Non-steroidal anti-inflammatory drugs and renal response to exercise: a comparison of indomethacin and nabumetone

1999 ◽  
Vol 97 (4) ◽  
pp. 457 ◽  
Author(s):  
Niels Vidiendal OLSEN ◽  
Niels Georg JENSEN ◽  
Jesper Melchior HANSEN ◽  
Niels Juel CHRISTENSEN ◽  
Niels FOGH-ANDERSEN ◽  
...  
Keyword(s):  
Renal Response ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Response To Exercise

The influence of nonsteroidal anti-inflammatory drugs and probenecid on the renal response to and kinetics of piretanide in man

1988 ◽  
Vol 44 (5) ◽  
pp. 531-539 ◽  
Author(s):  
Josh J Dixey ◽  
Faruq H Noormohamed ◽  
Jenender S Pawa ◽  
Ariel F Lant ◽  
Derrick A Brewerton
Keyword(s):  
Renal Response ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Kinetics Of

Non-steroidal anti-inflammatory drugs and renal response to exercise: a comparison of indomethacin and nabumetone

1999 ◽  
Vol 97 (4) ◽  
pp. 457-465 ◽  
Author(s):  
Niels Vidiendal OLSEN ◽  
Niels Georg JENSEN ◽  
Jesper Melchior HANSEN ◽  
Niels Juel CHRISTENSEN ◽  
Niels FOGH-ANDERSEN ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Plasma Flow ◽  
Plasma Catecholamines ◽  
Free Water ◽  
Free Water Clearance ◽  
Renal Response ◽  
Arterial Blood ◽  
Anti Inflammatory ◽  
Exercise Induced ◽  
Response To Exercise

Nabumetone, a newer non-steroidal anti-inflammatory drug (NSAID) which preferentially blocks cyclo-oxygenase-2 activity, may be less nephrotoxic than indomethacin. This study tested whether nabumetone has effects different from those of indomethacin on exercise-induced changes in renal function and the renin–aldosterone system. In a randomized fashion, ten subjects were studied after indomethacin (100 mg), nabumetone (1 g) or no medication (control) administered orally at 22.00 hours on the day before each study day, and again at 8.00 hours upon arrival at the laboratory. Renal function was studied at baseline, during graded 20-min exercise sessions at 25%, 50% and 75% of the maximal oxygen uptake rate, and subsequently during two 1-h recovery periods. Heart rate, arterial blood pressure, cardiac output and plasma catecholamines at rest and during exercise were not altered by indomethacin or nabumetone. Indomethacin decreased urinary rates of excretion of 6-oxo-prostaglandin F1α (6-oxo-PGF1α) and thromboxane B2 in all study periods. Nabumetone decreased 6-oxo-PGF1α excretion during and after exercise. Excretion rates for PGE2 did not change. Neither indomethacin nor nabumetone changed baseline values or exercise-induced decreases in renal plasma flow or glomerular filtration rate. Indomethacin, but not nabumetone, decreased sodium excretion, urine flow rate and free water clearance. The renal response to exercise, however, remained unchanged. In contrast with nabumatone, indomethacin decreased the plasma renin concentration. Thus, during exercise, nabumetone may decrease the excretion of 6-oxo-PGF1α by inhibition of cyclo-oxygenase-1 or by inhibition of specific exercise-induced activation of cyclo-oxygenase-2, or both. None of the drugs changed the renal response to exercise. Inhibition by indomethacin of angiotensin II and thromboxane A2 synthesis may, during exercise, counterbalance renal vasoconstriction caused by blockade of vasodilatory prostaglandins.

Polyphenols from Cymbopogon citratus inhibit iNOS expression and NO production – a promising source of new anti-inflammatory drugs

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
V Francisco ◽  
A Figueirinha ◽  
B Neves ◽  
C Garcia-Rodriguez ◽  
M Lopes ◽  
...  
Keyword(s):  
Inos Expression ◽  
No Production ◽  
Cymbopogon Citratus ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Promising Source

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

Non-Steroidal Anti-inflammatory Drugs (NSAIDs): Synthesis of Ibuprofen, Naproxen and Nabumetone

2019 ◽  
pp. 19-27
Keyword(s):  
Review Paper ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Synthetic Approaches

This review paper covers the major synthetic approaches attempted towards the synthesis of some Non-Steroidal Anti-Inflammatory Drugs (Naproxen, Ibuprofen and Nabumetone)

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