Relationship of skeletal muscle mass, muscle strength and bone mineral density in adults with cystic fibrosis

2000 ◽  
Vol 99 (4) ◽  
pp. 309 ◽  
Author(s):  
Sarah L. ELKIN ◽  
Lauren WILLIAMS ◽  
Margaret MOORE ◽  
Margaret E. HODSON ◽  
Olga M. RUTHERFORD
2020 ◽  
Vol 7 ◽  
Author(s):  
Kiyonori Ito ◽  
Susumu Ookawara ◽  
Yutaka Hibino ◽  
Sojiro Imai ◽  
Mariko Fueki ◽  
...  

2000 ◽  
Vol 99 (4) ◽  
pp. 309-314 ◽  
Author(s):  
Sarah L. ELKIN ◽  
Lauren WILLIAMS ◽  
Margaret MOORE ◽  
Margaret E. HODSON ◽  
Olga M. RUTHERFORD

Few studies have investigated peripheral muscle strength and quality in patients with cystic fibrosis (CF). The present study tested the isometric and isokinetic strength of the quadriceps and hamstrings using an isokinetic dynamometer and a strength-testing chair in 25 CF adults and 25 controls. Total body and leg muscle mass were determined by dual-energy X-ray absorptiometry, and bone mineral density (BMD) was also measured. Both muscle strength and muscle mass (total body and leg) were decreased in the CF group. In both groups there was a highly significant relationship between quadriceps strength and leg muscle mass (CF, r = 0.7, P = 0.0002; controls, r = 0.6, P = 0.0013). When strength was normalized for muscle size, there was no significant difference between the two groups. Total body and leg BMD were significantly reduced in CF subjects compared with controls. However, when corrected for height, the differences disappeared. There was a significant relationship found between leg muscle mass and leg BMD. We conclude that CF adults are significantly weaker than controls. This is due to lower muscle mass, and not to a reduced force-generating capacity of the muscle, implying that there is no decrease in the quality of CF muscle. BMD is also reduced in CF subjects, and this appears to be related to shorter stature in this group.


2014 ◽  
Vol 17 (3) ◽  
pp. 291-296 ◽  
Author(s):  
Takashi Abe ◽  
Vinayak K. Nahar ◽  
Kaelin C. Young ◽  
Kaitlyn M. Patterson ◽  
Caitlin D. Stover ◽  
...  

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0154692 ◽  
Author(s):  
Xiao-wei Dong ◽  
Hui-yuan Tian ◽  
Juan He ◽  
Chen Wang ◽  
Rui Qiu ◽  
...  

2007 ◽  
Vol 25 (4) ◽  
pp. 237-242 ◽  
Author(s):  
Marco Di Monaco ◽  
Fulvia Vallero ◽  
Roberto Di Monaco ◽  
Rosa Tappero ◽  
Alberto Cavanna

2019 ◽  
Vol Volume 12 ◽  
pp. 2645-2654 ◽  
Author(s):  
Nara Nóbrega Crispim Carvalho ◽  
Vinícius José Baccin Martins ◽  
João Modesto-Filho ◽  
Francisco Bandeira ◽  
Flávia Cristina Fernandes Pimenta ◽  
...  

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