scholarly journals Mechanically responsive luminescent films based on copper iodide clusters

2021 ◽  
Author(s):  
Raquel Utrera-Melero ◽  
Brendan Huitorel ◽  
Marie Cordier ◽  
Florian Massuyeau ◽  
Jean-Yves Mevellec ◽  
...  
Keyword(s):  
Mechanical Stress ◽  
Underlying Mechanism ◽  
Copper Iodide ◽  
Luminescent Films

A mechanochromic luminescent copper iodide cluster is reported whose luminescence is exalted in response to mechanical stress. The underlying mechanism has been investigated along with the preparation of mechanically responsive films.

scholarly journals The Airways’ Mechanical Stress in Lung Disease: Implications for COPD Pathophysiology and Treatment Evaluation

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Pierachille Santus ◽  
Matteo Pecchiari ◽  
Francesco Tursi ◽  
Vincenzo Valenti ◽  
Marina Saad ◽  
...  
Keyword(s):  
Mechanical Stress ◽  
Inhaled Corticosteroids ◽  
Treatment Strategies ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Underlying Mechanism ◽  
Current Evidence ◽  
Chronic Obstructive ◽  
Copd Exacerbations ◽  
Long Acting

The airway epithelium stretches and relaxes during the normal respiratory cycle, and hyperventilation exaggerates this effect, resulting in changes in lung physiology. In fact, stretching of the airways influences lung function and the secretion of airway mediators, which in turn may cause a potentially injurious inflammatory response. This aim of the present narrative review was to illustrate the current evidence on the importance of mechanical stress in the pathophysiology of lung diseases with a particular focus on chronic obstructive pulmonary disease (COPD) and to discuss how this may influence pharmacological treatment strategies. Overall, treatment selection should be tailored to counterpart the effects of mechanical stress, which influences inflammation both in asthma and COPD. The most suitable treatment approach between a long-acting β2-agonists/long-acting antimuscarinic-agonist (LABA/LAMA) alone or with the addition of inhaled corticosteroids should be determined based on the underlying mechanism of inflammation. Noteworthy, the anti-inflammatory effects of the glycopyrronium/indacaterol combination on hyperinflation and mucociliary clearance may decrease the rate of COPD exacerbations, and it may synergistically improve bronchodilation with a double action on both the cyclic adenosine monophosphate (cAMP) and the acetylcholine pathways.

scholarly journals Molecular copper iodide clusters: a distinguishing family of mechanochromic luminescent compounds

2021 ◽  
Author(s):  
Sandrine Perruchas
Keyword(s):  
Underlying Mechanism ◽  
Luminescence Properties ◽  
Copper Iodide ◽  
The Family ◽  
Mechanochromic Luminescence

This perspective describes the survey of the family of mechanochromic luminescent cubane copper iodide clusters. Studies of their mechanochromic luminescence properties are presented along with investigations to elucidate the underlying mechanism.

scholarly journals Mechanical Stress-Induced IGF-1 Facilitates col-I and col-III Synthesis via the IGF-1R/AKT/mTORC1 Signaling Pathway

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Bin Yan ◽  
Canjun Zeng ◽  
Yuhui Chen ◽  
Minjun Huang ◽  
Na Yao ◽  
...  
Keyword(s):  
Mechanical Stress ◽  
Signaling Pathway ◽  
Ligamentum Flavum ◽  
Neutralizing Antibody ◽  
Underlying Mechanism ◽  
Mrna Levels ◽  
Stress Exposure ◽  
Collagen Iii ◽  
Mtorc1 Signaling ◽  
The Relationship

Mechanical stress promotes human ligamentum flavum cells (LFCs) to synthesize multitype collagens, leading to ligamentum flavum hypertrophy (LFH). However, the mechanism of mechanical stress in the formation of collagen remains unclear. Therefore, we investigated the relationship between mechanical stress and collagen synthesis in the present study. First, LFCs were isolated from 9 patients and cultured with or without mechanical stress exposure for different times. IGF-1, collagen I (col-I), and collagen III (col-III) protein and mRNA levels were then detected via ELISA and qPCR, respectively. Moreover, the activation of pIGF-1R, pAKT, and pS6 was examined by Western blot analysis. To further explore the underlying mechanism, an IGF-1 neutralizing antibody, NVP-AEW541, and rapamycin were used. IGF-1, col-I, and col-III were significantly increased in stressed LFCs compared to nonstressed LFCs. In addition, the activation of pIGF-1R, pAKT, and pS6 was obviously enhanced in stressed LFCs. Interestingly, col-I protein, col-I mRNA, col-III protein, col-III mRNA, and IGF-1 protein, but not IGF-1 mRNA, were inhibited by IGF-1 neutralizing antibody. In addition, col-I and col-III protein and mRNA, but not IGF-1, were inhibited by both NVP-AEW541 and rapamycin. Moreover, the activation of pIGF-1R, pAKT, and pS6 was reduced by the IGF-1 neutralizing antibody and NVP-AEW541, and the activation of pS6 was reduced by rapamycin. In summary, these results suggested that mechanical stress promotes LFCs to produce IGF-1, which facilitates col-I and col-III synthesis via the IGF-1R/AKT/mTORC1 signaling pathway.

scholarly journals BAF57/SMARCE1 Interacting with Splicing Factor SRSF1 Regulates Mechanical Stress-Induced Alternative Splicing of Cyclin D1

Genes ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 306
Author(s):  
Jianguo Feng ◽  
Xichao Xu ◽  
Xin Fan ◽  
Qian Yi ◽  
Liling Tang
Keyword(s):  
Alternative Splicing ◽  
Cyclin D1 ◽  
Mechanical Stress ◽  
Cellular Proliferation ◽  
Critical Factor ◽  
Underlying Mechanism ◽  
Cyclic Stretch ◽  
Splicing Factor ◽  
Protein Kinase Activity ◽  
Mechanical Stimuli

Background: Cyclin D1 regulates cyclin-dependent protein kinase activity of the cell cycle, and cyclin D1 alternative splicing generates a cyclin D1b isoform, acting as a mediator of aberrant cellular proliferation. As alternative splicing processes are sensitive to mechanical stimuli, whether the alternative splicing of cyclin D1 is regulated by mechanical stress and what kinds of factors may act as the regulator of mechano-induced alternative splicing remain unknown. Methods: The alternative splicing of Cyclin D1 was examined using reverse transcription polymerase chain reaction (RT-PCR) in osteoblast cell lines and keratinocyte cells loaded by a cyclic stretch. The expression of splicing factors and switching defective/sucrose non-fermenting (SWI/SNF) complex subunits were detected in stretched cells using real-time quantitative PCR (RT-qPCR). The protein interaction was tested by co-immunoprecipitation assay (Co-IP). Results:Cyclin D1 expression decreased with its splice variant upregulated in stretched cells. Serine/arginine-rich splicing factor 1 (SRSF1) and SWI/SNF complex subunit Brahma-related gene-1-associated factor 57 (BAF57), also named SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1), could respond to mechanical stimuli. Overexpression and knockdown experiments indicated the BAF57/SMARCE1 is probably a critical factor regulating the alternative splicing of cyclin D1. Co-IP showed an interaction between BAF57/SMARCE1 and SRSF1, implying a possible underlying mechanism of the regulator role of BAF57/SMARCE1 in the splicing process of cyclin D1. Conclusions: The splicing factor SRSF1 and BAF57/SMARCE1 are possibly responsible for the mechanical stress-induced alternative splicing of cyclin D1.

Face Inversion Effect Emerges Under Critical Configural Discrepancy

2010 ◽  
Vol 69 (3) ◽  
pp. 161-167 ◽  
Author(s):  
Jisien Yang ◽  
Adrian Schwaninger
Keyword(s):  
Face Recognition ◽  
Face Processing ◽  
Underlying Mechanism ◽  
Inversion Effect ◽  
Configural Processing ◽  
Major Contributor ◽  
Face Inversion Effect ◽  
Configural Information ◽  
Face Inversion ◽  
The Face

Configural processing has been considered the major contributor to the face inversion effect (FIE) in face recognition. However, most researchers have only obtained the FIE with one specific ratio of configural alteration. It remains unclear whether the ratio of configural alteration itself can mediate the occurrence of the FIE. We aimed to clarify this issue by manipulating the configural information parametrically using six different ratios, ranging from 4% to 24%. Participants were asked to judge whether a pair of faces were entirely identical or different. The paired faces that were to be compared were presented either simultaneously (Experiment 1) or sequentially (Experiment 2). Both experiments revealed that the FIE was observed only when the ratio of configural alteration was in the intermediate range. These results indicate that even though the FIE has been frequently adopted as an index to examine the underlying mechanism of face processing, the emergence of the FIE is not robust with any configural alteration but dependent on the ratio of configural alteration.

The Underlying Mechanism for Spatial Symmetry in Bimanual Tapping

2004 ◽  
Author(s):  
Tin-Cheung Chan ◽  
Ling-Po Shiu
Keyword(s):  
Underlying Mechanism ◽  
Spatial Symmetry ◽  
Bimanual Tapping

Improving Math With Number Sense Training: An Investigation of its Underlying Mechanism

2013 ◽  
Author(s):  
Joonkoo Park ◽  
Elizabeth M. Brannon
Keyword(s):  
Number Sense ◽  
Underlying Mechanism

Behaviour of Ni-Mn-Ga alloys under mechanical stress

2003 ◽  
Vol 112 ◽  
pp. 943-946 ◽  
Author(s):  
K. Koho ◽  
J. Vimpari ◽  
L. Straka ◽  
N. Lanska ◽  
O. Sôderberg ◽  
...  
Keyword(s):  
Mechanical Stress
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