scholarly journals Understanding the binding properties of phosphorylated glycoluril-derived molecular tweezers and selective nanomolar binding of natural polyamines in aqueous solution

2021 ◽  
Vol 19 (16) ◽  
pp. 3628-3633
Author(s):  
Michael Heilmann ◽  
Melina Knezevic ◽  
GiovanniMaria Piccini ◽  
Konrad Tiefenbacher
Keyword(s):  
Aqueous Solution ◽  
High Selectivity ◽  
Binding Properties ◽  
Molecular Tweezers ◽  
Biosynthetic Precursor ◽  
Molecular Tweezer

Selective nanomolar binding of biological polyamines to a novel glycoluril-derived molecular tweezer is reported. The high selectivity over their biosynthetic precursor may be of interest, as elevated polyamine levels are linked to several diseases.

Determination of the complexation properties of a crosslinked poly(acrylic acid) gel with copper(II), nickel(II), and lead(II) in dilute aqueous solution

2001 ◽  
Vol 79 (4) ◽  
pp. 370-376 ◽  
Author(s):  
Catherine Morlay ◽  
Yolande Mouginot ◽  
Monique Cromer ◽  
Olivier Vittori
Keyword(s):  
Aqueous Solution ◽  
Ionic Strength ◽  
Acrylic Acid ◽  
Metal Ion ◽  
Conditional Stability ◽  
Binding Properties ◽  
Complex Species ◽  
Complexing Capacity ◽  
Dilute Aqueous Solution ◽  
Poly Acrylic Acid

The possible removal of copper(II), nickel(II), or lead(II) by an insoluble crosslinked poly(acrylic acid) was investigated in dilute aqueous solution. The binding properties of the polymer were examined at pH = 6.0 or 4.0 with an ionic strength of the medium µ = 0.1 or 1.0 M (NaNO3) using differential pulse polarography as an investigation means. The highest complexing capacity of the polyacid was obtained with lead(II) at pH = 6.0 with µ = 0.1 M, 4.8 mmol Pb(II)/g polymer. The conditional stability constants of the complex species formed were determined using the method proposed by Ruzic assuming that only the 1:1 complex species was formed; for lead(II) at pH = 6.0 and µ = 0.1 M, log K' = 5.3 ± 0.2. It appeared that the binding properties of the polymer increased, depending on the metal ion, in the following order: Ni(II) < Cu(II) < Pb(II). The complexing capacity and log K' values decreased with the pH or with an increase of the ionic strength. These results were in agreement with the conclusions of our previous studies of the hydrosoluble linear analogues. Finally, with the insoluble polymer, the log K' values were comparable to those previously obtained with the linear analogue whereas the complexing capacity values expressed in mmol g-1 were slightly lower.Key words: insoluble crosslinked poly(acrylic acid), copper(II), nickel(II), and lead(II) complexation.

scholarly journals Binding Properties of a Dinuclear Zinc(II) Salen-Type Molecular Tweezer with a Flexible Spacer in the Formation of Lewis Acid-Base Adducts with Diamines

Inorganics ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 49
Author(s):  
Gabriella Munzi ◽  
Giuseppe Consiglio ◽  
Salvatore Failla ◽  
Santo Di Bella
Keyword(s):  
Lewis Acid ◽  
Degrees Of Freedom ◽  
Binding Constants ◽  
Molecular Structures ◽  
Acid Base ◽  
Binding Properties ◽  
Binding Characteristics ◽  
Fluorescence Studies ◽  
Flexible Spacer ◽  
Molecular Tweezer

In this paper we report the binding properties, by combined 1H NMR, optical absorption, and fluorescence studies, of a molecular tweezer composed of two Zn(salen)-type Schiff-base units connected by a flexible spacer, towards a series of ditopic diamines having a strong Lewis basicity, with different chain length and rigidity. Except for the 1,2-diaminoethane, in all other cases the formation of stable 1:1 Lewis acid-base adducts with large binding constants is demonstrated. For α,ω-aliphatic diamines, binding constants progressively increase with the increasing length of the alkyl chain, thanks to the flexible nature of the spacer and the parallel decreased conformational strain upon binding. Stable adducts are also found even for short diamines with rigid molecular structures. Given their preorganized structure, these latter species are not subjected to loss of degrees of freedom. The binding characteristics of the tweezer have been exploited for the colorimetric and fluorometric selective and sensitive detection of piperazine.

Colorimetric and Fluorescent Probe for Hypochlorite with High Selectivity

2013 ◽  
Vol 295-298 ◽  
pp. 475-478 ◽  
Author(s):  
Zhi Xiang Han ◽  
Ming Hui Du ◽  
Guo Xi Liang ◽  
Xiang Yang Wu
Keyword(s):  
Reactive Oxygen Species ◽  
Aqueous Solution ◽  
Detection Limit ◽  
Fluorescent Probe ◽  
Rhodamine B ◽  
High Selectivity ◽  
Reactive Oxygen ◽  
Living Cells ◽  
Oxygen Species ◽  
Turn On

Rhodamine B thiohydrazide (RBS) was firstly employed as turn-on fluorescent probe for hypochlorite in aqueous solution and living cells. It exhibits a stable response to hypochlorite from 1.0×10-6to 1.0×10-5M with a detection limit of 3.3×10-7M. The response of this probe to hypochlorite is fast and highly selective compared with other reactive oxygen species (such as.OH,1O2, H2O2) and other common anions (such as X-, ClO2-, ClO4-, NO3-, NO2-, OH-, Ac-, CO32-, SO42-).

Xanthurenic acid: a natural ionophore with high selectivity and sensitivity for potassium ions in an aqueous solution

2016 ◽  
Vol 40 (3) ◽  
pp. 1930-1934 ◽  
Author(s):  
M. Raju ◽  
Tapasya J. Patel ◽  
Ratish R. Nair ◽  
Pabitra B. Chatterjee
Keyword(s):  
Aqueous Solution ◽  
Detection Limit ◽  
Metal Ions ◽  
High Selectivity ◽  
Xanthurenic Acid ◽  
Potassium Ions ◽  
Turn On ◽  
Tryptophan Metabolite

Synopsis: A well-known tryptophan metabolite, xanthurenic acid, a natural non-fluorescent intermediate siderophore, showed a very selective turn-on response to K+ over other competing metal ions and the detection limit of this natural ionophore was found to be 53 nM at physiological pH.

A Rhodamine Derivative Based Chemosensor with High Selectivity and Quick Respond to Cr3+ in Aqueous Solution

2018 ◽  
Vol 28 (3) ◽  
pp. 809-814 ◽  
Author(s):  
Zhenglong Yang ◽  
Sai Chen ◽  
Feng Li ◽  
Yilong Bu ◽  
Yuchuan Du ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
High Selectivity ◽  
Rhodamine Derivative

9. pH Triggered Molecular Tweezers for Drug Delivery Applications

2016 ◽  
Author(s):  
Caitlin Miron
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Chemical Potential ◽  
Cancer Drug ◽  
Molecular Tweezers ◽  
Binding Domains ◽  
Non Covalent Interactions ◽  
Molecular Tweezer ◽  
First Time ◽  
Covalent Interactions

Molecular tweezers are simple synthetic receptors that are generally composed of two binding domains connected by a spacer group. The non-covalent interactions that occur between the tweezer and its substrate are usually reversible, which facilitates the release of the bound substrate at a target site when triggered by a stimulus such as light, temperature, pH,] or change in chemical potential. In the field of cancer research, one strategy for targeting drug delivery relies on the pH drop in cancerous tissues compared to healthy tissues. We recently showed, for the first time, that it is possible to use pH to tune the binding affinity of molecular tweezers for substrates such as the cancer drug MitoxantroneTM. The molecular tweezer switches conformation from a closed (binding) state to an open (release) state upon acidification. As a result, the targeted delivery of MitoxantroneTM is achieved. This proof of concept shows that molecular tweezers are promising tools for selective drug delivery.

scholarly journals Highly-selective solvent-free catalytic isomerization of α-pinene to camphene over reusable titanate nanotubes

RSC Advances ◽  
2020 ◽  
Vol 10 (18) ◽  
pp. 10606-10611
Author(s):  
Geng Huang ◽  
Shuolin Zhou ◽  
Jian Liu ◽  
Shengpei Su ◽  
Dulin Yin
Keyword(s):  
Aqueous Solution ◽  
High Selectivity ◽  
Solvent Free ◽  
Titanate Nanotubes ◽  
Selective Solvent ◽  
Catalytic Isomerization ◽  
Post Modification

Titanate nanotubes prepared by hydrothermal reconstitution and post-modification with HCl aqueous solution were studied in α-pinene isomerization showing high selectivity to camphene.

A reusable fluorescent sensor from electrosynthesized water-soluble oligo(1-pyrenesulfonic acid) for effective detection of Fe3+

2018 ◽  
Vol 42 (24) ◽  
pp. 19450-19457 ◽  
Author(s):  
Nannan Jian ◽  
Kaiwen Lin ◽  
Bin Guo ◽  
Ge Zhang ◽  
Ximei Liu ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Detection Limit ◽  
High Selectivity ◽  
Fluorescent Sensor ◽  
Water Soluble ◽  
Low Detection Limit

Electrosynthesized oligo(1-pyrenesulfonic acid) displays high selectivity, low detection limit and outstanding reversibility in the detection of Fe3+ in aqueous solution.

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