scholarly journals Nanotechnology in cardiac stem cell therapy: cell modulation, imaging and gene delivery

RSC Advances ◽  
2021 ◽  
Vol 11 (55) ◽  
pp. 34572-34588
Author(s):  
Elangovan Sarathkumar ◽  
Marina Victor ◽  
Jaivardhan A. Menon ◽  
Kunnumpurathu Jibin ◽  
Suresh Padmini ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Gene Delivery ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Cardiac Stem Cell

This review summarizes the potential challenges present in cardiac stem cell therapy and the major role of nanotechnology to overcome these challenges including cell modulation, tracking and imaging of stem cells.

scholarly journals Cardiac Stem Cells in the Postnatal Heart: Lessons from Development

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Cristina Aguilar-Sanchez ◽  
Melina Michael ◽  
Sari Pennings
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Heart Development ◽  
Cell Populations ◽  
Cell Renewal ◽  
Cardiac Stem Cell ◽  
Stem Cell Populations

Heart development in mammals is followed by a postnatal decline in cell proliferation and cell renewal from stem cell populations. A better understanding of the developmental changes in cardiac microenvironments occurring during heart maturation will be informative regarding the loss of adult regenerative potential. We reevaluate the adult heart’s mitotic potential and the reported adult cardiac stem cell populations, as these are two topics of ongoing debate. The heart’s early capacity for cell proliferation driven by progenitors and reciprocal signalling is demonstrated throughout development. The mature heart architecture and environment may be more restrictive on niches that can host progenitor cells. The engraftment issues observed in cardiac stem cell therapy trials using exogenous stem cells may indicate a lack of supporting stem cell niches, while tissue injury adds to a hostile microenvironment for transplanted cells. Engraftment may be improved by preconditioning the cultured stem cells and modulating the microenvironment to host these cells. These prospective areas of further research would benefit from a better understanding of cardiac progenitor interactions with their microenvironment throughout development and may lead to enhanced cardiac niche support for stem cell therapy engraftment.

scholarly journals Efficient Isolation of Cardiac Stem Cells from Brown Adipose

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Zhiqiang Liu ◽  
Haibin Wang ◽  
Ye Zhang ◽  
Jin Zhou ◽  
Qiuxia Lin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Previous Method ◽  
New Method ◽  
Cardiac Stem Cell ◽  
Cardiac Stem Cells ◽  
Isolated Cells ◽  
Brown Adipose

Cardiac stem cells represent a logical cell type to exploit in cardiac regeneration. The efficient harvest of cardiac stem cells from a suitable source would turn promising in cardiac stem cell therapy. Brown adipose was recently found to be a new source of cardiac stem cells, instrumental to myocardial regeneration. Unfortunately, an efficient method for the cell isolation is unavailable so far. In our study we have developed a new method for the efficient isolation of cardiac stem cells from brown adipose by combining different enzymes. Results showed that the total cell yield dramatically increased (more than 10 times,P<.01) compared with that by previous method. The content of CD133-positive cells (reported to differentiate into cardiomyocytes with a high frequency) was much higher than that in the previous report (22.43% versus 3.5%). Moreover, the isolated cells could be the efficiently differentiated into functional cardiomyocytes in optimized conditions. Thus, the new method we established would be of great use in further exploring cardiac stem cell therapy.

scholarly journals Role of Imaging in Cardiac Stem Cell Therapy

2007 ◽  
Vol 49 (11) ◽  
pp. 1137-1148 ◽  
Author(s):  
Saskia L.M.A. Beeres ◽  
Frank M. Bengel ◽  
Jozef Bartunek ◽  
Douwe E. Atsma ◽  
Jonathan M. Hill ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Cardiac Stem Cell

Cellular signaling in neural stem cells: implications for restorative neurosurgery

2005 ◽  
Vol 19 (3) ◽  
pp. 1-4 ◽  
Author(s):  
Yvette D. Marquez ◽  
Michael Y. Wang ◽  
Charles Y. Liu
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Cellular Signaling ◽  
Neurological Diseases ◽  
Neural Cells ◽  
Ample Evidence ◽  
Cell Niche

Over the course of the past few decades, it has become apparent that in contrast to previously held beliefs, the adult central nervous system (CNS) may have the capability of regeneration and repair. This greatly expands the possibilities for the future treatment of CNS disorders, with the potential strategies of treatment targeting the entire scope of neurological diseases. Indeed, there is now ample evidence that stem cells exist in the CNS throughout life, and the progeny of these stem cells may have the ability to assume the functional role of neural cells that have been lost. The existence of stem cells is no longer in dispute. In addition, once transplanted, stem cells have been shown to survive, migrate, and differentiate. Nevertheless, the clinical utility of stem cell therapy for neurorestoration remains elusive. Without question, the control of the behavior of stem cells for therapeutic advantage poses considerable challenges. In this paper, the authors discuss the cellular signaling processes that influence the behavior of stem cells. These signaling processes take place in the microenvironment of the stem cell known as the niche. Also considered are the implications attending the replication and manipulation of elements of the stem cell niche to restore function in the CNS by using stem cell therapy.

scholarly journals Stem Cell-Based Therapies in Hearing Loss

2021 ◽  
Vol 9 ◽  
Author(s):  
Zuhong He ◽  
Yanyan Ding ◽  
Yurong Mu ◽  
Xiaoxiang Xu ◽  
Weijia Kong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Inner Ear ◽  
Stem Cell Therapy ◽  
Treatment Method ◽  
Signal Pathways ◽  
Multiple Organs ◽  
New Treatment

In recent years, neural stem cell transplantation has received widespread attention as a new treatment method for supplementing specific cells damaged by disease, such as neurodegenerative diseases. A number of studies have proved that the transplantation of neural stem cells in multiple organs has an important therapeutic effect on activation and regeneration of cells, and restore damaged neurons. This article describes the methods for inducing the differentiation of endogenous and exogenous stem cells, the implantation operation and regulation of exogenous stem cells after implanted into the inner ear, and it elaborates the relevant signal pathways of stem cells in the inner ear, as well as the clinical application of various new materials. At present, stem cell therapy still has limitations, but the role of this technology in the treatment of hearing diseases has been widely recognized. With the development of related research, stem cell therapy will play a greater role in the treatment of diseases related to the inner ear.

Mesenchymal stem cells: Stem cell therapy perspectives for type 1 diabetes

2009 ◽  
Vol 35 (2) ◽  
pp. 85-93 ◽  
Author(s):  
L. Vija ◽  
D. Farge ◽  
J.-F. Gautier ◽  
P. Vexiau ◽  
C. Dumitrache ◽  
...  
Keyword(s):  
Stem Cells ◽  
Type 1 Diabetes ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy

The promises of stem cells: stem cell therapy for movement disorders

2014 ◽  
Vol 20 ◽  
pp. S128-S131 ◽  
Author(s):  
Hideki Mochizuki ◽  
Chi-Jing Choong ◽  
Toru Yasuda
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Movement Disorders

scholarly journals Current Perspectives on Imaging Cardiac Stem Cell Therapy

2010 ◽  
Vol 51 (Supplement_1) ◽  
pp. 128S-136S ◽  
Author(s):  
J. C. Wu ◽  
M. R. Abraham ◽  
D. L. Kraitchman
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Cardiac Stem Cell
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