Novel Polymorphisms in the Angiotensin II type 2 Receptor Gene: Common Haplotypes and Implications for Intrauterine Growth Restriction (IUGR)

2002 ◽  
Vol 103 (s47) ◽  
pp. 60P-61P
Author(s):  
Clare Tower ◽  
Sally Plummer ◽  
Pedro Alonso ◽  
Linda Morgan ◽  
Philip Baker ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Intrauterine Growth Restriction ◽  
Receptor Gene ◽  
Growth Restriction ◽  
Intrauterine Growth

scholarly journals Changes in 11 -hydroxysteroid dehydrogenase type 2 expression in a low-protein rat model of intrauterine growth restriction

2010 ◽  
Vol 25 (10) ◽  
pp. 3195-3203 ◽  
Author(s):  
I. Ostreicher ◽  
J. R. Almeida ◽  
V. Campean ◽  
M. Rauh ◽  
C. Plank ◽  
...  
Keyword(s):  
Rat Model ◽  
Intrauterine Growth Restriction ◽  
Hydroxysteroid Dehydrogenase ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Low Protein

scholarly journals Reduced Placental 11β-Hydroxysteroid Dehydrogenase Type 2 mRNA Levels in Human Pregnancies Complicated by Intrauterine Growth Restriction: An Analysis of Possible Mechanisms

2001 ◽  
Vol 86 (10) ◽  
pp. 4979-4983 ◽  
Author(s):  
C. L. McTernan ◽  
N. Draper ◽  
H. Nicholson ◽  
S. M. Chalder ◽  
P. Driver ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Intrauterine Growth Restriction ◽  
Subsequent Development ◽  
Hydroxysteroid Dehydrogenase ◽  
Underlying Mechanism ◽  
Growth Restriction ◽  
Mrna Levels ◽  
Intrauterine Growth ◽  
Apparent Mineralocorticoid Excess

11β-Hydroxysteroid dehydrogenase type 2 (11β-HSD2) inactivates cortisol to cortisone. In the placenta 11β-HSD2 activity is thought to protect the fetus from the deleterious effects of maternal glucocorticoids. Patients with apparent mineralocorticoid excess owing to mutations in the 11β-HSD2 gene invariably have reduced birth weight, and we have recently shown reduced placental 11β-HSD2 activity in pregnancies complicated by intrauterine growth restriction. This is reflected in the literature by evidence of hypercortisolemia in the fetal circulation of small babies. In this study we have determined the levels of placental 11β-HSD2 mRNA expression across normal gestation (n = 86 placentae) and in pregnancies complicated by intrauterine growth restriction (n = 19) and evaluated the underlying mechanism for any aberrant 11β-HSD2 mRNA expression in intrauterine growth restriction. 11β-HSD2 mRNA expression increased more than 50-fold across gestation, peaking at term. Placental 11β-HSD2 mRNA levels were significantly decreased in intrauterine growth restriction pregnancies when compared with gestationally matched, appropriately grown placentae [e.g. at termΔ Ct (11β-hydroxysteroid dehydrogenase type 2/18S) 12.8 ± 0.8 (mean ± se) vs. 10.2 ± 0.2, respectively, P < 0.001]. These differences were not attributable to changes in trophoblast mass in intrauterine growth restriction placentae, as assessed by parallel analyses of cytokeratin-8 mRNA expression. No mutations were found in the 11β-HSD2 gene in the intrauterine growth restriction cohort, and imprinting analysis revealed that the 11β-HSD2 gene was not imprinted. Although the underlying cause is unknown, 11β-HSD2 gene expression is reduced in intrauterine growth restriction pregnancies. These data highlight the important role of 11β-HSD2 in regulating fetal growth, a known factor in determining fetal morbidity but also the subsequent development of cardiovascular disease in adulthood.

scholarly journals Alteration in 11 Beta-Hydroxysteroid Dehydrogenase Type-2 (HSD11B2) Gene as A Potential Candidate Parameter for Early Detection of Intrauterine Growth Restriction (IUGR) Events

2021 ◽  
Vol 5 (3) ◽  
pp. 98
Author(s):  
Louis Fabio Jonathan Jusni ◽  
Patricia Patricia ◽  
Brigitte Leonie Rosadi
Keyword(s):  
Early Detection ◽  
Doppler Ultrasound ◽  
Intrauterine Growth Restriction ◽  
Prenatal Testing ◽  
Hydroxysteroid Dehydrogenase ◽  
Growth Restriction ◽  
Diagnostic Parameter ◽  
Intrauterine Growth ◽  
Non Invasive

Intrauterine Growth Restriction (IUGR) incidence in Indonesia ranks in the top 10 of the highest in Asia. It is the main perinatal death cause. IUGR also impairs fetal neurodevelopment, which can affect the development of children until later ages. Lack of 11β-hydroxysteroid dehydrogenase type-2 (11β-HSD2) enzyme is influenced by changes in the coding gene, HSD11B2, one of IUGR's causes. The main diagnostic method of IUGR at this time is by using Doppler ultrasound. However, Doppler ultrasound has several limitations as many cases are not detected. Its clinical predictive value in various women is poor, as Doppler ultrasound is not recommended for use in the first trimester, detection of abnormalities in the second trimester seems to be too late for helpful interventions. The study aim is to present an overview concerning HSD11B2 gene alteration in an non-invasive prenatal testing (NIPT) as a possible diagnostic parameter for early detection in IUGR infants. This literature review is based on selected articles and studies taken from the Pubmed, Proquest, and EBSCO databases. A total of 4 studies reported the tendency for DNA methylation and decreased expression of the HSD11B2 gene in IUGR cases. Changes in the HSD11B2 gene have the potential to become a diagnostic parameter in the early detection of infants with IUGR. Further study and investigation of this possibility are needed.Keywords: intrauterine growth restriction, HSD11B2, early detection, diagnostic, non-invasive prenatal testing

scholarly journals Oxidative Stress, Intrauterine Growth Restriction, and Developmental Programming of Type 2 Diabetes

Physiology ◽  
2018 ◽  
Vol 33 (5) ◽  
pp. 348-359 ◽  
Author(s):  
Cetewayo S. Rashid ◽  
Amita Bansal ◽  
Rebecca A. Simmons
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Intrauterine Growth Restriction ◽  
Metabolic Diseases ◽  
Growth Restriction ◽  
Mitochondria Dysfunction ◽  
Intrauterine Growth ◽  
And Oxidative Stress

Intrauterine growth restriction (IUGR) leads to reduced birth weight and the development of metabolic diseases such as Type 2 diabetes in adulthood. Mitochondria dysfunction and oxidative stress are commonly found in key tissues (pancreatic islets, liver, and skeletal muscle) of IUGR individuals. In this review, we explore the role of oxidative stress in IUGR-associated diabetes etiology.

scholarly journals Sex‐specific mechanisms contribute to the pressor response to acute angiotensin II in a rat model of intrauterine growth restriction

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Suttira Intapad ◽  
F Lee Tull ◽  
John Henry Dasinger ◽  
Norma Ojeda ◽  
Barbara T Alexander
Keyword(s):  
Angiotensin Ii ◽  
Rat Model ◽  
Intrauterine Growth Restriction ◽  
Pressor Response ◽  
Growth Restriction ◽  
Intrauterine Growth

scholarly journals Influence of Aerobic Training on the Reduced Vasoconstriction to Angiotensin II in Rats Exposed to Intrauterine Growth Restriction: Possible Role of Oxidative Stress and AT2 Receptor of Angiotensin II

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e113035 ◽  
Author(s):  
Vanessa Oliveira ◽  
Eliana Hiromi Akamine ◽  
Maria Helena C. Carvalho ◽  
Lisete Compagno Michelini ◽  
Zuleica Bruno Fortes ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Angiotensin Ii ◽  
Intrauterine Growth Restriction ◽  
Aerobic Training ◽  
Growth Restriction ◽  
At2 Receptor ◽  
Intrauterine Growth

scholarly journals 11Beta-hydroxysteroid dehydrogenase type 2 in human pregnancy and reduced expression in intrauterine growth restriction

1998 ◽  
Vol 13 (4) ◽  
pp. 799-804 ◽  
Author(s):  
M. Shams ◽  
M. D. Kilby ◽  
D. A. Somerset ◽  
A. J. Howie ◽  
A. Gupta ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Hydroxysteroid Dehydrogenase ◽  
Growth Restriction ◽  
Human Pregnancy ◽  
Intrauterine Growth
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