Controversies in transfusion medicine: should a febrile transfusion response occasion the return of the blood component to the blood bank? Pro

Transfusion ◽  
1994 ◽  
Vol 34 (4) ◽  
pp. 356-358 ◽  
Author(s):  
FK Widmann
1999 ◽  
Vol 123 (8) ◽  
pp. 672-676
Author(s):  
Ronald A. Sacher ◽  
S. Gerald Sandler

Abstract The final decade of the last century of the second millennium ad has seen dramatic changes in all aspects of science and health care. In transfusion medicine, the blood supply is the safest it has ever been. Newer refinements and innovations are continuously being researched and implemented to achieve and further enhance safety. Advances in blood conservation, pharmacologic manipulation, engineered blood derivatives, and recombinant growth factors can now provide safer and more effective alternatives to blood transfusions for many patients. This overview highlights selective innovations in transfusion medicine and emphasizes some significant advances that have occurred in blood donor screening, blood component collections and therapy, and laboratory testing. Newer technologies are anticipated that will further enhance the safety of blood and transfusions and potentially augment annually the blood supply on a worldwide basis.


2002 ◽  
Vol 126 (8) ◽  
pp. 909-914 ◽  
Author(s):  
David A. Novis ◽  
Richard C. Friedberg ◽  
Stephen W. Renner ◽  
Frederick A. Meier ◽  
Molly K. Walsh

Abstract Objectives.—To determine the normative distribution of time elapsed for blood bank personnel to fill nonscheduled operating room (OR) blood component orders in hospital communities throughout the United States, and to examine hospital blood bank practices associated with faster blood component delivery times. Design.—Participants in the College of American Pathologists Q-Probes laboratory quality improvement program collected data prospectively on the times elapsed for blood bank personnel to fill nonscheduled emergent orders from hospital ORs for red blood cell (RBC) products, fresh frozen plasma (FFP), and platelets (PLTs). Participants also completed questionnaires describing their hospitals' and blood banks' laboratory and transfusion practices. Setting and Participants.—Four hundred sixty-six public and private institutions located in 48 states in the United States (n = 444), Canada (n = 9), Australia (n = 8), the United Kingdom (n = 4), and Spain (n = 1). Main Outcome Measures.—The median time elapsed between requests for blood components by OR personnel and the retrieval of those components by blood component transport personnel, and the median time elapsed between requests for blood components by OR personnel and the arrival of those components in ORs. Results.—Participants submitted data on 12 647 units of RBCs, FFP, and PLTs. The median aggregate request-to-retrieval turnaround times (TATs) for RBCs, FFP, and PLTs ranged from 30 to 35 minutes, and the median aggregate request-to-arrival TATs for RBCs, FFP, and PLTs ranged from 33 to 39 minutes. Most of the TAT was consumed by events occurring prior to, rather than after release of components from blood banks. Shorter prerelease TATs were associated with having surgical schedules that listed patients' names and procedures available to blood bank personnel prior to surgeries, and having adequate clotted specimens in the blood bank and completed type-and-screen procedures performed before requests for blood components were submitted to blood banks. Among the fastest-performing 10% of participants (90th percentile and above), request-to-retrieval TATs ranged from 12 to 24 minutes for the 3 blood components, whereas among the slowest-performing 10% of participants (10th percentile and below), request-to-retrieval TATs ranged from 63 to 115 minutes for the 3 components. Median TATs ranged from 33 to 37 minutes for the 3 components. Institutions with TATs in the fastest-performing 25th percentile more frequently stored cross-matched RBCs in the OR daily, stocked PLTs for unexpected surgical use, stored PLTs in or near the OR, and had laboratory rather than nonlaboratory personnel deliver components to the OR than did those institutions with TATs in the slowest-performing 25th percentile. Conclusions.—Hospital blood bank personnel can deliver blood components to the OR in slightly longer than 30 minutes, measured from the time that those units are requested by OR personnel. Practices aimed at saving time before components are released from blood banks will be more efficient in reducing overall TAT than those practices aimed at saving time after components are released from blood banks. Specific practices associated with shorter blood delivery TATs included providing blood bank personnel with access to the names of surgical patients potentially requiring blood components, having pretransfusion testing completed on those patients prior to surgery, having ample blood products on hand, and having laboratory personnel control blood product delivery.


2018 ◽  
Author(s):  
Maulik Rajyaguru ◽  
Jill Yaung

Venous thromboembolism (VTE) and transfusion medicine are frequently encountered issues in the intensive care unit. VTE can significantly worsen the risk of morbidity and mortality in any hospitalized patient, but proper preventive measures can reduce its incidence. Blood product transfusions can be lifesaving in appropriate situations but can also be both medically and economically detrimental if used without proper clinical judgment. In this review, we present an overview of VTE diagnosis, pharmacologic and mechanical prophylaxis, and treatment. Additionally, we review current indications for blood product use in various clinical situations, basics of massive transfusions, and adverse medical reactions to transfusions. This review contains 2 figures, 6 tables, and 50 references. Key Words: anticoagulation, blood component separation, venous thrombosis, immunohematology, massive transfusion, superficial venous thrombosis, transfusion threshold, venous thromboembolism


Transfusion ◽  
2018 ◽  
Vol 58 (11) ◽  
pp. 2490-2494
Author(s):  
Debra Berry ◽  
Margaret DiGuardo ◽  
Yunchuan Delores Mo ◽  
Gay Wehrli

2020 ◽  
Vol 40 (04) ◽  
pp. 500-508
Author(s):  
Michel Prudent

AbstractThe characterization of platelet concentrates (PCs) in transfusion medicine has been performed with different analytical methods and platelet lesions (from biochemistry to cell biology) have been documented. In routine quality assessment and validation of manufacturing processes of PCs for transfusion purposes, only basic parameters are monitored and the platelet functions are not included. However, PCs undergo several manipulations during the processing and the basic parameters do not provide sensitive analyses to properly picture out the impact of the blood component preparation and storage on platelets. To improve the transfusion supply chain and the platelet functionalities, additional parameters should be used. The present short review will focus on the different techniques to monitor ex vivo platelet lesions from phenotype characterization to advanced omic analyses. Then, the opportunities to use these methods in quality control, process validation, development, and research will be discussed. Functional markers should be considered because they would be an advantage for the future developments in transfusion medicine.


1970 ◽  
Vol 28 (6) ◽  
Author(s):  
Zerihun Ataro ◽  
Fekadu Urgessa ◽  
Tagesachew Wasihun

BACKGROUND: Acquisition of transfusion transmissible infections in the process of therapeutic blood transfusion is a major global health challenge in transfusion medicine. This study aimed to determine the prevalence and trends of major transfusion transmissible infections among blood donors.METHOD: A retrospective analysis of consecutive blood donors’ records covering the period between July 2010 and June 2013 was conducted at Dire Dawa Blood Bank, Eastern Ethiopia.RESULT: A total of 6376 blood donors were tested, out of which 5647(88.57%) were replacement donors and 729(11.43%) were voluntary donors. The majority of them were male, 5430(85.16%), and aged between 18–32 years, 4492(70.45%). A total of 450(7.06%) donors had serological evidence of infection with at least one pathogen. The overall positivity rates of HBV, HIV, HCV and syphilis were 4.67%, 1.24%, 0.96%, and 0.44% respectively. Trends for transfusion-transmissible infections showed a significant decrease from 9.51% in 2010 to 6.95% in 2013 with the least prevalence in 2012 (5.90% (P = 0.004). The prevalence of transfusion transmissible infections was significantly higher among male blood donors compared to female donors, among the age group of 25-32 years and 33-40 years compared to the age group of 18-24 years old, and among unemployed and private workers compared to students.CONCLUSION: A significant percentage of the blood donors harbor transfusion-transmissible infections. Stringent donor selection using standard methods is highly recommended to ensure the safety of blood for the recipient. Furthermore, efforts on motivating and creating awareness in the community are required to increase voluntary blood donors. 


Author(s):  
Rejla Rahim ◽  
Sheela Varghese ◽  
Renu Thambi ◽  
M. S. Suma

Background: Blood transfusion is a routine life- saving medical intervention which is generally regarded as safe when done appropriately. Without blood transfusion, many medical and surgical conditions like anemia, road traffic accidents, obstetric hemorrhage, cardiothoracic surgeries are nearly impossible to manage. However, this life-saving procedure is often associated with adverse effects ranging from minor chills and rigors to life-threatening anaphylaxis. Incidence of transfusion reactions is estimated at 0.001% -10%. The knowledge about the adverse transfusion reaction (ATRs) will help in early identification, management, and prevention of adverse transfusion reactions.Methods: Descriptive cross-sectional study done in 1047 patients, admitted and received at least one unit of whole blood and blood components in the surgery department, Government Medical College, Kottayam during the study period. Information regarding the issue of blood component collected from the transfusion medicine department and the details of the reactions were collected from the patients, and the transfusion reaction workups were done in the transfusion medicine department. The collected data was analysed using Microsoft Excel sheets.Results: The frequency of acute transfusion reaction in this study is 1%. The majority of the reactions were seen with a packed PRBC transfusion. Febrile non-hemolytic transfusion accounted for 54.64% followed by allergic reactions (36.36%) and Transfusion associated cardiac overload (9%).Conclusions: The frequency of ATR in our study was 1%. Febrile non-hemolytic transfusion (FNHTR) and allergic reactions were common patterns followed by transfusion associated cardiac overload (TACO) seen.


2021 ◽  
Vol 3 (1) ◽  
pp. 063-069
Author(s):  
Ramune Sepetiene ◽  
Vaiva Patamsyte ◽  
Ninette F Robbins ◽  
Mohamed Ali ◽  
Alexander Carterson

Background: This review describes and evaluates the most relevant preanalytical errors and their impact on subsequent laboratory diagnostics. Quality management for laboratory processes remains extremely important, despite current advancements in information technologies and fully automated routine procedures. Methods: This review is focused on specific preanalytical requirements for the blood bank and transfusion laboratory. Conclusions are done based on literature review. Results: Human errors, or lack of procedures, continue to be the cause of many errors within laboratory processes. The medical laboratory needs an impetus and stipulation to improve processes, to help eliminate errors, and meet regulatory guidelines. Conclusions: General preanalytical rules exist for clinical and research laboratories but differences in laboratory specialty and provided services influence compliance


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