The association between dietary zinc intake and risk of pancreatic cancer: a meta-analysis

Previous reports have suggested a potential association on dietary zinc intake with the risk of pancreatic cancer. Since the associations between different studies were controversial, we therefore conducted a meta-analysis to reassess the relationship between dietary zinc intake and pancreatic cancer risk. A comprehensive search from the databases of PubMed, Embase, Web of Science, and Medline was performed until January 31, 2017. Relative risk (RR) with 95% confidence intervals (CI) derived by using random effect model was used. Sensitivity analysis and publication bias were conducted. Our meta-analysis was based on seven studies involving 1659 cases, including two prospective cohort studies and five case–control studies. The total RR of pancreatic cancer risk for the highest versus the lowest categories of dietary zinc intake was 0.798 (0.621–0.984), with its significant heterogeneity among studies (I2=58.2%, P=0.026). The average Newcastle–Ottawa scale (NOS) score was 7.29, suggesting a high quality. There was no publication bias in the meta-analysis about dietary zinc intake on the risk of pancreatic cancer. Subgroup analyses showed that dietary zinc intake could reduce the risk of pancreatic cancer in case–control studies and among American populations. In conclusion, we found that highest category of dietary zinc intake can significantly reduce the risk of pancreatic cancer, especially among American populations.

Download Full-text

The association between dietary vitamin A intake and pancreatic cancer risk: a meta-analysis of 11 studies

Bioscience Reports ◽

10.1042/bsr20160341 ◽

2016 ◽

Vol 36 (6) ◽

Cited By ~ 6

Author(s):

Tao Zhang ◽

Hongqiang Chen ◽

Shiyong Qin ◽

Minghai Wang ◽

Xianming Wang ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Risk ◽

Vitamin A ◽

Publication Bias ◽

Meta Analysis ◽

Epidemiological Studies ◽

Case Control ◽

Dietary Vitamin ◽

Case Control Studies ◽

Pancreatic Cancer Risk

Whether dietary vitamin A intake could reduce pancreatic cancer risk is still conflicting. We therefore conducted a meta-analysis to summarize the evidence from epidemiological studies. We searched the databases of PubMed and Web of Knowledge up to July 2016. Random model was used to combine study-specific relative risks (RR) and 95% confidence interval (CI). Publication bias was assessed by Egger regression asymmetry test and Begg's funnel plot. Eleven studies (10 case-control studies and 1 cohort study) involving 2705 pancreatic cancer cases were included in the present study. The RR (95% CI) of pancreatic cancer for highest category of vitamin A intake compared with lowest category was 0.839 (95% CI=0.712–0.988) with low heterogeneity detected (I2=17.8%, Pheterogeneity=0.274). The relationships were also significant for studies designed by case-control [RR=0.808, 95% CI=0.690–0.947], as well as in European population [RR=0.821, 95% CI=0.693–0.972]. No evidence of publication bias was found. This meta-analysis demonstrated that dietary vitamin A intake might inversely associated with the risk of pancreatic cancer.

Download Full-text

Abstract 4297: Serum B6 vitamers (pyridoxal-5’-phosphate, pyridoxal, and 4’-pyridoxic acid) and pancreatic cancer risk: Two nested case-control studies in Asian populations

10.1158/1538-7445.am2016-4297 ◽

2016 ◽

Author(s):

Joyce Y. Huang ◽

Lesley M. Butler ◽

Øivind Midttun ◽

Per M. Ueland ◽

Woon-Puay Koh ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Risk ◽

Case Control ◽

Case Control Studies ◽

Pancreatic Cancer Risk ◽

Asian Populations ◽

Nested Case Control

Download Full-text

Association between serum copper levels and cervical cancer risk: a meta-analysis

Bioscience Reports ◽

10.1042/bsr20180161 ◽

2018 ◽

Vol 38 (4) ◽

Cited By ~ 8

Author(s):

Min Zhang ◽

Min Shi ◽

Yan Zhao

Keyword(s):

Cervical Cancer ◽

Cancer Risk ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Case Control ◽

Serum Copper ◽

Significant Heterogeneity ◽

Case Control Studies ◽

Cervical Cancer Risk

Whether serum copper levels were higher in patients with cervical cancer than that in controls was controversial. Hence, we conducted the present study to explore the relationship between serum copper levels and cervical cancer. We searched PubMed, WanFang, and China National Knowledge Internet (CNKI) for relevant studies before November 30, 2017. Standardized mean difference (SMD) and 95% confidence interval (CI) were used to combine results across studies using the random-effect model. A total of 14 publications involving 747 patients with cervical cancer and 1014 controls were eligible through inclusion criteria. In comparison with controls, serum copper levels were significantly higher in patients with cervical cancer [summary SMD = 1.35; 95%CI: 0.10–2.59], with significant heterogeneity (I2 = 98.8%; P<0.001) was found. Significant association was also found among Asian populations [summary SMD = 1.39; 95%CI: 0.06–2.71]. The association was positive in subgroup analysis of population-based case–control studies (PBCC) [summary SMD = 1.64; 95%CI: 0.02–3.34], but not in hospital-based case–control studies (HBCC). Through a sensitivity analysis, we did not identify any single study to strongly influence the results of our serum copper levels and cervical cancer risk. No publication bias was found in our analysis. In conclusion, our study provided significant evidence of higher serum copper levels in patients with cervical cancer than in controls, suggesting that serum copper exposure was a risk factor on cervical cancer.

Download Full-text

Metabolic syndrome and pancreatic cancer risk: a case-control study in Italy and meta-analysis

Metabolism ◽

10.1016/j.metabol.2011.03.005 ◽

2011 ◽

Vol 60 (10) ◽

pp. 1372-1378 ◽

Cited By ~ 50

Author(s):

Valentina Rosato ◽

Alessandra Tavani ◽

Cristina Bosetti ◽

Claudio Pelucchi ◽

Renato Talamini ◽

...

Keyword(s):

Pancreatic Cancer ◽

Metabolic Syndrome ◽

Cancer Risk ◽

Case Control Study ◽

Meta Analysis ◽

Case Control ◽

Pancreatic Cancer Risk ◽

Control Study

Download Full-text

Association between apurinic/apyrimidinic endonuclease 1 rs1760944 T>G polymorphism and susceptibility of cancer: a meta-analysis involving 21764 subjects

Bioscience Reports ◽

10.1042/bsr20190866 ◽

2019 ◽

Vol 39 (12) ◽

Cited By ~ 1

Author(s):

Guowen Ding ◽

Yu Chen ◽

Huiwen Pan ◽

Hao Qiu ◽

Weifeng Tang ◽

...

Keyword(s):

Cancer Risk ◽

Publication Bias ◽

Protective Factor ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Pooled Analysis ◽

Case Control ◽

Current Evidence ◽

Case Control Studies ◽

Risk Of Cancer

Abstract Background: Previous case–control studies have suggested that apurinic/apyrimidinic endonuclease 1 (APE1) rs1760944 T>G polymorphism may be associated with cancer risk. Here, we carried out an updated meta-analysis to focus on the correlation between APE1 rs1760944 T>G locus and the risk of cancer. Methods: We used the crude odds ratios (ORs) with their 95% confidence intervals (CIs) to evaluate the possible relationship between the APE1 rs1760944 T>G polymorphism and cancer risk. Heterogeneity, publication bias and sensitivity analysis were also harnessed to check the potential bias of the present study. Results: Twenty-three independent studies involving 10166 cancer cases and 11598 controls were eligible for this pooled analysis. We found that APE1 rs1760944 T>G polymorphism decreased the risk of cancer in four genetic models (G vs. T: OR, 0.87; 95% CI, 0.83–0.92; P<0.001; GG vs. TT: OR, 0.77; 95% CI, 0.69–0.86; P<0.001; GG/TG vs. TT: OR, 0.83; 95% CI, 0.77–0.89, P<0.001 and GG vs. TT/TG: OR, 0.85; 95% CI, 0.80–0.92, P<0.001). Results of subgroup analyses also demonstrated that this single-nucleotide polymorphism (SNP) modified the risk among lung cancer, breast cancer, osteosarcoma, and Asians. Evidence of publication bias was found in the present study. When we treated the publication bias with ‘trim-and-fill’ method, the adjusted ORs and CIs were not significantly changed. Conclusion: In conclusion, current evidence highlights that the APE1 rs1760944 T>G polymorphism is a protective factor for cancer susceptibility. In the future, case–control studies with detailed risk factors are needed to confirm or refute our findings.

Download Full-text