Interferon regulatory factor 1 inactivation in human cancer
Keyword(s):
Interferon regulatory factors (IRFs) are a group of closely related proteins collectively referred to as the IRF family. Members of this family were originally recognized for their roles in inflammatory responses; however, recent research has suggested that they are also involved in tumor biology. This review focusses on current knowledge of the roles of IRF-1 and IRF-2 in human cancer, with particular attention paid to the impact of IRF-1 inactivation. The different mechanisms underlying IRF-1 inactivation and their implications for human cancers and the potential importance of IRF-1 in immunotherapy are also summarized.
2008 ◽
Vol 32
(4)
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pp. 509-514
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2010 ◽
Vol 5
(2)
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pp. 260-265
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2012 ◽
Vol 51
(2)
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pp. 219-226
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1995 ◽
Vol 15
(9)
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pp. 799-810
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2006 ◽
Vol 18
(9)
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pp. 991-997
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1994 ◽
Vol 14
(2)
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pp. 1500-1509