HLA Antigens in Spanish Patients with Essential Hypertension

1981 ◽  
Vol 61 (s7) ◽  
pp. 367s-368s ◽  
Author(s):  
A. Fernandez-Cruz ◽  
M. Luque Otero ◽  
L. Llorente Perez ◽  
C. Fernandez Pinilla ◽  
N. Martell Claros
Keyword(s):  
Diabetes Mellitus ◽  
Essential Hypertension ◽  
Blood Donors ◽  
Positive Family History ◽  
Hla Antigens ◽  
Control Group ◽  
Hypertensive Patients ◽  
History Of ◽  
Diabetic Population ◽  
Family History Of Hypertension

1. Human leucocyte AB antigens were determined by means of a lymphocyte toxicity test in 84 patients with essential hypertension and in 1000 blood donors. 2. The prevalence of HLA B8 was 16.4% in hypertensive patients and 8.9% in controls (P = 0.07). 3. The prevalence of HLA B12 was 34.5% in hypertensive patients and 26.9% in the control group (N.S.). In WHO stage III hypertension HLA B12 was found in six out of 10 patients. 4. The prevalence of HLA B15 was 1.2% in hypertensive patients and 6.4% in controls (P < 0.05). 5. In view of a previous report of HLA antigens in a Spanish diabetic population, this study does not support the suggestion of a genetic and possibly HLA-linked connection between essential hypertension and diabetes mellitus among the Spanish population. 6. A positive family history of hypertension tended to be more common in those patients with essential hypertension associated with HLA B8.

Intracellular Na+ and Ca2+ Activities in Essential Hypertension

1982 ◽  
Vol 63 (s8) ◽  
pp. 41s-43s ◽  
Author(s):  
W. Zidek ◽  
H. Vetter ◽  
K.-G. Dorst ◽  
H. Zumkley ◽  
H. Losse
Keyword(s):  
Essential Hypertension ◽  
Family History ◽  
Secondary Hypertension ◽  
Genetic Trait ◽  
Hypertensive Patients ◽  
Intracellular Na Activity ◽  
History Of ◽  
Family History Of Hypertension ◽  
Normotensive Subjects

1. The intracellular Na+ and Ca2+ activity and Na+ concentration were measured in erythrocytes of normotensive subjects, with and without a familial disposition to hypertension, in essential hypertensive patients with and without a family history of hypertension, and in patients with secondary hypertension. 2. In normotensive subjects without a genetic trait of hypertension intracellular Na+ activity and concentration were 7.00 ± 1.38 mmol/l and 5.67 ± 0.95 mmol/l respectively. The intracellular Ca2+ activity was 4.82 ± 4.49 μmol/l. In normotensive subjects with a familial hypertensive disposition intracellular Na+ activity and concentration were 9.74 ± 1.43 mmol/l (P < 0.01) and 6.63 ± 0.88 mmol/l (P < 0.05). Intracellular Ca2+ was 9.59 ± 9.71 μmol/l (P < 0.05). 3. Essential hypertensive patients without a familial genetic trait had an elevated intracellular Na+ activity (8.35 ± 2.08 mmol/l, P < 0.05). Intracellular Na+ concentration was 6.64 ± 0.79 mmol/l (P < 0.05). The intracellular Ca2+ activity was markedly elevated to 25.33 ± 19.03 μmol/l (P < 0.01). The essential hypertensive patients with a familial disposition had an elevated intracellular Na+ activity (17.19 ± 4.37 mmol/l, P < 0.001) and Ca2+ activity (32.8 ± 32.51 μmol/l, P < 0.01). The intracellular Na+ concentration was 6.25 ± 1.23 mmol/l. 4. The results indicate that in essential hypertension intracellular Na+ activity is increased, particularly in patients with a familial disposition for hypertension. Intracellular Ca2+ is increased in essential hypertension whether or not there was a family disposition to hypertension.

scholarly journals A study of the dermatoglyphic pattern in essential hypertension subjects in Kalaburagi test

2021 ◽  
Vol 8 (2) ◽  
pp. 102-105
Author(s):  
Arshiya Zeba ◽  
Mohd Ibrahim Pasha ◽  
Mohammed Mateen Ahmed ◽  
Khwaja Nawazuddin Sarwari
Keyword(s):  
Essential Hypertension ◽  
Positive Family History ◽  
Control Group ◽  
Ridge Count ◽  
Hypertensive Patients ◽  
Normal Individuals ◽  
Hereditary Disorders ◽  
Genetically Determined ◽  
And Control ◽  
Control Study

Dermatoglyphics sterms from the ancient art of palmistry, which was practiced from time immemorial and is still followed throughout India by the Joshi caste. There appears to exist an extremely old volume, on the markings on the hands possessed and treasured by the Hindus. From here, this art has spread throughout the world.Essential hypertension is the category of hypertension that has no identifiable cause, it is associated with aging and inherited genetic factors. Positive family history increases the risk. Dermatoglyphic patterns are genetically determined and can be used as supportive for diagnosis of various hereditary disorders including essential hypertension. This study was carried out to compare palmar dermatoglyphic pattern in, essential hypertension and control group and compare with previous studies.A hospital based case control study was conducted 100 essential hypertensive patients are taken from Basaweshwar hospital Gulbarga, and another 100 persons are included as control group. The palms and fingers are smeared with ink to bring out the dermatoglyphiic patterns which were subsequently studied.There was increased number of whorls and decreased number of ulnar loops in essential hypertensive patients compared with normal individuals. Total finger ridge count and Absolute finger ridge count is increased in Essential hypertension patients and there is also increased atd angle.The knowledge of dermatoglyphics in patients with essential hypertension can be utilized to find out genetic correlation. The existence of such relation might be important for the screening programme for prevention of essential hypertension.

Clinical Features of Hypertension in Frequent and Heavy Alcohol Drinkers

1982 ◽  
Vol 27 (3) ◽  
pp. 207-211 ◽  
Author(s):  
L. E. Ramsay
Keyword(s):  
Alcohol Use ◽  
Clinical Features ◽  
Positive Family History ◽  
Vascular Complications ◽  
Hypertensive Patients ◽  
Lower Blood ◽  
History Of ◽  
Family History Of Hypertension ◽  
One Year ◽  
Alcohol Users

An association between regular alcohol use and hypertension is firmly established. The clinical features of hypertensive patients who used alcohol frequently or heavily were compared with those of age and sex matched hypertensive patients who used alcohol only occasionally or never. Regular alcohol use was associated with milder hypertension, lower blood urea concentrations and fewer electrocardiographic abnormalities. However, there was no evidence that major vascular complications, including myocardial infarction, were less common in regular drinkers, perhaps because of their associated heavy cigarette smoking. Regular alcohol users were as likely to give a positive family history of hypertension, but were less likely to have an abnormal intravenous pyelogram. Heavy drinkers were twice as likely to default within one year.

7. Relationship between HLA-antigens and hypertension in individuals with a positive family history of hypertension

1991 ◽  
Vol 9 (6) ◽  
pp. S423
Author(s):  
M. Beckman Suurk??la ◽  
Bj??rn Dahl??f ◽  
Hans Herlitz ◽  
T. Gudbrandsson ◽  
E. Hilme ◽  
...  
Keyword(s):  
Family History ◽  
Positive Family History ◽  
Hla Antigens ◽  
History Of ◽  
Family History Of Hypertension

7. Relationship between HLA-antigens and hypertension in individuals with a positive family history of hypertension

1991 ◽  
Vol 9 ◽  
pp. S423
Author(s):  
M. Beckman Suurküla ◽  
Björn Dahlöf ◽  
Hans Herlitz ◽  
T. Gudbrandsson ◽  
E. Hilme ◽  
...  
Keyword(s):  
Family History ◽  
Positive Family History ◽  
Hla Antigens ◽  
History Of ◽  
Family History Of Hypertension

Human Leucocyte Antigens in Patients with Previous Essential Malignant Hypertension

1980 ◽  
Vol 59 (s6) ◽  
pp. 431s-434s ◽  
Author(s):  
T. Gudbrandsson ◽  
H. Herlitz ◽  
L. Hansson ◽  
L. Rydberg
Keyword(s):  
Family History ◽  
Blood Donors ◽  
Positive Family History ◽  
Malignant Hypertension ◽  
Negative Family History ◽  
History Of ◽  
Human Leucocyte Antigens ◽  
Family History Of Hypertension ◽  
Leucocyte Antigens ◽  
Rule Out

1. Human leucocyte ABC antigens were determined by means of a lymphocytotoxicity test in 27 patients with previous essential malignant hypertension and in 500 blood donors. 2. In 18 patients with grade IV retinopathy human leucocyte antigen B15 (HLA B15) was found in 44%, as compared with 23% in the control subjects (P = 0.888). 3. All patients with HLA B15 had a positive family history for hypertension. 4. In 18 patients with grade IV retinopathy HLA B15 was found in eight whereas none of the nine patients with grade III retinopathy had this antigen (P = 0.039). 5. Of the 27 patients, 19 had a positive family history of hypertension and of these eight had HLA B15, whereas none of the eight patients with a negative family history had this antigen (P = 0.068). 6. The findings do not rule out that HLA B15 may be associated with the development of the malignant phase in patients with essential hypertension, but a statistically significant relationship could not be established.

Blood Pressure and Intra-Erythrocyte Sodium during Normal and High Salt Intake in Middle-Aged Men: Relationship to Family History of Hypertension, and Neurogenic and Hormonal Variables

1984 ◽  
Vol 66 (4) ◽  
pp. 427-433 ◽  
Author(s):  
Ottar Gudmundsson ◽  
Hans Herlitz ◽  
Olof Jonsson ◽  
Thomas Hedner ◽  
Ove Andersson ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Family History ◽  
Salt Intake ◽  
Sodium Intake ◽  
Positive Family History ◽  
Sodium Content ◽  
High Salt Intake ◽  
History Of ◽  
Family History Of Hypertension ◽  
Erythrocyte Sodium

1. During 4 weeks 37 normotensive 50-year-old men identified by screening in a random population sample were given 12 g of NaCl daily, in addition to their usual dietary sodium intake. Blood pressure, heart rate, weight, urinary excretion of sodium, potassium and catecholamines, plasma aldosterone and noradrenaline and intra-erythrocyte sodium content were determined on normal and increased salt intake. The subjects were divided into those with a positive family history of hypertension (n = 11) and those without such a history (n = 26). 2. Systolic blood pressure and weight increased significantly irrespective of a positive family history of hypertension. 3. On normal salt intake intra-erythrocyte sodium content was significantly higher in those with a positive family history of hypertension. During high salt intake intra-erythrocyte sodium content decreased significantly in that group and the difference between the hereditary subgroups was no longer significant. 4. In the whole group urinary excretion of noradrenaline, adrenaline and dopamine increased whereas plasma aldosterone decreased during the increased salt intake. 5. Thus, in contrast to some earlier studies performed in young subjects, our results indicate that moderately increased sodium intake acts as a pressor agent in normotensive middle-aged men whether there was a positive family history of hypertension or not. We confirm that men with positive family history of hypertension have an increased intra-erythrocyte sodium content, and that an increase in salt intake seems to increase overall sympathetic activity.

scholarly journals Genotyping of Essential Hypertension Single-Nucleotide Polymorphisms by a Homogeneous PCR Method with Universal Energy Transfer Primers

2002 ◽  
Vol 48 (12) ◽  
pp. 2131-2140 ◽  
Author(s):  
Chikh Bengra ◽  
Theodore E Mifflin ◽  
Yuri Khripin ◽  
Paolo Manunta ◽  
Scott M Williams ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Single Nucleotide Polymorphisms ◽  
Restriction Endonucleases ◽  
Control Group ◽  
Italian Population ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Hypertensive Patients ◽  
Unique Restriction ◽  
Set Up

Abstract Background: Human hypertension is a complex, multifactorial disease with a heritability of more than 30–50%. A genetic screening test based on analysis of multiple single-nucleotide polymorphisms (SNPs) to assess the likelihood of developing hypertension would be helpful for disease management. Methods: Tailed allele-specific primers were designed to amplify by PCR six biallelic SNP loci [three in G protein-coupled receptor kinase type 4 (GRK4): R65L, A142V, and A486V; two in angiotensinogen: −6G→A and M235T; and one in aldosterone synthase: −344C→T] associated with essential hypertension. PCRs of SNP loci were coupled (via a common sequence of 21 nucleotide tails) to incorporate Universal Amplifluor™ primers labeled with fluorescein or sulforhodamine in a homogeneous format. Use of Amplifluors in SNP PCRs produced labeled amplicons, the fluorescence of which was quantified by a microplate reader and then analyzed via an Excel macro to provide genotypes for all six SNP loci. Unique restriction endonucleases were identified for five SNP loci that could independently confirm homogeneous PCR results when needed. Results: We developed six homogeneous PCR assays that were set up, performed, and fluorometrically analyzed in 96-well microplates. Allele frequencies were determined for six SNPs in 60 Italian hypertensive patients and a control group of 60 normotensive persons. A significant correlation (P = 0.034) between one SNP [GRK4 (A486V)] and the hypertensive patients was observed. Genotyping results for five of six SNPs were confirmed by digesting corresponding amplicons with locus-specific restriction endonucleases. Conclusions: We developed a simple and homogeneous fluorescent protocol that has been used to determine the SNP genotype for six loci in a population of hypertensive and normotensive persons. We also observed a significant association (P = 0.034) between one SNP (A486V) and an Italian population of mildly hypertensive patients.

scholarly journals Study of risk factors and its correlation with constraint induced movement therapy for atherosclerosis in patients of coronary artery disease and their offspring

2020 ◽  
Vol 7 (3) ◽  
pp. 446
Author(s):  
Venugopal Margekar ◽  
Shweta Thakur ◽  
O. P. Jatav ◽  
Pankaj Yadav
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Positive Family History ◽  
Surrogate Marker ◽  
Control Group ◽  
Medical College ◽  
Constraint Induced Movement Therapy ◽  
Group Data ◽  
History Of ◽  
Artery Disease

Background: A significant percent of cardiovascular event occurs without well-known modifiable risk. A new tool for early identification for atherosclerosis is required for early intervention. Aims and objectives of the study was to study the risk factors for CAD and its correlation with CIMT.Methods: One hundred and forty subjects were studied for the risk factors of CAD in Department of Medicine of G.R. Medical College, Gwalior from 2012 to 2013. Out of 140 subjects, 100 were patients having CAD and 40 age matched subjects were included as control group. Data was also recorded from their offspring. High resolution B mode ultrasonography was performed to assess CIMT of carotid arteries. The maximum CIMT of any one side of carotid artery was taken for study.Results: CAD was more prevalent among males (78%). Majority of the offspring of cases had age between 28-42 years and majority were male (73%). Most common risk factors for CAD was dyslipidemia (48%), hypertension (24%), diabetes (12%) and smoking (21%), whereas in offspring’s of CAD patients, dyslipidemia was seen in 28%, hypertension in 3%, diabetes and tobacco smoking in 12% and 24% respectively. The CIMT of CAD patients was significantly increased with increasing the number of risk factors and the same pattern was also seen in controls.  The CIMT of asymptomatic offspring’s having positive family history was significantly more than the asymptomatic offspring without positive family history of CAD.Conclusions: CIMT measurements can be used as a surrogate marker of atherosclerosis as it has showed a direct link with number of risk factors of CAD. 

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