Cholesterol-lowering effect of bile salt hydrolase from a Lactobacillus johnsonii strain mediated by FXR pathway regulation

2021 ◽  
Author(s):  
Huanjing Zhu ◽  
Fang Zhao ◽  
Wenjun Zhang ◽  
Wenxu Xia ◽  
Yin Chen ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Bile Salt ◽  
Major Risk Factor ◽  
Bile Salt Hydrolase ◽  
Cholesterol Reduction ◽  
High Cholesterol ◽  
Lactobacillus Johnsonii ◽  
Pathway Regulation ◽  
Cholesterol Lowering Effect

Hypercholesterolemia is a major risk factor for cardiovascular diseases worldwide. In this study, recombinant bile salt hydrolase (BSH) from the strain L. johnsonii 334 with high cholesterol reduction ability was...

Effect and Mechanism of Cholesterol-Lowering by Kluyveromyces from Tibetan Kefir

2011 ◽  
Vol 343-344 ◽  
pp. 1290-1298 ◽  
Author(s):  
Hui Liu ◽  
Yuan Hong Xie ◽  
Li Xia Xiong ◽  
Rui Ting Dong ◽  
Chang Li Pan ◽  
...  
Keyword(s):  
Bile Salt ◽  
Bile Salt Hydrolase ◽  
High Cholesterol ◽  
Cholesterol Lowering ◽  
Fermentation Time ◽  
Fermentation Conditions ◽  
Lowering Effect ◽  
Yeast Strains ◽  
Lactose Fermentation ◽  
Cholesterol Lowering Effect

Screening lower high cholesterol and secretion of bile salt hydrolase (BSH) from yeast strains, and study the environmental factors for increasing the activity of BSH, then investigate the mechanism of cholesterol lowering. We obtained two yeasts to lower cholesterol by high-throughput screening technology and o-phthalaldehyde : strain K1 and strain M3 are Kluyveromyces marxianus, are the highest rate of cholesterol-reducing strains by far, the lower cholesterol rates were 68.14% ~ 70.34% , 80.51% ~ 99.12%. The two yeasts can secretion BSH in the metabolic process with the Oxford cup method, and the BSH activity is proportional to the rates of cholesterol-reducing. Strain M3 has a higher BSH production capacity than strain K1, and high cholesterol-lowering effect. That indicating efficient yeast strains to lower cholesterol production is due to their abundant or high activity BSH. The BSH secretion of strain K1 and strain M3 demonstrated a key enzyme in cholesterol-lowering effect for the first time. BSH can hydrolyze conjugated bile salt and free bile salt, which can precipitate with cholesterol state, to reduce the effect of cholesterol. To aim directly at 4 major factors can affect the synthesis of BSH, the fermentation conditions of strain M3 producing BSH highly were determined with four factors and three levels［L9(34)］orthogonal experiment: fermentation temperature is 32 °C, fermentation time is 24h, the initial pH of medium is 6.0, inoculums is 3%. The activity of BSH secreted by Strain M3 increased 50% in the optimization of fermentation conditions. Strain K1 and M3 fermented milk with excellent performance, we could research and develop functional fermented dairy products and micro-ecology preparation, by using the characteristics of efficient to lower cholesterol and complementary advantages of lactose fermentation performance of the two strains.

scholarly journals A CASE STUDY ON ESSENTIAL HYPERTENSION MANAGING THROUGH AYURVEDA W.S.R. RAKTAGATA VYAN VAISHAMYA

2021 ◽  
Vol p5 (4) ◽  
pp. 2965-2968
Author(s):  
Ruhi Zahir ◽  
Iqbal Khan
Keyword(s):  
Blood Pressure ◽  
Renal Failure ◽  
Risk Factor ◽  
Essential Hypertension ◽  
Cardiovascular Diseases ◽  
High Blood Pressure ◽  
Direct Reference ◽  
Major Risk Factor ◽  
End Stage

Essential hypertension is high blood pressure that doesn't have any known etiopathology. Most of sufferers (85%) are asymptomatic and as per available reports, in more than 95% cases of hypertension under lying cause is not found. It is estimated that 600 million people are affected worldwide. Hypertension is a major risk factor for the development of cardiovascular diseases (CVD). Its impact is greatest on stroke, MI and end stage is renal failure as it’s known as a Silent Killer. Hence there is no direct reference of hypertension in Ayurvedic classics by name as well as by its path physiological views. Many works have been carried out on hypertension to evaluate the perfect diagnosis and mode of treatment on the basis of Different nomenclatures also have been adopted by Ayurveda experts like Raktagata Vata, Raktagata Vyana Vaisamya, Uccha Rakta Chapa, Raktavrita Vata, Siragata Vata etc. Keywords: Essential hypertension, Raktagata Vyana Vaisamya, Uccha Rakta Chapa, Cardiovascular diseases, Silent Killer.

scholarly journals Early myocardial injury biomarkers in diabetic hyperlipidemic rats: Impact of 10-dehydrogingerdione and vitamin D3

2020 ◽  
Vol 245 (15) ◽  
pp. 1326-1334
Author(s):  
Mohamed M Elseweidy ◽  
Sousou I Aly ◽  
Sally K Hammad ◽  
Noura I Shershir
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Vitamin D3 ◽  
Rat Model ◽  
Myocardial Injury ◽  
Major Risk Factor ◽  
Albino Rats ◽  
Fatty Acid Binding ◽  
Reactive Protein ◽  
Hypercholesterolemic Diet

Hyperlipidemia represents a major risk factor for cardiovascular diseases leading to myocardial injury. The present study aimed to illustrate the myocardial injury induced in a diabetic hyperlipidemic rat model and the effect of vitamin D3, 10-DHGD intake either individually or in combination form. Male albino rats were selected for the study, received alloxan, hypercholesterolemic diet, and categorized into four groups. The first one (DHC), received hypercholesterolemic diet only and referred to as control. The remaining groups (2, 3, 4) received vitamin D3, 10-DHGD, and combination of both, respectively. Certain biomarkers that were selected for MI evaluation included blood glucose, lipogram pattern, Copeptin, C-reactive protein, myeloperoxidase, heart fatty acid-binding protein, and histopathological changes in myocardium and aorta. Vitamin D3 and 10-DHGD intake induced significant hypoglycemic, hypolipidemic effects, decreased inflammation, and MI biomarkers. Decreased myocardial vacuoles, foam cells, and intimal lesions were also observed compared to DHC. Their combination intake induced more marked reduction in all biomarkers and showed a histopathological pattern similar to normal features of myocardium and aorta. Our findings suggest the therapeutic roles of vitamin D3, 10-DHGD, and their combination against myocardial injury in diabetic hyperlipidemic rats. Impact statement Hyperlipidemia represents a major risk factor for cardiovascular diseases leading to myocardial injury (MI). The present study aimed to illustrate the pattern of myocardial injury induced in diabetic hyperlipidemic rat model and the effect of vitamin D3, 10-dehydrogingerdione (10-DHGD) intake either individually or in combination form.

A focus on inflammation as a major risk factor for atherosclerotic cardiovascular diseases

2015 ◽  
Vol 14 (3) ◽  
pp. 391-403 ◽  
Author(s):  
Ida Gregersen ◽  
Sverre Holm ◽  
Tuva B Dahl ◽  
Bente Halvorsen ◽  
Pål Aukrust
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Major Risk Factor ◽  
Atherosclerotic Cardiovascular Diseases

scholarly journals Which One to Endorse Among the Multitude of Lipid Guidelines?

2015 ◽  
Vol 11 (1) ◽  
pp. 32
Author(s):  
Alper Sonmez ◽  
Keyword(s):  
Risk Assessment ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Major Risk Factor ◽  
Treatment Target ◽  
Advantages And Disadvantages ◽  
Lipid Guidelines ◽  
Atherosclerotic Cardiovascular Diseases

Dyslipidemia is the major risk factor for atherosclerotic cardiovascular diseases. A multitude of lipid guidelines exist, with several controversies, and the best approach in dyslipidemia management is not clear. The tools and lipoproteins used for risk assessment, whether to use a treatment target and implementing drugs other than statins are all controversial points. Until the time for the publication of an agreeable lipid guideline, physicians should choose their way by considering the advantages and disadvantages of the existing guidelines.

Cholesterol-lowering potentials of Lactobacillus strain overexpression of bile salt hydrolase on high cholesterol diet-induced hypercholesterolemic mice

2019 ◽  
Vol 10 (3) ◽  
pp. 1684-1695 ◽  
Author(s):  
Guangqiang Wang ◽  
Wenli Huang ◽  
Yongjun Xia ◽  
Zhiqiang Xiong ◽  
Lianzhong Ai
Keyword(s):  
Bile Salt ◽  
Lactobacillus Strain ◽  
Bile Salt Hydrolase ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Cholesterol Lowering

Lactobacillus strain overexpression of bile salt hydrolase can exert a cholesterol-reducing effect in vivo.

scholarly journals Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders

2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Hao Qian ◽  
Na Luo ◽  
Yuling Chi
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Molecular Mechanism ◽  
Major Risk Factor ◽  
Cardiovascular Disorders ◽  
Endothelium Dysfunction ◽  
Age Related ◽  
Endothelium Function ◽  
Available Information ◽  
Age Related Changes

Age-associated endothelium dysfunction is a major risk factor for the development of cardiovascular diseases. Endothelium-synthesized prostaglandins and thromboxane are local hormones, which mediate vasodilation and vasoconstriction and critically maintain vascular homeostasis. Accumulating evidence indicates that the age-related changes in endothelial eicosanoids contribute to decline in endothelium function and are associated with pathological dysfunction. In this review we summarize currently available information on aging-shifted prostaglandin profiles in endothelium and how these shifts are associated with cardiovascular disorders, providing one molecular mechanism of age-associated endothelium dysfunction and cardiovascular diseases.

Sign in / Sign up

Export Citation Format

Share Document