The Screening of Drug-induced Nephrotoxicity Using Gold Nanocluster-based Ratiometric Fluorescent Probes

Nanoscale ◽  
2021 ◽  
Author(s):  
Qin Liu ◽  
Junyao Li ◽  
Xiao Liu ◽  
Lin Yuan ◽  
Lingzhi Zhao ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Fluorescent Probes ◽  
Medication Safety ◽  
Screening Methods ◽  
Drug Induced ◽  
Gold Nanocluster ◽  
Current Screening

Herbal medicine are potential candidates for the treatment of various diseases, but its medication safety remains poorly regulated. Current screening methods for the herbal medicine-induced nephrotoxic effects include histological and...

Gold nanocluster-based ratiometric fluorescent probes for hydrogen peroxide and enzymatic sensing of uric acid

2018 ◽  
Vol 185 (6) ◽  
Author(s):  
Dongqin Yang ◽  
Minchuan Luo ◽  
Junwei Di ◽  
Yifeng Tu ◽  
Jilin Yan
Keyword(s):  
Hydrogen Peroxide ◽  
Uric Acid ◽  
Fluorescent Probes ◽  
Gold Nanocluster

scholarly journals The Acute Extracellular Flux (XF) Assay to Assess Compound Effects on Mitochondrial Function

2014 ◽  
Vol 20 (3) ◽  
pp. 422-429 ◽  
Author(s):  
Ruolan Wang ◽  
Steven J. Novick ◽  
James B. Mangum ◽  
Kennedy Queen ◽  
David A. Ferrick ◽  
...  
Keyword(s):  
Mitochondrial Function ◽  
Mitochondrial Activity ◽  
Screening Methods ◽  
Drug Induced ◽  
Whole Cells ◽  
Drug Candidates ◽  
Adverse Health Outcomes ◽  
Extracellular Flux ◽  
Screening Platform ◽  
The Impact

Numerous investigations have linked mitochondrial dysfunction to adverse health outcomes and drug-induced toxicity. The pharmaceutical industry is challenged with identifying mitochondrial liabilities earlier in drug development and thereby reducing late-stage attrition. Consequently, there is a demand for reliable, higher-throughput screening methods for assessing the impact of drug candidates on mitochondrial function. The extracellular flux (XF) assay described here is a plate-based method in which galactose-conditioned HepG2 cells were acutely exposed to test compounds, then real-time changes in the oxygen consumption rate and extracellular acidification rate were simultaneously measured using a Seahorse Bioscience XF-96 analyzer. The acute XF assay was validated using marketed drugs known to modulate mitochondrial function, and data analysis was automated using a spline curve fitting model developed at GlaxoSmithKline. We demonstrate that the acute XF assay is a robust, sensitive screening platform for evaluating drug-induced effects on mitochondrial activity in whole cells.

scholarly journals Current Screening Strategy Poses Risk of Spreading of Hepatitis C Virus Infection

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Sajjad Ullah ◽  
Sohail Ahmad ◽  
Qaisar Ali ◽  
Arshad Jamal ◽  
Muhammad Zubair Yousaf ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Blood Donors ◽  
Screening Strategy ◽  
Core Antigen ◽  
Screening Methods ◽  
Hepatitis C Virus Infection ◽  
Antigen Antibody ◽  
Final Confirmation ◽  
Current Screening

Background: Hepatitis C virus is one of the significant causes of morbidity and mortality in the World. Surprisingly, despite national screening campaigns, new cases of HCV are still on the rise. Methods and Results: A total of 5914 healthy blood donors was included in this study after informed consent. Anti-HCV ELISA was used to check presence of antigen in participant’s plasma.using Monlisa HCV Antigen-Antibody Ultra kit. Final confirmation was done by using real time PCR considered as a gold standard. Results: 0.5% of anti-HCV ELISA negative samples showed presence of antigen in plasma, when checked through core Ag detection method. Conclusion: Our result suggested that HCV core antigen detection and/or combo testing are far safer screening methods for the detection of HCV and the use of these methods can avoid/reduce further spread of this deadly disease.

scholarly journals A case of drug-induced allergic hepatitis by herbal medicine.

Kanzo ◽  
1985 ◽  
Vol 26 (3) ◽  
pp. 376-379 ◽  
Author(s):  
Yasuhiro MIZOGUCHI ◽  
Katsujiro YOSHIYASU ◽  
Hiroko TSUTSUI ◽  
Keiji MIYAJIMA ◽  
Yoshihide SAKAGAMI ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Drug Induced

scholarly journals Drug-induced cystitis caused by herbal medicine (Bofutsushosan)

2021 ◽  
pp. 101644
Author(s):  
Kumiko Kato ◽  
Aika Matsushita ◽  
Shoji Suzuki ◽  
Hiroki Sai ◽  
Hiroki Hirabayashi ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Drug Induced

scholarly journals Management of Post-LASiK Keratoectasia with a Piggyback Contact Lens System

2015 ◽  
Vol 77 (1) ◽  
pp. 7
Author(s):  
Lacey Haines ◽  
Luigina Sorbara
Keyword(s):  
Contact Lens ◽  
Ocular Surface ◽  
Contact Lenses ◽  
Single Case ◽  
Treatment Options ◽  
Ocular Surface Disease ◽  
Screening Methods ◽  
Lens System ◽  
Intrastromal Corneal Ring ◽  
Current Screening

This case report highlights the clinical challenges involved in managing a patient with post-LASiK keratoectasia. A single case is presented with a focus on contact lens fitting and concurrent ocular surface disease. A review of the literature indicates that current screening methods prior to refractive surgery have made improvements for detecting patients at higher risk of serious complications. Possible treatment options for iatrogenic keratoconus include contact lenses, intrastromal corneal ring segments, corneal cross linking, and keratoplasty. This report demonstrates that post-LASiK keratoectasia with concurrent ocular surface disease can be successfully managed with a piggyback contact lens system.

scholarly journals Liver Disease in Sri Lanka

2017 ◽  
Vol 7 (1) ◽  
pp. 78-81 ◽  
Author(s):  
Hasitha S Wijewantha
Keyword(s):  
Liver Disease ◽  
Sri Lanka ◽  
Herbal Medicine ◽  
South Asian ◽  
Dengue Infection ◽  
Published Data ◽  
Biliary Cirrhosis ◽  
Asian Countries ◽  
Traditional Herbal Medicine ◽  
Drug Induced

ABSTRACT Liver disease in Sri Lanka is mainly due to alcoholic liver disease and nonalcoholic fatty liver disease. In contrast to other South Asian countries, the prevalence of hepatitis B and C is low in Sri Lanka and prevalence of hepatitis A is intermediate. The few reported cases of hepatitis E in Sri Lanka are mainly in people who have traveled to neighboring South Asian countries. Wilson's disease, autoimmune hepatitis, hemochromatosis, drug-induced liver disease, and primary biliary cirrhosis are recognized causes of liver disease in Sri Lanka. Pyogenic and amebic liver abscesses and dengue infection are the other causes of liver disease. Some of the commonly used plants as traditional herbal medicine in Sri Lanka have been shown to have deleterious effects on the liver in animal studies. Considering the high popularity of traditional herbal medicine in the country, it is likely that herbal medicine is an etiological factor for liver disease in Sri Lanka, but no published data are available. Address reprint requests to: Wijewantha HS. Liver Disease in Sri Lanka. Euroasian J Hepato-Gastroenterol 2017;7(1):78-81.

Bone health risk assessment in a clinical setting: an evaluation of a new screening tool for active populations (Preprint)

2021 ◽  
Author(s):  
Nicola Keay ◽  
Gavin Francis ◽  
Karen Hind
Keyword(s):  
Lumbar Spine ◽  
Femoral Neck ◽  
Clinical Setting ◽  
Bone Health ◽  
Screening Tool ◽  
Health Screening ◽  
Screening Methods ◽  
Mineral Density ◽  
Screening Questionnaire ◽  
Current Screening

BACKGROUND Risk factors for poor bone health are not restricted to older, sedentary populations for whom current screening is focused. Furthermore, access to dual X-ray absorptiometry scanning can be limited in clinical practice. OBJECTIVE The purpose of the current study was to develop a bone health-screening tool suitable for inclusion of both younger and active populations, combined with radiofrequency echographic multi spectrometry technology (REMS). METHODS 88 participants attending a physiotherapy clinic in the UK were recruited to the study: 71 women (mean age 41.5 SD 14.0 years); 17 men (mean age 40.2 SD 14.9 years). Participants completed an online bone health-screening questionnaire developed specifically for this study covering a range of lifestyle, physiological factors, combined with medical interview and received bone mineral density (BMD) measurement at the lumbar spine and femoral neck using REMS. RESULTS Scoring of the bone health-screening questionnaire produced a distribution of bone health scores, with lower scores suggesting a higher risk for poor bone health. In women, scores ranged from -10 to +12, mean score 2.2 (SD 4.8). In men, scores ranged from 0 to 12, mean score 6.9 (SD 3.2). A positive correlation was observed between the bone health score derived from the questionnaire and lumbar spine and femoral neck BMD Z-scores (p<0.01). CONCLUSIONS This new and comprehensive bone health-screening questionnaire with interview was effective in identifying active individuals at risk of bone fragility, who might be missed by current screening methods. The use of REMS technology to measure bone health, was feasible in the clinical setting. CLINICALTRIAL NA

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