Effect of intrathecal fentanyl on oxytocin secretion in pregnant women not in labour

2001 ◽  
Vol 101 (4) ◽  
pp. 415-419 ◽  
Author(s):  
K.U. SHIBLI ◽  
A.R. DHILLON ◽  
J.A. GOODE ◽  
C.L. GILBERT ◽  
J.W. THOMPSON ◽  
...  
Keyword(s):  
Caesarean Section ◽  
Pregnant Women ◽  
Spinal Anaesthesia ◽  
Caesarean Delivery ◽  
Intrathecal Injection ◽  
Intrathecal Administration ◽  
Group I ◽  
Before And After ◽  
Pooled Samples ◽  
Elective Caesarean Delivery

We studied the effects of spinal intrathecal fentanyl on oxytocin secretion in 20healthy women prior to an elective caesarean delivery at term under spinal anaesthesia. The women were randomly allocated into two groups with respect to spinal anaesthesia. Group I (n = 10) received intrathecal bupivacaine (15mg) plus fentanyl (25μg), and Group II (n = 10) received intrathecal bupivacaine (15mg) alone, prior to caesarean section. The two groups were comparable demographically. Altogether, ten samples of 4.5ml of blood (taken every 60 s) were obtained before and ten samples were obtained after the intrathecal administration of the drug and establishment of the T6 block, and plasma oxytocin concentrations were assayed for each subject. Oxytocin was measured by RIA. We found no significant differences in plasma oxytocin concentrations of individual subjects before and after intrathecal injection. In addition, there were no significant differences in plasma oxytocin concentrations between the two groups when pooled samples from the subjects were compared for the pre- and post-intrathecal injection phases. We conclude that the spinal intrathecal administration of fentanyl does not suppress oxytocin secretion in pregnant women who are not in labour at term.

scholarly journals On demand caesarean section: What’s women’s attitude?

1970 ◽  
Vol 2 (2) ◽  
pp. 12-15
Author(s):  
Nira S Shrestha ◽  
Sumita Pradhan
Keyword(s):  
Caesarean Section ◽  
Pregnant Women ◽  
Vaginal Delivery ◽  
Caesarean Delivery ◽  
Mode Of Delivery ◽  
University Teaching ◽  
Normal Vaginal Delivery ◽  
On Demand ◽  
Assisted Delivery ◽  
The Right

Objectives: To evaluate the knowledge and attitude of Nepalese women towards mode of delivery and caesarean on demand. Study design: Hospital based cross sectional descriptive study where 200 pregnant women after 37 completed weeks of gestation were recruited randomly and interviewed, and their answers were analyzed. Results: Of the 200 interviewed pregnant women, all of them knew about normal vaginal delivery and caesarean delivery, but only 30% knew about instrumentally assisted delivery and 9% had heard about painless labour. Vaginal delivery was the preferred mode in 93% and 7% preferred caesarean delivery. Only 35% of the interviewed women believed that women should have the right to demand a caesarean section Conclusion: Knowledge assessment of two hundred women regarding the mode of delivery clearly indicates the need for strengthening counseling aspect of antenatal care and awareness program regarding mode of delivery. In Nepal on demand caesarean section is not provided in the University Teaching Hospital. However one third of women still felt that women should have the right to choose caesarean section on demand. Key words: Attitude, mode of delivery, Caesarean on demand. doi:10.3126/njog.v2i2.1448 N. J. Obstet. Gynaecol 2007 Nov-Dec; 2 (2): 12 - 15

The efficacy of onion extract in the management of subsequent abdominal hypertrophic scar formation

2020 ◽  
Vol 29 (10) ◽  
pp. 612-616
Author(s):  
Emre Sinan Güngör ◽  
Duygu Güzel ◽  
Ali Galip Zebitay ◽  
Gülşah İlhan ◽  
Fatma Ferda Verit
Keyword(s):  
Caesarean Section ◽  
Allium Cepa ◽  
Hypertrophic Scar ◽  
Caesarean Delivery ◽  
Control Group ◽  
Surgical Removal ◽  
Study Group ◽  
Caesarean Scar ◽  
Prophylactic Use ◽  
Elective Caesarean Delivery

Objective: Development of postoperative scars is often a problem. This study aimed to evaluate the efficacy of gel containing Allium cepa extract, allantoin and heparin (Contractubex, Merz Pharmaceuticals GmbH, Frankfurt, Germany) in reducing scarring after a caesarean section by comparing it with a control group, and also intra-individually, using the Vancouver Scar Scale (VSS). Method: A total of 120 patients who underwent a second elective caesarean delivery and who presented with hypertrophic scar development after their first caesarean section were included in the study. A scar revision was performed for all patients during the second caesarean operation. Patients in the study group (n=60) were advised to apply the topical scar gel postoperatively for a period of 6 months. The control group (n=60) received no treatment. Results: Significant reductions were observed in the vascularity, pigmentation and height subgroups of the VSS for those in the group who continued the treatment to 24 weeks. An intra-individual analysis showed that the gel effectively reduced scarring after the second caesarean section. Conclusion: The prophylactic use of the gel to reduce scar development offers better results for vascularity, pigmentation and height subscales of the VSS after surgical removal of the primary caesarean scar during the second caesarean section. The results were better both intra-individually, and also in comparison with the control group and support the use of a gel containing Allium cepa extract, allantoin and heparin to reduce scarring after a caesarean section.

scholarly journals Repeat Spinal Anaesthesia for Caesarean section: An Experience at Paropakar Maternity and Women’s Hospital

2018 ◽  
Vol 12 (2) ◽  
pp. 58-60
Author(s):  
Ritu Pradhan ◽  
Sangeeta Shrestha ◽  
Tara Gurung ◽  
Amirbabu Shrestha
Keyword(s):  
Caesarean Section ◽  
General Anaesthesia ◽  
Spinal Anaesthesia ◽  
Intrathecal Injection ◽  
Common Adverse Effect ◽  
Haemodynamic Effects ◽  
Sensory Blockade ◽  
Repeat Administration ◽  
Complete Failure ◽  
Motor Effects

Aims: This study aims to review the haemodynamic effects of the repeat spinal anaesthesia and to identify the different doses of Bupivacaine heavy used for the repeat spinal anaesthesia for the failed spinal in caesarean section.Methods: This study was conducted by reviewing medical anaesthesia records of the cases of the repeat spinal anesthesia regarding any adverse haemodynamic effects. The second dose of bupivacaine heavy, maximum sensory blockade and intraoperative events like bradycardia, hypotension, high spinal, nausea vomiting, conversion to general anaesthesia and inadequate block were also reviewed.Results: Out of 8040 caesarean section under subarachnoid block, 51(0.63%) cases were conducted under repeat spinal anaesthesia from April 2014 to December2016. All the cases had complete spinal failure with no sensory and motor effects even after 10 minutes of the intrathecal injection. The second dose of bupivacaine heavy used was variable but reduced than the first dose. The most common adverse effect was hypotension (27.5%). 50% of cases were uneventful. One case was converted to general anaesthesia even after repeat spinal anaesthesia and 9.8% cases had high spinal above T4.Conclusions: Repeat administration of Bupivacaine heavy in reduced dose and volume can be used in complete failure of administration of first spinal anaesthesia. However, it always requires careful assessment and the judicious monitoring.

scholarly journals Accidental intrathecal administration of dopamine in spinal anaesthesia for caesarean section: A case report

2017 ◽  
Vol 33 (2) ◽  
pp. 205-207 ◽  
Author(s):  
Udita Naithani ◽  
Devendra Verma ◽  
Abhilasha Thanvi ◽  
Rekha Bayer
Keyword(s):  
Case Report ◽  
Caesarean Section ◽  
Spinal Anaesthesia ◽  
Intrathecal Administration

scholarly journals Spinal Anaesthesia Induced Hypotension and Related Adverse Effects in Caesarean Section Delivery and Neonatal Outcome: A Comparison of Using Crystalloid Pre-Loading and Co- Loading in Caesarean Patients

2020 ◽  
Vol 5 (1) ◽  
pp. 90
Author(s):  
Taneem Mohammad ◽  
Moinul Hossain Chowdhury ◽  
Shamima Akter ◽  
Mohammad Abdul Karim Miah ◽  
Mohammad Mohsin ◽  
...  
Keyword(s):  
Caesarean Section ◽  
Adverse Effects ◽  
Spinal Anaesthesia ◽  
Apgar Score ◽  
Neonatal Outcome ◽  
Induced Hypotension ◽  
Group I ◽  
Caesarean Section Delivery ◽  
Group Ii ◽  
The Difference

Background: Volume loading by rapid infusion of crystalloid solution before/during induction of spinal anaesthesia may effectively reduce the incidence of anaesthesia induced hypotension.Objective:To compare the efficacy of crystalloid pre-loading and co-loading to preventhypotension and related adverse effects as well aspoor neonatal outcome in caesarean section delivery under spinal anaesthesia.Methods:This single blinded randomized controlled clinical trial was conducted in the Department of Anaesthesia, Analgesia & Intensive Care, Dhaka Medical College Hospital, Dhaka, between January 2013 and December 2014. A total of 90 patients were selected –45patients of group I received co-loading with Ringer’s lactatesolution, while another 45 patients of group II received a pre-loading of the same fluid.Blood pressure and heart rate were recorded. Ephedrine and adrenaline were administered as needed to treat hypotension.APGAR scores of the newborn were recorded at 1st minute and 5th minute after delivery. Adverse effects like nausea, vomiting, light headedness and shivering was observed all through during operation and post-operative phase in all patients, if any, and recorded.Results:The incidence of hypotension was 17 (37.8%) in group I (co-loading) and 27 (60%) in group II (pre-loading), which was significantly higher in group II (p<0.05).Adverse effects – nausea, vomiting, light headedness and shivering was observed more in group II patients; however, the difference was not statistically significant. In neonates, APGAR score at 1 minute was found ≤7 in 18 (40.0%) from group I, while 28 (62.2%) from group II; the difference was statistically significant (p<0.05). No significant difference was observed in APGAR score at 5 minutes, as found ≤7 in 6 (13.3%) and 3 (6.7%) in group I andgroup II respectively.Conclusion:Severity of hypotension, increased ephedrine requirement and poor APGAR score wereevident in patients who received crystalloid pre-loading group(group II), which meanscrystalloid co-loading group(group I) procedurewas more effective in preventing spinal anaesthesia induced hypotension and secured better neonatal outcome.International Journal of Human and Health Sciences Vol. 05 No. 01 January’21 Page: 90-95

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