Cerebrospinal fluid levels of catechols in patients with neurogenic orthostatic hypotension

2003 ◽  
Vol 104 (6) ◽  
pp. 649-654 ◽  
Author(s):  
David S. GOLDSTEIN ◽  
Courtney HOLMES ◽  
Nicholas PATRONAS ◽  
Irwin J. KOPIN
Keyword(s):  
Cerebrospinal Fluid ◽  
Orthostatic Hypotension ◽  
Sympathetic Nerves ◽  
Control Group ◽  
Postural Tachycardia Syndrome ◽  
Cerebrospinal Fluid Levels ◽  
Postural Tachycardia ◽  
Post Mortem Findings ◽  
Fluid Levels

In multiple system atrophy (MSA) and pure autonomic failure (PAF), orthostatic hypotension (OH) results from deficient noradrenaline release from sympathetic nerves during standing. Post-mortem findings have indicated loss of central noradrenergic cells in both diseases. The present study sought in vivo neurochemical evidence for central noradrenergic deficiency in patients with OH due to MSA or PAF. A total of 28 patients with OH (18 with MSA; 10 with PAF) had cerebrospinal fluid and blood sampled for levels of noradrenaline and its neuronal metabolite dihydroxyphenylglycol. A control group of 44 subjects included 10 elderly normal volunteers, 10 patients with Alzheimer's disease, 18 patients with dysautonomia (postural tachycardia syndrome or neurocardiogenic syncope) and six patients with MSA in the absence of OH. Patients with OH had lower cerebrospinal fluid concentrations of noradrenaline (0.53±0.07 nmol/l) and dihydroxyphenylglycol (6.52±0.46 nmol/l) than did control subjects (0.90±0.09 and 9.64±0.46 nmol/l respectively; P=0.0001). The MSA + OH group had higher plasma levels of both catechols (noradrenaline, 1.31±0.16 nmol/l; dihydroxyphenylglycol, 5.08±0.43 nmol/l) than did the PAF group (noradrenaline, 0.38±0.08 nmol/l; dihydroxyphenylglycol, 2.53±0.30 nmol/l; P<0.001), despite similarly low cerebrospinal fluid levels. Among MSA patients, those with OH had lower cerebrospinal fluid levels of noradrenaline and dihydroxyphenylglycol than those without OH (noradrenaline, 1.71±0.64 nmol/l; dihydroxyphenylglycol, 10.41±1.77 nmol/l respectively; P=0.006). The findings are consistent with central noradrenergic deficiency in both MSA + OH and PAF. In MSA, central noradrenergic deficiency seems to relate specifically to OH.

scholarly journals Quantification of Fas protein in CSF of patients with neurocysticercosis

2012 ◽  
Vol 70 (4) ◽  
pp. 262-266 ◽  
Author(s):  
José Augusto Camargo ◽  
Paulo Henrique Ferreira Bertolucci
Keyword(s):  
Cerebrospinal Fluid ◽  
Present Finding ◽  
Neuronal Damage ◽  
Epileptic Seizures ◽  
Control Group ◽  
Cerebrospinal Fluid Levels ◽  
Cystic Form ◽  
Soluble Fas ◽  
The Central Nervous System ◽  
Fluid Levels

Neurocysticercosis is a parasitic disease that affects the central nervous system. The objective of this study was to investigate the correlation between neuronal death evaluated by the quantification of Fas apoptotic factor and the different evolutive forms of neurocysticercosis accompanied or not by epileptic seizures. METHODS: Cerebrospinal fluid samples from 36 patients with a diagnosis of neurocysticercosis divided into the following groups: active cystic form (n=15), 9 patients with and 6 without seizures, and calcified form (=21), 9 with and 12 without seizures. Fourteen patients comprised the control group. Fas protein concentrations were determined by ELISA. RESULTS: Only the group of patients with calcified cysts without seizures presented cerebrospinal fluid levels of Fas similar to those of the control group. Higher levels were observed for the other groups. CONCLUSIONS: The present finding suggests high cerebrospinal fluid levels of soluble Fas protein, except for patients with calcified cysts without seizures. Significant differences were observed for the group with calcified cysts and seizures, suggesting greater neuronal damage in these patients. Replacement of the term inactive cyst with reactive inactive cyst is suggested.

Orthostatic hypotension is associated with decreased cerebrospinal fluid levels of chromogranin A in early stage of Parkinson disease

2015 ◽  
Vol 25 (5) ◽  
pp. 339-342 ◽  
Author(s):  
Michaela Kaiserova ◽  
Hana Prikrylova Vranova ◽  
Jan Galuszka ◽  
David Stejskal ◽  
Katerina Mensikova ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Parkinson Disease ◽  
Orthostatic Hypotension ◽  
Chromogranin A ◽  
Early Stage ◽  
Cerebrospinal Fluid Levels ◽  
Fluid Levels

Genomic Variation Within the C4 Locus and Cerebrospinal Fluid Levels of C4 Isotype Proteins in Acute and Chronic Schizophrenia

2021 ◽  
Vol 89 (9) ◽  
pp. S34
Author(s):  
Jessica Gracias ◽  
Elin Hörbeck ◽  
Jessica Holmen-Larsson ◽  
Aurimantas Pelanis ◽  
Carleton Goold ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Chronic Schizophrenia ◽  
Genomic Variation ◽  
Cerebrospinal Fluid Levels ◽  
Fluid Levels

Cerebrospinal fluid levels of alpha-tocopherol (vitamin E) in Alzheimer's disease

1997 ◽  
Vol 104 (6-7) ◽  
pp. 703-710 ◽  
Author(s):  
F. J. Jiménez-Jiménez ◽  
F. de Bustos ◽  
J. A. Molina ◽  
J. Benito-León ◽  
A. Tallón-Barranco ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Vitamin E ◽  
Alpha Tocopherol ◽  
Cerebrospinal Fluid Levels ◽  
Fluid Levels

scholarly journals Comparison of cortisol levels in patients with vasovagal syncope and postural tachycardia syndrome

2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Humaira Fayyaz ◽  
Shazadi Ambreen ◽  
Hammad Raziq ◽  
Azmat Hayyat
Keyword(s):  
Vasovagal Syncope ◽  
Serum Cortisol ◽  
Tilt Test ◽  
Control Group ◽  
Postural Tachycardia Syndrome ◽  
P Value ◽  
Cross Sectional ◽  
Postural Tachycardia ◽  
Significant Difference ◽  
Cortisol Levels

Objectives: To compare the levels of cortisol in patients of vasovagal syncope (VVS) and postural tachycardia syndrome (POTS). Methods: A cross-sectional analytical study was conducted at Islamic International Medical College, Rawalpindi and Electrophysiology Department at (AFIC). This study included 80 subjects, comprising of 35 patients in each group of vasovagal syncope and postural tachycardia syndrome and 10 healthy subjects. Patients with complaint of syncope was evaluated for vasovagal syncope and postural tachycardia syndrome using Head Up Tilt Test (HUTT). Blood samples of all the participants were taken and serum cortisol was analyzed using ELISA method. Results were analyzed on SPSS Statistics 21 using ANOVA with a p-value of ≤0.05 regarded as significant. Results: Hormonal analysis shows that cortisol levels in the vasovagal, postural tachycardia syndrome and in control group was 153±16.7pg/ml, 160.17±pg/ml, and 69.65±5.8pg/ml respectively. Cortisol levels were significantly higher in both vasovagal and POTS groups as compared to controls with a p-value of 0.04 and 0.023 respectively. However, there was no significant difference between vasovagal and POTS patients with p value 0.570. Conclusion: It is concluded from the study that cortisol responses of VVS and POTS were positive. doi: https://doi.org/10.12669/pjms.38.1.4122 How to cite this:Khan HF, Ambreen S, Raziq H, Hayat A. Comparison of cortisol levels in patients with vasovagal syncope and postural tachycardia syndrome. Pak J Med Sci. 2022;38(1):---------. doi: https://doi.org/10.12669/pjms.38.1.4122 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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