scholarly journals Extramedullar plasmocytoma of the oral cavity

2020 ◽  
Vol 26 (4) ◽  
pp. 40
Author(s):  
Helen Olugbeje ◽  
Arthur Fourcade
Keyword(s):  
Multiple Myeloma ◽  
Differential Diagnosis ◽  
Oral Cavity ◽  
Histological Examination ◽  
Plasma Cell ◽  
Soft Tissues ◽  
Cell Disease ◽  
X Ray ◽  
The Right

Introduction: Extramedullar plasmocytoma (EMP) is a plasma cell disease, such as solitary plasmocytoma of the bone and multiple myeloma. It is developed in the soft tissues. Observation: A 79-year-old patient consulted for a painful tumefaction of the gum associated to a radiolucent area on the right side of the mandible on the panoramic x-ray. After surgical enucleation, histological examination showed that the diagnosis was either an IgA extramedullar plasmocytoma or a multiple myeloma. The spreading assessment eliminated the diagnosis of multiple myeloma. The patient was then treated with radiotherapy. Discussion: EMP is a rare tumoral disease. Few cases described oral localisation. The main differential diagnosis, that must be excluded is multiple myeloma. Transformation in multiple myeloma exists. The first intention treatment is radiotherapy of the lesion. Conclusion: EMP of the oral cavity is very rare. After treatment, follow-up is required to detect second localisation or progression in multiple myeloma.

Tooth Extraction Locally Stimulates Proliferation of Multiple Myeloma in a Patient with Mandibular Localizations

2017 ◽  
Vol 138 (4) ◽  
pp. 201-207 ◽  
Author(s):  
Jean-Daniel Kün-Darbois ◽  
Léonie Quenel ◽  
Smaïl Badja ◽  
Daniel Chappard
Keyword(s):  
Multiple Myeloma ◽  
Tooth Extraction ◽  
Soft Tissues ◽  
Plasma Cells ◽  
Osteonecrosis Of The Jaw ◽  
Surgical Trauma ◽  
Osteolytic Lesions ◽  
X Ray ◽  
Extraction Site ◽  
The Right

Objectives: Multiple myeloma (MM) is characterized by the occurrence of osteolytic lesions. MM treatment usually involves antiresorptive drugs (mainly bisphosphonates). Case Report: A patient with an MM presented osteolytic lesions of the mandible. Extraction of teeth 45 and 46 was performed 5 years after the diagnosis of periodontitis. Four months later, osteonecrosis of the jaw (ONJ) was diagnosed at the extraction site. X-ray showed an extension of osteolytic lesions on the right side, close to the extraction site, without modification of the lesions on the left side. Two months later, a curettage was performed because of a painful bone sequestration. X-ray showed an extension of the osteolytic lesions on the right side. Results: Histological analysis found a vascularized plasmacytoma of the soft tissues around the ONJ. Analysis of the bone showed mixed lesions with osteonecrotic areas and living bone resorbed by active osteoclasts surrounding a plasmacytoma. The surface area of the osteolytic foci has considerably increased only close to the extraction site. Conclusions: Tooth extraction triggered an ONJ associated with bisphosphonate treatment. However, it also seemed to induce a considerable proliferation of plasma cells at the extraction site; we hypothesize that it is due to the increase in bone remodeling related to the surgical trauma.

Metastatic Angiosarcoma Masquerading as Diffuse Pulmonary Hemorrhage

2001 ◽  
Vol 125 (12) ◽  
pp. 1562-1565
Author(s):  
Camilo Adem ◽  
Marie-Christine Aubry ◽  
Henry D. Tazelaar ◽  
Jeffrey L. Myers
Keyword(s):  
Differential Diagnosis ◽  
Soft Tissues ◽  
Pulmonary Hemorrhage ◽  
Additional Patient ◽  
Autopsy Examination ◽  
Vascular Channels ◽  
Clinical Considerations ◽  
The Right ◽  
Lost To Follow Up

Abstract Context.—Diffuse pulmonary hemorrhage is an uncommon presenting manifestation of angiosarcoma. Objective.—To review the clinical, radiologic, and pathologic findings of patients with metastatic angiosarcoma who presented with diffuse pulmonary hemorrhage. Design.—Patients fulfilling inclusion criteria were identified from the consultation files. Clinical and radiologic data were obtained from referring pathologists. Histologic slides were reviewed in all patients. Results.—Our patients included 6 men and 1 woman, aged 31 to 73 years; 4 patients were younger than 40 years. Six patients presented with hemoptysis, and all had diffuse abnormalities on radiographic studies. Clinical considerations prior to biopsy included pulmonary hemorrhage syndrome (n = 2), acute respiratory failure (n = 1), and infection (n = 1). Metastatic disease was included in the differential diagnosis in only 1 patient. None had a diagnosis of malignancy prior to lung biopsy. All biopsies showed hemorrhage associated with atypical epithelioid and spindle cells, forming anastomosing vascular channels, distributed along and within lymphatics and arteries. Neoplastic cells were immunoreactive for factor VIII–related protein or CD31 in all cases for which special stains were available. Three patients with complete follow-up died of their disease. Primary sites were discovered in all 3 patients who underwent autopsy examination. Two tumors arose in the heart and 1 in the pelvic soft tissues. One additional patient had a likely primary site identified in the right atrium by cardiac ultrasound and was subsequently lost to follow-up. Conclusion.—Angiosarcoma should be included in the differential diagnosis of diffuse pulmonary hemorrhage, especially in young adults.

scholarly journals Inflammatory Pseudotumor (Plasma Cell Granuloma) of the Temporal Bone

2010 ◽  
Vol 89 (7) ◽  
pp. E1-E13 ◽  
Author(s):  
Dare V. Ajibade ◽  
Iwao K. Tanaka ◽  
Kapila V. Paghda ◽  
Neena Mirani ◽  
Huey-Jen Lee ◽  
...  
Keyword(s):  
Temporal Bone ◽  
Plasma Cell ◽  
Inflammatory Pseudotumor ◽  
Soft Tissues ◽  
Plasma Cell Granuloma ◽  
Tissue Mass ◽  
Tegmen Tympani ◽  
The Right ◽  
Multiple Recurrences

We report the case of a 41-year-old man who presented with progressive right-sided ear pressure, otalgia, hearing loss, tinnitus, and intermittent otorrhea. Computed tomography and magnetic resonance imaging detected a soft-tissue mass in the right mastoid with intracranial invasion and erosion through the tegmen tympani and mastoid cortex. Histopathologic examination was consistent with an inflammatory pseudotumor (plasma cell granuloma). These lesions rarely occur in the temporal bone. When they do, they are locally destructive and can erode bone and soft tissues. Aggressive surgery is recommended as a first-line treatment, with adjunctive steroid or radiotherapy reserved for residual or refractory disease. Our patient subsequently experienced multiple recurrences, and his treatment required all of these modalities. At the most recent follow-up, he was disease-free and doing well.

scholarly journals Diagnóstico e tratamento do plasmocitoma solitário ósseo em mandíbula / Diagnosis and treatment of solitary bone plasmacytoma in mandible

2020 ◽  
Vol 65 (1) ◽  
pp. 1
Author(s):  
Dayane Mendonça dos Santos ◽  
Claudia Rebecca Costa Cavalcante Silva ◽  
Ney Morgado Vieira Filho ◽  
Luiz Felipe Lins de Sousa Santos ◽  
Valtuir Barbosa Felix
Keyword(s):  
Multiple Myeloma ◽  
Differential Diagnosis ◽  
Clinical Characteristics ◽  
Plasma Cells ◽  
Solitary Plasmacytoma ◽  
Plasma Cell Disorders ◽  
Accurate Treatment ◽  
Solitary Bone Plasmacytoma ◽  
The Right

Introdução: O plasmocitoma solitário pertence a um conjunto de desordens de células plasmáticas. É representado por uma massa lítica que pode ser encontrada nos ossos, sendo classificado como plasmocitoma solitário ósseo. O seu diagnóstico precoce é fundamental de modo a prevenir a progressão da doença para mieloma múltiplo. Relato de caso: Paciente do sexo feminino, de raça branca, com 81 anos, diagnosticada com plasmocitoma solitário ósseo em mandíbula à direita e tratada com radioterapia de 45Gy. Resultados: Dois anos após a conclusão do tratamento, a paciente continua em acompanhamento odontológico e hematológico, não demonstrando a evidência de transformação para mieloma múltiplo. Conclusão: Devido as características clínicas inespecíficas do plasmocitoma solitário ósseo, a correta utilização dos recursos atuais disponíveis para investigação da lesão possibilita um diagnóstico diferencial, assim como um acurado tratamento e uma proservação contínua da doença.Palavras Chave: Plasmócitos, Mandíbula, Mieloma múltiploABSTRACTIntroduction: Solitary plasmacytoma belongs to a set of plasma cell disorders. It is represented by a lytic mass that can be found in the bones, being classified as solitary bone plasmacytoma. Its precocious diagnosis is essential in order to prevent the progression of the disease for multiple myeloma. Case report: Female patient, Caucasian, 81 years old, diagnosed with solitary bone plasmacytoma in the right mandible and treated with 45Gy radiotherapy. Results: Two years after completion of treatment, the patient continues in dental and hematological follow-up, showing no evidence of transformation for multiple myeloma. Conclusion: Due the not specific clinical characteristics of solitary bone plasmacytoma, the correct use of available resources for investigation of injuries enables for a differential diagnosis, as well as an accurate treatment and a continuous disease preservation.Keywords: Plasma cells, Mandible, Multiple myeloma

The massive nodular cutaneous and soft tissues lesions of the right shoulder and the arm as the extramedullary manifestation of the advanced stage of multiple myeloma

Oncoreview ◽  
2017 ◽  
Vol 7 (4) ◽  
pp. 180-183
Author(s):  
Arkadiusz Drobiecki ◽  
Marcin Pasiarski ◽  
Agnieszka Stelmach-Gołdyś ◽  
Bartosz Garus
Keyword(s):  
Multiple Myeloma ◽  
Soft Tissues ◽  
Advanced Stage ◽  
The Right

Depth of response and minimal residual disease status in ultra high-risk multiple myeloma and plasma cell leukemia treated with daratumumab, bortezomib, lenalidomide, cyclophosphamide and dexamethasone (Dara-CVRd): Results of the UK optimum/MUKnine trial.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 8001-8001
Author(s):  
Martin F. Kaiser ◽  
Andrew Hall ◽  
Katrina Walker ◽  
Ruth De Tute ◽  
Sadie Roberts ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
High Risk ◽  
Minimal Residual Disease ◽  
Plasma Cell ◽  
Residual Disease ◽  
Cell Leukemia ◽  
Ultra High Risk ◽  
Grade 3 ◽  
Minimal Residual

8001 Background: Patients with ultra high-risk (UHiR) newly diagnosed multiple myeloma (NDMM) and patients with plasma cell leukemia (PCL) continue to have dismal outcomes and are underrepresented in clinical trials. Recently, improved responses with anti-CD38 monoclonal antibody combination therapy have been reported for NDMM patients. We report here outcomes for NDMM UHiR and PCL patients treated in the OPTIMUM/MUKnine (NCT03188172) trial with daratumumab, cyclophosphamide, bortezomib, lenalidomide, dexamethasone (Dara-CVRd) induction, augmented high-dose melphalan (HDMEL) and ASCT. With final analysis follow-up surpassed in Feb 2021, we report here early protocol defined endpoints from induction to day 100 post ASCT. Methods: Between Sep 2017 and Jul 2019, 107 patients with UHiR NDMM by central trial genetic (≥2 high risk lesions: t(4;14), t(14;16), t(14;20), gain(1q), del(1p), del(17p)) or gene expression SKY92 (SkylineDx) profiling, or with PCL (circulating plasmablasts > 20%) were included in OPTIMUM across 39 UK hospitals. Patients received up to 6 cycles of Dara-CVRd induction, HDMEL and ASCT augmented with bortezomib, followed by Dara-VR(d) consolidation for 18 cycles and Dara-R maintenance. Primary trial endpoints are minimal residual disease (MRD) status post ASCT and progression-free survival. Secondary endpoints include response, safety and quality of life. Data is complete but subject to further data cleaning prior to conference. Results: Median follow-up for the 107 patients in the safety population was 22.2 months (95% CI: 20.6 – 23.9). Two patients died during induction due to infection. Bone marrow aspirates suitable for MRD assessment by flow cytometry (10-5 sensitivity) were available for 81% of patients at end of induction and 78% at D100 post ASCT. Responses in the intention to treat population at end of induction were 94% ORR with 22% CR, 58% VGPR, 15% PR, 1% PD, 5% timepoint not reached (TNR; withdrew, became ineligible or died) and at D100 post ASCT 83% ORR with 47% CR, 32% VGPR, 5% PR, 7% PD, 10% TNR. MRD status was 41% MRDneg, 40% MRDpos and 19% not evaluable post induction and 64% MRDneg, 14% MRDpos and 22% not evaluable at D100 post ASCT. Responses at D100 post ASCT were lower in PCL with 22% CR, 22% VGPR, 22% PR, 22% PD, 12% TNR. Most frequent grade 3/4 AEs during induction were neutropenia (21%), thrombocytopenia (12%) and infection (12%). Grade 3 neuropathy rate was 3.7%. Conclusions: This is to our knowledge the first report on a trial for UHiR NDMM and PCL investigating Dara-CVRd induction and augmented ASCT. Response rates were high in this difficult-to-treat patient population, with toxicity comparable to other induction regimens. However, some early progressions highlight the need for innovative approaches to UHiR NDMM. Clinical trial information: NCT03188172.

scholarly journals Pulsatile Midline Solitary Plasmacytoma in the Frontal Head Region-A Case Report”

2016 ◽  
Vol 32 (1) ◽  
pp. 39-42
Author(s):  
Md Atikur Rahman ◽  
Aklaque Hossain Khan ◽  
Kanak Kanti Barua
Keyword(s):  
Multiple Myeloma ◽  
Differential Diagnosis ◽  
Case Report ◽  
Histological Examination ◽  
Plasma Cells ◽  
Extramedullary Plasmacytoma ◽  
Solitary Plasmacytoma ◽  
Rare Entity ◽  
Head Region ◽  
Malignant Plasma Cell

Primary craniocerebral plasmacytomas are uncommon and represent only 0.7 % of all plasmacytomas. In this case solitary plasmacytoma in the midline frontal head region of the skull and discuss the clinical features and prognosis of this tumor. Plasmacytoma can present as multiple myeloma, solitary plasmacytoma of the bone or extramedullary plasmacytoma. Solitary plasmacytoma is a rare entity that composes of malignant plasma cells and involves the bone to form only one or two lesions without evidence of disease dissemination. It accounts for only 4% of malignant plasma cell tumors. 50 years old male was suffering from plasmacytoma in the frontal head region in our case which is pulsatile. On images showed multiple differential diagnosis but after operation histological examination revealed plasmacytoma. Bangladesh Journal of Neuroscience 2016; Vol. 32 (1): 39-42

scholarly journals A Conservative Approach to a Peripheral Ameloblastoma

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Rocco Borrello ◽  
Elia Bettio ◽  
Christian Bacci ◽  
Marialuisa Valente ◽  
Stefano Sivolella ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Soft Tissues ◽  
Complete Removal ◽  
The Other ◽  
Conservative Approach ◽  
Choice Of Treatment ◽  
Long Term Follow Up ◽  
One Year

Peripheral Ameloblastoma (PA) is the rarest variant of ameloblastoma. It differs from the other subtypes of ameloblastoma in its localization: it arises in the soft tissues of the oral cavity coating the tooth bearing bones. Generally, it manifests nonaggressive behavior and it can be treated with complete removal by local conservative excision. In this study we report a case of PA of the maxilla in a 78-year-old female patient and we describe the four different histopathological patterns revealed by histological examination. After local excision and diagnosis, we planned a long term follow-up: in one year no recurrence had been reported. The choice of treatment is illustrated in Discussion.

Primary Plasmacytoma of the Breast

2001 ◽  
Vol 125 (8) ◽  
pp. 1078-1080 ◽  
Author(s):  
Annarosaria De Chiara ◽  
Simona Losito ◽  
Luigi Terracciano ◽  
Raimondo Di Giacomo ◽  
Giancarla Iaccarino ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Differential Diagnosis ◽  
Correct Diagnosis ◽  
Extramedullary Plasmacytoma ◽  
Frozen Sections ◽  
Solitary Extramedullary Plasmacytoma ◽  
Extramedullary Plasmacytomas

Abstract We describe a solitary extramedullary plasmacytoma of the breast in a 37-year-old woman. No other involvement was detected in the bone marrow or in any other site during a 15-month follow-up period. Extramedullary plasmacytomas of the breast are extremely rare, especially those that are not associated with multiple myeloma. We review the histologic features of the previously reported cases with an emphasis on differential diagnosis and the difficulties encountered in arriving at the correct diagnosis in frozen sections.

Serum Alpha Fetal Protein in a Three Year Old Child with Hepatoma

1976 ◽  
Vol 62 (4) ◽  
pp. 407-414 ◽  
Author(s):  
Yehuda Shoenfeld ◽  
Albert I. Pick ◽  
Sarah Schreibman ◽  
Helena Kessler ◽  
Moshe Dintzman
Keyword(s):  
Hepatocellular Carcinoma ◽  
Differential Diagnosis ◽  
Surgical Procedure ◽  
Tumor Recurrence ◽  
Clinical Laboratory ◽  
Sharp Decrease ◽  
Normal Serum ◽  
Primary Hepatocellular Carcinoma ◽  
X Ray

A 3 year old child with primary hepatocellular carcinoma and high AFP concentrations is described. Following hemihepatectomy, a sharp decrease and return to normal of serum AFP concentrations indicated the completeness of the surgical procedure. Repeat-normal serum AFP concentrations (less than 19 ng/ml), found during a three year follow-up, correlated well with the absence of clinical, laboratory and x-ray evidence of tumor recurrence. The differential diagnosis of abnormal AFP concentrations in childhood is discussed, and the importance of the AFP assay in the follow-up of post-hemihepatectomy patients for the assessment of the completeness of the surgical procedure, the prognosis, and the early detection of tumor recurrence is stressed.

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