scholarly journals Oral Malignant Melanoma: A Case Report

2021 ◽  
Vol 122 (3) ◽  
pp. 222-227
Author(s):  
Suman Sen ◽  
Sheuli Sen ◽  
M. Geetha Kumari ◽  
Sufia Khan ◽  
Subhasini Singh
Keyword(s):  
Malignant Melanoma ◽  
Poor Prognosis ◽  
Hard Palate ◽  
Middle Age ◽  
Early Recognition ◽  
Malignant Neoplasm ◽  
Pigmented Lesions ◽  
The Poor ◽  
Pigmented Lesion ◽  
Oral Malignant Melanoma

Melanoma is a malignant neoplasm of the epidermal melanocytes. Awareness and early recognition of pigmented lesion inside oral cavity helps in initial diagnosis and further investigation and treatment. Oral malignant melanoma is a rare aggressive neoplasm commonly seen among middle age. The diagnosis of melanoma initiates from the pre-existing pigmented lesions. The poor prognosis of oral melanomas requires that pigmented lesions of undetermined origin be routinely biopsied. A case of malignant melanoma of hard palate with its clinical, radiological and histopathological presentation along with brief review is presented. Prognosis of these lesion is poor with survival rate of 5 years.

scholarly journals Oral malignant melanoma: History of malignant degeneration of a pigmented lesion

2019 ◽  
Vol 25 (2) ◽  
pp. 19 ◽  
Author(s):  
Nour Mellouli ◽  
Samah Sioud ◽  
Maroua Garma ◽  
Abdellatif Chokri ◽  
Habib Hamdi ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Malignant Transformation ◽  
Oral Mucosa ◽  
Malignant Lesion ◽  
Final Diagnosis ◽  
Malignant Degeneration ◽  
Close Monitoring ◽  
Pigmented Lesions ◽  
Pigmented Lesion ◽  
Oral Malignant Melanoma

Introduction: Oral malignant melanoma (OMM) is a rare malignant lesion of the oral mucosa. It accounts for 0.5% of oral cavity cancers and less than 1% of all melanomas. Most cases arise on the palate or gingiva. OMM is caused by unknown factors. Benign pigmentation may precede the neoplasm by several years. The malignant transformation of benign melanosis is poorly understood. Observation: The aim of this work is to present a new clinical case of oral malignant melanoma which appeared on benign melanosis with a brief review of the literature. A 37-year-old woman presented with a blackish pigmented plaque that covered the hard palate and vestibular maxillary gingiva and a soft, friable 2 cm nodule with ulcerated surface next to the 11, 12 and 13. Fifteen years ago, the patient underwent a biopsy that was in favor of benign melanosis. Unfortunately, the patient was followed for one year and then was lost. Recently, in front of the rapidity of the extension of the lesion, she came again. After biopsy, a final diagnosis of OMM is retained. Commentaries: OMM is often asymptomatic. It presents usually as a 1.5–4 cm, blackish grey, irregular, flat or nodular lesion. The neoplasm can appear on apparently normal oral mucosa and may be preceded by benign pigmented lesions. Few articles discussed malignant transformation of benign melanosis. OMM is characterized by its poor prognosis. The treatment of choice for OMM remains surgery with wide clear margins. Conclusion: Close monitoring is needed to detect signs of transformation and to early diagnose melanoma.

scholarly journals Primary Malignant Melanoma of Maxilla: Report of a Case with Discussion

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
G. Shirisha Rani ◽  
T. Vinay Kumar ◽  
Balaram Kolasani ◽  
Md Rezwana Begum ◽  
Anu Priya Srinivasan
Keyword(s):  
Surgical Treatment ◽  
Malignant Melanoma ◽  
Oral Cavity ◽  
Head And Neck ◽  
Cutaneous Melanoma ◽  
Dental Clinic ◽  
Oral Melanoma ◽  
Pigmented Lesion ◽  
Oral Malignant Melanoma ◽  
Rule Out

Primary oral malignant melanoma, very rare neoplasm of melanocytic origin, usually presents as a bluish black to tan-brown colored lesion Which is accounting for 0.2 to 8% of all melanomas, 1.6% of all head and neck malignancies, and 0.5% of all oral neoplasia. In general, the prognosis of oral melanoma is poor and worse than that of cutaneous melanoma. Here a case of oral malignant melanoma is presented, which was undetected during the first visit to a dental clinic. When a simple oral surgical treatment was carried out in that region, it resulted in the appearance of a massive pigmented lesion which was histopathologically diagnosed as malignant melanoma. This paper is presented to reemphasize the fact that any pigmented lesion in the oral cavity should be viewed with suspicion and proper investigation (biopsy) should be carried out to rule out any untoward experiences later.

scholarly journals Pigmented Lesion of Buccal Mucosa

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Manas Bajpai ◽  
Malay Kumar ◽  
Manish Kumar ◽  
Deshant Agarwal
Keyword(s):  
Differential Diagnosis ◽  
Male Patient ◽  
Case History ◽  
Buccal Mucosa ◽  
Malignant Neoplasm ◽  
Aspiration Cytology ◽  
Pigmented Lesions ◽  
Pigmented Lesion ◽  
Laboratory Investigations

Pigmented lesions are commonly found in the mouth. Such lesions represent a variety of clinical entities, ranging from physiologic changes to manifestation of systemic illness and malignant neoplasm. Diagnosis of such lesions requires a proper case history, extraoral and intraoral examination, and, in some cases, biopsy, aspiration cytology, and laboratory investigations. Here we present a case of purple lesion on the buccal mucosa of a 34-year-old male patient which was provisionally diagnosed as mucocele but on the basis of histopathological picture it was finally diagnosed as angiofibroma, and we also discuss the clinical and histopathological differential diagnosis.

scholarly journals Malignant Melanoma in the Anterior Region of Maxillary Gingiva: A Rare Case Report

2015 ◽  
Vol 3 (4) ◽  
pp. 42-45
Author(s):  
Rajesh Twyana ◽  
Zhang Hong Yi ◽  
Jiang Wen ◽  
Saroj Kumar Suwal
Keyword(s):  
Malignant Melanoma ◽  
Poor Prognosis ◽  
Rare Case ◽  
Interesting Case ◽  
Review Of Literature ◽  
Great Tendency ◽  
Rare Case Report ◽  
Oral Malignant Melanoma ◽  
Oral Malignancies ◽  
Malignant Condition

Malignant melanoma is extremely rare neoplasm arising from uncontrolled growth of melanocytes, accounting for 0.5% of all oral malignancies. It has a great tendency to metastasize and locally invade tissues more readily than any other malignant tumor of the oral cavity. It present as the rare oral malignant condition, asymptomatic and poor prognosis. The necessity of a highly specialized treatment is factors that should be seriously considered by the involved health care provider. Herein, we report a rare and interesting case of oral malignant melanoma of the maxillary anterior gingiva, which was clinically and histo-pathologically diagnosed with a brief review of literature, has been discussed.

Electron Microscopy of Carcinomas of the Lung

1974 ◽  
Vol 32 ◽  
pp. 16-17
Author(s):  
B. Mackay ◽  
M. Mandavia ◽  
J. M. Lukeman ◽  
C. F. Mountain
Keyword(s):  
Electron Microscopy ◽  
Poor Prognosis ◽  
Light And Electron Microscopy ◽  
Malignant Neoplasm ◽  
Therapeutic Modalities ◽  
The Poor ◽  
Diagnosis And Classification ◽  
Methods Of Treatment ◽  
Insight Into

Carcinoma of the lung is the most common malignant neoplasm in males and the incidence continues to rise. The inadequacy of current methods of treatment is reflected in the poor prognosis: only 5% of patients survive for more than five years following diagnosis.In order to assess the effectiveness of new therapeutic modalities, accurate pathologic diagnosis is essential, and it is recognized that a proportion of these tumors can not be accurately classified by light microscopy alone. We have now studied over one hundred lung carcinomas with correlated light and electron microscopy, and our findings indicate that electron microscopy can be an invaluable aid in the diagnosis and classification of the tumors. Study of the fine structure of the tumor cells can provide the basis for a more precise classification than is currently used in clinical studies, and additionally give insight into problems of histogenesis.

scholarly journals Treatment of recurrent mucosal melanoma of the oral cavity with topical imiquimod and pembrolizumab achieves complete histopathologic remission

2021 ◽  
Vol 9 (10) ◽  
pp. e001219
Author(s):  
Tejus Satish ◽  
Shaheer Khan ◽  
Matt Levin ◽  
Richard Carvajal ◽  
Angela J Yoon
Keyword(s):  
Malignant Melanoma ◽  
Hard Palate ◽  
Mucosal Melanoma ◽  
Topical Imiquimod ◽  
Melanoma In Situ ◽  
Oral Melanoma ◽  
Pigmented Lesions ◽  
Adjuvant Temozolomide ◽  
Oral Mucosal Melanoma

Mucosal melanomas constitute a subtype of melanoma with less effective treatments than cutaneous melanomas. We present a case of oral mucosal melanoma that recurred despite multiple resections and adjuvant temozolomide. Treatment with topical imiquimod combined with pembrolizumab achieved remission. A 56-year-old woman presented with a pigmented mass on her left anterior hard palate. Biopsy revealed malignant melanoma. The patient had resection with neck dissection with 3 months of adjuvant temozolomide due to positive margins. Malignant melanoma involving the hard palate recurred 1 year later requiring additional resection. Two years later, two additional pigmented lesions were found; further resections were deferred due to expected morbidity. Following 6 weeks of topical imiquimod treatment, the lesions shrunk significantly. Adjuvant pembrolizumab was added and complete histopathologic remission was observed in 6 months. The patient remained in remission for 4 years before new melanoma in situ was diagnosed, requiring five additional months of imiquimod. As of April 2021, there is no clinical evidence of melanoma. There are limited reports of oral melanoma treated with topical imiquimod. Here, imiquimod administered in combination with pembrolizumab achieved complete pathologic response.

scholarly journals Oral manifestations of a sinus melanoma: case report and literature review

2019 ◽  
Vol 25 (4) ◽  
pp. 35
Author(s):  
Mélanie Le Donne ◽  
Anne-Gaëlle Bodard ◽  
Candice Lesage ◽  
Bertrand Fleury
Keyword(s):  
Case Report ◽  
Oral Mucosa ◽  
Poor Prognosis ◽  
Metastatic Progression ◽  
Pigmented Lesions ◽  
Pigmented Lesion ◽  
Rare Malignancy ◽  
Late Stages ◽  
Treatment Consensus ◽  
Melanoma Case

Introduction: Mucosal melanoma (MM) is a rare malignancy of the head and neck. Sinonasal melanomas are the most frequent, followed by oral melanomas. Observation: A 67-year-old patient with a known left sinus melanoma initially treated with immunotherapy was referred for consultation concerning mobile teeth. A pigmented lesion infiltrating the left maxillary arch in the molar area was detected. The malignancy had invaded the oral mucosa. Despite many proposed treatments (immunotherapy, chemotherapy, and radiotherapy), the patient showed metastatic progression, which resulted in death. Discussion: Sinus MMs are malignancies with poor prognosis because these are often diagnosed in the late stages of disease progression. As these tumors are rare, there is no treatment consensus and surgery remains the best option. Diagnosis of pigmented lesions of the oral mucosa is sometimes complicated because of various implied etiologies. Conclusion: This case report shows that sinus MMs can induce pigmentation in the oral mucosa. These are rare malignancies with poor prognosis, for which no treatment consensus exists to date.

scholarly journals Solitary Pigmented Melanocytic Lesion on the Palatal and Gingival Mucosa: Should It Rise Dentist’s Concerns?

2017 ◽  
Vol 1 ◽  
Author(s):  
Cut Mytha Fitriana ◽  
Yuniardini Septorini Wimardhani
Keyword(s):  
Oral Mucosa ◽  
Malignant Lesion ◽  
Melanocytic Lesion ◽  
Oral Mucosal Lesion ◽  
Pigmented Lesions ◽  
Pigmented Lesion ◽  
Dental Hospital ◽  
Oral Malignant Melanoma ◽  
Gingival Mucosa ◽  
The Right

<p class="AbstractContent"><strong>Background:</strong> Solitary pigmented melanocytic lesions of the oral mucosa are sometimes presented asymptomatically. Therefore, the patient does not realize their presence. To establish a diagnosis is challenging since there are similarities with other lesions. Once pigmented lesions on the oral mucosa are found, we need to do a proper diagnosis pathway to rule out the possibility of missing the detection of a malignant lesion. This report presents a case of pigmented oral mucosa located on the palatal and gingival mucosa that had to raise the suspicion to malignant pigmented lesion.</p><p class="AbstractContent"><strong>Case Report and Management:</strong> A 46-years-old female with an asymptomatic dark bluish hue at the right hard palate towards the soft palate with a purplish at the 48-retro molar pad area for ten years ago, until a family general dentist concerned about the lesion and made the referral to our Dental Hospital. Based on the history and clinical assessment of the lesion using a diagnostic pathway, a provisional diagnosis of oral malignant melanoma was made. The biopsy for histopathological evaluation was decided. However, some obstacles prevent the patient to do the procedure. The differences in the level of awareness about pigmented lesion in the oral mucosa of the dentists involve in this patient care complicated the process of diagnosis of the lesion.</p><p class="AbstractContent"><strong>Conclusion: </strong>The dentist’s awareness on the possibility of finding a nonbenign lesion in the oral cavity is needed. It is important for the dentist to make a diagnosis pathway when finding pigmented oral mucosal lesion.</p>

Immunohistochemical evaluation of suspected oral malignant melanoma in cats

2021 ◽  
pp. 030098582110257
Author(s):  
Kelly M. Saverino ◽  
Amy C. Durham ◽  
Matti Kiupel ◽  
Alexander M. Reiter
Keyword(s):  
Malignant Melanoma ◽  
Malignant Neoplasm ◽  
Malignant Neoplasms ◽  
Survival Times ◽  
Diagnostic Challenge ◽  
Positive Expression ◽  
Biopsy Report ◽  
Oral Neoplasms ◽  
Oral Malignant Melanoma ◽  
Variable Morphology

Oral malignant melanoma (OMM) is considered the third most common oral malignant neoplasm in cats, but its variable morphology and frequent lack of melanin pigment make it a diagnostic challenge. Twenty-two cases of cats with malignant oral neoplasms that were diagnosed as OMM or listed OMM as a suspected differential diagnosis on the biopsy report were examined using an immunohistochemistry (IHC) panel for S100, melan-A, PNL2, laminin, CD34, and pan-cytokeratin. Although OMM was suspected ( n = 14) or previously diagnosed ( n = 8), only 2 cases were immunohistochemically confirmed as OMM. Seven cases were classified as soft tissue sarcoma based on positive expression of CD34 or laminin, and one was classified as carcinoma based on positive expression of pan-cytokeratin. The majority of cases ( n = 12) were categorized as unclassified malignant neoplasms because they did not express melan-A, PNL2, laminin, CD34, or pan-cytokeratin; however, a proportion of these did express S100 ( n = 7). Long-term prognosis of all 22 cats was poor, with a median survival time of 87 days (range = 2–249 days). Cases with longer survival times (>100 days) were treated with surgery, radiation therapy, or a combination. For feline oral malignant neoplasms thought to be OMM, routine use of IHC is required for an accurate diagnosis.

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