Enzymatically synthesised MnO2 nanoparticles for efficient near-infrared photothermal therapy and dual-responsive magnetic resonance imaging

Nanoscale ◽  
2021 ◽  
Author(s):  
Jin Liu ◽  
Liandong Feng ◽  
Yuzhou Wu

Manganese dioxide (MnO2) nanoparticles (NPs) are highly attractive for biomedical applications due to their biocompatibility, stimuli-responsive magnetic resonance imaging (MRI) properties and capability to modulate the hypoxic tumour microenvironment (TME)....

2021 ◽  
Author(s):  
Jin Liu ◽  
Meizhou Zhang ◽  
Yuzhou Wu

Multifunctional nanocomposites have drawn great attention in clinical applications because of their ability to integrate diagnostic and therapeutic functions. Manganese dioxide (MnO2), owing to its biocompatibility and magnetic resonance imaging...


2018 ◽  
pp. 1424-1447
Author(s):  
Irshad Ahmad Wani

Magnetic nanoparticles due to their unique magnetic phenomenon, are gaining immense interest due to the utilization of these properties for a wide variety of applications in various arena especially in biomedical field. This book chapter, therefore, summarizes the synthesis of various types of magnetic nanoparticles using different approaches depending of their ability to generate either single core of multcore magnetic nanoparticles. The various biomedical applications of magnetic nanoparticles like Magnetic Resonance Imaging (MRI), drug delivery etc. along with possible limitations and challenges for their extended applications in medicine are also discussed.


2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
William M. Payne ◽  
Tanner K. Hill ◽  
Denis Svechkarev ◽  
Megan B. Holmes ◽  
Balasrinivasa R. Sajja ◽  
...  

Surgical resection remains the most promising treatment strategy for many types of cancer. Residual malignant tissue after surgery, a consequence in part due to positive margins, contributes to high mortality and disease recurrence. In this study, multimodal contrast agents for integrated preoperative magnetic resonance imaging (MRI) and intraoperative fluorescence image-guided surgery (FIGS) are developed. Self-assembled multimodal imaging nanoparticles (SAMINs) were developed as a mixed micelle formulation using amphiphilic HA polymers functionalized with either GdDTPA for T1 contrast-enhanced MRI or Cy7.5, a near infrared fluorophore. To evaluate the relationship between MR and fluorescence signal from SAMINs, we employed simulated surgical phantoms that are routinely used to evaluate the depth at which near infrared (NIR) imaging agents can be detected by FIGS. Finally, imaging agent efficacy was evaluated in a human breast tumor xenograft model in nude mice, which demonstrated contrast in both fluorescence and magnetic resonance imaging.


Author(s):  
Irshad Ahmad Wani

Magnetic nanoparticles due to their unique magnetic phenomenon, are gaining immense interest due to the utilization of these properties for a wide variety of applications in various arena especially in biomedical field. This book chapter, therefore, summarizes the synthesis of various types of magnetic nanoparticles using different approaches depending of their ability to generate either single core of multcore magnetic nanoparticles. The various biomedical applications of magnetic nanoparticles like Magnetic Resonance Imaging (MRI), drug delivery etc. along with possible limitations and challenges for their extended applications in medicine are also discussed.


Microscopy ◽  
2015 ◽  
Vol 64 (suppl 1) ◽  
pp. i142.1-i142
Author(s):  
Doan Thi Kim Dung ◽  
Shoichiro Fukushima ◽  
Taichi Furukawa ◽  
Hirohiko Niioka ◽  
Masayoshi Ichimiya ◽  
...  

2016 ◽  
Vol 4 (40) ◽  
pp. 6510-6515
Author(s):  
Shengping Gao ◽  
Xiaoli Liu ◽  
Chunqiu Zhao ◽  
Meina Su ◽  
Hui Jiang ◽  
...  

New multifunctional nanospheres have been designed and synthesized through a green and facile strategy, which could be readily used in multi-modality tumor imaging through near-infrared fluorescence (NIRF) imaging, magnetic resonance imaging (MRI) and computed tomography (CT) imaging.


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