scholarly journals Indications for transit-timing variations in the exo-Neptune HAT-P-26b

2019 ◽  
Vol 628 ◽  
pp. A116
Author(s):  
C. von Essen ◽  
S. Wedemeyer ◽  
M. S. Sosa ◽  
M. Hjorth ◽  
V. Parkash ◽  
...  
Keyword(s):  
Light Curves ◽  
Optical Telescope ◽  
Timing Variability ◽  
Transit Times ◽  
Bibliographic Data ◽  
Global Fit ◽  
The Individual ◽  
Rule Out

Upon its discovery, the low-density transiting Neptune HAT-P-26b showed a 2.1σ detection drift in its spectroscopic data, while photometric data showed a weak curvature in the timing residuals, the confirmation of which required further follow-up observations. To investigate this suspected variability, we observed 11 primary transits of HAT-P-26b between March, 2015, and July, 2018. For this, we used the 2.15 m Jorge Sahade Telescope placed in San Juan, Argentina, and the 1.2 m STELLA and the 2.5 m Nordic Optical Telescope, both located in the Canary Islands, Spain. To add to valuable information on the transmission spectrum of HAT-P-26b, we focused our observations in the R-band only. To contrast the observed timing variability with possible stellar activity, we carried out a photometric follow-up of the host star over three years. We carried out a global fit to the data and determined the individual mid-transit times focusing specifically on the light curves that showed complete transit coverage. Using bibliographic data corresponding to both ground and space-based facilities, plus our new characterized mid-transit times derived from parts-per-thousand precise photometry, we observed indications of transit timing variations in the system, with an amplitude of ~4 min and a periodicity of ~270 epochs. The photometric and spectroscopic follow-up observations of this system will be continued in order to rule out any aliasing effects caused by poor sampling and the long-term periodicity.

scholarly journals Myopericytoma in the Antitragus of the Auricle: A Rare Tumor

2020 ◽  
pp. 014556132098457
Author(s):  
Tae Seong Eo ◽  
Jeong Hae Kie ◽  
Hyun Seung Choi ◽  
Junhui Jeong
Keyword(s):  
Large Firm ◽  
Rare Tumor ◽  
Long Term Follow Up ◽  
Slow Growing ◽  
Rule Out

A myopericytoma in the auricle is rare. If an auricle contains a large, firm, red-brown mass, excision should be considered because the mass may be a myopericytoma. After excision, histopathological and immunohistochemical diagnoses are essential to rule out malignancy. Long-term follow-up is required because the tumor is slow-growing.

Stability in Waking-Sleep States in Neonates as a Predictor of Long-Term Neurologic Outcome

PEDIATRICS ◽  
1985 ◽  
Vol 76 (1) ◽  
pp. 52-63
Author(s):  
Cesare T. Lombroso ◽  
Yoichi Matsumiya
Keyword(s):  
Statistical Significance ◽  
Observation Time ◽  
Long Term Outcomes ◽  
Newborn Period ◽  
Waking And Sleep ◽  
Total Observation Time ◽  
Total Observation ◽  
The Individual

Thirty-three full-term neonates were ranked blindly on a scale ranging from the least to the highest "risk" for future neurologic complications on the basis of available perinatal biographies, tests, and examinations performed during the newborn period. Four prolonged polygraphic-behavioral recordings were obtained one week apart beginning at ten days after birth. Five waking and sleep states were scored in each session as percentages of total observation time, giving a total of 20 scores for each baby to be subjected to analysis of variance. These measures also provided individual profile consistency or variability in maintaining waking-sleep states over the selected period of postnatal time. The whole cohort, except three infants who could not be followed adequately, was then reexamined periodically over a period ranging from 3 to 4 years (±6 months) for neurologic and developmental assessments. Except for two scores that produced a low level of statistical significance (P < .05), the other 18 scores were found to be not associated with long-term outcomes. Even the first two scores were not satisfactory discriminators for the outcome of the individual babies. However, when coefficients of concordance (W) were computed from each individual baby profile, significant statistics (P < .001) emerged to indicate good correlations between high or low W values in the newborn period and long-term outcomes. All 17 newborns who had W scores greater than 0.9 were found to be normal at follow-up regardless of the poor ranking given several of them during the newborn period. Among the 13 newborns who had W scores less than 0.9, 11 had a poor clinical outcome at follow-up, though several had been ranked initially as falling within the least "risk" group.

scholarly journals Pediatric Glaucoma: A Literature’s Review and Analysis of Surgical Results

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Gianluca Scuderi ◽  
Daniela Iacovello ◽  
Federica Pranno ◽  
Pasquale Plateroti ◽  
Luca Scuderi
Keyword(s):  
Success Rates ◽  
Older Children ◽  
Advantages And Disadvantages ◽  
Pediatric Glaucoma ◽  
First Choice ◽  
Surgical Options ◽  
Aphakic Eyes ◽  
The Individual

The purpose of this paper is to review the surgical options available for the management of pediatric glaucoma, to evaluate their advantages and disadvantages together with their long-term efficacy, all with the intent to give guidelines to physicians on which elements are to be considered when taking a surgical decision. Currently there is a range of surgical procedures that are being used for the management of pediatric glaucoma. Within these, some are completely new approaches, while others are improvements of the more traditional procedures. Throughout this vast range of surgical options, angle surgery remains the first choice in mild cases and both goniotomy and trabeculotomy have good success rates. Trabeculectomy with or without mitomycin C (MMC) is preferred in refractory cases, in aphakic eyes, and in older children. GDIs have a good success rate in aphakic eyes. Nonpenetrating deep sclerectomy is still rarely used; nevertheless the results of ongoing studies are encouraging. The different clinical situations should always be weighed against the risks associated with the procedures for the individual patients. Glaucomatous progression can occur many years after its stabilization and at any time during the follow-up period; for this reason life-long assessment is necessary.

1156Coronary artery bypass grafting vs. FFR-guided PCI in diabetic patients with multivessel disease

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
G Di Gioia ◽  
N Soto Flores ◽  
D Franco ◽  
I Colaiori ◽  
J Sonck ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Artery Bypass ◽  
Diabetic Patients ◽  
Bypass Grafting ◽  
Fractional Flow ◽  
Artery Bypass Grafting ◽  
The Individual ◽  
The Impact

Abstract Background In diabetic patients with multivessel coronary disease (MVD), coronary artery bypass grafting (CABG) has shown long-term benefits in mortality over percutaneous coronary revascularization (PCI). Nevertheless, the impact of fractional flow reserve (FFR)-guided PCI on clinical outcomes has never been investigated in these patients. Purpose To evaluate the long-term (5-year) clinical outcome of diabetic patients with MVD treated with FFR-guided PCI compared to CABG. Methods From February 2010 to February 2018, all diabetic patients undergoing coronary angiography in one centre (n=4622) were screened for inclusion. The inclusion criterion was presence of at least two-vessels CAD defined as with diameters stenosis ≥50%. In case of intermediate coronary stenosis (%DS 30–70%), FFR was performed at the discretion of the operator. Revascularization was performed when FFR ≤0.80. Exclusion criteria were ST-elevation myocardial infarction, prior CABG, and moderate or severe valvular heart dysfunction. To account for confounders, we compared outcomes by calculating an adjusted Kaplan-Meier estimator using inverse probability of treatment weighting (IPTW). Propensity score variables included age, sex, smoking habit, hypertension, hyperlipidemia, insulin therapy, family history of CAD, chronic obstructive pulmonary disease (COPD), glomerular filtration rate (GFR), prior myocardial infarction, peripheral vascular disease (PVD), admission for NSTEMI, ejection fraction, number of angiographic stenotic vessels. Odds ratios were calculated using generalized linear models (GLM). The primary endpoint was major adverse cardiovascular and cerebrovascular events (MACCE), defined as all-cause death, myocardial infarction and stroke. Secondary endpoints were the individual component of MACCE and any repeated revascularization. Results A total of 538 diabetic patients with MVD were included in the analysis. Among them, 317 (59%) patients underwent CABG and 221 (41%) FFR-guided PCI. Patients treated with FFR-guided PCI had more often COPD as compared to patients in the CABG-group, but patients treated with CABG had lower GFR, more PVD, higher number of angiographic stenotic vessels (2.8±0.4 vs. 2.5±0.5; p<0.01) and higher Syntax score (20±7 vs. 14±6; p<0.01) as compared to the FFR-guided PCI group. Clinical follow-up was obtained in 95% of the patients at a median follow-up of 5 years. The incidence of MACCE was similar in the CABG and in the FFR-guided PCI group [27% vs. 29%; OR (95% CI) 1.05 (0.68–1.63); p=0.74]. No differences were found in the individual components of MACCE. Repeat revascularization was more frequent in the FFR-guided PCI group than in the CABG group [27% vs. 7%; OR (95% CI) 4.3 (2.35–7.9); p<0.01]. Conclusions In diabetic patients with MVD undergoing FFR-guided PCI, no differences in major adverse events were observed at a median follow-up of 5 years compared with CABG.

scholarly journals Long-term weight status in regainers after weight loss by lifestyle intervention: status and challenges

2014 ◽  
Vol 73 (4) ◽  
pp. 509-518 ◽  
Author(s):  
Marta Stelmach-Mardas ◽  
Marcin Mardas ◽  
Jarosław Walkowiak ◽  
Heiner Boeing
Keyword(s):  
Weight Loss ◽  
Weight Status ◽  
Dietary Intervention ◽  
Self Regulation ◽  
Energy Restriction ◽  
Behaviour Therapy ◽  
Main Determinants ◽  
The Individual

After having participated in a weight loss trial, most participants do not stabilise the obtained weight loss but return to their initial weight. The aim of this review is to describe the main determinants of continued low weight status after weight loss, and the effectiveness of physical activity (PA), energy restriction and macronutrient composition of the diet for low long-term weight regain. Studies with intervention periods of at least 3 months duration of weight reduction measures and a follow-up at least 2 years after the intervention period were considered as eligible for the review. Owing to limited data, the studies describing the role of PA in weight management were eligible with a follow-up of 1 year only. It appears that a diet with self-regulation of dietary intake seems to be given a prominent role in the strategy of successful long-term weight loss among the obese. This measure could be combined with behaviour therapy and PA and tailored to the individual situation. However, considering available evidence it is difficult to conclude regarding unambiguous measures and to recommend a specific dietary intervention. Nevertheless, interventions should be effective in promoting intrinsic motivation and self-efficacy. The harmonisation and standardisation of data collection in the follow-up period of long-term weight loss studies is a major challenge.

Effect of relative cumulative dose-intensity on survival of patients with urothelial cancer treated with M-VAC.

1993 ◽  
Vol 11 (3) ◽  
pp. 400-407 ◽  
Author(s):  
H I Scher ◽  
N L Geller ◽  
T Curley ◽  
Y Tao
Keyword(s):  
Cumulative Dose ◽  
Urothelial Cancer ◽  
Cox Regression ◽  
Dose Intensity ◽  
Complete Response ◽  
Data Set ◽  
The Individual ◽  
Long Term Survivors

PURPOSE To evaluate the received dose-intensity in a mature data set of patients with advanced urothelial cancer who received at least one cycle of the methotrexate (M), vinblastine (V), Adriamycin ([A], doxorubicin; Adria Laboratories, Columbus, OH), and cisplatin (C) regimen (M-VAC). PATIENTS AND METHODS Received dose-intensity was evaluated over time by summing doses over cycles for each patient, cumulating treatment times, and assuming four cycles of chemotherapy were planned. Relative cumulative dose-intensity was then calculated for individual patients at the end of each cycle. To assess a relationship with survival, relative cumulative dose-intensity was then used as a time-dependent covariate in Cox regression. RESULTS The median follow-up was 6 years and median survival 13.3 months, with 20 patients alive at the time of analysis. Out of a maximum of 1.0, the median relative dose-intensity for the M-VAC combination decreased from .69 to .59 from cycle 1 to cycle 4. Similarly, a decrease from .68 to .62 and from .80 to .72 was observed for A and C, respectively. The median received dose-intensity for A was 6.0 mg/m2/wk, and for C 14 mg/m2/wk. Neither the four-cycle relative cumulative dose-intensity for the M-VAC combination, nor the relative cumulative dose-intensities for A or C were found to be significant prognostic factors. CONCLUSION The absence of an effect for received dose-intensity on survival may reflect the low dose-intensities of the components of the regimen actually delivered in this study. The results question whether the individual agents can be escalated sufficiently, with growth factor support, to improve significantly complete response proportions, a prerequisite for increasing the proportion of long-term survivors.

scholarly journals Optical Coherence Tomographic Study of a Chronically Retained Coronary Guidewire

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Natasha Corballis ◽  
Sreekumar Sulfi ◽  
Alisdair Ryding
Keyword(s):  
Rare Complication ◽  
Coronary Intervention ◽  
Bare Metal Stent ◽  
Optical Coherence ◽  
Percutaneous Coronary Angioplasty ◽  
Subsequent Fracture ◽  
Percutaneous Coronary ◽  
The Individual

Guidewire entrapment is a rare complication of coronary intervention, and management depends on the individual circumstances. This is a case of an urgent percutaneous coronary angioplasty in which a guidewire became entrapped behind a bare metal stent with subsequent fracture of the core filament, which could not be retrieved. Using optical coherence tomography, our case demonstrates extensive tissue coverage of the retained guidewire at twelve months. Five-year follow-up suggests that retained guidewires can be managed without long-term anticoagulation, even when there is substantial intra-aortic material.

scholarly journals Experience with various occluder types for endovascular hemodynamic isolation of the left atrium appendage in patients with non-valvular atrial fibrillation

2021 ◽  
Vol 28 (3) ◽  
pp. 45-54
Author(s):  
D. V. Pevzner ◽  
E. V. Merkulov ◽  
G. K. Arutyunyan ◽  
A. L. Komarov ◽  
O. O. Shakhmatova ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Left Atrium ◽  
Individual Choice ◽  
Device Implantation ◽  
Comparison Groups ◽  
Anatomic Variants ◽  
Short And Long Term ◽  
The Individual

The aim of our study was to evaluate implantation efficacy and safety across various occluder types and to identify factors determining device selection.Methods. This single-site prospective observational study included patients above the age of 40 years with non-valvular atrial fibrillation (AF) and high thromboembolic risk, undergoing endovascular isolation of the left atrium appendage (LAA) with Watchman or Amplatzer Cardiac Plug/Amulet devices. Occluders were implanted to patients without either had contraindications to anticoagulant therapy (ACT) or refused ACT. We evaluated technical aspects of device implantation, short- and long-term outcomes of the intervention over 3 years of follow-up.Results. 90 patients were enrolled in the study (62 into the Watchman arm and 28 into the Amplatzer arm). Interventions were technically successful in 89 cases. In 1 patient (1/90, 1.1%) technical success was not achieved due to device migration (Amplatzer Amulet). The incidence of early (occurring within˂ 24 hours) implantation complications was 0% in the Watchman arm, and 3.6% in the Amplatzer arm (1/28) (р=0.135) (device migration). The cumulative incidence of all in-hospital complications was 11.3% and 14.3%, respectively (р=0.734). No significant differences between arms were found in the incidence of device thrombosis within 90 days post-implantation (3.3% in the Watchman’s arm and 8.3% in the Amplatzer arm, р=0.316). During the observation period, there were no significant differences in comparison groups in the incidence of net clinical efficacy endpoint events (р=0.58). The bleeding rate was 17.7% and 14.3%, respectively, р=0.769. No factors influencing the choice of the device could be identified reliably; however, there was a trend towards Watchman preference for appendage anatomic variants such as broccoli and cactus. Amplatzer was preferred in patients with contraindications to ACT.Conclusion. Implantation of Watchman and Amplatzer Amulet occluders is equally effective and safe in preventing thromboembolism in patients with AF not receiving ACT for various reasons. The individual choice of a device may be influenced by appendage anatomy and indications to occluder implantation.

scholarly journals Dorsal instrumentation with and without vertebral body replacement in patients with thoracolumbar osteoporotic fractures shows comparable outcome measures

2021 ◽  
Author(s):  
Maximilian Schwendner ◽  
Stefan Motov ◽  
Yu-Mi Ryang ◽  
Bernhard Meyer ◽  
Sandro M. Krieg
Keyword(s):  
Vertebral Body ◽  
Thoracolumbar Spine ◽  
Osteoporotic Fractures ◽  
The Elderly ◽  
Vertebral Body Replacement ◽  
Inclusion Criteria ◽  
Dorsal Instrumentation ◽  
The Individual

Abstract Purpose In the surgical treatment of osteoporotic spine fractures, there is no clear recommendation, which treatment is best for the individual patient with vertebra plana and/or neurological deficit requiring instrumentation. The aim of this study was to evaluate clinical and radiological outcomes after dorsal or 360° instrumentation of osteoporotic fractures of the thoracolumbar spine in a cohort of patients representing clinical reality. Methods A total of 116 consecutive patients were operated on between 2008 and 2020. Inclusion criteria were osteoporotic fracture, thoracolumbar location, and dorsal instrumentation. In 79 cases, vertebral body replacement (VBR) was performed additionally. Patient outcomes including complications, EQ-5D at follow-up, and sagittal correction were analyzed. Results Medical and surgical complications occurred in 59.5% of patients with 360° instrumentation compared to 64.9% of patients with dorsal instrumentation only (p = 0.684). Dorsal instrumentation plus VBR resulted in a sagittal correction of 9.3 ± 7.4° (0.1–31.6°) compared to 6.0 ± 5.6° (0.2–22.8°) after dorsal instrumentation only, respectively (p = 0.0065). EQ-5D was completed by 79 patients after 4.00 ± 2.88 years (0.1–11.8 years) and was 0.56 ± 0.32 (− 0.21–1.00) for VBR compared to 0.56 ± 0.34 (− 0.08–1.00) without VBR after dorsal instrumentation (p = 0.994). Conclusion 360° instrumentation represents a legitimate surgical technique with no additional morbidity even for the elderly and multimorbid osteoporotic population. Particularly, if sufficient long-term construct stability is in doubt or ventral stenosis is present, there is no need to abstain from additional ventral reinforcement and decompression.

scholarly journals A study of gamma-ray burst afterglows as they first come into view of the SwiftUltraviolet and Optical Telescope

2019 ◽  
Vol 488 (2) ◽  
pp. 2855-2863
Author(s):  
M J Page ◽  
S R Oates ◽  
M De Pasquale ◽  
A A Breeveld ◽  
S W K Emery ◽  
...  
Keyword(s):  
Gamma Ray ◽  
Light Curves ◽  
Field Of View ◽  
Prompt Gamma ◽  
Optical Telescope ◽  
Gamma Ray Burst ◽  
Thick Shells ◽  
Temporal Indices ◽  
Rule Out

ABSTRACT We examine the emission from optically bright gamma-ray burst (GRB) afterglows, as the Ultraviolet and Optical Telescope (UVOT) on the Neil Gehrels Swift Observatory first begins observing, following the slew to target the GRB, while the pointing of the Swift satellite is still settling. We verify the photometric quality of the UVOT settling data using bright stars in the field of view. In the majority of cases, we find no problems with the settling exposure photometry, but in one case, we excise the first second of the exposure to mitigate a spacecraft attitude reconstruction issue, and in a second case, we exclude the first second of the exposure in which the UVOT photocathode voltage appears to be ramping up. Of a sample of 23 afterglows which have peak V magnitudes <16, we find that all are detected in the settling exposures, when Swift arrives on target. For nine of the GRBs, the UVOT settling exposure took place before the conclusion of the prompt gamma-ray emission. Five of these GRBs have well-defined optical peaks after the settling exposures, with rises of >0.5 mag in their optical light curves, and there is a marginal trend for these GRBs to have long T90. Such a trend is expected for thick-shell afterglows, but the temporal indices of the optical rises and the timing of the optical peaks appear to rule out thick shells.

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