Serum and urine markers of type I collagen metabolism in elderly women with high and low bone mineral density

Objective: Duchenne muscular dystrophy (DMD) is a severe X-linked progressive neuromuscular disease that brings a significantly increased risk of osteoporosis and bone fractures. We prospectively evaluated the effects of oral and intravenous bisphosphonates on the bones of children with DMD. Methods: This study included a total of 52 children with DMD. They were divided into zoledronic acid (ZOL), alendronate (ALN), and control groups according to bone mineral density (BMD) and history of fragility fractures. For 2 years, all patients took calcium, vitamin D, and calcitriol. Meanwhile, 17 patients received infusions of ZOL, and 18 patients received ALN. BMD, serum levels of alkaline phosphatase (ALP) and the cross-linked C-telopeptide of type I collagen (β-CTX) were evaluated. Results: After 24 months of treatment, the percentage changes in lumbar spine BMD were 23.2 ± 9.7% and 23.6 ± 8.8% in the ZOL and ALN groups (all P<.01 vs. baseline). The increases did not differ between the ZOL and ALN groups, but were significantly larger than those of the control group ( P<.01). Serum β-CTX and ALP levels, respectively, were decreased by 44.4 ± 18.0% and 31.9 ± 26.7% in the ZOL group and by 36.0 ± 20.3% and 25.8 ± 14.4% in the ALN group (all P<.01 vs. baseline). Conclusion: Zoledronic acid and alendronate had similar protective effects to increase bone mineral density and reduce bone resorption in children with DMD, which were superior to treatment of calcium, vitamin D, and calcitriol. Abbreviations: 25OHD = 25 hydroxyvitamin D; ALN = alendro-nate; ALP = alkaline phosphatase; ALT = alanine aminotransferase; BMD = bone mineral density; BP = bisphosphonate; Ca = calcium; β-CTX = cross-linked C-telopeptide of type I collagen; DMD = Duchenne muscular dystrophy; FN = femoral neck; GC = glucocorticoid; LS = lumbar spine; ZOL = zoledronic acid

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Genetic polymorphisms of collagen type I α1 chain (COL1A1) gene increase the frequency of low bone mineral density in the subgroup of children with juvenile idiopathic arthritis

The EPMA Journal ◽

10.1186/1878-5085-4-15 ◽

2013 ◽

Vol 4 (1) ◽

Cited By ~ 10

Author(s):

Mikhail M Kostik ◽

Arseniy M Smirnov ◽

Grigory S Demin ◽

Marina M Mnuskina ◽

Larisa A Scheplyagina ◽

...

Keyword(s):

Bone Mineral Density ◽

Juvenile Idiopathic Arthritis ◽

Genetic Polymorphisms ◽

Bone Mineral ◽

Collagen Type ◽

Collagen Type I ◽

Type I ◽

Mineral Density ◽

Col1a1 Gene ◽

Low Bone Mineral Density

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Assessment of Gait Symmetry in Elderly Women with Low Bone Mineral Density Using a Portable Trunk Accelerometer: A Pilot Study

Medical Science Monitor ◽

10.12659/msm.916763 ◽

2019 ◽

Vol 25 ◽

pp. 6669-6674 ◽

Cited By ~ 2

Author(s):

Yumi Takano ◽

Tatsushi Mutoh ◽

Yasuko Tatewaki ◽

Shuzo Yamamoto ◽

Hideo Shimomura ◽

...

Keyword(s):

Bone Mineral Density ◽

Pilot Study ◽

Bone Mineral ◽

Elderly Women ◽

Mineral Density ◽

Gait Symmetry ◽

Low Bone Mineral Density

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Relationships among Silent Brain Infarction, Low Bone Mineral Density and Milk Consumption in Elderly Women.

JOURNAL OF THE JAPANESE ASSOCIATION OF RURAL MEDICINE ◽

10.2185/jjrm.46.833 ◽

1998 ◽

Vol 46 (5) ◽

pp. 833-839

Author(s):

Kazuya YAMASHITA ◽

Kenichi IIJIMA ◽

Akira SHIRASAWA ◽

Yuji WATANABE ◽

Satoru KURODA ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Elderly Women ◽

Brain Infarction ◽

Milk Consumption ◽

Mineral Density ◽

Low Bone Mineral Density ◽

Silent Brain Infarction

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N-terminal telopeptides of type I collagen and bone mineral density for early diagnosis of nonunion: An experimental study in rabbits

Indian Journal of Orthopaedics ◽

10.4103/0019-5413.185608 ◽

2016 ◽

Vol 50 (4) ◽

pp. 421

Author(s):

Zhan-Jun Shi ◽

Jian-Ping Lin ◽

Ning-Jiang Shen ◽

Jian Wang ◽

Zao-Min Li ◽

...

Keyword(s):

Bone Mineral Density ◽

Experimental Study ◽

Early Diagnosis ◽

Bone Mineral ◽

Type I Collagen ◽

Type I ◽

Mineral Density

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Genetic polymorphisms and their influence on therapeutic response to alendronate-a pilot study

Balneo Research Journal ◽

10.12680/balneo.2019.264 ◽

2019 ◽

Vol 10 (Vol.10, No.3) ◽

pp. 243-251

Author(s):

Alina Deniza CIUBEAN ◽

Laszlo IRSAY ◽

Rodica Ana UNGUR ◽

Viorela Mihaela CIORTEA ◽

Ileana Monica BORDA ◽

...

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Bone Turnover ◽

Postmenopausal Women ◽

Bone Mineral ◽

Bone Turnover Markers ◽

Type I Collagen ◽

Type I ◽

Mineral Density ◽

Turnover Markers

Introduction: Osteoporosis has a strong genetic contribution, and several genes have been shown to influence bone mineral density. Variants in the human genome are considered important causes of differences in drug responses observed in clinical practice. In terms of bone mineral density, about 26–53% of patients do not respond to amino-bisphosphonate therapies, of which alendronate is the most widely used. Material and method: The current study is prospective, observational, analytical, longitudinal and cohort type. It included 25 postmenopausal women treated with alendronate for 1 year. Bone mineral density at lumbar spine and proximal femur was measured and bone turnover markers (C-terminal telopeptide of type I collagen and procollagen 1N-terminal propeptide) were evaluated at 0 and 12 months of treatment. Six single nucleotide polymorphisms in osteoporosis-candidate genes were genotyped (FDPS rs2297480, LRP5 rs3736228, SOST rs1234612, VKORC1 rs9934438, GGPS1 rs10925503 and RANKL rs2277439). Treatment response was evaluated by percentage changes in bone mineral density and bone turnover markers. Results: The heterozygous CT of FDPS rs2297480 showed lower increases in BMD values in the lumbar spine region and the homozygous CC of the GGPS1 rs10925503 showed lower increases in terms of BMD at the total hip region. No association was found for LRP5 rs3736228, SOST rs1234612, VKORC1 rs9934438 and RANKL rs2277439. Conclusions: Romanian postmenopausal women with osteoporosis carrying the CT genotype of FDPS rs2297480 or the CC genotype of GGPS1 rs10925503 could have an unsatisfactory response to alendronate treatment. Key words: osteoporosis; genetic polymorphism; alendronate; bone mineral density; bone turnover markers,

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Association Between Polymorphisms of VDR, COL1A1, and LCT Genes and Bone Mineral Density in Belarusian Women With Severe Postmenopausal Osteoporosis

Medicina ◽

10.3390/medicina49040028 ◽

2013 ◽

Vol 49 (4) ◽

pp. 28 ◽

Cited By ~ 4

Author(s):

Pavel Marozik ◽

Irma Mosse ◽

Vidmantas Alekna ◽

Ema Rudenko ◽

Marija Tamulaitienė ◽

...

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Osteoporosis ◽

Bone Mineral ◽

Type I Collagen ◽

Control Group ◽

Type I ◽

Osteoporosis Prevention ◽

Mineral Density ◽

Vdr Gene ◽

Predisposition Genes

Background and Objective. Variation of osteoporosis in the population is the result of an interaction between the genotype and the environment, and the genetic causes of osteoporosis are being widely investigated. The aim of this study was to analyze the association between the polymorphisms of the vitamin D receptor (VDR), type I collagen (COL1A1), and lactase (LCT) genes and severe postmenopausal osteoporosis as well as bone mineral density (BMD). Material and Methods. A total of 54 women with severe postmenopausal osteoporosis and 77 controls (mean age, 58.3 years [SD, 6.2] and 56.7 years [SD, 7.42], respectively) were included into the study. The subjects were recruited at the City Center for Osteoporosis Prevention (Minsk, Belarus). Dual-energy x-ray absorptiometry was used to measure bone mineral density at the lumbar spine and the femoral neck. Severe osteoporosis was diagnosed in the women with the clinical diagnosis of postmenopausal osteoporosis and at least 1 fragility fracture. The control group included women without osteoporosis. Polymorphic sites in osteoporosis predisposition genes (ApaI, BsmI, TaqI, and Cdx2 of the VDR gene, G2046T of the COL1A1 gene, and T-13910C of the LCT gene) were determined using the polymerase chain reaction on the deoxyribonucleic acid isolated from dried bloodspots. Results. The data showed that the ApaI and BsmI polymorphisms of the VDR gene and T- 13910C of the LCT gene were associated with severe postmenopausal osteoporosis in the analyzed Belarusian women (P<0.01). A statistically significant positive correlation between the VDR risk genotypes ApaI and TaqI and bone mineral density was found (P<0.05). Conclusions. The findings of this study suggest that at least the ApaI and BsmI polymorphisms of the VDR gene and T-13910C of the LCT gene are associated with the risk of postmenopausal osteoporosis in our sample of the Belarusian women.

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Alterations of Bone Metabolism in Patients with Diabetes Mellitus

International Journal of Endocrinology ◽

10.1155/2019/5984681 ◽

2019 ◽

Vol 2019 ◽

pp. 1-5 ◽

Cited By ~ 3

Author(s):

Sain S. Safarova

Keyword(s):

Bone Mineral Density ◽

Bone Metabolism ◽

Bone Remodeling ◽

Bone Mineral ◽

Type I Collagen ◽

Bone Microarchitecture ◽

Type I ◽

Mineral Density ◽

Bone Remodeling Markers ◽

Patients With Diabetes

Aim. The study aims to develop a practical model for screening bone turnover state in patients with diabetes and evaluate its clinical usefulness to identify diabetic osteopathy. Materials. The study was conducted in 2015–2017 in the Endocrinology Department of the Therapeutic Clinic of AM University. A total of 235 patients were assessed in the study (98 with T1DM and 137 with T2DM). 89 nondiabetic subjects served as controls. Bone mineral density (BMD) [by dual energy X-ray absorptiometry (DXA)] and serum markers of bone remodeling [aminoterminal propeptide of procollagen type I (P1NP) and c-terminal telopeptide of type I collagen (CTX)], parathyrin, and 25(OH)D were measured in all 235 patients. Results. Our results show that patients with T2DM have lower b-CTx values and relatively higher levels of P1NP, reflecting less pronounced changes in bone metabolism compared to patients with T1DM, regardless of age or duration of the disease. Osteoporosis was detected in 50% of patients with T1DM, compared to 13% of patients with T2DM. Conclusion. In some cases, bone remodeling markers are useful for improving the assessment of the state of bone tissue in early stages of diabetes, while alterations in bone microarchitecture may not always be captured by bone mineral density measurements.

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