scholarly journals Direct photo-induced reductive Heck cyclization of indoles for the efficient preparation of polycyclic indolinyl compounds

2021 ◽  
Author(s):  
Daohong Yu ◽  
Wai-Pong To ◽  
Yungen Liu ◽  
Liang-Liang Wu ◽  
Tingjie You ◽  
...  
Keyword(s):  
Natural Product ◽  
Light Irradiation ◽  
Polycyclic Compounds ◽  
Heck Cyclization

Metal- and photocatalyst-free reductive Heck cyclization of indoles under light irradiation was developed and used to prepare polycyclic compounds and functionalize natural product analogues in moderate to good yields.

scholarly journals Highly Effective Conditions for Nickel-Mediated Heck Cyclization Cascades Starting from Aryl and Vinyl Triflates

2022 ◽  
Author(s):  
Jonathan Keim ◽  
Andrew Cummins ◽  
Scott Snyder
Keyword(s):  
Natural Product ◽  
Product Formation ◽  
Heck Reactions ◽  
Bond Forming ◽  
Heck Cyclization ◽  
Alkene Isomerization ◽  
Highly Effective ◽  
Vinyl Triflates ◽  
Effective Conditions

In contrast to the tremendous power of Pd-based Mizoroki–Heck reactions, methods to achieve such processes with other metals, particularly Ni, are generally lacking. Herein, we delineate specific conditions that can enable cascade variants of these C–C bond forming events to proceed smoothly under Ni catalysis. Critically, these reactions work with equal facility as their Pd-initiated counterparts when conducted intramolecularly, and in many cases are devoid of any Ni–H-mediated alkene isomerization within the starting materials and/or products as has typically been observed with previous Ni-based protocols. When conducted intermolecularly, the developed variant affords unique regioselectivity in product formation, substantively favoring 6-endo additions over the more standard 5-exo counterparts observed under Pd-based conditions. Finally, applications of the developed procedures to two different natural product syntheses are described

Synthetic studies toward inducamide C

2021 ◽  
Author(s):  
Ardalan A. Nabi ◽  
Lydia M. Scott ◽  
Daniel P. Furkert ◽  
Jonathan Sperry
Keyword(s):  
Natural Product ◽  
Structural Revision ◽  
Synthetic Studies

The rare benzoxazepine ring in the alkaloid inducamide C is unstable and prone to rearrangement, indicating that structural revision of the natural product may be necessary.

Lessons learned from the optimization of natural product based kinase inhibitors through molecular calculations

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
V Myrianthopoulos ◽  
P Magiatis ◽  
AL Skaltsounis ◽  
L Meijer ◽  
E Mikros
Keyword(s):  
Natural Product ◽  
Kinase Inhibitors ◽  
Lessons Learned ◽  
Molecular Calculations

New Antileishmanial Drug Leads from a Library of Natural Product Fractions Prepared by a High Throughput Fractionation Paradigm*

Planta Medica ◽  
2012 ◽  
Vol 78 (05) ◽  
Author(s):  
SK Jain ◽  
R Sahu ◽  
J Zhang ◽  
MR Jacob ◽  
XC Li ◽  
...  
Keyword(s):  
Natural Product ◽  
High Throughput ◽  
Antileishmanial Drug ◽  
Drug Leads

High throughput huaman pancreactic lipase screening of natural product library for lipase inhibition activity

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
P Jiao ◽  
J Zhao ◽  
J Yeop Lee ◽  
J Tseng-Crank ◽  
B Corneliusen ◽  
...  
Keyword(s):  
Natural Product ◽  
High Throughput ◽  
Inhibition Activity ◽  
Natural Product Library ◽  
Lipase Screening ◽  
Lipase Inhibition
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