Deferoxamine-induced bone changes in haemodialysis patients: A histomorphometric study

1987 ◽  
Vol 73 (2) ◽  
pp. 227-234 ◽  
Author(s):  
Sam A. Charhon ◽  
Pascale Chavassieux ◽  
Georges Boivin ◽  
May Parisien ◽  
Marie-Claire Chapuy ◽  
...  
Keyword(s):  
Bone Mineralization ◽  
Bone Lesion ◽  
Chronic Haemodialysis ◽  
Serum Parathyroid Hormone ◽  
Histomorphometric Study ◽  
Bone Biopsies ◽  
Bone Changes ◽  
High Bone ◽  
Tetracycline Labelling ◽  
Osteoid Volume

1. The histological effects of deferoxamine therapy were assessed on transiliac bone biopsies taken after double tetracycline labelling from 16 uraemic patients undergoing chronic haemodialysis, all having aluminium deposits in bone. Eight patients had osteomalacia, five had an ‘aplastic’ bone lesion and three a high bone turnover with a marked increase in osteoid volume. 2. Deferoxamine was administered intravenously once a week at doses ranging from 1 to 6 g for a mean duration of 7.6 ± 3.3 (sd) months. 3. Deferoxamine therapy was associated with significant reductions in stainable aluminium deposits, osteoid volume, osteoid surfaces and thickness index of osteoid seams. The osteoblastic osteoid surfaces as well as the bone formation rates also increased significantly. 4. A rise in resorption parameters and in serum parathyroid hormone levels was observed in patients with osteomalacia. The percentage reductions in stainable aluminium and in osteoid volume were correlated with the degree of hyperparathyroidism. 5. These data show that deferoxamine therapy reduces stainable bone aluminium and improves bone mineralization in low turnover osteomalacia and that the presence of hyperparathyroidism is associated with an increased response to deferoxamine therapy.

Socket preservation using xenograft does not impair implant primary stability in sheep: clinical, histological and histomorphometric study

2020 ◽  
Author(s):  
Yaniv Mayer ◽  
Ofir Ginesin ◽  
Hadar Zigdon-Giladi
Keyword(s):  
Bone Biopsy ◽  
Primary Stability ◽  
Insertion Torque ◽  
Socket Preservation ◽  
Histomorphometric Study ◽  
Implant Placement ◽  
High Bone ◽  
Delayed Implant Placement ◽  
Natural Healing

Implant primary stability, which depends mainly on the amount and quality of bone, is important for implant survival. Socket preservation aims to reduce bone volumetric changes following tooth extraction. This animal study aims to examine whether preserving a ridge by using xenograft impairs the primary stability of the implant. Eighteen artificial bone defects were prepared in four sheep (5mmØ and 8mm length).  Defects were randomly grafted with xenografts: Bio-Oss (BO), Bioactive Bone (BB), or left for natural healing (control). After 8 weeks, bone biopsy was harvested and dental implants installed. During installation, peak insertion torque (IT) was measured by hand ratchet, and primary stability by the Osstell method. Histomorphometric analysis showed a higher percentage of new bone formation in the naturally healed defects compared to sites with xenograft (control 68.66 ± 4.5%, BB 48.75 ± 4.34%, BO 50.33 ± 4.0%). Connective tissue portion was higher in the BO and BB groups compared to control (44.25 ± 2.98%, 41 ± 6%, and 31.33 ± 4.5, p<0.05, respectively). Residual grafting material was similar in BO and BB (7 ± 2.44%, 8.66 ± 2.1 %, respectively). Mean IT and ISQ values were not statistically different among the groups. A positive correlation was found between IT and ISQ (r=0.65, p=0.00). In conclusion, previously grafted defects with xenograft did not influence primary stability and implant insertion torque in delayed implant placement. These results may be attributed to a relatively high bone fill of the defect (~50%) two months after grafting.

scholarly journals Distribution of strontium and mineralization in iliac bone biopsies from osteoporotic women treated long-term with strontium ranelate

2011 ◽  
Vol 165 (3) ◽  
pp. 469-476 ◽  
Author(s):  
Audrey Doublier ◽  
Delphine Farlay ◽  
Mohamed T Khebbab ◽  
Xavier Jaurand ◽  
Pierre J Meunier ◽  
...  
Keyword(s):  
Bone Mineralization ◽  
Progressive Increase ◽  
Tissue Level ◽  
Term Treatment ◽  
Iliac Bone ◽  
X Ray ◽  
Long Term Treatment ◽  
Bone Biopsies

ObjectiveTo investigate interactions between strontium (Sr) and bone mineral and its effects on mineralization in osteoporotic women treated long-term with Sr ranelate (SrRan).DesignIn this study, 34 iliac bone biopsies were analyzed after 2, 12, 24, 36, 48, and 60 months of treatment with SrRan.MethodsSr global distribution was analyzed by X-ray cartography and the percentage of bone area containing Sr was calculated in the bone samples. The focal distribution of Sr in all bone samples was investigated by X-ray microanalysis. The degree of mineralization was assessed by quantitative microradiography.ResultsAbsent from old bone formed before the beginning of treatment, Sr was exclusively present in bone formed during this treatment with a much higher focal Sr content in new bone structural units than in old ones. A progressive increase in the extent of areas containing Sr was observed during treatment. The focal bone Sr content in recently formed bone was constant over treatment. Secondary mineralization was maintained at a normal level during treatment.ConclusionThus, the quality of bone mineralization (density and heterogeneity at tissue level) was preserved after a long-term treatment with SrRan.

scholarly journals Bone mineralization defects and vitamin D deficiency: Histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients

2009 ◽  
Vol 25 (2) ◽  
pp. 305-312 ◽  
Author(s):  
Matthias Priemel ◽  
Christoph von Domarus ◽  
Till Orla Klatte ◽  
Steffen Kessler ◽  
Julia Schlie ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Iliac Crest ◽  
Bone Mineralization ◽  
Histomorphometric Analysis ◽  
Hydroxyvitamin D ◽  
Bone Biopsies ◽  
25 Hydroxyvitamin D

scholarly journals A Suspected Pelvic Aneurysmal Bone Cyst in Pregnancy

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Rayan Elkattah ◽  
Brooke Foulk
Keyword(s):  
Clinical Outcomes ◽  
Aneurysmal Bone Cyst ◽  
Bone Fractures ◽  
Bone Cyst ◽  
Bone Lesion ◽  
Pelvic Bone ◽  
Bone Lesions ◽  
Bone Changes ◽  
Challenging Situation ◽  
In Pregnancy

Albeit rare, the majority of identified bone lesions in pregnancy spare the pelvis. Once encountered with a pelvic bone lesion in pregnancy, the obstetrician may face a challenging situation as it is difficult to determine and predict the effects that labor and parturition impart on the pelvic bones. Bone changes and pelvic bone fractures have been well documented during childbirth. The data regarding clinical outcomes and management of pregnancies complicated by pelvic ABCs is scant. Highly suspected to represent an aneurysmal bone cyst, the clinical evaluation of a pelvic lesion in the ilium of a pregnant individual is presented, and modes of delivery in such a scenario are discussed.

Interrelationships between serum 25-hydroxycholecalciferol, serum parathyroid hormone and morphometric bone changes in anticonvulsant osteomalacia. Therapeutic effect of vitamin D2

1976 ◽  
Vol 22 (S1) ◽  
pp. 473-478 ◽  
Author(s):  
F. Melsen ◽  
L. Mosekilde ◽  
M. S. Christensen ◽  
B. Lund ◽  
O. H. Sørensen
Keyword(s):  
Parathyroid Hormone ◽  
Therapeutic Effect ◽  
Vitamin D2 ◽  
Serum Parathyroid Hormone ◽  
Bone Changes ◽  
25 Hydroxycholecalciferol

TETRACYCLINE LABELLING OF BONE AND THE ZONE OF DEMARCATION OF OSTEOID SEAMS

1962 ◽  
Vol 40 (1) ◽  
pp. 485-489 ◽  
Author(s):  
Harold M. Frost
Keyword(s):  
Bone Mineralization ◽  
Lamellar Bone ◽  
Tetracycline Antibiotics ◽  
Tetracycline Labelling

In human lamellar bone, mineralization begins in a plane, termed the zone of demarcation, which separates osteoid seams from mineralized bone. Permanently fixed tetracycline antibiotics are deposited in the zone of demarcation in vivo, and in no other locus in lamellar bone.

scholarly journals Training of Lemuru Fish Nuggets Processing for Stunting Children’s Mothers In Pantai Labu Sub-District Deli Serdang Regency

2020 ◽  
Vol 3 (1) ◽  
pp. 60-70
Author(s):  
Dini Lestrina ◽  
Novriani Tarigan ◽  
Oslida Martony
Keyword(s):  
Bone Mineralization ◽  
Work Productivity ◽  
Zinc Intake ◽  
Average Value ◽  
High Incidence ◽  
Simple Processing ◽  
High Bone ◽  
North Sumatra ◽  
Initial Knowledge ◽  
And Training

Failure of stunting in children will produce human resources that cannot compete in the era of globalization, affect work productivity, increase the risk of obesity, and lead to metabolic syndrome. Indonesia has a high incidence of stunting among children under five and school children, including North Sumatra with a prevalence of 42.3%, ranked fourth in the province with a high stunting prevalence. The prevalence of stunting in children aged 5-12 years increases every year. During the growth of very high bone mineralization, low intake of protein, calcium, and zinc influences linear growth. Aged 5-12 years is an opportunity to catch up and improve height. In terms of overcoming the lack of protein, calcium, and zinc intake as well as spurring the growth of schoolchildren, it can be done by giving Lemuru fish nuggets. Fish nugget processing is a simple processing method and has a long shelf life, with storage life in the freezer was 2 weeks. From the results of conseling and training conducted an initial and final knowledge assessment, it is known that initial knowledge is still lacking with an average value of 64.69 after the activity has increased to 83.95. Participants better understand the benefits of local food such as lemuru fish to cope with the stunting situation experienced by their child.

Static and dynamic bone changes in hospitalized patients suffering from rickets — a histomorphometric study

1997 ◽  
Vol 31 (1) ◽  
pp. 12-17 ◽  
Author(s):  
E.J. RAUBENHEIMER ◽  
W.F.P. VAN HEERDEN ◽  
D. POTGIETER ◽  
R. GOLELE
Keyword(s):  
Hospitalized Patients ◽  
Histomorphometric Study ◽  
Bone Changes

Abnormally high bone mineralization in children with osteogenesis imperfecta is neither associated with specific collagen mutations nor with clinical severity of the disease

Bone ◽  
2009 ◽  
Vol 45 ◽  
pp. S105
Author(s):  
N. Fratzl-Zelman ◽  
P. Roschger ◽  
B.M. Misof ◽  
F. Rauch ◽  
F.H. Glorieux ◽  
...  
Keyword(s):  
Osteogenesis Imperfecta ◽  
Bone Mineralization ◽  
Clinical Severity ◽  
High Bone ◽  
Severity Of The Disease
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