Oral manifestations of a sinus melanoma: case report and literature review

Introduction: Mucosal melanoma (MM) is a rare malignancy of the head and neck. Sinonasal melanomas are the most frequent, followed by oral melanomas. Observation: A 67-year-old patient with a known left sinus melanoma initially treated with immunotherapy was referred for consultation concerning mobile teeth. A pigmented lesion infiltrating the left maxillary arch in the molar area was detected. The malignancy had invaded the oral mucosa. Despite many proposed treatments (immunotherapy, chemotherapy, and radiotherapy), the patient showed metastatic progression, which resulted in death. Discussion: Sinus MMs are malignancies with poor prognosis because these are often diagnosed in the late stages of disease progression. As these tumors are rare, there is no treatment consensus and surgery remains the best option. Diagnosis of pigmented lesions of the oral mucosa is sometimes complicated because of various implied etiologies. Conclusion: This case report shows that sinus MMs can induce pigmentation in the oral mucosa. These are rare malignancies with poor prognosis, for which no treatment consensus exists to date.

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Congenital melanocytic nevus of the oral mucosa: report of a rare pigmented lesion and review of the literature

Clinics and Practice ◽

10.4081/cp.2011.e17 ◽

2011 ◽

Vol 1 (1) ◽

pp. 17 ◽

Cited By ~ 4

Author(s):

Melanie Louise Gilbert ◽

Weddad Hanna ◽

Danny Ghazarian ◽

Dean Dover ◽

Hagen Benjamin Edward Klieb

Keyword(s):

Oral Mucosa ◽

Melanocytic Nevus ◽

Congenital Melanocytic Nevus ◽

Review Of The Literature ◽

Melanocytic Nevi ◽

Pigmented Lesions ◽

Pigmented Lesion ◽

Congenital Melanocytic Nevi

Oral pigmented lesions are uncommon and congenital melanocytic nevi are especially rare. We report a case of a patient with multiple congenital melanocytic nevi including a palatal lesion. This is reported to add to the scant literature that exists on this subject. Prognosis and management are discussed.

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Primary Gastric Melanoma: Case Report of a Rare Malignancy

Rare Tumors ◽

10.4081/rt.2015.5683 ◽

2015 ◽

Vol 7 (1) ◽

pp. 46-49 ◽

Cited By ~ 6

Author(s):

Alexander Augustyn ◽

Emma Diaz de Leon ◽

Adam C. Yopp

Keyword(s):

Case Report ◽

Rare Malignancy ◽

Melanoma Case

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Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature

Case Reports in Hematology ◽

10.1155/2011/818469 ◽

2011 ◽

Vol 2011 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Anders Kindberg Boysen ◽

Paw Jensen ◽

Preben Johansen ◽

Karen Dybkær ◽

Mette Nyegaard

Keyword(s):

Case Report ◽

Complete Remission ◽

Poor Prognosis ◽

Nk Cell ◽

Clinical Course ◽

Standard Of Care ◽

Cytotoxic Agents ◽

Review Of The Literature ◽

Cell Leukemia ◽

Rare Malignancy

Aggressive NK-cell leukemia is a rare malignancy with neoplastic proliferation of natural killer cells. It often presents with constitutional symptoms, a rapid declining clinical course, and a poor prognosis with a median survival of a few months. The disease is usually resistant to cytotoxic agents, and no treatment has emerged as the standard of care for these patients. We report a case of an 18-year-old male who obtains complete remission following two lines of combination chemotherapy. We describe in details our regimens for induction chemotherapy and perform a review of existing literature concerning treatment of aggressive NK-cell leukemia.

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Case Report: A rare presentation and diagnosis of gingival melanoacanthoma caused by teeth whitening strips: A Case Report

F1000Research ◽

10.12688/f1000research.27999.2 ◽

2020 ◽

Vol 9 ◽

pp. 1452

Author(s):

Hamad Albagieh ◽

Ashwag Aloyouny ◽

Shatha Alharthi

Keyword(s):

Case Report ◽

Oral Cavity ◽

Clinical Presentation ◽

Rare Presentation ◽

Pigmented Lesions ◽

Pigmented Lesion ◽

Causative Factors ◽

Local Sources ◽

Mucous Membranes

Background: Oral melanoacanthoma is not common. It occurs mostly on the buccal mucosa. Since it happens suddenly and progresses rapidly, it clinically resembles melanoma. Melanoacanthoma occurs in regions susceptible to trauma. The clinical presentation of the lesion is not enough to diagnose it; therefore, tissue biopsy is necessary to exclude malignancy. Case report: We report a case of oral melanoacanthoma in a rare mucosal location in a 21-year old female patient in whom generalized gingival melanoacanthoma was related to the use of the teeth whitening strips. This irritating factor increased melanocyte activity in the gingival tissues and labial mucosa. Discussion: Oral melanoacanthoma is a rarely encountered pigmented lesion in the oral cavity and is especially uncommon in the gingiva. It is a reactive lesion affecting the mucous membranes with no risk of malignant transformation. This case report shows that teeth whitening strips may trigger oral melanoacanthoma in susceptible individuals. Long-term irritation of the oral tissues may increase the number of dendritic melanocytes throughout the epithelium and accordingly increase the brown pigmentation of the oral cavity. Eliminating all possible local sources of irritation and ruling out other causative factors are the standard first step in the treatment of oral melanoacanthoma. Conclusions: This case shows the importance of including oral melanoacanthoma in the differential diagnosis of diffuse gingival pigmented lesions.

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Oral Malignant Melanoma: A Case Report

Prague Medical Report ◽

10.14712/23362936.2021.20 ◽

2021 ◽

Vol 122 (3) ◽

pp. 222-227

Author(s):

Suman Sen ◽

Sheuli Sen ◽

M. Geetha Kumari ◽

Sufia Khan ◽

Subhasini Singh

Keyword(s):

Malignant Melanoma ◽

Poor Prognosis ◽

Hard Palate ◽

Middle Age ◽

Early Recognition ◽

Malignant Neoplasm ◽

Pigmented Lesions ◽

The Poor ◽

Pigmented Lesion ◽

Oral Malignant Melanoma

Melanoma is a malignant neoplasm of the epidermal melanocytes. Awareness and early recognition of pigmented lesion inside oral cavity helps in initial diagnosis and further investigation and treatment. Oral malignant melanoma is a rare aggressive neoplasm commonly seen among middle age. The diagnosis of melanoma initiates from the pre-existing pigmented lesions. The poor prognosis of oral melanomas requires that pigmented lesions of undetermined origin be routinely biopsied. A case of malignant melanoma of hard palate with its clinical, radiological and histopathological presentation along with brief review is presented. Prognosis of these lesion is poor with survival rate of 5 years.

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Oral malignant melanoma: History of malignant degeneration of a pigmented lesion

Journal of Oral Medicine and Oral Surgery ◽

10.1051/mbcb/2019003 ◽

2019 ◽

Vol 25 (2) ◽

pp. 19 ◽

Cited By ~ 1

Author(s):

Nour Mellouli ◽

Samah Sioud ◽

Maroua Garma ◽

Abdellatif Chokri ◽

Habib Hamdi ◽

...

Keyword(s):

Malignant Melanoma ◽

Malignant Transformation ◽

Oral Mucosa ◽

Malignant Lesion ◽

Final Diagnosis ◽

Malignant Degeneration ◽

Close Monitoring ◽

Pigmented Lesions ◽

Pigmented Lesion ◽

Oral Malignant Melanoma

Introduction: Oral malignant melanoma (OMM) is a rare malignant lesion of the oral mucosa. It accounts for 0.5% of oral cavity cancers and less than 1% of all melanomas. Most cases arise on the palate or gingiva. OMM is caused by unknown factors. Benign pigmentation may precede the neoplasm by several years. The malignant transformation of benign melanosis is poorly understood. Observation: The aim of this work is to present a new clinical case of oral malignant melanoma which appeared on benign melanosis with a brief review of the literature. A 37-year-old woman presented with a blackish pigmented plaque that covered the hard palate and vestibular maxillary gingiva and a soft, friable 2 cm nodule with ulcerated surface next to the 11, 12 and 13. Fifteen years ago, the patient underwent a biopsy that was in favor of benign melanosis. Unfortunately, the patient was followed for one year and then was lost. Recently, in front of the rapidity of the extension of the lesion, she came again. After biopsy, a final diagnosis of OMM is retained. Commentaries: OMM is often asymptomatic. It presents usually as a 1.5–4 cm, blackish grey, irregular, flat or nodular lesion. The neoplasm can appear on apparently normal oral mucosa and may be preceded by benign pigmented lesions. Few articles discussed malignant transformation of benign melanosis. OMM is characterized by its poor prognosis. The treatment of choice for OMM remains surgery with wide clear margins. Conclusion: Close monitoring is needed to detect signs of transformation and to early diagnose melanoma.

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Case report: a camouflaged parathyroid carcinoma with initial misdiagnosis

BMC Surgery ◽

10.1186/s12893-019-0638-x ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Hongtao Cao ◽

Weibin Wang

Keyword(s):

Case Report ◽

Preoperative Diagnosis ◽

Poor Prognosis ◽

Parathyroid Carcinoma ◽

Clinical Manifestations ◽

Rare Condition ◽

Optimal Management ◽

Case Presentation ◽

Preoperative Ultrasonography ◽

Rare Malignancy

Abstract Background Parathyroid carcinoma is a rare malignancy with an increasing incidence. Most patients are characterized by the presence of severe primary hyperparathyroidism, especially hypercalcemia, while patients with normal level of serum calcium are extremely rare. Unfortunately, patients free of hypercalcemia are usually diagnosed at a later stage and suffer from a rather poor prognosis. Case presentation We describe a patient diagnosed with intrathyroidal normocalcemic parathyroid carcinoma, whose preoperative ultrasonography suggests that the tumor is located inside the thyroid gland and present without obvious clinical manifestations, which makes it more challenging for diagnosis. Conclusions Preoperative suspicion of malignancy is of great importance for advanced management while preoperative diagnosis is rather challenging with the limited contribution of imaging examinations. Any abnormality in serum level of calcium or parathormone may help to make an initial diagnosis especially when the level is extremely high. We introduce this case of initial misdiagnosis of an intrathyroidal parathyroid carcinoma, mimicking a suspicious thyroid nodule, to focus on the possible anomalous presentations of this rare condition and on its optimal management.

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Tick infestation masquerading as a nodule in the eye lid

Nepalese Journal of Ophthalmology ◽

10.3126/nepjoph.v12i1.27351 ◽

2020 ◽

Vol 12 (1) ◽

pp. 106-109

Author(s):

Nirsara Shrestha ◽

Sangeeta Shrestha ◽

Arjun Shrestha ◽

Barsha Suwal ◽

Samata Sharma

Keyword(s):

Case Report ◽

Tick Infestation ◽

Tick Bite ◽

Diagnostic Dilemma ◽

Recent Onset ◽

Pigmented Lesions ◽

Pigmented Lesion ◽

The Right ◽

High Index Of Suspicion ◽

Pigmented Nevi

Introduction: Ticks are ectoparasites which can lead to various blood borne diseases. Tick bite may resemble pigmented nevi, mole or nodule resulting a diagnostic dilemma. Tick bite in eye lid is rare and this case report describes tick bite in lower eye lid mimicking a traumatized pigmented nodule where the tick was identified only on magnification and was successfully removed mechanically. Case: A 61-year-old man presented to the eye out patient department with a sudden and painful black pigmented lesion on the right lower lid for four days. The tick was manually removed with forceps. Conclusion: This case report explains the need for a high index of suspicion as tick bite in sudden or recent onset pigmented lesions especially in endemic areas.

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MESENCHYMAL TUMOR LEIOMYOSARCOMA OF PROSTATE, A RARE CASE REPORT

10.36106/ijar/9301016 ◽

2021 ◽

pp. 21-22

Author(s):

Ekta Rani ◽

Sarita Nibhoria ◽

Bikramjit Singh ◽

Aradhana Singh Hada ◽

Parminderjeet Singh Sandhu

Keyword(s):

Smooth Muscle ◽

Case Report ◽

Tumor Cells ◽

Poor Prognosis ◽

Rare Case ◽

Smooth Muscle Actin ◽

Mesenchymal Tumor ◽

Muscle Actin ◽

Rare Case Report ◽

Rare Malignancy

Primary prostate sarcoma is a rare malignancy of the prostate with poor prognosis. It accounts for <1% of the tumors of the prostate. Leiomyosarcoma is the most common sarcoma involving the prostate in adults affecting men between the ages of 40 and 78 years. Tumor cells commonly express vimentin, smooth muscle actin and desmin, and up to 25% express cytokeratins.

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