Disease Models & Mechanisms ◽

10.1242/dmm.038844 ◽

2019 ◽

Vol 13 (2) ◽

pp. dmm038844 ◽

Cited By ~ 2

Author(s):

Alexis A. Chagovetz ◽

Dana Klatt Shaw ◽

Erin Ritchie ◽

Kazuyuki Hoshijima ◽

David J. Grunwald

Keyword(s):

Ryanodine Receptor ◽

Muscle Fiber ◽

Fiber Type ◽

Muscle Fiber Type ◽

And Function

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Peripheral nerve transfers change target muscle structure and function

Science Advances ◽

10.1126/sciadv.aau2956 ◽

2019 ◽

Vol 5 (1) ◽

pp. eaau2956 ◽

Cited By ~ 13

Author(s):

Konstantin D. Bergmeister ◽

Martin Aman ◽

Silvia Muceli ◽

Ivan Vujaklija ◽

Krisztina Manzano-Szalai ◽

...

Keyword(s):

Motor Neurons ◽

Muscle Fiber ◽

Fiber Type ◽

Muscle Fiber Type ◽

Body Parts ◽

Prosthetic Control ◽

Nerve Transfers ◽

Neural Information ◽

Extremity Reconstruction ◽

And Function

Selective nerve transfers surgically rewire motor neurons and are used in extremity reconstruction to restore muscle function or to facilitate intuitive prosthetic control. We investigated the neurophysiological effects of rewiring motor axons originating from spinal motor neuron pools into target muscles with lower innervation ratio in a rat model. Following reinnervation, the target muscle’s force regenerated almost completely, with the motor unit population increasing to 116% in functional and 172% in histological assessments with subsequently smaller muscle units. Muscle fiber type populations transformed into the donor nerve’s original muscles. We thus demonstrate that axons of alternative spinal origin can hyper-reinnervate target muscles without loss of muscle force regeneration, but with a donor-specific shift in muscle fiber type. These results explain the excellent clinical outcomes following nerve transfers in neuromuscular reconstruction. They indicate that reinnervated muscles can provide an accurate bioscreen to display neural information of lost body parts for high-fidelity prosthetic control.

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