The effect of the type and the concentration of the lipophilic surfactant on the stability and release kinetics of the W/O/W multiple emulsions

Curcumin, a natural polyphenol, has many biological properties, such as anti-inflammatory, antioxidant, and anti-carcinogenic properties, yet, its sensitivity to light, oxygen, and heat, and its low solubility in water renders its preservation and bioavailability challenging. To increase its bioaccessibility, we fabricated nanoliposomes and chitosan-coated nanoliposomes encapsulating curcumin, and we evaluated the systems in terms of their physicochemical characteristics and release profiles in simulated gastrointestinal mediums. Chitosan-coating enhanced the stability of nanoliposomes and slowed the release of curcumin in the simulated gastrointestinal (GI) environment. This study demonstrates that nanoliposomes and chitosan-coated nanoliposomes are promising carriers for poorly soluble lipophilic compounds with low oral bioavailability, such as curcumin.

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Atypical Effects of Salts on the Stability and Iron Release Kinetics of Human Transferrin

The Journal of Physical Chemistry B ◽

10.1021/jp903257c ◽

2009 ◽

Vol 113 (36) ◽

pp. 12400-12409 ◽

Cited By ~ 13

Author(s):

Rajesh Kumar ◽

A. Grant Mauk

Keyword(s):

Release Kinetics ◽

Iron Release ◽

Human Transferrin ◽

The Stability ◽

Kinetics Of

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Thermally Mediated Double Emulsion Breakup in Bifurcating Bi-Layer Microchannel

Journal of Thermal Science and Engineering Applications ◽

10.1115/1.4046608 ◽

2020 ◽

Vol 12 (6) ◽

Author(s):

Yong Ren ◽

Yue Chan ◽

Can Yang ◽

Jing Wang

Keyword(s):

Interfacial Tension ◽

Silicone Oil ◽

Release Kinetics ◽

Double Emulsion ◽

Dodecanoic Acid ◽

Emulsion Droplets ◽

Flow Through ◽

The Stability ◽

Novel Applications ◽

Kinetics Of

Abstract In this paper, we report the breakup dynamics of double emulsion droplets, as they flow through the bifurcating junction in bi-layer microchannel. Two cases have been investigated: the first involves double emulsion with core of water and shell of silicone oil with constant interfacial tension, this case shows that breakup dynamics of double emulsion can be demarcated into three regimes when the thermal effect is not dominant; whilst the second involves double emulsion with core of water and shell of dodecanoic acid where the thermocapillarity effect arises from change of interfacial tension subject to temperature variations. As demonstrated in the case, the Marangoni stress induced by the thermocapillary effect plays an important role in controlling the stability and release kinetics of double emulsion when flowing through complex microstructures. Our work will inspire novel applications, including droplet fission and actuation controlled by Marangoni flow via thermal mediation.

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Pectin-Based Nanomaterials: Synthesis, Toxicity and Applications

Asian Journal of Chemistry ◽

10.14233/ajchem.2021.23382 ◽

2021 ◽

Vol 33 (11) ◽

pp. 2579-2588

Author(s):

Mandeep Kaur ◽

Aditya Wadhwa ◽

Vineet Kumar

Keyword(s):

Drug Delivery ◽

Human Body ◽

Release Kinetics ◽

Drug Carrier ◽

Biological Origin ◽

Nanomaterials Synthesis ◽

The Stability ◽

Kinetics Of

Nanomaterials of biological origin are very useful for drug delivery applications. The stability, biodegradability and biocompatibility of pectin nanomaterials in the human body make them an effective drug carrier. This review focus on different aspect of synthesis, drug encapsulation, drug release and safety of pectin-based nanomaterials. The nanomaterials can be used for the delivery of different hydrophilic and hydrophobic drugs to various organs. The release kinetics of drug loaded pectin-based nanoparticles can be studied in vitro as well as in vivo. The pectin-based nanomaterials have good pharmaco-kinetics and can ensure controlled drug delivery. However, the toxicity of pectin-based nanomaterials to human body needs to be evaluated carefully before industrial scale application.

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Ball Milling to Build the Hybrid Mesocrystals of Ibuprofen and Aragonite

Journal of Nanomaterials ◽

10.1155/2015/163190 ◽

2015 ◽

Vol 2015 ◽

pp. 1-9

Author(s):

Kyoung A Cho ◽

Insil Choi ◽

Il Won Kim

Keyword(s):

Calcium Carbonate ◽

Solid State ◽

Ball Milling ◽

Release Kinetics ◽

Drug Formulation ◽

Controlling Factor ◽

Release Behavior ◽

State Process ◽

The Stability ◽

Kinetics Of

Mesocrystal formation is one of the new paradigms of the nonclassical crystallization, where the assembly of crystal domains is observed. Also, it has been recently employed in studies on drug formulation to utilize controlled dissolution of the drug domains. In this report, ibuprofen was attempted to form hybrid mesocrystals with calcium carbonate crystals. Two polymorphs of calcium carbonate (aragonite and calcite) were used during the solid-state process of ball milling. Structural analyses confirmed the mesocrystal formation of ibuprofen with aragonite but not with calcite. The origin of the observed behavior was found from the higher affinity of ibuprofen to aragonite, especially its (0 1 0) surface, compared to calcite. The hybrid mesocrystals of ibuprofen and aragonite showed the environment-responsive release behavior, where the stability of aragonite was the controlling factor for the release kinetics of ibuprofen.

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