The influence of nonsteroidal anti-inflammatory drugs and probenecid on the renal response to and kinetics of piretanide in man

1988 ◽  
Vol 44 (5) ◽  
pp. 531-539 ◽  
Author(s):  
Josh J Dixey ◽  
Faruq H Noormohamed ◽  
Jenender S Pawa ◽  
Ariel F Lant ◽  
Derrick A Brewerton
Keyword(s):  
Renal Response ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Kinetics Of

Non-steroidal anti-inflammatory drugs and renal response to exercise: a comparison of indomethacin and nabumetone

1999 ◽  
Vol 97 (4) ◽  
pp. 457 ◽  
Author(s):  
Niels Vidiendal OLSEN ◽  
Niels Georg JENSEN ◽  
Jesper Melchior HANSEN ◽  
Niels Juel CHRISTENSEN ◽  
Niels FOGH-ANDERSEN ◽  
...  
Keyword(s):  
Renal Response ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Response To Exercise

scholarly journals TiO2 and Active Coated Glass Photodegradation of Ibuprofen

Catalysts ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 560
Author(s):  
Samer Khalaf ◽  
Jawad H. Shoqeir ◽  
Filomena Lelario ◽  
Sabino A. Bufo ◽  
Rafik Karaman ◽  
...  
Keyword(s):  
Emerging Contaminants ◽  
Active Surface ◽  
Heterogeneous Photocatalysis ◽  
Ion Cyclotron Resonance ◽  
Aquatic Life ◽  
Coated Glass ◽  
Promising Tool ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Kinetics Of

Commercial non-steroidal anti-inflammatory drugs (NSAIDs) are considered as toxic to the environment since they induce side effects when consumed by humans or aquatic life. Ibuprofen is a member of the NSAID family and is widely used as an anti-inflammatory and painkiller agent. Photolysis is a potentially important method of degradation for several emerging contaminants, and individual compounds can undergo photolysis to various degrees, depending on their chemical structure. The efficiency oftitanium dioxide (TiO2) and photocatalysis was investigated for the removal of ibuprofen from the aquatic environment, and the performance of these different processes was evaluated. In heterogeneous photocatalysis, two experiments were carried out using TiO2 as (i) dispersed powder, and (ii) TiO2 immobilized on the active surface of commercial coated glass. The kinetics of each photoreaction was determined, and the identification of the photoproducts was carried out by liquid chromatography coupled with Fourier-transform ion cyclotron resonance mass spectrometry (LC-FTICR MS). The overall results suggest that the TiO2 active thin layer immobilized on the glass substrate can avoid recovery problems related to the use of TiO2 powder in heterogeneous photocatalysis and may be a promising tool toward protecting the environment from emerging contaminants such as ibuprofen and its derivatives.

scholarly journals Deposition of Ibuprofen Crystals on Hydroxypropyl Cellulose/Polyacrylamide Gel: Experimental and Mathematic Modeling Releasing

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Claudia Alicia Castillo-Miranda ◽  
Ana Beatriz Morales-Cepeda ◽  
Carlos Fernando Castro-Guerrero ◽  
Homero Salas-Papayanopolos ◽  
Hugo Alberto Velasco-Ocejo ◽  
...  
Keyword(s):  
Release Kinetics ◽  
Hydroxypropyl Cellulose ◽  
Fickian Diffusion ◽  
Solution Temperature ◽  
Phenyl Propionic Acid ◽  
Diffusion Media ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Kinetics Of ◽  
Made In

The crystallization of nonsteroidal anti-inflammatory drug [2-(4-isobutyl-phenyl) propionic acid] ibuprofen (IBP) on a hydroxypropyl cellulose (HPC) and polyacrylamide (PAAm) gel was studied as well as the release kinetics of the drug. The IBP was crystallized on the gel surface of HPC/PAAm. It had a prismatic shape and the growth was made in an aqueous medium; the crystallinity grade of the gels HPC/PAAm and HPC/PAAm-IBU increased to 68% and to 58%, respectively. The release of IBP is performed by two means: by a non-Fickian diffusion process and by relaxation of the chains of the gel; without regard to temperature and the diffusion media, this correlates with the lower critical solution temperature (LCST) of the proposed gel. This polymer matrix provides an option for releasing nonsteroidal anti-inflammatory drugs in a temperature range of 35–39°C. Korsmeyer and Peppas mathematical model was simulated for data releases, statistically significant at 95% confidence level.

Kinetics of Analgesic Response in Man; an Example with Two Non-Steroidal Anti-Inflammatory Analgesic Drugs

1978 ◽  
Vol 6 (4) ◽  
pp. 312-316 ◽  
Author(s):  
G Sacchetti ◽  
G C Ferrati ◽  
L Parrinello ◽  
A Salami
Keyword(s):  
Half Life ◽  
Fixed Time ◽  
Controlled Clinical Trial ◽  
Time Intervals ◽  
Double Blind ◽  
Post Operative Pain ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Kinetics Of ◽  
Plasma Half Life

A double-blind, controlled clinical trial is described in which a total of forty hospital in-patients suffering from severe post-operative pain were randomly allocated to treatment with one of two non-steroidal anti-inflammatory drugs, namely, either indoprofen which has a short half-life (two hours) or naproxen which has a long half-life (thirteen hours). The drugs were administered orally on a single-dose-only basis. The doses used in this way were 300 mg of indoprofen or 250 mg of naproxen. Patients scored the severity of their pain on a five-point scale and these scores were recorded prior to and at fixed time intervals up to eight hours following administration of medication. No significant differences emerged between the two test drugs and the duration of the response was also found to be similar for the two compounds despite their very different plasma half-life values.

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