Interactions between cardiology and oncology drugs in precision cardio-oncology

2021 ◽  
Vol 135 (11) ◽  
pp. 1333-1351
Author(s):  
Sailaja Kamaraju ◽  
Meera Mohan ◽  
Svetlana Zaharova ◽  
Brianna Wallace ◽  
Joseph McGraw ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Treatment Approach ◽  
Interdisciplinary Collaboration ◽  
Multidisciplinary Treatment ◽  
Close Attention ◽  
Glycoprotein P ◽  
Patients With Cancer ◽  
P Glycoprotein ◽  
Cardiovascular Side Effects

Abstract Recent advances in treatment have transformed the management of cancer. Despite these advances, cardiovascular disease remains a leading cause of death in cancer survivors. Cardio-oncology has recently evolved as a subspecialty to prevent, diagnose, and manage cardiovascular side effects of antineoplastic therapy. An emphasis on optimal management of comorbidities and close attention to drug interactions are important in cardio-oncologic care. With interdisciplinary collaboration among oncologists, cardiologists, and pharmacists, there is potential to prevent and reduce drug-related toxicities of treatments. The cytochrome P450 (CYP450) family of enzymes and the P-glycoprotein (P-g) transporter play a crucial role in drug metabolism and drug resistance. Here we discuss the role of CYP450 and P-g in drug interactions in the field of cardio-oncology, provide an overview of the cardiotoxicity of a spectrum of cancer agents, highlight the role of precision medicine, and encourage a multidisciplinary treatment approach for patients with cancer.

Role of P-glycoprotein in Statin Drug Interactions

2006 ◽  
Vol 26 (11) ◽  
pp. 1601-1607 ◽  
Author(s):  
Carol W Holtzman ◽  
Barbara S Wiggins ◽  
Sarah A Spinler
Keyword(s):  
Drug Interactions ◽  
P Glycoprotein ◽  
Statin Drug

Role of Interventional Radiology in Children with Biliary and Gallbladder Diseases

2021 ◽  
Vol 38 (03) ◽  
pp. 356-363
Author(s):  
Anel Yakupovich ◽  
Shankar Rajeswaran ◽  
Jared Green ◽  
James S. Donaldson
Keyword(s):  
Interventional Radiology ◽  
Treatment Approach ◽  
Multidisciplinary Treatment ◽  
Anatomical Variations ◽  
Vital Role ◽  
High Morbidity ◽  
Comprehensive Overview ◽  
Gallbladder Diseases ◽  
Fundamental Understanding

AbstractBiliary and gallbladder diseases in infants and children often present unique diagnostic and therapeutic challenges that require a fundamental understanding of notable biliary diseases and anatomical variations. Surgical and endoscopic approaches that are often the gold standard in adult biliary treatment may be technically challenging and are associated with a high morbidity that may warrant a multidisciplinary treatment approach. This article will provide a comprehensive overview of the biliary conditions where interventional radiology can play a vital role in the diagnosis, management, and treatment. Differences in approach or technique between children and adults will be highlighted.

scholarly journals Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter

2021 ◽  
Author(s):  
Robert W. Robey ◽  
Andrea N. Robinson ◽  
Fatima Ali-Rahmani ◽  
Lyn M. Huff ◽  
Sabrina Lusvarghi ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Multidrug Transporter ◽  
Glycoprotein P ◽  
Tissue Localization ◽  
Brain Vasculature ◽  
P Glycoprotein ◽  
Capillary Endothelial Cells ◽  
The Brain ◽  
Viable Model

ABSTRACTGiven its similarities with mammalian systems, the zebrafish has emerged as a potential model to study the blood-brain barrier (BBB). Capillary endothelial cells at the human BBB express high levels of P-glycoprotein (P-gp, encoded by the ABCB1 gene) and ABCG2 (encoded by the ABCG2 gene). However, little information has been available about ATP-binding cassette transporters expressed at the zebrafish BBB. In this study, we focus on the characterization and tissue localization of two genes that are similar to human ABCB1, zebrafish abcb4 and abcb5. Cytotoxicity assays with stably-transfected cell lines revealed that zebrafish Abcb5 cannot efficiently transport the substrates doxorubicin and mitoxantrone compared to human P-gp and zebrafish Abcb4. Additionally, zebrafish Abcb5 did not transport the fluorescent probes BODIPY-ethylenediamine or LDS 751, while they were readily transported by Abcb4 and P-gp. A high-throughput screen conducted with 90 human P-gp substrates confirmed that zebrafish Abcb4 has overlapping substrate specificity with P-gp. Basal ATPase activity of zebrafish Abcb4 and Abcb5 was comparable to that of human P-gp. In the brain vasculature, RNAscope probes to detect abcb4 colocalized with staining by the P-gp antibody C219, while abcb5 was not detected. Zebrafish abcb4 also colocalized with claudin-5 expression in brain endothelial cells. Abcb4 and Abcb5 had different tissue localizations in multiple zebrafish tissues, consistent with different functions. The data suggest that zebrafish Abcb4 most closely phenocopies P-gp and that the zebrafish may be a viable model to study the role of the multidrug transporter P-gp at the BBB.

Emphysematous osteomyelitis of the clavicle: a pleural process?

2020 ◽  
Vol 13 (7) ◽  
pp. e235764
Author(s):  
Amira Elshikh ◽  
Niraj Gowda ◽  
Lisa Glass ◽  
Robert B Maximos
Keyword(s):  
Pleural Cavity ◽  
Treatment Approach ◽  
Bone Biopsy ◽  
Multidisciplinary Treatment ◽  
Fatal Outcome ◽  
Review Of The Literature ◽  
Fatal Disease ◽  
Associated Risk Factors ◽  
Pleural Involvement

Emphysematous osteomyelitis (EO) is a rare infection associated with intraosseous gas. EO is an often fatal disease with an estimated 34% mortality. We present a case of a 63-year-old man with sternoclavicular EO with pleural involvement and significant subcutaneous emphysema diagnosed by CT. Extension of intraosseous gas into the pleural cavity is an extremely interesting presentation that has not been previously reported. The patient underwent a multidisciplinary treatment approach with surgical debridement and an extended antibiotic course. Intraoperative cultures of the pectoralis muscle and bone biopsy grew pan-sensitive Escherichia coli. Prompt recognition and treatment are paramount to avoid a potentially fatal outcome. A review of the literature of the previous 46 cases of EO is presented for associated risk factors, the role of surgical management and antibiotic therapy.

Role of P-glycoprotein in the brain disposition of seletalisib: Evaluation of the potential for drug-drug interactions

2020 ◽  
Vol 142 ◽  
pp. 105122
Author(s):  
Jean-Marie Nicolas ◽  
Hugues Chanteux ◽  
Johan Nicolaï ◽  
Frédéric Brouta ◽  
Delphine Viot ◽  
...  
Keyword(s):  
Drug Interactions ◽  
P Glycoprotein ◽  
The Brain

scholarly journals Functional Role of P-Glycoprotein and Binding Protein Effect on the Placental Transfer of Lopinavir/Ritonavir in the Ex Vivo Human Perfusion Model

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Pierre-Francois Ceccaldi ◽  
Laurent Gavard ◽  
Laurent Mandelbrot ◽  
Elisabeth Rey ◽  
Robert Farinotti ◽  
...  
Keyword(s):  
Internal Control ◽  
Efflux Pump ◽  
Placental Transfer ◽  
Ex Vivo ◽  
Glycoprotein P ◽  
Control Phase ◽  
P Glycoprotein ◽  
Ciclosporin A ◽  
High Albumin

Aims. To study the influence of P-glycoprotein (P-glycoprotein, ABCB1, MDR1) function on placental transfer of lopinavir with ritonavir at different albumin concentrations.Methods. Cotyledons were perfused with lopinavir, ritonavir, and the internal control antipyrin, at various albumin concentrations (10, 30, 40 g/L). After the control phase of each experiment, the P-glycoprotein inhibitor ciclosporin A was added at middle perfusion (45 minutes). Fetal Transfer Rate (FTR) and Clearance Index (CLI) were compared between the 2 phases.Results. In the control phase, the clearance index of lopinavir decreased from 0.401±0.058 to 0.007±0.027, as albumin concentrations increased from 10 g/L to higher concentrations (30, 40 g/L). When adding ciclosporin A at physiological albumin concentrations, the clearance index of lopinavir increased significantly 10.3 fold (95% of CI difference [−0.156,−0.002],P=.046) and became positive for ritonavir.Conclusions. Even at high albumin concentrations, inhibition of placental P-glycoprotein increased placental transfer of lopinavir, suggesting that this efflux pump actively reduces placental transfer of the drug. This mechanism may play a role in fetal exposure to maternal antiretroviral therapy.

Role of P-glycoprotein in pharmacokinetics and drug interactions of digoxin and β-methyldigoxin in rats

2003 ◽  
Vol 92 (7) ◽  
pp. 1455-1463 ◽  
Author(s):  
Sachiyo Funakoshi ◽  
Teruo Murakami ◽  
Ryoko Yumoto ◽  
Yoshie Kiribayashi ◽  
Mikihisa Takano
Keyword(s):  
Drug Interactions ◽  
P Glycoprotein

Role of P-Glycoprotein Inhibition for Drug Interactions

2007 ◽  
Vol 46 (12) ◽  
pp. 1039-1049 ◽  
Author(s):  
Sonja Eberl ◽  
Bertold Renner ◽  
Antje Neubert ◽  
Mareike Reisig ◽  
Iouri Bachmakov ◽  
...  
Keyword(s):  
Drug Interactions ◽  
P Glycoprotein ◽  
Glycoprotein Inhibition

scholarly journals Multidisciplinary Treatment Approach of a Patient with Amelogenesis Imperfecta Superimposed by Thumb Sucking Habit: A Case Report

2017 ◽  
Vol 24 (4) ◽  
pp. 31-39
Author(s):  
Raed R. Gholman ◽  
Omar A. El Meligy
Keyword(s):  
Stainless Steel ◽  
Composite Resin ◽  
Treatment Approach ◽  
Multidisciplinary Treatment ◽  
Self Esteem ◽  
Amelogenesis Imperfecta ◽  
Effective Management ◽  
Socioeconomic Condition ◽  
Thumb Sucking

A seven-year-old boy was presented with discontent of his teeth appearance, mild teeth sensitiveness, bad masticatory effectiveness, difficulty in speech and low self-esteem. The clinical and radiographic results indicated amelogenesis imperfecta. Because of uncooperative behavior, treatment was accomplished under general anesthesia. The use of composite resin and stainless steel crowns produced effective and satisfying improvement of the patient’s aesthetic looks, in addition to prevention of further sensitivity and wear so enhancing his functional needs. The lastingness of the thorough management of this patient needed powerful stress on careful oral hygiene. There is a major role of multidisciplinary team to the effective management of patients with hypomaturation type of amelogenesis imperfecta. Many factors have a significant part in treatment planning of amelogenesis imperfecta cases such as patient’s age, socioeconomic condition, seriousness of the defect, the patient’s collaboration and association with other medical conditions.

scholarly journals Overcoming Multidrug Resistance: Flavonoid and Terpenoid Nitrogen-Containing Derivatives as ABC Transporter Modulators

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3364 ◽  
Author(s):  
Bruno M. F. Gonçalves ◽  
David S. P. Cardoso ◽  
Maria-José U. Ferreira
Keyword(s):  
Multidrug Resistance ◽  
Natural Product ◽  
Abc Transporter ◽  
Efflux Pumps ◽  
Cancer Resistance ◽  
Glycoprotein P ◽  
Multidrug Resistance Protein 1 ◽  
P Glycoprotein ◽  
Resistance Protein

Multidrug resistance (MDR) in cancer is one of the main limitations for chemotherapy success. Numerous mechanisms are behind the MDR phenomenon wherein the overexpression of the ATP-binding cassette (ABC) transporter proteins P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance protein 1 (MRP1) is highlighted as a prime factor. Natural product-derived compounds are being addressed as promising ABC transporter modulators to tackle MDR. Flavonoids and terpenoids have been extensively explored in this field as mono or dual modulators of these efflux pumps. Nitrogen-bearing moieties on these scaffolds were proved to influence the modulation of ABC transporters efflux function. This review highlights the potential of semisynthetic nitrogen-containing flavonoid and terpenoid derivatives as candidates for the design of effective MDR reversers. A brief introduction concerning the major role of efflux pumps in multidrug resistance, the potential of natural product-derived compounds in MDR reversal, namely natural flavonoid and terpenoids, and the effect of the introduction of nitrogen-containing groups are provided. The main modifications that have been performed during last few years to generate flavonoid and terpenoid derivatives, bearing nitrogen moieties, such as aliphatic, aromatic and heterocycle amine, amide, and related functional groups, as well as their P-gp, MRP1 and BCRP inhibitory activities are reviewed and discussed.

Sign in / Sign up

Export Citation Format

Share Document