Association of miR-146a, miR-149 and miR-196a2 polymorphisms with neuroblastoma risk in Eastern Chinese population: a three-center case–control study

Abstract Neuroblastoma is one of the most common malignancy in childhood, which originates from the developing sympathetic nervous system. Single nucleotide polymorphisms (SNPs) in primary miRNA (pri-miRNA) have shown to associate with cancer susceptibility, including neuroblastoma. Three precursor miRNA (pre-miRNA) SNPs (pre-miR-146a rs2910164, pre-miR-149 rs2292832 and pre-miR-196a2 rs11614913) were found to contribute to pathogenesis of various diseases. Here, to evaluate the association among these three pre-miRNA SNPs and neuroblastoma susceptibility in Eastern Chinese children, we carried out a three-center case–control study involving 312 neuroblastoma cases and 762 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the association of these three polymorphisms with neuroblastoma risk. However, no significant association was observed among these three SNPs and neuroblastoma susceptibility, in either overall or subgroups analysis by tumor sites, gender and age. Further larger studies consisting of diverse ethnic populations are required to clarify the associations among these three pre-miRNAs polymorphisms and neuroblastoma risk.

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Single-nucleotide Polymorphisms in Genes Encoding Toll-like Receptor -2, -3, -4, and -9 in a Case–Control Study with Bladder Cancer Susceptibility in a North Indian Population

Archives of Medical Research ◽

10.1016/j.arcmed.2012.10.008 ◽

2013 ◽

Vol 44 (1) ◽

pp. 54-61 ◽

Cited By ~ 25

Author(s):

Vibha Singh ◽

Neena Srivastava ◽

Rakesh Kapoor ◽

Rama Devi Mittal

Keyword(s):

Indian Population ◽

Case Control Study ◽

Cancer Susceptibility ◽

Case Control ◽

Nucleotide Polymorphisms ◽

Toll Like Receptor ◽

Single Nucleotide ◽

Genes Encoding ◽

Toll Like Receptor 2 ◽

Control Study

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Comprehensive Association Analysis of 30 Single Nucleotide Polymorphisms Related with Metabolic Syndrome on Cancer Susceptibility in Japanese Population: A Case – Control Study

Health Science Journal ◽

10.21767/1791-809x.1000545 ◽

2018 ◽

Vol 12 (1) ◽

Cited By ~ 1

Author(s):

Cuneyd Parlayan ◽

Shinobu Ikeda ◽

Noriko Sato ◽

Motoji Sawabe ◽

Masaaki Muramatsu ◽

...

Keyword(s):

Metabolic Syndrome ◽

Single Nucleotide Polymorphisms ◽

Association Analysis ◽

Japanese Population ◽

Case Control Study ◽

Cancer Susceptibility ◽

Case Control ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Control Study

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Screening of 214 Single Nucleotide Polymorphisms in 44 Candidate Cancer Susceptibility Genes: A Case–Control Study on Gastric and Colorectal Cancers in the Japanese Population

The American Journal of Gastroenterology ◽

10.1111/j.1572-0241.2008.01810.x ◽

2008 ◽

Vol 103 (6) ◽

pp. 1476-1487 ◽

Cited By ~ 20

Author(s):

Shinobu Ikeda ◽

Shizuka Sasazuki ◽

Syusuke Natsukawa ◽

Kozo Shaura ◽

Yoichi Koizumi ◽

...

Keyword(s):

Single Nucleotide Polymorphisms ◽

Japanese Population ◽

Case Control Study ◽

Cancer Susceptibility ◽

Case Control ◽

Colorectal Cancers ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Cancer Susceptibility Genes ◽

Control Study

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Correction to: Associations between prenatal exposure to cadmium and lead with neural tube defect risks are modified by single-nucleotide polymorphisms of fetal MTHFR and SOD2: a case–control study

Environmental Health ◽

10.1186/s12940-021-00762-7 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Mengyuan Liu ◽

Jinhui Yu ◽

Zaiming Su ◽

Ying Sun ◽

Yaqiong Liu ◽

...

Keyword(s):

Single Nucleotide Polymorphisms ◽

Prenatal Exposure ◽

Neural Tube ◽

Neural Tube Defect ◽

Case Control Study ◽

Case Control ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Cadmium And Lead ◽

Control Study

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Single nucleotide polymorphisms of TRAF2 and TRAF5 gene in ankylosing spondylitis: a case–control study

Clinical and Experimental Medicine ◽

10.1007/s10238-021-00719-7 ◽

2021 ◽

Author(s):

Shanshan Xu ◽

Jiangping Kong ◽

Li Huang ◽

Huimin Xie ◽

Feier Wang ◽

...

Keyword(s):

Ankylosing Spondylitis ◽

Single Nucleotide Polymorphisms ◽

Case Control Study ◽

Case Control ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Control Study

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Association between CTSS gene polymorphism and the risk of acute atherosclerotic cerebral infarction in Chinese population: a case–control study

Bioscience Reports ◽

10.1042/bsr20180586 ◽

2018 ◽

Vol 38 (6) ◽

Cited By ~ 2

Author(s):

Lian Luo ◽

Mingli Zhu ◽

Jiajun Zhou

Keyword(s):

Cerebral Infarction ◽

Case Control Study ◽

Case Control ◽

Cathepsin S ◽

Control Group ◽

Study Group ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Independent Risk Factors ◽

Control Study

Objective: To investigate the association between the gene polymorphisms of rs774320676, rs768437857, rs928508030, and rs2275235 loci of Cathepsin S (CTSS) and risk of acute atherosclerotic cerebral infarction. Methods: A total of 315 patients with acute atherosclerotic cerebral infarction (study group) and 220 healthy subjects (control group) were enrolled in the present study. The genetic polymorphism of rs774320676, rs768437857, rs928508030, and rs2275235 loci of CTSS of subjects was analyzed by PCR-Sanger sequencing. Results: The proportion of carriers with mutant T allele at rs774320676 locus and mutant G allele at rs928508030 locus of CTSS in study group was significantly higher than the proportion in control group (P=0.000, adjusted odds ratio (OR) = 1.332, 95% confidence interval (CI) = 1.200–1.460; P<0.001, adjusted OR = 1.185, 95% CI = 1.055–1.314; P=0.002). The T allele at rs774320676 locus and the G allele at rs928508030 locus of CTSS were independent risk factors for acute atherosclerotic cerebral infarction (OR = 2.534, 95% CI = 1.020–4.652, P=0.006; OR = 2.016, 95% CI = 1.031–4.385, P=0.031). Conclusion: The single nucleotide polymorphisms (SNPs) of rs774320676 and rs928508030 of CTSS gene were related with risk for acute atherosclerotic cerebral infarction. The T allele at rs774320676 locus and G allele at rs928508030 locus of CTSS were genetic susceptibility genes of acute atherosclerotic cerebral infarction.

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