Double pH-sensitive Nanotheranostics of Polypeptide Nanoparticle-Encapsulated BODIPY with Both NIR Activated Fluorescence and Enhanced Photodynamic Therapy

2021 ◽  
Author(s):  
Huiping Dang ◽  
Quan Cheng ◽  
Youliang Tian ◽  
Changchang Teng ◽  
Kai Xie ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Fluorescence Imaging ◽  
Intelligent Systems ◽  
Ph Sensitive ◽  
Nir Fluorescence

To achieve accurate fluorescence imaging-guided cancer therapy, intelligent systems with specific responsiveness to the tumor microenvironment need to be designed. Here, we have achieved both enhanced NIR fluorescence and photodynamic...

scholarly journals Near-Infrared Fluorescence Imaging and Photodynamic Therapy for Liver Tumors

2021 ◽  
Vol 11 ◽  
Author(s):  
Masaki Kaibori ◽  
Hisashi Kosaka ◽  
Kosuke Matsui ◽  
Morihiko Ishizaki ◽  
Hideyuki Matsushima ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Liver Tumors ◽  
Nir Fluorescence ◽  
Recent Developments ◽  
Fluorescent Agent ◽  
Stable Particles ◽  
And Function ◽  
Cancer Tissues

Surgery with fluorescence equipment has improved to treat the malignant viscera, including hepatobiliary and pancreatic neoplasms. In both open and minimally invasive surgeries, optical imaging using near-infrared (NIR) fluorescence is used to assess anatomy and function in real time. Here, we review a variety of publications related to clinical applications of NIR fluorescence imaging in liver surgery. We have developed a novel nanoparticle (indocyanine green lactosome) that is biocompatible and can be used for imaging cancer tissues and also as a drug delivery system. To date, stable particles are formed in blood and have an ~10–20 h half-life. Particles labeled with a NIR fluorescent agent have been applied to cancer tissues by the enhanced permeability and retention effect in animals. Furthermore, this article reviews recent developments in photodynamic therapy with NIR fluorescence imaging, which may contribute and accelerate the innovative treatments for liver tumors.

A photo and tumor microenvironment activated nano-enzyme with enhanced ROS generation and hypoxia relief for efficient cancer therapy

2021 ◽  
Vol 9 (39) ◽  
pp. 8253-8262
Author(s):  
Yali Chen ◽  
Yujun Cai ◽  
Xingsu Yu ◽  
Hong Xiao ◽  
Haozhe He ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Tumor Therapy ◽  
Reactive Oxygen ◽  
Ros Generation ◽  
Oxygen Species ◽  
Therapy Strategies

Reactive oxygen species (ROS) mediated tumor therapy strategies have exhibited great prospects and attracted increasing attention, among which photodynamic therapy (PDT) has been well-established.

Tumor microenvironment-activated NIR-II reagents for tumor imaging and therapy

2020 ◽  
Vol 8 (22) ◽  
pp. 4738-4747 ◽  
Author(s):  
Xue Zhang ◽  
Lu An ◽  
Qiwei Tian ◽  
Jiaomin Lin ◽  
Shiping Yang
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Tumor Imaging ◽  
Photoacoustic Imaging ◽  
Tumor Diagnosis ◽  
Diagnosis And Treatment ◽  
Recent Advances

This review summarizes the recent advances of tumor microenvironment-activated NIR-II agents for tumor diagnosis and treatment, including smart NIR-II fluorescence imaging, photoacoustic imaging, photothermal therapy and photodynamic therapy.

Tumor Microenvironment Stimuli‐Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon‐Dot–Cu 2+ Nanoassemblies

2020 ◽  
Vol 132 (47) ◽  
pp. 21227-21234
Author(s):  
Shan Sun ◽  
Qiao Chen ◽  
Zhongdi Tang ◽  
Chuang Liu ◽  
Zhongjun Li ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Fluorescence Imaging ◽  
Stimuli Responsive ◽  
Carbon Dot

A redox-responsive mesoporous silica based nanoplatform for in vitro tumor-specific fluorescence imaging and enhanced photodynamic therapy

2018 ◽  
Vol 6 (1) ◽  
pp. 96-100 ◽  
Author(s):  
Fan Yuan ◽  
Jiang-Lan Li ◽  
Han Cheng ◽  
Xuan Zeng ◽  
Xian-Zheng Zhang
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Mesoporous Silica ◽  
Fluorescence Imaging ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle ◽  
Specific Fluorescence ◽  
Redox Responsive ◽  
Multifunctional Peptides

A mesoporous silica nanoparticle-based redox-responsive platform modified with multifunctional peptides was successfully developed for in vitro tumor microenvironment-enhanced photodynamic therapy.

A theranostic nanoplatform: magneto-gold@fluorescence polymer nanoparticles for tumor targeting T1&T2-MRI/CT/NIR fluorescence imaging and induction of genuine autophagy mediated chemotherapy

Nanoscale ◽  
2018 ◽  
Vol 10 (22) ◽  
pp. 10467-10478 ◽  
Author(s):  
Guannan Wang ◽  
Kun Qian ◽  
Xifan Mei
Keyword(s):  
Cancer Therapy ◽  
Contrast Agent ◽  
Fluorescence Imaging ◽  
Tumor Targeting ◽  
Polymer Nanoparticles ◽  
Nir Fluorescence ◽  
T2 Mri

Novel contrast agent were designed for in vivo T1&T2-MRI/CT/NIR fluorescence imaging and induction of genuine autophagy-mediated chemosensitization for cancer therapy.

Cancer cell membrane-coated magnetic nanoparticles for MR/NIR fluorescence dual-modal imaging and photodynamic therapy

2018 ◽  
Vol 6 (7) ◽  
pp. 1834-1845 ◽  
Author(s):  
Jiong Li ◽  
Xuandong Wang ◽  
Dongye Zheng ◽  
Xinyi Lin ◽  
Zuwu Wei ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Magnetic Nanoparticles ◽  
Cell Membrane ◽  
Fluorescence Imaging ◽  
Cancer Cell ◽  
Nir Fluorescence

A photosensitizer-loaded magnetic nanobead with surface coated with a cancer cell membrane to enhance MR/NIR fluorescence imaging and PDT efficacy.

Two- and three-photon excitable quaternized imidazo[1,2-a]pyridines as mitochondrial imaging and potent cancer therapy agents

2020 ◽  
Vol 18 (38) ◽  
pp. 7571-7576
Author(s):  
Eiji Hase ◽  
Hiroki Takanari ◽  
Keita Hoshi ◽  
Masaki Okamoto ◽  
Atsushi Tabata ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Fluorescence Imaging ◽  
Imaging Agent ◽  
Targeted Photodynamic Therapy ◽  
Photon Fluorescence

We have synthesized four blue fluorescent imidazo[1,2-a]pyridines. One specific compound work as not only a two- and three-photon fluorescence imaging agent for the visualization of mitochondria, but also a potent mitochondria-targeted photodynamic therapy agent.

Multifunctional magnetic nanoparticles for simultaneous cancer near-infrared imaging and targeting photodynamic therapy

RSC Advances ◽  
2014 ◽  
Vol 4 (107) ◽  
pp. 62153-62159 ◽  
Author(s):  
Xueling Zhao ◽  
Zongyan Chen ◽  
Hongli Zhao ◽  
Denghao Zhang ◽  
Liang Tao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Magnetic Nanoparticles ◽  
Fluorescence Imaging ◽  
Drug Delivery System ◽  
Delivery System ◽  
Potential Application ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Nir Fluorescence

In this work, a multifunctional drug delivery system was developed for potential application in NIR fluorescence imaging and targeting PDT.

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