Mitochondrial donation — hope for families with mitochondrial DNA disease

2020 ◽  
Vol 4 (2) ◽  
pp. 151-154
Author(s):  
Lyndsey Craven ◽  
Julie L. Murphy ◽  
Doug M. Turnbull
Keyword(s):  
Mitochondrial Dna ◽  
Research Study ◽  
In Vitro Fertilisation ◽  
Major Advance ◽  
Reproductive Choice ◽  
Mtdna Mutations ◽  
Mitochondrial Donation ◽  
The Uk ◽  
Fertilisation Treatment

In 2015, the UK became the first country to approve the use of mitochondrial donation. This novel in vitro fertilisation treatment was developed to prevent transmission of mitochondrial DNA (mtDNA) disease and ultimately give more reproductive choice to women at risk of having severely affected offspring. The policy change was a major advance that surmounted many scientific, legislative and clinical challenges. Further challenges have since been addressed and there is now an NHS clinical service available to families with pathogenic mtDNA mutations that provides reproductive advice and options, and a research study to look at the outcome at 18 months of children born after mitochondrial donation.

scholarly journals Men report good mental health 20 to 23 years after in vitro fertilisation treatment

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Gunilla Sydsjö ◽  
Josefin Vikström ◽  
Marie Bladh ◽  
Barbara Jablonowska ◽  
Agneta Skoog Svanberg
Keyword(s):  
Mental Health ◽  
In Vitro Fertilisation ◽  
Good Mental Health ◽  
Fertilisation Treatment

Progesterone elevation on the day of oocyte retrieval and live birth rate after in vitro fertilisation treatment

2021 ◽  
pp. 1-5
Author(s):  
Maria Angeles Roque Fernandez ◽  
Cristina Alvarez Lleo ◽  
Esteban Gonzalez Mirasol ◽  
Maria Resta Serra ◽  
Carmen Garcia Garrido ◽  
...  
Keyword(s):  
Live Birth ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Oocyte Retrieval ◽  
In Vitro Fertilisation ◽  
Fertilisation Treatment

scholarly journals Why Are the Proportions of In-Vitro Fertilisation Interventions for Same Sex Female Couples Increasing?

Healthcare ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1657
Author(s):  
Catherine Meads ◽  
Laura-Rose Thorogood ◽  
Katy Lindemann ◽  
Susan Bewley
Keyword(s):  
In Vitro Fertilisation ◽  
Donor Insemination ◽  
Same Sex ◽  
Vitro Fertilization ◽  
Human Fertilization ◽  
Frozen Semen ◽  
First Choice ◽  
The Government ◽  
The Uk

Same-sex female couples who wish to become pregnant can choose donor insemination or in-vitro fertilization (IVF)—a technique intended for infertile women. In general, women in same-sex female partnerships are no more likely to be infertile than those in opposite sex partnerships. This article investigates data available from the Government Regulator of UK fertility clinics—the Human Fertilization and Embryology Authority, which is the only data available worldwide on same-sex female couples and their fertility choices. IVF is increasing both in absolute numbers and relative proportions year on year in the UK, compared to licensed donor insemination for same-sex female couples. As IVF has greater human and financial costs than donor insemination, policies should not encourage it as the first choice for fertile women requiring sperm. Commercial transactions are taking place where fertile lesbians receive cut price, and arguably unnecessary, IVF intervention in exchange for selling their eggs to be used for other infertile customers. If women are not told about the efficacy of fresh vs. frozen semen, and the risks of egg ‘sharing’ or intra-couple donation, exploitation becomes possible.

Use and Success of In Vitro Fertilisation Following Restorative Proctocolectomy and Ileal Pouch-anal Anastomosis. A Nationwide 17-year Cohort Study

2019 ◽  
Vol 13 (10) ◽  
pp. 1283-1286 ◽  
Author(s):  
Frederik R Pachler ◽  
Gunnar Toft ◽  
Thue Bisgaard ◽  
Søren Laurberg
Keyword(s):  
Ulcerative Colitis ◽  
Live Birth ◽  
Restorative Proctocolectomy ◽  
Ileal Pouch ◽  
In Vitro Fertilisation ◽  
Birth Registry ◽  
Danish Patient ◽  
Medical Birth Registry ◽  
Fertilisation Treatment

Abstract Background and Aims Fertility decreases in women following restorative proctocolectomy for ulcerative colitis. The use and success of in vitro fertilisation [IVF] after restorative proctocolectomy for ulcerative colitis is not systematically studied. We aimed to estimate the use and success of in vitro fertilisation treatment in female ulcerative colitis patients, with and without restorative proctocolectomy. Methods Women of fertile age [15–49 years] with restorative proctocolectomy for ulcerative colitis were compared with females with ulcerative colitis without restorative proctocolectomy. Data from the IVF registry from 1994–2010 were cross-linked with data from the National Danish Patient Registry and the Medical Birth Registry. Results In vitro fertilisation is significantly more frequent in females with restorative proctocolectomy compared with females without restorative proctocolectomy, adjusted hazard ratio 3.2, 95% confidence interval [CI] [2.5;4.0]. The odds for having a live birth after in vitro fertilisation are no different in females with restorative proctocolectomy compared with females without restorative proctocolectomy, adjusted odds ratio 0.8, 95% CI [0.6;1.1]. The percentage of children born as a result of in vitro fertilisation is significantly higher in females with restorative proctocolectomy compared with females without restorative proctocolectomy (31.0%, 95% CI [24.1; 37.7] vs 5.0%, 95% CI [4.4; 5.6]). Conclusions Females with restorative proctocolectomy for ulcerative colitis have increased incidence of in vitro fertilisation by more than a factor three, the odds that a treatment results in a live birth are similar and six times more children are born as a result of in vitro fertilisation compared with females without restorative proctocolectomy.

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